-
1
-
-
0032900953
-
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
-
Ambudkar S., Dey S., Hrycyna C.A., Ramachandra M., Pastan I., Gottesman M.M. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999, 39:361-398.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 361-398
-
-
Ambudkar, S.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Pastan, I.5
Gottesman, M.M.6
-
2
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
Szakács G., Paterson J.K., Ludwig J.A., Booth-Genthe C., Gottesman M.M. Targeting multidrug resistance in cancer. Nat Rev Drug Discov 2005, 5:219-234.
-
(2005)
Nat Rev Drug Discov
, vol.5
, pp. 219-234
-
-
Szakács, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
3
-
-
79953804775
-
ABC proteins protect the human body and maintain optimal health
-
Ueda K. ABC proteins protect the human body and maintain optimal health. Biosci Biotechnol Biochem 2011, 75:401-409.
-
(2011)
Biosci Biotechnol Biochem
, vol.75
, pp. 401-409
-
-
Ueda, K.1
-
4
-
-
0022923890
-
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein
-
Ueda K., Cornwell M.M., Gottesman M.M., Pastan I., Roninson I.B., Ling V., et al. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun 1986, 141:956-962.
-
(1986)
Biochem Biophys Res Commun
, vol.141
, pp. 956-962
-
-
Ueda, K.1
Cornwell, M.M.2
Gottesman, M.M.3
Pastan, I.4
Roninson, I.B.5
Ling, V.6
-
5
-
-
4344602767
-
Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells
-
Kitagawa S., Nabekura T., Kamiyama S. Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells. J Pharm Pharmacol 2004, 56:1001-1005.
-
(2004)
J Pharm Pharmacol
, vol.56
, pp. 1001-1005
-
-
Kitagawa, S.1
Nabekura, T.2
Kamiyama, S.3
-
6
-
-
28744436977
-
Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
-
Kitagawa S., Nabekura T., Takahashi T., Nakamura Y., Sakamoto H., Tano H., et al. Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol Pharm Bull 2005, 28:2274-2278.
-
(2005)
Biol Pharm Bull
, vol.28
, pp. 2274-2278
-
-
Kitagawa, S.1
Nabekura, T.2
Takahashi, T.3
Nakamura, Y.4
Sakamoto, H.5
Tano, H.6
-
7
-
-
11844301652
-
Effects of dietary chemopreventive phytochemicals on P-glycoprotein function
-
Nabekura T., Kamiyama S., Kitagawa S. Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. Biochem Biophys Res Commun 2005, 327:866-870.
-
(2005)
Biochem Biophys Res Commun
, vol.327
, pp. 866-870
-
-
Nabekura, T.1
Kamiyama, S.2
Kitagawa, S.3
-
8
-
-
49749143424
-
Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
-
Nabekura T., Yamaki T., Ueno K., Kitagawa S. Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. Cancer Chemother Pharmacol 2008, 62:867-873.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 867-873
-
-
Nabekura, T.1
Yamaki, T.2
Ueno, K.3
Kitagawa, S.4
-
9
-
-
40849083469
-
Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1
-
Nabekura T., Yamaki T., Ueno K., Kitagawa S. Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1. Biochem Biophys Res Commun 2008, 369:363-368.
-
(2008)
Biochem Biophys Res Commun
, vol.369
, pp. 363-368
-
-
Nabekura, T.1
Yamaki, T.2
Ueno, K.3
Kitagawa, S.4
-
10
-
-
55949090550
-
Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1
-
Nabekura T., Yamaki T., Kitagawa S. Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1. Eur J Pharmacol 2008, 600:45-49.
-
(2008)
Eur J Pharmacol
, vol.600
, pp. 45-49
-
-
Nabekura, T.1
Yamaki, T.2
Kitagawa, S.3
-
11
-
-
33745298519
-
Nuclear factor-κB in cancer development and progression
-
Karin M. Nuclear factor-κB in cancer development and progression. Nature 2006, 441:431-436.
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
12
-
-
33846685017
-
NF-κB activation in development and progression of cancer
-
Inoue J., Gohda J., Akiyama T., Semba K. NF-κB activation in development and progression of cancer. Cancer Sci 2007, 98:268-274.
-
(2007)
Cancer Sci
, vol.98
, pp. 268-274
-
-
Inoue, J.1
Gohda, J.2
Akiyama, T.3
Semba, K.4
-
13
-
-
84856641109
-
NF-κB, the first quarter-century: remarkable progress and outstanding questions
-
Hayden M.S., Ghosh S. NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 2012, 26:203-234.
-
(2012)
Genes Dev
, vol.26
, pp. 203-234
-
-
Hayden, M.S.1
Ghosh, S.2
-
14
-
-
0142166328
-
Cancer chemoprevention with dietary phytochemicals
-
Surh Y.-J. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003, 3:768-780.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 768-780
-
-
Surh, Y.-J.1
-
15
-
-
33646028804
-
Molecular targets of dietary agents for prevention and therapy of cancer
-
Aggarwal B.B., Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006, 71:1397-1421.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1397-1421
-
-
Aggarwal, B.B.1
Shishodia, S.2
-
16
-
-
56249132710
-
Potential of spice-derived phytochemicals for cancer prevention
-
Aggarwal B.B., Kunnumakkara A.B., Harikumar K.B., Tharakan S.T., Sung B., Anand P. Potential of spice-derived phytochemicals for cancer prevention. Planta Med 2008, 74:1560-1569.
-
(2008)
Planta Med
, vol.74
, pp. 1560-1569
-
-
Aggarwal, B.B.1
Kunnumakkara, A.B.2
Harikumar, K.B.3
Tharakan, S.T.4
Sung, B.5
Anand, P.6
-
17
-
-
0027217026
-
Functional expression of human P-glycoprotein in Schizosaccaromycespombe
-
Ueda K., Shimabuku A.M., Konishi H., Fujii Y., Takabe S., Nishi K., et al. Functional expression of human P-glycoprotein in Schizosaccaromycespombe. FEBS Lett 1993, 330:279-282.
-
(1993)
FEBS Lett
, vol.330
, pp. 279-282
-
-
Ueda, K.1
Shimabuku, A.M.2
Konishi, H.3
Fujii, Y.4
Takabe, S.5
Nishi, K.6
-
18
-
-
0026722467
-
Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase
-
Sarkadi B., Price E.M., Boucher R.C., Germann U.A., Scarborough G.A. Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. J Biol Chem 1992, 267:4854-4858.
-
(1992)
J Biol Chem
, vol.267
, pp. 4854-4858
-
-
Sarkadi, B.1
Price, E.M.2
Boucher, R.C.3
Germann, U.A.4
Scarborough, G.A.5
-
19
-
-
0029810902
-
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB
-
Natarajan K., Singh S., Burke T.R., Grunberger D., Aggarwal B.B. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc Natl Acad Sci USA 1996, 93:9090-9095.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9090-9095
-
-
Natarajan, K.1
Singh, S.2
Burke, T.R.3
Grunberger, D.4
Aggarwal, B.B.5
-
20
-
-
70349337442
-
Licochalcone A potently inhibits tumor necrosis factor a-induced nuclear factor-κB activation through the direct inhibition of IκB kinase complex activation
-
Funakoshi-Tago M., Tanabe S., Tago K., Itoh H., Mashino T., Sonoda Y., et al. Licochalcone A potently inhibits tumor necrosis factor a-induced nuclear factor-κB activation through the direct inhibition of IκB kinase complex activation. Mol Pharmacol 2009, 76:745-753.
-
(2009)
Mol Pharmacol
, vol.76
, pp. 745-753
-
-
Funakoshi-Tago, M.1
Tanabe, S.2
Tago, K.3
Itoh, H.4
Mashino, T.5
Sonoda, Y.6
-
21
-
-
46749127067
-
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBa kinase, leading to potentiation of apoptosis
-
Sung B., Pandey M.K., Ahn K.S., Yi T., Chaturvedi M.M., Liu M., et al. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBa kinase, leading to potentiation of apoptosis. Blood 2008, 111:4880-4891.
-
(2008)
Blood
, vol.111
, pp. 4880-4891
-
-
Sung, B.1
Pandey, M.K.2
Ahn, K.S.3
Yi, T.4
Chaturvedi, M.M.5
Liu, M.6
-
22
-
-
33750008443
-
Inhibition of NF-κB activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid
-
Lee J.H., Koo T.H., Yoon H., Jung H.S., Jin H.Z., Lee K., et al. Inhibition of NF-κB activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem Pharmacol 2006, 72:1311-1321.
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1311-1321
-
-
Lee, J.H.1
Koo, T.H.2
Yoon, H.3
Jung, H.S.4
Jin, H.Z.5
Lee, K.6
-
23
-
-
61949193344
-
Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB-regulated gene products and potentiation of apoptosis in leukemia cells
-
Harikumar K.B., Kunnumakkara A.B., Ahn K.S., Anand P., Krishnan S., Guha S., et al. Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood 2009, 113:2003-2013.
-
(2009)
Blood
, vol.113
, pp. 2003-2013
-
-
Harikumar, K.B.1
Kunnumakkara, A.B.2
Ahn, K.S.3
Anand, P.4
Krishnan, S.5
Guha, S.6
-
24
-
-
33749321904
-
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway
-
Ahn K.S., Sethi G., Shishodia S., Sung B., Arbiser J.L., Aggarwal B.B. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol Cancer Res 2006, 4:621-633.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 621-633
-
-
Ahn, K.S.1
Sethi, G.2
Shishodia, S.3
Sung, B.4
Arbiser, J.L.5
Aggarwal, B.B.6
-
25
-
-
3142676732
-
Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice
-
Saleem M., Afaq F., Adhami V.M., Mukhtar H. Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene 2004, 23:5203-5214.
-
(2004)
Oncogene
, vol.23
, pp. 5203-5214
-
-
Saleem, M.1
Afaq, F.2
Adhami, V.M.3
Mukhtar, H.4
-
26
-
-
33847094161
-
Mechanisms underlying the inhibitory actions of the pentacyclic triterpene α-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate
-
Medeiros R., Otuki M.F., Avellar M.C., Calixto J.B. Mechanisms underlying the inhibitory actions of the pentacyclic triterpene α-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol 2007, 559:227-235.
-
(2007)
Eur J Pharmacol
, vol.559
, pp. 227-235
-
-
Medeiros, R.1
Otuki, M.F.2
Avellar, M.C.3
Calixto, J.B.4
-
27
-
-
81255158024
-
Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B
-
Huang L., Guan T., Qian Y., Huang M., Tang X., Li Y., et al. Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B. Eur J Pharmacol 2011, 672:169-174.
-
(2011)
Eur J Pharmacol
, vol.672
, pp. 169-174
-
-
Huang, L.1
Guan, T.2
Qian, Y.3
Huang, M.4
Tang, X.5
Li, Y.6
-
28
-
-
33947530134
-
Withaferin A strongly elicits IκB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity
-
Kaileh M., Vanden Berghe W., Heyerick A., Horion J., Piette J., Libert C., et al. Withaferin A strongly elicits IκB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem 2007, 282:4253-4264.
-
(2007)
J Biol Chem
, vol.282
, pp. 4253-4264
-
-
Kaileh, M.1
Vanden Berghe, W.2
Heyerick, A.3
Horion, J.4
Piette, J.5
Libert, C.6
-
29
-
-
46449138184
-
Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-κB signaling
-
Jiang J., Grieb B., Thyagarajan A., Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-κB signaling. Int J Mol Med 2008, 21:577-584.
-
(2008)
Int J Mol Med
, vol.21
, pp. 577-584
-
-
Jiang, J.1
Grieb, B.2
Thyagarajan, A.3
Sliva, D.4
-
30
-
-
34547125342
-
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)- κB and NF-κB-regulated gene expression through direct inhibition of IκBα kinase β on cysteine 179 residue
-
Pandey M.K., Sandur S.K., Sung B., Sethi G., Kunnumakkara A.B., Aggarwal B.B. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)- κB and NF-κB-regulated gene expression through direct inhibition of IκBα kinase β on cysteine 179 residue. J Biol Chem 2007, 282:17340-17350.
-
(2007)
J Biol Chem
, vol.282
, pp. 17340-17350
-
-
Pandey, M.K.1
Sandur, S.K.2
Sung, B.3
Sethi, G.4
Kunnumakkara, A.B.5
Aggarwal, B.B.6
-
31
-
-
27144512700
-
Zerumbone abolishes NF-κB and IκBα kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
-
Takada Y., Murakami A., Aggarwal B.B. Zerumbone abolishes NF-κB and IκBα kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 2005, 24:6957-6969.
-
(2005)
Oncogene
, vol.24
, pp. 6957-6969
-
-
Takada, Y.1
Murakami, A.2
Aggarwal, B.B.3
-
32
-
-
50349098189
-
Targeting nuclear factor-κB activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis
-
Sethi G., Ahn K.S., Aggarwal B.B. Targeting nuclear factor-κB activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res 2008, 6:1059-1070.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1059-1070
-
-
Sethi, G.1
Ahn, K.S.2
Aggarwal, B.B.3
-
33
-
-
15444356379
-
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-κB activation, IκB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells
-
Kumar A., Dhawan S., Aggarwal B.B. Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-κB activation, IκB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene 1998, 17:913-918.
-
(1998)
Oncogene
, vol.17
, pp. 913-918
-
-
Kumar, A.1
Dhawan, S.2
Aggarwal, B.B.3
-
34
-
-
77956196134
-
Down-regulation of MMP-2 through the p38 MAPK-NF-κB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion
-
Lin M.L., Lu Y.C., Chung J.G., Wang S.G., Lin H.T., Kang S.E., et al. Down-regulation of MMP-2 through the p38 MAPK-NF-κB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion. Mol Carcinog 2010, 49:783-797.
-
(2010)
Mol Carcinog
, vol.49
, pp. 783-797
-
-
Lin, M.L.1
Lu, Y.C.2
Chung, J.G.3
Wang, S.G.4
Lin, H.T.5
Kang, S.E.6
-
35
-
-
0034622079
-
Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-κB, AP-1, JNK, MAPKK and apoptosis
-
Chainy G.B., Manna S.K., Chaturvedi M.M., Aggarwal B.B. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-κB, AP-1, JNK, MAPKK and apoptosis. Oncogene 2000, 19:2943-2950.
-
(2000)
Oncogene
, vol.19
, pp. 2943-2950
-
-
Chainy, G.B.1
Manna, S.K.2
Chaturvedi, M.M.3
Aggarwal, B.B.4
-
36
-
-
0345688182
-
Transcriptional regulation of ABC drug transporters
-
Scotto K.W. Transcriptional regulation of ABC drug transporters. Oncogene 2003, 22:7496-7511.
-
(2003)
Oncogene
, vol.22
, pp. 7496-7511
-
-
Scotto, K.W.1
-
37
-
-
0035921734
-
Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance
-
Um J.H., Kang C.D., Lee B.G., Kim D.W., Chung B.S., Kim S.H. Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance. Oncogene 2001, 20:6048-6056.
-
(2001)
Oncogene
, vol.20
, pp. 6048-6056
-
-
Um, J.H.1
Kang, C.D.2
Lee, B.G.3
Kim, D.W.4
Chung, B.S.5
Kim, S.H.6
-
38
-
-
0037150228
-
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling
-
Kuo M.T., Liu Z., Wei Y., Lin-Lee Y.C., Tatebe S., Mills G.B., et al. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling. Oncogene 2002, 21:1945-1954.
-
(2002)
Oncogene
, vol.21
, pp. 1945-1954
-
-
Kuo, M.T.1
Liu, Z.2
Wei, Y.3
Lin-Lee, Y.C.4
Tatebe, S.5
Mills, G.B.6
-
39
-
-
2642537787
-
Effect of tumor necrosis factor-a and interferon-y on intestinal P-glycoprotein expression, activity, and localization in Caco-2 cells
-
Belliard A.M., Lacour B., Farinotti R., Leroy C. Effect of tumor necrosis factor-a and interferon-y on intestinal P-glycoprotein expression, activity, and localization in Caco-2 cells. J Pharm Sci 2004, 93:1523-1536.
-
(2004)
J Pharm Sci
, vol.93
, pp. 1523-1536
-
-
Belliard, A.M.1
Lacour, B.2
Farinotti, R.3
Leroy, C.4
-
40
-
-
0242322421
-
Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT-PCR and cDNA microarrays
-
Lee G., Piquette-Miller M. Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT-PCR and cDNA microarrays. J Pharm Sci 2003, 92:2152-2163.
-
(2003)
J Pharm Sci
, vol.92
, pp. 2152-2163
-
-
Lee, G.1
Piquette-Miller, M.2
-
41
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A., Eichelbaum M., Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001, 276:14581-14587.
-
(2001)
J Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
|