Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

Cancer Letters

Volumn 177, Issue 1, 2002, Pages 89-93

  Ikegawa, Tomomi ^a   Ohtani, Hisakazu ^a   Koyabu, Noriko ^a   Juichi, Motoharu ^b   Iwase, Yukiko ^b   Ito, Chihiro ^c   Furukawa, Hiroshi ^c   Naito, Mikihiko ^d   Tsuruo, Takashi ^d   Sawada, Yasufumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^c MEIJO UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Flavonoid derivatives; Multidrug resistance; P glycoprotein; Vincristine

Indexed keywords

3,3',4',5,7 PENTAETHOXYFLAVONE; ANTINEOPLASTIC AGENT; CYCLOSPORIN A; DOXORUBICIN; FLAVONE DERIVATIVE; GLYCOPROTEIN P; MORIN; MORIN PENTAALLYL ETHER; MORIN PENTABUTYL ETHER; MORIN PENTAETHYL ETHER; MORIN PENTAPROPYL ETHER; PENTAMETHOXYMORIN; PENTAMETHOXYQUERCETIN; QUERCETIN; QUERCETIN DERIVATIVE; QUERCETIN PENTAALLYL ETHER; QUERCETIN PENTABUTYL ETHER; QUERCETIN PENTAPROPYL ETHER; TRITIUM; UNCLASSIFIED DRUG; VERAPAMIL; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CELL STRAIN K 562; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG UPTAKE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MULTIDRUG RESISTANCE; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FLAVONOIDS; HUMANS; K562 CELLS; P-GLYCOPROTEINS; QUERCETIN; VINCRISTINE;

EID: 18244403795     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00761-3     Document Type: Article

References (11)

1. Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo
2. Reduced permeability in CHO cells as a mechanism of resistance to colchicine
3. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines
4. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
5. Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance
6. Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4
7. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein, but not cytochrome P450 3A4
8. Inhibition of P-glycoprotein by orange juice components in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells
9. Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors
10. Potentiation of the reversal activity of SDZ PSC833 on multi-drug resistance by anti-glycoprotein monoclonal antibody MRK-16
11. Protein measurement with the Forin phenol reagent