A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans

Genetics

Volumn 187, Issue 4, 2011, Pages 1235-1240

  Segref, Alexandra ^a   Torres, Serena ^a   Hoppe, Thorsten ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; UBIQUITIN;

ARTICLE; CAENORHABDITIS ELEGANS; ENDOPLASMIC RETICULUM STRESS; GENETIC SCREENING; HEAT STRESS; IN VIVO STUDY; METABOLIC STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; RNA INTERFERENCE; UBIQUITINATION; WILD TYPE;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE REGULATORY NETWORKS; GENES, HELMINTH; GENOME, HELMINTH; IMMUNOBLOTTING; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; UBIQUITIN;

CAENORHABDITIS ELEGANS; EUKARYOTA;

EID: 79955366725     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.111.126797     Document Type: Article

References (30)

1. Ben-Zvi, A., E. A. Miller and R. I. Morimoto, 2009 Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc. Natl. Acad. Sci. USA 106: 14914-14919.
2. Ciechanover, A., A. Orian and A. L. Schwartz, 2000 Ubiquitinmediated proteolysis: biological regulation via destruction. Bioessays 22: 442-451.
3. Dantuma, N. P., K. Lindsten, R.Glas, M. Jellne and M. G.Masucci, 2000 Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells. Nat. Biotechnol. 18: 538-543.
4. Doitsidou, M., N. Flames, A. C. Lee, A. Boyanov and O. Hobert, 2008 Automated screening for mutants affecting dopaminergicneuron specification in C. elegans. Nat. Methods 5: 869-872.
5. Finley, D., 2009 Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem. 78: 477-513.
6. Gidalevitz, T., E. A. Kikis and R. I.Morimoto, 2009 A cellular perspective on conformational disease: the role of genetic background and proteostasis networks. Curr. Opin. Struct. Biol. 20: 23-32.
7. Gu, T., S. Orita and M. Han, 1998 Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. Mol. Cell. Biol. 18: 4556-4564.
8. Hamer, G., O. Matilainen and C. I. Holmberg, 2010 A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nat. Methods 7: 473-478.
9. Hoppe, T., 2005 Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all. Trends Biochem. Sci. 30: 183-187.
10. Johnson, E. S., P. C. Ma, I.M. Ota and A. Varshavsky, 1995 A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem. 270: 17442-17456.
11. Jungmann, J., H. A. Reins, C. Schobert and S. Jentsch, 1993 Resistance to cadmium mediated by ubiquitin-dependent proteolysis. Nature 361: 369-371.
12. Kerscher, O., R. Felberbaum and M. Hochstrasser, 2006 Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 22: 159-180.
13. Komatsu, M., and Y. Ichimura, 2010 Selective autophagy regulates various cellular functions. Genes Cells 15: 923-933.
14. Lindsten, K., V. Menendez-Benito, M. G. Masucci and N. P. Dantuma, 2003 A transgenic mouse model of the ubiquitin/ proteasome system. Nat. Biotechnol. 21: 897-902.
15. Maduro, M., and D. Pilgrim, 1995 Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141: 997-988.
16. Maier, W., B. Adilov, M. Regenass and J. Alcedo, 2010 A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8: e1000376.
17. Meusser, B., C. Hirsch, E. Jarosch and T. Sommer, 2005 ERAD: the long road to destruction. Nat. Cell Biol. 7: 766-772.
18. Mouysset, J., A. Deichsel, S. Moser, C. Hoege, A. A. Hyman et al., 2008 Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc. Natl. Acad. Sci. USA 105: 12879-12884.
19. Powers, E. T., R. I. Morimoto, A. Dillin, J. W. Kelly and W. E. Balch, 2009 Biological and chemical approaches to diseases of proteostasis deficiency. Annu. Rev. Biochem. 78: 959-991.
20. Praitis, V., E. Casey, D. Collar and J. Austin, 2001 Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157: 1217-1226.
21. Rape, M., T. Hoppe, I. Gorr, M. Kalocay, H. Richly et al., 2001 Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL-4), a ubiquitin-selective chaperone. Cell 107: 667-677.
22. Richly, H., M. Rape, S. Braun, S. Rumpf, C. Hoege et al., 2005 A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell 120: 73-84.
23. Sarin, S., S. Prabhu, M. M. O'Meara, I. Pe'er and O. Hobert, 2008 Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Nat. Methods 5: 865-867.
24. Urano, F., M. Calfon, T. Yoneda, C. Yun, M. Kiraly et al., 2002 A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J. Cell Biol. 158: 639-646.
25. Varshavsky, A., 1992 The N-end rule. Cell 69: 725-735.
26. Zhang, D., T. Chen, I. Ziv, R. Rosenzweig, Y. Matiuhin et al., 2009 Together, Rpn10 and Dsk2 can serve as a polyubiquitin chain-length sensor. Mol. Cell 36: 1018-1033.
27. BRENNER, S., 1974 The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
28. MOUYSSET, J., A. DEICHSEL, S. MOSER, C. HOEGE, A. A. HYMAN et al., 2008 Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A 105: 12879-12884.
29. PRAITIS, V., E. CASEY, D. COLLAR and J. AUSTIN, 2001 Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157: 1217-1226.
30. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Habor Laboratory Press, Cold Spring Habor, NY.