Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines

Clinical Cancer Research

Volumn 5, Issue 9, 1999, Pages 2580-2587

  Kurdoglu, Belma ^a   Cheong, Nge ^a   Guan, Jun ^a   Corn, Benjamin W ^a   Curran Jr , Walter J ^a   Iliakis, George ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PACLITAXEL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER RADIOTHERAPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROTUBULE; PREDICTION; PRIORITY JOURNAL; RADIOSENSITIZATION;

NON-PROGRAMMATIC;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; GROWTH INHIBITORS; HELA CELLS; HT29 CELLS; HUMANS; MALE; NEOPLASMS; PACLITAXEL; PREDICTIVE VALUE OF TESTS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 0032862087     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Holmes, F. A. Paclitaxel combination therapy in the treatment of metastatic breast cancer: a review. Semin. Oncol., 23: 46-56, 1996.
2. Legha, S. S., Ring, S., Papadopoulos, N., Raber, M., and Benjamin R. S. A phase II trial of Taxol in metastatic melanoma. Cancer (Phila.), 65: 2478-2481, 1989.
3. Seewaldt, V. L., Greer, B. E., Cain, J. M., Figge, D. C., Tamimi, H. K., Brown, W. S., and Miller, S. A. Paclitaxel (Taxol) treatment for refractory ovarian cancer: Phase II clinical trial. Am. J. Obstet. Gynecol., 770: 1666-1671, 1994.
4. Thigpen, T., Vance, R., Khansur, T., and Malamud, F. The role of paclitaxel in the management of patients with carcinoma of the cervix. Semin. Oncol., 24: S2-S46, 1997.
5. Ettinger, D. S. Single-agent paclitaxel in the treatment of small cell lung cancer. Semin. Oncol., 23: 16-17, 1996.
6. Schiff, P. B., Fant, J., and Horwitz, S. B. Promotion of microtubule assembly in vitro by Taxol. Nature (Lond.), 277: 665-667, 1979.
7. Schiff, P. B., and Horwitz, S. B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA, 77: 1561-1565, 1980.
8. Parness, J., and Horwitz, S. B. Taxol binds to polymerized tubulin in vitro. J. Cell Biol., 91: 479-487, 1981.
9. Kumar, N. Taxol-induced polymerization of purified tubulin. J. Biol. Chem., 256: 10435-10441, 1981.
10. Wilson, L., Miller, H. P., Farrell, K. W., Synder, K. B., Thompson, W. C., and Purich, D. L. Taxol stabilization of microtubules in vitro: dynamics of tubulin addition and loss at opposite microtubule ends. Biochemistry, 24: 5254-5262, 1985.
11. Hamel, E., del Campo, A. A., Lowe, M. C., and Lin, C. M. Interactions of taxol, microtubule-associated proteins, and guanine nucleotides in tubulin polymerization. J. Biol. Chem., 256: 11887-11894, 1981.
12. Jordan, M. A., Toso, R. J., Thrower, D., and Wilson, L. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations. Proc. Natl. Acad. Sci. USA, 90: 9552-9556, 1993.
13. 1 Phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Res., 54: 4355-4361, 1994.
14. Rowinsky, E. K., and Donehower, R. C. Paclitaxel (Taxol). N. Engl. J. Med., 332: 1004-1014, 1995.
15. Diaz, J. F., and Andreu, J. M. Assembly of purified GDP-tubulin into microtubules induced by Taxol and Taxotere: reversibility, ligand stoichiometry, and competition. Biochemistry, 32: 2747-2755, 1993.
16. Schiff, P. B., and Horwitz, S. B. Taxol assembles tubulin in the absence of exogenous guanosine 5′-triphosphate or microtubule-associated proteins. Biochemistry, 20: 3248-3252, 1981.
17. Terasima, T., and Tolmach, L. J. X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells. Science (Washington DC), 140: 490-492, 1963.
18. Sinclair, W. K., and Morton, R. A. X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat. Res., 29: 450-474, 1966.
19. Leonard, C. E., Chan, D. C., Chou, CT-C., Kumar, R., and Bunn, P. A. Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neck. Cancer Res., 56: 5198-5204, 1996.
20. Tishler, R. B., Geard, C. R., Jall, E. J., and Schiff, B. Taxol sensitizes human astrocytoma cells to radiation. Cancer Res., 52: 3495-3497, 1992.
21. Geard, C. R., Jones, J. M., and Schiff, P. B. Taxol and Radiation. J. Natl. Cancer Inst. Monogr., 15: 89-94, 1993.
22. Gupta, N., Hu, L. J., and Deen, D. F. Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent and in combination with ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys., 37: 885-895, 1997.
23. Choy, H., Rodriguez, F. F., Koester, S., Hilsenbeck, S., and Von Hoff, D. D. Investigation of Taxol as a potential radiation sensitizer. Cancer (Phila.), 71: 3774-37781, 1993.
24. Liebmann, J., Cook, J. A., Fisher, J., Teague, D., and Mitchell, J. B. In vitro studies of Taxol as a radiation sensitizer in human tumor cells. J. Natl. Cancer Inst., 86: 441-446, 1994.
25. Steren, A., Sevin, B-U., Perras, J., Angioli, R., Nguyen, H., Guerra, L., Koechli, O., and Averette, H. E. Taxol sensitizes human ovarian cancer cells to radiation. Gynecol. Oncol., 48: 252-258, 1993.
26. Rodriguez, M., Sevin, B. U., Perras, J., Nguyen, H. N., Pham, C., Steren, A. J., Kocchli, O. R., and Averette, H. E. Paclitaxel. A radiation sensitizer of human cervical cancer cells. Gynecol. Oncol., 57: 165-169, 1995.
27. Lokeshwar, B. L., Ferrell, S. M., and Block, N. L. Enhancement of radiation response of prostatic carcinoma by Taxol: therapeutic potential for late-stage malignancy. Anticancer Res., 15: 93-98, 1995.
28. Geard, C. R., and Jones, J. M. Radiation and Taxol effects on synchronized human cervical carcinoma cells. Int. J. Radiat. Oncol. Biol. Phys., 29: 565-569, 1994.
29. Minarik, L., and Hall, E. J. Taxol in combination with acute and low dose rate irradiation. Radiother. Oncol., 32: 124-128, 1994.
30. Ingram, M. L., and Redpath, J. L. Subadditive interaction of radiation and Taxol in vitro. Int. J. Radiat. Oncol. Biol. Phys., 37: 1139-1144, 1997.
31. Stromberg, J. S., Lee, Y. J., Armour, E. P., Martinez, A. A., and Corry, P. M. Lack of radiosensitization after paclitaxel treatment of three human carcinoma cell lines. Cancer (Phila.), 75: 2262-2268, 1995.
32. van Rijn, J., van den Berg, J., and Meijer, O. W. M. Proliferation and clonal survival of human lung cancer cells treated with fractionated irradiation in combination with paclitaxel. Int. J. Radiat. Oncol. Biol. Phys., 33: 635-639, 1995.
33. Waterman, M. J. F., Waterman, J. L. F., and Halazonetis, T. D. An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants. Cancer Res., 56: 158-163, 1996.
34. Jordan, M. A., Wendall, K., Gardiner, S., Derry, W. B., Copp, H., and Wilson, L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res., 56: 816-825, 1996.
35. Donaldson, K. L., Goolsby, G. L., Kierner, P. A., and Wahl, A. F. Activation of p34cdc2 coincident with Taxol-induced apoptosis. Cell Growth Differ., 5: 1041-1050, 1994.
36. Liebmann, J., Cook, J. A., Fisher, J., Teague, D., and Mitchell, J. B. Changes in radiation survival curve parameters in human tumor and rodent cells exposed to paclitaxel (Taxol). Int. J. Radiat. Oncol. Biol. Phys., 29: 559-564, 1994.
37. Wahl, A. F., Donaldson, K. L., Fairchild, C., Lee, F. Y. F., Foster, S. A., Demers, G. W., and Galloway, D. A. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nature Med., 2: 72-79, 1996.
38. Lanni, J. S., Lowe, S. W., Licitra, E. J., Liu, J. O., and Jacks, T. p53-independent apoptosis induced by paclitaxel through an indirect mechanism. Proc. Natl. Acad. Sci. USA, 94: 9679-9683, 1997.
39. Saito, Y., Milross, C. G., Hittelman, W. N., Li, D., Jibu, T., Peters, L. J., and Milas, L. Effect of radiation and paclitaxel on p53 expression in murine tumors sensitive or resistant to apoptosis induction. Int. J. Radiat. Oncol. Biol. Phys., 38: 623-631, 1997.
40. Hawkins, D. S., Demers, G. W., and Galloway, D. A. Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents. Cancer Res., 56: 892-898, 1996.
41. Debernardis, D., Siré, E. G., De Feudis, P., Vikhanskaya, F., Valenti, M., Russo, P., Parodi, S., D'Inclaci, M., and Broggini. M. p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel. Cancer Res., 57: 870-874, 1997.
42. Strobel, T., Swanson, L., Korsmeyer, S., and Cannistra, S. A. BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc. Natl. Acad. Sci. USA, 93: 14094-14099, 1996.
43. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
44. Fisher, D. E. Apoptosis in cancer therapy. Crossing the threshold. Cell, 78: 539-542, 1994.
45. Blagosklonny, M. V., Schulte, T. W., Nguyen, P., Mimnaugh, E. G., Trepel, J., and Neckers, L. Taxol induction of p21WAF1 and p53 requires c-raf-1. Cancer Res., 55: 4623-4626, 1995.
46. Haldar, S., Jena, N., and Croce, C. Inactivation of Bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. USA, 92: 4507-4511, 1995.
47. Haldar, S., Chintapalli, J., and Croce, C. M. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res., 56: 1253-1255, 1996.
48. Haldar, S., Basu, A., and Croce, C. M. Bcl2 is the guardian of microtubule integrity. Cancer Res., 57: 229-233, 1997.
49. Poruchynsky, M. S., Wang, E. E., Rudin, C. M., Blagosklonny, M. V., and Fojo, T. Bcl-xL is phosphorylated in malignant cells following microtubule disruption. Cancer Res., 58: 3331-3338, 1998.
50. Blagosklonny, M. V., Schulte, T., Nguyen, P., Trepel, J., and Neckers, L. M. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res., 56: 1851-1854, 1996.
51. Torres, K., and Horwitz, S. B. Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res., 58: 3620-3626, 1998.
52. Wu, G. S., and El-Deiry, W. S. Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2. Clin. Cancer Res., 2: 623-633, 1996.
53. Milas, L., Hunter, N. R., Mason, K. A., Kurdoglu, B., and Peters, L. J. Enhancement of tumor radioresponse of a murine mammary carcinoma by paclitaxel. Cancer Res., 54: 3506-3510, 1994.
54. Milas, L., Hunter, N. R., Mason, K. A., Milross, C. G., Saito, Y., and Peters, L. Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res., 55: 3564-3568, 1995.
55. Milross, C. G., Mason, K. A., Hunter, N. R., Chung, W-K., Peters, L. J., and Milas, L. Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel. J. Natl. Cancer Inst., 88: 1308-1314, 1996.
56. Mason, K. A., Hunter, N. R., Milas, M., Abbruzzese, J. L., and Milas, L. Docetaxel enhances tumor radioresponse in vivo. Clin. Cancer Res., 3: 2431-2438, 1997.