Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice

Chemico-Biological Interactions

Volumn 170, Issue 1, 2007, Pages 49-58

  Parihar, Vipan Kumar ^a   Dhawan, Jatin ^a   Kumar, Suryakant ^a   Manjula, S N ^a   Subramanian, G ^a   Unnikrishnan, M K ^a   Rao, C Mallikarjuna ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

Antioxidant enzymes; Dehydrozingerone; Free radicals; Jejunum; Micronuclei; Radioprotection; Spleen index

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS (3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); BENZOTHIAZOLINE DERIVATIVE; DEHYDROZINGERONE; FERRIC ION; FERROUS ION; GLUTATHIONE; GLUTATHIONE TRANSFERASE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENAZINE METHOSULFATE; RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SCAVENGER; SULFONIC ACID DERIVATIVE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BASEMENT MEMBRANE; BONE MARROW; CELL FREE SYSTEM; CELL PROLIFERATION; CELL REGENERATION; COLONY FORMING UNIT; CONTROLLED STUDY; CRYPT CELL; ERYTHROCYTE; GAMMA IRRADIATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM; LETHAL DOSE; MEMBRANE DAMAGE; MITOSIS; MORTALITY; MOUSE; NONHUMAN; PH; RADIATION EXPOSURE; RADIATION PROTECTION; REDUCTION; SPLEEN; SURVIVAL TIME; WHOLE BODY RADIATION;

ANIMALS; BENZOTHIAZOLES; CATALASE; FREE RADICAL SCAVENGERS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; JEJUNUM; MICE; MICRONUCLEUS TESTS; NITRIC OXIDE; PHENETHYLAMINES; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; STYRENES; SULFONIC ACIDS; SUPEROXIDES; SURVIVAL ANALYSIS; WHOLE-BODY IRRADIATION;

MUS;

EID: 34548570431     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.07.006     Document Type: Article

References (41)

1. Greaves M. Cancer: The Evolutionary Legacy (2000), Oxford University Press, Oxford
2. Conklin K.A. Dietary polyunsaturated fatty acids: impact on cancer chemotherapy and radiation. Altern. Med. Rev. 7 (2002) 4-21
3. Weiss J.E., and Landauer M.R. Radioprotection by antioxidants. Ann. N. Y. Acad. Sci. 899 (2000) 44-60
4. Rajakumar D.V., and Rao M.N. Dehydrozingerone and isoeugenol as inhibitors of lipid peroxidation and as free radical scavengers. Biochem. Pharmacol. 46 (1993) 2067-2072
5. Motohashi N., Ashihara Y., Yamagami C., and Saito Y. Antimutagenic effects of dehydrozingerone and its analogs on UV-induced mutagenesis in Escherichia coli. Mutat. Res. 377 (1997) 17-25
6. Rajakumar D.V., and Rao M.A. Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates. Mol. Cell. Biochem. 140 (1994) 73-79
7. Elias G., and Rao M.N. Inhibition of albumin denaturation and anti-inflammatory activity of dehydrozingerone and its analogs. Indian J. Exp. Biol. 26 (1988) 540-542
8. Kuo C., Damu A.G., Cherng C.Y., Jeng J.F., Teng C.M., Lee E.J., and Wu T.S. Isolation of a natural antioxidant, dehydrozingerone from Zingiber officinale and synthesis of its analogues for recognition of effective antioxidant and antityrosinase agents. Arch. Pharm. Res. 28 (2005) 518-528
9. Satyamitra M., Uma Devi P., Murase H., and Stomas Kagiya V. In vivo radioprotection by α-TMG: preliminary studies. Mutat. Res. 479 (2001) 53-61
10. Uma Devi P., Ganasoundari A., Rao B.S.S., and Srinivasan K.K. In vivo radioprotection by ocimum flavanoids: survival of mice. Radiat. Res. 151 (1996) 74-78
11. Samarth R.M., Saini M.R., Maharwal J., Dhaka A., and Kumar A. Mentha (Linn) leaf extract provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice. Indian J. Exp. Biol. 40 (2002) 1245-1249
12. Uma Devi P., and Prasanna P.G.S. Comparative radioprotection of mouse hemopoietic study by some thiols and a polysaccharide. Proc. Natl. Acad. Sci. Lett. 65B (1995) 89-92
13. Lowry O.H., Rosenhrough N.J., Farr A.L., and Rand A. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193 (1951) 265-267
14. Moran M.A., De P.J.W., and Mannervick B. Levels of glutathione, glutathione reductase, glutathione-S-transferase activities in rat liver. Biochem. Biophys. Acta 582 (1979) 67-68
15. Aebi H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-126
16. Misra H.P., and Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247 (1972) 3170-3175
17. Miao L.H. Measurement of protein thiol and glutathione in plasma. Methods Enzymol. 233 (1994) 380-385
18. Jakoby W.B. Glutathione transverses: as overview. Methods Enzymol. 113 (1985) 495-499
19. Konings A.W.T., and Driver E.B. Radiation effects on membranes. I. Vitamin E deficiency and lipid peroxidation. Radiat. Res. 80 (1979) 494-501
20. Sudheer M.K., Unnikrishnan M.K., and Devi P.U. Effect of 5-aminosalicylic acid on radiation-induced micronuclei in mouse bone marrow. Mutat. Res. 527 (2003) 7-14
21. Sreejayan N., and Rao M.N.A. Free radical scavenging activity of curcumoinoids. Arzneim.-Forsch/Drug Res. 46 (1996) 169-171
22. Kunchandy E., and Rao M.N.A. Effect of curcumin on hydroxyl radical generation through Fenton reaction. Int. J. Pharm. 57 (1987) 237-240
23. Picker S.D., and Fridovich I. One the mechanism of production of superoxide radical by reaction mixtures containing NAD, phenazine methosulfate, and nitroblue tetrazolium. Arch. Biochem. Biophys. 228 (1984) 155-158
24. Sreejayan N., and Rao M.N. Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49 (1997) 105-107
25. Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence. Lancet 344 (1994) 721-724
26. Umegaku K., Aoki S., and Esashi T. Whole body irradiation to mice decreases ascorbic acid concentrations in bone marrow: comparison with vitamin E. Free Radic. Biol. Med. 19 (1995) 493-497
27. Jagetia G.C., and Baliga M.S. Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study. Phytomedicine 12 (2005) 209-215
28. Uma Devi P., Ganasoundari A., Vrinda B., Srinivasan K.K., and Unnikrishnan M.K. Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. Radiat. Res. 154 (2000) 455-460
29. Ramakrishnan N.N., Wolfe W.W., and Catravas G.N. Radioprotection of hematopoietic tissues in mice by lipoic acid. Radiat. Res. 130 (1992) 360-365
30. Sun J., Chen Y., Li M., and Ge Z. Role of antioxidant enzymes on ionizing radiation resistance. Free Radic. Biol. Med. 24 (1998) 586-593
31. Parihar V.K., Prabhakar K.R., Veerapur V.P., Kumar M.S., Reddy Y.R., Joshi R., Unnikrishnan M.K., and Mallikarjuna Rao C. Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. Mutat. Res. 611 (2006) 9-16
32. Wang W., and Ballatoria N. Endogenous glutathione conjugates: occurrence and biological functions. Pharmacol. Rev. 50 (1998) 335-356
33. Parihar V.K., Prabhakar K.R., Veerapur V.P., Priyadarsini K.I., Unnikrishnan M.K., and Mallikarjuna Rao C. Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Eur. J. Pharmacol. 557 (2007) 58-65
34. Prabhakar K.R., Veerapur V.P., Parihar V.K., Priyadarsini K.I., Rao B.S.S., and Unnikrishnan M.K. Evaluation and optimization of radioprotective activity of Coronopus didymus Linn. in gamma-irradiated mice. Int. J. Radiat. Biol. 82 (2006) 525-536
35. Baliga M.S., Jagetia G.C., Venkatesh P., Reddy R., and Ulloor J.N. Radiprotective effect of abana, a polyherbal drug following total body irradiation. Br. J. Radiol. 77 (2004) 1027-1035
36. Abraham S.K., Sarma L., and Kesavan P.C. Protective effects of chlorogenic acid, curcumin and beta-caroteneagainst gamma-radiation-induced in vivo chromosomal damage. Mutat. Res. 303 (1993) 109-112
37. Prabhakar K.R., Veerapur V.P., Bansal P., Parihar V.K., Reddy Kandadi M., Bhagath Kumar P., Priyadarsini K.I., and Unnikrishnan M.K. Antioxidant and radioprotective effect of the active fraction of Pilea microphylla (L.) ethanolic extract. Chem. Biol. Interact. 165 (2007) 22-32
38. Agarwal O.P., and Nagaratnam A. Radioprotective property of flavonoids in mice. Toxicon 19 (1981) 201-204
39. Uma Devi P., and Sharma A.S.K.V.S. Mouse bonemarrow response to low doses of whole-body gamma irradiation: induction of micronuclei. Int. J. Radiat. Biol. 57 (1990) 97-101
40. Chaubey R.C., Bhilwade H.N., Joshi B.N., and Chauhan P.S. Studies on the migration of micronucleated erythrocytes frombone marrow to the peripheral blood in irradiated Swiss mice. Int. J. Radiat. Biol. 63 (1993) 239-245
41. Sasaki M.S., and Matsubara S. Free radical scavenging in protection of human lymphocytes against chromosome aberration formation by gamma-ray irradiation. Int. J. Radiat. Biol. 32 (1977) 439-445