Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition

Chemico-Biological Interactions

Volumn 190, Issue 1, 2011, Pages 9-15

  Yang, Eun Sun ^a   Choi, Min Jung ^a   Kim, Jin Hee ^a   Choi, Kyeong Sook ^b   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

Apoptosis; Bcl 2; Radiation; Reactive oxygen species; Withaferin A

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; WITHAFERIN A;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; KIDNEY CANCER; PROTEIN CLEAVAGE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; RADIOSENSITIZATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; G1 PHASE; HUMANS; PLANTS, MEDICINAL; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; WITHANIA; WITHANOLIDES;

WITHANIA SOMNIFERA;

EID: 79952701908     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.01.015     Document Type: Article

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