TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

PLoS Genetics

Volumn 9, Issue 12, 2013, Pages

  Ferguson, Annabel A ^a   Roy, Sudipa ^b   Kormanik, Kaitlyn N ^a   Kim, Yongsoon ^c   Dumas, Kathleen J ^c   Ritov, Vladimir B ^d   Matern, Dietrich ^e   Hu, Patrick J ^c,f   Fisher, Alfred L ^b,g  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^e Mayo Clinic   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^g SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; PROTEIN CRH 1; PROTEIN TATN 1; RNA; SOMATOMEDIN RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; TYROSINE; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

AAK 2 GENE; AMINO ACID METABOLISM; AMPK GENE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DAF 16 GENE; DAF 2 GENE; DIET; ENVIRONMENT; ENZYME ACTIVITY; FOXO GENE; GENE; GENE EXPRESSION; GENE MUTATION; INSULIN GENE; INTRACELLULAR SIGNALING; LIFESPAN; LONGEVITY; METABOLIC REGULATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; TATN 1 GENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LARVA; LONGEVITY; METABOLIC NETWORKS AND PATHWAYS; MUTATION; RECEPTOR, INSULIN; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TYROSINE; TYROSINE TRANSAMINASE;

EID: 84892753640     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004020     Document Type: Article

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