epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans

Autophagy

Volumn 5, Issue 5, 2009, Pages 608-615

  Tian, E ^a,b   Wang, Fuxin ^b   Han, Jinghua ^b   Zhang, Hong ^b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

Atg13; Autophagy; C. Elegans; epg 1; unc 51

Indexed keywords

CELL PROTEIN; GREEN FLUORESCENT PROTEIN; LGG 1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN SERINE THREONINE KINASE; UNC 51 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATG13 GENE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL DEATH; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EPG 1 GENE; GENE; GENE EXPRESSION; GENE INTERACTION; IMMUNOFLUORESCENCE; LARVAL DEVELOPMENT; LIFESPAN; MUTANT; NERVE CELL DEGENERATION; NONHUMAN; PHYLOGENY; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REPORTER GENE; RNA INTERFERENCE; STARVATION; WILD TYPE;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 67650249774     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5.5.8624     Document Type: Article

References (23)

1. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6:463-477 (Pubitemid 38456176)
2. van der Vaart A, Mari M, Reggiori F. A picky eater: exploring the mechanisms of selective autophagy in human pathologies. Traffic 2008; 9:281-289 (Pubitemid 351188990)
3. Scott SV, Nice DC, 3rd, Nau JJ, Weisman LS, Kamada Y, Keizer-Gunnink I, et al. Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem 2000; 275:25840-25849
4. Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000; 150:1507-1513 (Pubitemid 30728921)
5. Suzuki K, Kubota Y, Sekito T, Ohsumi Y. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 2007; 12:209-218 (Pubitemid 46152659)
6. Cheong H, Nair U, Geng J, Klionsky DJ. The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell 2008; 19:668-681 (Pubitemid 351272154)
7. Chan EY, Longatti A, McKnight NC, Tooze SA. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol 2009; 29:157-171
8. Reggiori F, Tucker KA, Stromhaug PE, Klionsky DJ. The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell 2004; 6:79-90. (Pubitemid 38089207)
9. Young AR, Chan EY, Hu XW, Köchl R, Crawshaw SG, High S, et al. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J Cell Sci 2006; 119:3888-3900 (Pubitemid 44614440)
10. Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 2008; 181:497-510. (Pubitemid 351645039)
11. Ogura K, Shirakawa M, Barnes TM, Hekimi S, Ohshima Y. The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. Genes Dev 1997; 11:1801-1811
12. Tóth ML, Simon P, Kovács AL, Vellai T. Influence of autophagy genes on ion-channeldependent neuronal degeneration in Caenorhabditis elegans. J Cell Sci 2007; 120:1134-1141
13. Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ 2008; 15:105-112
14. Kang C, You YJ, Avery L. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev 2007; 21:2161-2171
15. Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003; 301:1387-1391 (Pubitemid 37075816)
16. Zhang YX, Yan LB, Zhou Z, Yang PG, Tian E, Zhang K, et al. SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell 2009; 136:308-321
17. Kuma A, Matsui M, Mizushima N. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy 2007; 3:323-328 (Pubitemid 46986336)
18. Jia K, Hart AC, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy 2007; 3:21-25
19. Tóth ML, Sigmond T, Borsos E, Barna J, Erdélyi P, Takács-Vellai K, et al. Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy 2008; 4:330-338
20. Khan LA, Yamanaka T, Nukina N. Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans. Biochem Biophys Res Commun 2008; 368:729-735
21. Ogura K, Wicky C, Magnenat L, Tobler H, Mori I, Müller F, Ohshima Y. Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase. Genes Dev 1994; 8:2389-2400
22. Aladzsity I, Tóth ML, Sigmond T, Szabó E, Bicsák B, Barna J, et al. Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. Genetics 2007; 177:655-660
23. Suzuki K, Kirisako T, Kamada Y, Mizushima N, Noda T, Ohsumi Y. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 2001; 20:5971-5981 (Pubitemid 33049272)