Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 37, 2012, Pages 14912-14917

  Van Der Goot, Annemieke T ^a   Zhu, Wentao ^b   Vázquez Manrique, Rafael P ^c,f   Seinstra, Renée I ^a   Dettmer, Katja ^b   Michels, Helen ^a   Farina, Francesca ^c   Krijnen, Jasper ^a   Melki, Ronald ^d   Buijsman, Rogier C ^e   Silva, Mariana Ruiz ^a   Thijssen, Karen L ^a   Kema, Ido P ^a   Neri, Christian ^c   Oefner, Peter J ^b   Nollen, Ellen A A ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c INSERM   (France)

^d LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^e Translational Research Centre BV   (Netherlands)

^f INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

Author keywords

Huntington; Longevity

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; POLYGLUTAMINE; TRYPTOPHAN;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; GENE MUTATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN HOMEOSTASIS;

AGING; ALPHA-SYNUCLEIN; AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CHROMATOGRAPHY, LIQUID; COMPUTATIONAL BIOLOGY; DNA PRIMERS; FERTILITY; HOMEOSTASIS; IMMUNOBLOTTING; LONGEVITY; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY; TRYPTOPHAN; TRYPTOPHAN OXYGENASE;

CAENORHABDITIS ELEGANS;

EID: 84866297918     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203083109     Document Type: Article

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