Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities

American Journal of Pathology

Volumn 180, Issue 3, 2012, Pages 963-972

  Tomaru, Utano ^a   Takahashi, Satomi ^a   Ishizu, Akihiro ^b   Miyatake, Yukiko ^a   Gohda, Aya ^a   Suzuki, Sayuri ^a   Ono, Ayako ^a   Ohara, Jiro ^a   Baba, Tomohisa ^c   Murata, Shigeo ^d   Tanaka, Keiji ^e   Kasahara, Masanori ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; PROTEIN BCL XL; RIBONUCLEASE L;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL AGING; CONTROLLED STUDY; FATTY LIVER; FEMALE; IN VIVO STUDY; LIFESPAN; LIPID DIET; LIPID STORAGE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOSE TISSUE; AGING; ANIMALS; BCL-X PROTEIN; CELLS, CULTURED; DIET, HIGH-FAT; ENDORIBONUCLEASES; FATTY LIVER; INSULIN; LEPTIN; LIVER; LONGEVITY; MALE; MEMBRANE PROTEINS; METABOLIC DISEASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY; PHENOTYPE; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; WEIGHT LOSS;

EID: 84863181604     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.11.012     Document Type: Article

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