Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

Aging Cell

Volumn 12, Issue 5, 2013, Pages 802-813

  Tsakiri, Eleni N ^a   Sykiotis, Gerasimos P ^b   Papassideri, Issidora S ^a   Terpos, Evangelos ^c   Dimopoulos, Meletios A ^c   Gorgoulis, Vassilis G ^c,d   Bohmann, Dirk ^e   Trougakos, Ioannis P ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Aging; Drosophila; Keap1; Nrf2; Proteasome; Somatic tissue

Indexed keywords

PROTEASOME; PROTEASOME INHIBITOR; PROTEOME; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME DEFECT; ENZYME INHIBITION; FEEDING; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GONAD; IN VIVO STUDY; LARVA; LETHALITY; LIFESPAN; LONGEVITY; MALE; MITOCHONDRION; MOTOR PERFORMANCE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; PROTEIN SUBUNIT; RNA INTERFERENCE; TISSUE SPECIFICITY; UPREGULATION;

DROSOPHILA MELANOGASTER; METAZOA;

AGING; DROSOPHILA; KEAP1; NRF2; PROTEASOME; SOMATIC TISSUE;

AGING, PREMATURE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOSTASIS DEFICIENCIES; REACTIVE OXYGEN SPECIES; TRANSCRIPTIONAL ACTIVATION;

EID: 84883750565     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12111     Document Type: Article

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