Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

PLoS Genetics

Volumn 12, Issue 2, 2016, Pages

  Keith, Scott A ^a   Maddux, Sarah K ^b   Zhong, Yayu ^b   Chinchankar, Meghna N ^b   Ferguson, Annabel A ^a   Ghazi, Arjumand ^c   Fisher, Alfred L ^b,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEASOME; RPN 10 PROTEN; TRANSCRIPTION FACTOR ELT 2; TRANSCRIPTION FACTOR SKN 1; UBIQUITIN; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DNA BINDING PROTEIN; ELT-2 PROTEIN, C ELEGANS; PROTEIN SUBUNIT; SKN-1 PROTEIN, C ELEGANS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA;

ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE EXPRESSION; GENETIC CODE; HEAT; INTESTINE; LONGEVITY; LOSS OF FUNCTION MUTATION; LYSOSOME; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; RNA INTERFERENCE; ADAPTATION; ANIMAL; CELL NUCLEUS; CELL SURVIVAL; CONSERVED SEQUENCE; DIGESTIVE SYSTEM; GENE EXPRESSION REGULATION; GENETICS; HEAT SHOCK RESPONSE; METABOLISM; MUTATION; PHYSIOLOGICAL STRESS; PROTEIN FOLDING; PROTEIN SUBUNIT; SEQUENCE ANALYSIS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; AUTOPHAGY; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL NUCLEUS; CELL SURVIVAL; CONSERVED SEQUENCE; DIGESTIVE SYSTEM; DNA-BINDING PROTEINS; GATA TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HEAT-SHOCK RESPONSE; LYSOSOMES; MUTATION; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN SUBUNITS; SEQUENCE ANALYSIS, RNA; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; UBIQUITIN;

EID: 84959863448     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005823     Document Type: Article

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