메뉴 건너뛰기




Volumn 171, Issue 7, 2003, Pages 3863-3871

Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; DEXAMETHASONE; INTERLEUKIN 6; JANUS KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 0141955061     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.7.3863     Document Type: Article
Times cited : (483)

References (73)
  • 1
    • 0031985198 scopus 로고    scopus 로고
    • Multiple myeloma: Increasing evidence for a multistep transformation process
    • Hallek, M., P. L. Bergsagel, and K. C. Anderson. 1998. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 91:3.
    • (1998) Blood , vol.91 , pp. 3
    • Hallek, M.1    Bergsagel, P.L.2    Anderson, K.C.3
  • 2
    • 0035675491 scopus 로고    scopus 로고
    • Diagnosis and management of multiple myeloma
    • UK myeloma forum. British Committee for Standards in Haemotology. 2001. Diagnosis and management of multiple myeloma. Br. J. Haematol. 115:522.
    • (2001) Br. J. Haematol. , vol.115 , pp. 522
  • 3
    • 85039627481 scopus 로고
    • Report
    • National Cancer Institute, Bethesda
    • Anonymous. 1992. Report. In 1973-1989 Annual Cancer Statistics Review. National Cancer Institute, Bethesda.
    • (1992) 1973-1989 Annual Cancer Statistics Review
  • 4
    • 0033121314 scopus 로고    scopus 로고
    • Role of NF-κB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2
    • Feinman, R., J. Koury, M. Thames, B. Barlogie, J. Epstein, and D. S. Siegel. 1999. Role of NF-κB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2. Blood 93:3044.
    • (1999) Blood , vol.93 , pp. 3044
    • Feinman, R.1    Koury, J.2    Thames, M.3    Barlogie, B.4    Epstein, J.5    Siegel, D.S.6
  • 6
    • 0028921477 scopus 로고
    • Interleukin-6 in human multiple myeloma
    • Klein, B., X. G. Zhang, Z. Y. Lu, and R. Bataille. 1995. Interleukin-6 in human multiple myeloma. Blood 85:863.
    • (1995) Blood , vol.85 , pp. 863
    • Klein, B.1    Zhang, X.G.2    Lu, Z.Y.3    Bataille, R.4
  • 7
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell, J. E., Jr. 1997. STATs and gene regulation. Science 277:1630.
    • (1997) Science , vol.277 , pp. 1630
    • Darnell J.E., Jr.1
  • 8
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga, T., and T. Kishimoto. 1997. Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15:797.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 797
    • Taga, T.1    Kishimoto, T.2
  • 10
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    • Turkson, J., T. Bowman, R. Garcia, E. Caldenhoven, R. P. De Groot, and R. Jove. 1998. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol. Cell Biol. 18:2545.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 2545
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhoven, E.4    De Groot, R.P.5    Jove, R.6
  • 11
    • 0031800697 scopus 로고    scopus 로고
    • Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
    • Garcia, R., and R. Jove. 1998. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. J. Biomed. Sci. 5:79.
    • (1998) J. Biomed. Sci. , vol.5 , pp. 79
    • Garcia, R.1    Jove, R.2
  • 13
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt, R. M., C. Egen, J. Wehinger, W. Ludwig, V. Gouilleux-Gruart, R. Mertelsmann, and J. Finke. 1996. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88:809.
    • (1996) Blood , vol.88 , pp. 809
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3    Ludwig, W.4    Gouilleux-Gruart, V.5    Mertelsmann, R.6    Finke, J.7
  • 19
    • 0029794419 scopus 로고    scopus 로고
    • Upregulated expression of BCL-2 in multiple myeloma cells induced by exposure to doxorubicin, etoposide, and hydrogen peroxide
    • Tu, Y., F. H. Xu, J. Liu, R. Vescio, J. Berenson, C. Fady, and A. Lichtenstein. 1996. Upregulated expression of BCL-2 in multiple myeloma cells induced by exposure to doxorubicin, etoposide, and hydrogen peroxide. Blood 88:1805.
    • (1996) Blood , vol.88 , pp. 1805
    • Tu, Y.1    Xu, F.H.2    Liu, J.3    Vescio, R.4    Berenson, J.5    Fady, C.6    Lichtenstein, A.7
  • 20
    • 0037305821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
    • Bharti, A. C., N. Donato, S. Singh, and B. B. Aggarwal. 2003. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101:1053.
    • (2003) Blood , vol.101 , pp. 1053
    • Bharti, A.C.1    Donato, N.2    Singh, S.3    Aggarwal, B.B.4
  • 22
    • 0037069939 scopus 로고    scopus 로고
    • Circumin-induced suppression of cell proliferation correlates with downregulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation
    • Mukhopadhyay, A., S. Banerjee, L. J. Stafford, X. Xia Chunzhi, M. Liu, and B. B. Aggarwal. Circumin-induced suppression of cell proliferation correlates with downregulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 21:8852.
    • Oncogene , vol.21 , pp. 8852
    • Mukhopadhyay, A.1    Banerjee, S.2    Stafford, L.J.3    Xia Chunzhi, X.4    Liu, M.5    Aggarwal, B.B.6
  • 23
    • 0030912739 scopus 로고    scopus 로고
    • Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes
    • Fujio, Y., K. Kunisada. H. Hirota, K. Yamauchi-Takihara, and T. Kishimoto. 1997. Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes. J. Clin. Invest. 99:2898.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2898
    • Fujio, Y.1    Kunisada, K.2    Hirota, H.3    Yamauchi-Takihara, K.4    Kishimoto, T.5
  • 25
    • 0014863885 scopus 로고
    • Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient
    • Nilsson, K., H. Bennich, S. G. Johansson, and J. Ponten. 1970. Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient. Clin. Exp. Immunol. 7:477.
    • (1970) Clin. Exp. Immunol. , vol.7 , pp. 477
    • Nilsson, K.1    Bennich, H.2    Johansson, S.G.3    Ponten, J.4
  • 27
    • 0026502886 scopus 로고
    • A mechanism of resistance to glucocorticoids in multiple myeloma: Transient expression of a truncated glucocorticoid receptor mRNA
    • Moalli, P. A., S. Pillay, D. Weiner, R. Leikin, and S. T. Rosen. 1992. A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA. Blood 79:213.
    • (1992) Blood , vol.79 , pp. 213
    • Moalli, P.A.1    Pillay, S.2    Weiner, D.3    Leikin, R.4    Rosen, S.T.5
  • 28
    • 0032557458 scopus 로고    scopus 로고
    • Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1
    • Manna, S. K., H. J. Zhang, T, Yan, L. W. Oberley, and B. B. Aggarwal. 1998. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1. J. Biol. Chem. 273:13245.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13245
    • Manna, S.K.1    Zhang, H.J.2    Yan, T.3    Oberley, L.W.4    Aggarwal, B.B.5
  • 31
    • 0026062164 scopus 로고
    • Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266
    • Schwab, G., C. B. Siegall, L. A. Aarden, L. M. Neckers, and R. P. Nordan. 1991. Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266. Blood 77:587.
    • (1991) Blood , vol.77 , pp. 587
    • Schwab, G.1    Siegall, C.B.2    Aarden, L.A.3    Neckers, L.M.4    Nordan, R.P.5
  • 32
    • 0027980663 scopus 로고
    • TNF and IL-6 are potent growth factors for OH-2, a novel human myeloma cell line
    • Borset, M., A. Waage, O. L. Brekke, and E. Helseth. 1994. TNF and IL-6 are potent growth factors for OH-2, a novel human myeloma cell line. Eur. J. Haematol. 53:31.
    • (1994) Eur. J. Haematol. , vol.53 , pp. 31
    • Borset, M.1    Waage, A.2    Brekke, O.L.3    Helseth, E.4
  • 33
    • 0025274112 scopus 로고
    • Autocrine growth by two cytokines, interleukin-6 and tumor necrosis factor α, in the myeloma cell line KHM-IA
    • Hata, H., H. Matsuzaki, and K. Takatsuki. 1990. Autocrine growth by two cytokines, interleukin-6 and tumor necrosis factor α, in the myeloma cell line KHM-IA. Acta Haematol. 83:133.
    • (1990) Acta Haematol. , vol.83 , pp. 133
    • Hata, H.1    Matsuzaki, H.2    Takatsuki, K.3
  • 34
    • 0024557081 scopus 로고
    • Spontaneous secretion of tumor necrosis factor-β by human myeloma cell lines
    • Bataille, R., B. Klein, M. Jourdan, J. F. Rossi, and B. G. Durie. 1989. Spontaneous secretion of tumor necrosis factor-β by human myeloma cell lines. Cancer 63:877.
    • (1989) Cancer , vol.63 , pp. 877
    • Bataille, R.1    Klein, B.2    Jourdan, M.3    Rossi, J.F.4    Durie, B.G.5
  • 37
    • 0032521284 scopus 로고    scopus 로고
    • Induction of Jak/STAT signaling by activation of the type 1 TNF receptor
    • Guo, D., J. D. Dunbar, C. H. Yang, L. M. Pfeffer, and D. B. Donner. 1998. Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J. Immunol. 160:2742.
    • (1998) J. Immunol. , vol.160 , pp. 2742
    • Guo, D.1    Dunbar, J.D.2    Yang, C.H.3    Pfeffer, L.M.4    Donner, D.B.5
  • 38
    • 0028920301 scopus 로고
    • Effect of IL-6 receptor antisense oligodeoxynucleotide on in vitro proliferation of myeloma cells
    • Keller, E. T., and W. B. Ershler. 1995. Effect of IL-6 receptor antisense oligodeoxynucleotide on in vitro proliferation of myeloma cells. J. Immunol. 154:4091.
    • (1995) J. Immunol. , vol.154 , pp. 4091
    • Keller, E.T.1    Ershler, W.B.2
  • 39
    • 0037097660 scopus 로고    scopus 로고
    • Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes
    • Natarajan, C., and J. J. Bright. 2002. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J. Immunol. 168:6506.
    • (2002) J. Immunol. , vol.168 , pp. 6506
    • Natarajan, C.1    Bright, J.J.2
  • 40
    • 0035284754 scopus 로고    scopus 로고
    • Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway
    • Li, W. Q., F. Dehnade, and M. Zafarullah. 2001. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J. Immunol. 166: 3491.
    • (2001) J. Immunol. , vol.166 , pp. 3491
    • Li, W.Q.1    Dehnade, F.2    Zafarullah, M.3
  • 41
    • 0037015683 scopus 로고    scopus 로고
    • IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells
    • Kopantzev, Y., M. Heller, N. Swaminathan, and S. Rudikoff. 2002. IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells. Oncogene 21:6791.
    • (2002) Oncogene , vol.21 , pp. 6791
    • Kopantzev, Y.1    Heller, M.2    Swaminathan, N.3    Rudikoff, S.4
  • 42
    • 0037160057 scopus 로고    scopus 로고
    • Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain
    • Schreiner, S. J., A. P. Schiavone, and T. E. Smithgall. 2002. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J. Biol. Chem. 277:45680.
    • (2002) J. Biol. Chem. , vol.277 , pp. 45680
    • Schreiner, S.J.1    Schiavone, A.P.2    Smithgall, T.E.3
  • 43
    • 0037064121 scopus 로고    scopus 로고
    • ErbB-2 activates Stat3 α in a Src- and JAK2-dependent manner
    • Ren, Z., and T. S. Schaefer. 2002. ErbB-2 activates Stat3 α in a Src- and JAK2-dependent manner. J. Biol. Chem. 277:38486.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38486
    • Ren, Z.1    Schaefer, T.S.2
  • 44
    • 85047699293 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
    • Zamo, A., R. Chiarle, R. Piva, J. Howes, Y. Fan, M. Chilosi, D. E. Levy, and G. Inghirami. 2002. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene 21:1038.
    • (2002) Oncogene , vol.21 , pp. 1038
    • Zamo, A.1    Chiarle, R.2    Piva, R.3    Howes, J.4    Fan, Y.5    Chilosi, M.6    Levy, D.E.7    Inghirami, G.8
  • 45
    • 0035799531 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
    • Garcia, R., T. L. Bowman, G. Niu, H. Yu, S. Minton, C. A. Muro-Cacho, C. E. Cox, R. Falcone, R. Fairclough, S. Parsons, et al. 2001. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 20:2499.
    • (2001) Oncogene , vol.20 , pp. 2499
    • Garcia, R.1    Bowman, T.L.2    Niu, G.3    Yu, H.4    Minton, S.5    Muro-Cacho, C.A.6    Cox, C.E.7    Falcone, R.8    Fairclough, R.9    Parsons, S.10
  • 48
    • 0034690026 scopus 로고    scopus 로고
    • Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity
    • Wang, Y. Z., W. Wharton, R. Garcia, A. Kraker, R. Jove, and W. J. Pledger. 2000. Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity. Oncogene 19:2075.
    • (2000) Oncogene , vol.19 , pp. 2075
    • Wang, Y.Z.1    Wharton, W.2    Garcia, R.3    Kraker, A.4    Jove, R.5    Pledger, W.J.6
  • 49
    • 0033588229 scopus 로고    scopus 로고
    • Protein kinase Cδ associates with and phosphorylates Stat3 in an interleukin-6-dependent manner
    • Jain, N., T. Zhang, W. H. Kee, W. Li, and X. Cao. 1999. Protein kinase Cδ associates with and phosphorylates Stat3 in an interleukin-6-dependent manner. J. Biol. Chem. 274:24392.
    • (1999) J. Biol. Chem. , vol.274 , pp. 24392
    • Jain, N.1    Zhang, T.2    Kee, W.H.3    Li, W.4    Cao, X.5
  • 50
    • 0033522985 scopus 로고    scopus 로고
    • Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase: Resultant effects on cell proliferation
    • Sellers, L. A., W. Feniuk, P. P. Humphrey, and H. Lauder. 1999. Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase: resultant effects on cell proliferation. J. Biol. Chem. 274:16423.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16423
    • Sellers, L.A.1    Feniuk, W.2    Humphrey, P.P.3    Lauder, H.4
  • 51
    • 0031742128 scopus 로고    scopus 로고
    • Activation of Stat3 by v-Src is through a Ras-independent pathway
    • Liu, J. J., K. Nakajima, T. Hirano, and H. F. Yang-Yen. 1998. Activation of Stat3 by v-Src is through a Ras-independent pathway. J. Biomed. Sci. 5:446.
    • (1998) J. Biomed. Sci. , vol.5 , pp. 446
    • Liu, J.J.1    Nakajima, K.2    Hirano, T.3    Yang-Yen, H.F.4
  • 52
    • 0032479519 scopus 로고    scopus 로고
    • c-Fes tyrosine kinase binds to and activates STAT3 after granulocyte-macrophage colony-stimulating factor stimulation
    • Park, W. Y., J. H. Ahn, R. A. Feldman, and J. S. Seo. 1998. c-Fes tyrosine kinase binds to and activates STAT3 after granulocyte-macrophage colony-stimulating factor stimulation. Cancer Lett. 129:29.
    • (1998) Cancer Lett. , vol.129 , pp. 29
    • Park, W.Y.1    Ahn, J.H.2    Feldman, R.A.3    Seo, J.S.4
  • 53
    • 0032473935 scopus 로고    scopus 로고
    • Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation
    • Chaturvedi, P., M. V. Reddy, and E. P. Reddy. 1998. Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. Oncogene 16:1749.
    • (1998) Oncogene , vol.16 , pp. 1749
    • Chaturvedi, P.1    Reddy, M.V.2    Reddy, E.P.3
  • 54
    • 0030447148 scopus 로고    scopus 로고
    • In vitro activation of Stat3 by epidermal growth factor receptor kinase
    • Park, O. K., T. S. Schaefer, and D. Nathans. 1996. In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc. Natl. Acad. Sci. USA 93:13704.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13704
    • Park, O.K.1    Schaefer, T.S.2    Nathans, D.3
  • 56
    • 0033861096 scopus 로고    scopus 로고
    • JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells
    • De Vos, J., M. Jourdan, K. Tarte, C. Jasmin, and B. Klein. 2000. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br. J. Haematol. 109:823.
    • (2000) Br. J. Haematol. , vol.109 , pp. 823
    • De Vos, J.1    Jourdan, M.2    Tarte, K.3    Jasmin, C.4    Klein, B.5
  • 57
    • 0028220931 scopus 로고
    • Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase
    • Reddy, S., and B. B. Aggarwal. 1994. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett. 341:19.
    • (1994) FEBS Lett. , vol.341 , pp. 19
    • Reddy, S.1    Aggarwal, B.B.2
  • 59
    • 0028556758 scopus 로고
    • Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells
    • Korutla, L., and R. Kumar. 1994. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim. Biophys. Acta 1224:597.
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 597
    • Korutla, L.1    Kumar, R.2
  • 60
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu, C. L., D. J. Meyer, G. S. Campbell, A. C. Larner, C. Carter-Su, J. Schwartz, and R. Jove. 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81.
    • (1995) Science , vol.269 , pp. 81
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6    Jove, R.7
  • 63
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
    • Takeda, K., T. Kaisho, N. Yoshida, J. Takeda, T. Kishimoto, and S. Akira. 1998. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161:4652.
    • (1998) J. Immunol. , vol.161 , pp. 4652
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 64
    • 0035852765 scopus 로고    scopus 로고
    • Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
    • Shen, Y., G. Devgan, J. E. Darnell, Jr., and J. F. Bromberg. 2001. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc. Natl. Acad. Sci. USA 98:1543.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1543
    • Shen, Y.1    Devgan, G.2    Darnell J.E., Jr.3    Bromberg, J.F.4
  • 65
    • 0034658499 scopus 로고    scopus 로고
    • STAT signaling in head and neck cancer
    • Song, J. I., and J. R. Grandis. 2000. STAT signaling in head and neck cancer. Oncogene 19:2489.
    • (2000) Oncogene , vol.19 , pp. 2489
    • Song, J.I.1    Grandis, J.R.2
  • 66
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa, H., K. Matsubara, G. S. Qian, P. Jackson, J. D. Groopman, J. E. Manning, C. C. Harris, and J. G. Herman. 2001. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. 28:29.
    • (2001) Nat. Genet. , vol.28 , pp. 29
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.S.3    Jackson, P.4    Groopman, J.D.5    Manning, J.E.6    Harris, C.C.7    Herman, J.G.8
  • 68
    • 0038784365 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
    • Galm, O., H. Yoshikawa, M. Esteller, R. Osieka, and J. G. Herman. 2003. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 101:2784.
    • (2003) Blood , vol.101 , pp. 2784
    • Galm, O.1    Yoshikawa, H.2    Esteller, M.3    Osieka, R.4    Herman, J.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.