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Volumn 91, Issue , 2016, Pages 52-60

Transcriptional control of cardiac fibroblast plasticity

Author keywords

Cardiac fibroblast; Fibrosis; Heart; Myocardial infarction; Myofibroblast; Transcription

Indexed keywords

CALCINEURIN; CCAAT ENHANCER BINDING PROTEIN; MYOCARDIN; PROTEIN TCF21; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERUM RESPONSE FACTOR; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; MKL1 PROTEIN, HUMAN; RHOA PROTEIN, HUMAN; SRF PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

EID: 84953294032     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.12.016     Document Type: Review
Times cited : (102)

References (189)
  • 1
    • 34548423254 scopus 로고    scopus 로고
    • Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse
    • Banerjee I., Fuseler J.W., Price R.L., Borg T.K., Baudino T.A. Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse. Am. J. Physiol. Heart Circ. Physiol. 2007, 293(3):H1883-H1891.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293 , Issue.3 , pp. H1883-H1891
    • Banerjee, I.1    Fuseler, J.W.2    Price, R.L.3    Borg, T.K.4    Baudino, T.A.5
  • 2
    • 73349122017 scopus 로고    scopus 로고
    • Cardiac fibroblast: the renaissance cell
    • Souders C.A., Bowers S.L., Baudino T.A. Cardiac fibroblast: the renaissance cell. Circ. Res. 2009, 105(12):1164-1176.
    • (2009) Circ. Res. , vol.105 , Issue.12 , pp. 1164-1176
    • Souders, C.A.1    Bowers, S.L.2    Baudino, T.A.3
  • 4
    • 85018219941 scopus 로고    scopus 로고
    • The multifaceted roles of cardiac fibroblasts
    • Evans S.M. The multifaceted roles of cardiac fibroblasts. J. Mol. Cell. Cardiol. 2015.
    • (2015) J. Mol. Cell. Cardiol.
    • Evans, S.M.1
  • 6
    • 79958799319 scopus 로고    scopus 로고
    • Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling
    • Smith C.L., Baek S.T., Sung C.Y., Tallquist M.D. Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ. Res. 2011, 108(12):e15-e26.
    • (2011) Circ. Res. , vol.108 , Issue.12 , pp. e15-e26
    • Smith, C.L.1    Baek, S.T.2    Sung, C.Y.3    Tallquist, M.D.4
  • 7
    • 0032518298 scopus 로고    scopus 로고
    • Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart
    • Dettman R.W., Denetclaw W., Ordahl C.P., Bristow J. Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart. Dev. Biol. 1998, 193(2):169-181.
    • (1998) Dev. Biol. , vol.193 , Issue.2 , pp. 169-181
    • Dettman, R.W.1    Denetclaw, W.2    Ordahl, C.P.3    Bristow, J.4
  • 9
    • 0029964385 scopus 로고    scopus 로고
    • Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ
    • Mikawa T., Gourdie R.G. Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev. Biol. 1996, 174(2):221-232.
    • (1996) Dev. Biol. , vol.174 , Issue.2 , pp. 221-232
    • Mikawa, T.1    Gourdie, R.G.2
  • 12
    • 41649102599 scopus 로고    scopus 로고
    • Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences
    • Burstein B., Libby E., Calderone A., Nattel S. Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences. Circulation 2008, 117(13):1630-1641.
    • (2008) Circulation , vol.117 , Issue.13 , pp. 1630-1641
    • Burstein, B.1    Libby, E.2    Calderone, A.3    Nattel, S.4
  • 13
    • 36348976915 scopus 로고    scopus 로고
    • The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology
    • Liu A.C., Joag V.R., Gotlieb A.I. The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am. J. Pathol. 2007, 171(5):1407-1418.
    • (2007) Am. J. Pathol. , vol.171 , Issue.5 , pp. 1407-1418
    • Liu, A.C.1    Joag, V.R.2    Gotlieb, A.I.3
  • 14
    • 79951785577 scopus 로고    scopus 로고
    • Heart valve structure and function in development and disease
    • Hinton R.B., Yutzey K.E. Heart valve structure and function in development and disease. Annu. Rev. Physiol. 2011, 73:29-46.
    • (2011) Annu. Rev. Physiol. , vol.73 , pp. 29-46
    • Hinton, R.B.1    Yutzey, K.E.2
  • 15
    • 74749090075 scopus 로고    scopus 로고
    • Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart
    • Zhou B., von Gise A., Ma Q., Hu Y.W., Pu W.T. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev. Biol. 2010, 338(2):251-261.
    • (2010) Dev. Biol. , vol.338 , Issue.2 , pp. 251-261
    • Zhou, B.1    von Gise, A.2    Ma, Q.3    Hu, Y.W.4    Pu, W.T.5
  • 18
    • 84862284813 scopus 로고    scopus 로고
    • Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease
    • von Gise A., Pu W.T. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ. Res. 2012, 110(12):1628-1645.
    • (2012) Circ. Res. , vol.110 , Issue.12 , pp. 1628-1645
    • von Gise, A.1    Pu, W.T.2
  • 20
    • 84910111838 scopus 로고    scopus 로고
    • Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation
    • Ali S.R., Ranjbarvaziri S., Talkhabi M., Zhao P., Subat A., Hojjat A., et al. Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation. Circ. Res. 2014, 115(7):625-635.
    • (2014) Circ. Res. , vol.115 , Issue.7 , pp. 625-635
    • Ali, S.R.1    Ranjbarvaziri, S.2    Talkhabi, M.3    Zhao, P.4    Subat, A.5    Hojjat, A.6
  • 21
    • 84908403146 scopus 로고    scopus 로고
    • Mesenchymal-endothelial transition contributes to cardiac neovascularization
    • Ubil E., Duan J., Pillai I.C., Rosa-Garrido M., Wu Y., Bargiacchi F., et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature 2014, 514(7524):585-590.
    • (2014) Nature , vol.514 , Issue.7524 , pp. 585-590
    • Ubil, E.1    Duan, J.2    Pillai, I.C.3    Rosa-Garrido, M.4    Wu, Y.5    Bargiacchi, F.6
  • 24
    • 77957729712 scopus 로고    scopus 로고
    • The origin of fibroblasts and mechanism of cardiac fibrosis
    • Krenning G., Zeisberg E.M., Kalluri R. The origin of fibroblasts and mechanism of cardiac fibrosis. J. Cell. Physiol. 2010, 225(3):631-637.
    • (2010) J. Cell. Physiol. , vol.225 , Issue.3 , pp. 631-637
    • Krenning, G.1    Zeisberg, E.M.2    Kalluri, R.3
  • 26
    • 33847084614 scopus 로고    scopus 로고
    • Formation and function of the myofibroblast during tissue repair
    • Hinz B. Formation and function of the myofibroblast during tissue repair. J. Investig. Dermatol. 2007, 127(3):526-537.
    • (2007) J. Investig. Dermatol. , vol.127 , Issue.3 , pp. 526-537
    • Hinz, B.1
  • 27
    • 84874958737 scopus 로고    scopus 로고
    • Function and fate of myofibroblasts after myocardial infarction
    • Turner N.A., Porter K.E. Function and fate of myofibroblasts after myocardial infarction. Fibrogenesis Tissue Repair 2013, 6(1):5.
    • (2013) Fibrogenesis Tissue Repair , vol.6 , Issue.1 , pp. 5
    • Turner, N.A.1    Porter, K.E.2
  • 29
    • 77957854278 scopus 로고    scopus 로고
    • Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-beta
    • Teekakirikul P., Eminaga S., Toka O., Alcalai R., Wang L., Wakimoto H., et al. Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-beta. J. Clin. Invest. 2010, 120(10):3520-3529.
    • (2010) J. Clin. Invest. , vol.120 , Issue.10 , pp. 3520-3529
    • Teekakirikul, P.1    Eminaga, S.2    Toka, O.3    Alcalai, R.4    Wang, L.5    Wakimoto, H.6
  • 30
    • 0031828004 scopus 로고    scopus 로고
    • The fibronectin domain ED-a is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1
    • Serini G., Bochaton-Piallat M.L., Ropraz P., Geinoz A., Borsi L., Zardi L., et al. The fibronectin domain ED-a is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J. Cell Biol. 1998, 142(3):873-881.
    • (1998) J. Cell Biol. , vol.142 , Issue.3 , pp. 873-881
    • Serini, G.1    Bochaton-Piallat, M.L.2    Ropraz, P.3    Geinoz, A.4    Borsi, L.5    Zardi, L.6
  • 31
    • 0031452945 scopus 로고    scopus 로고
    • Sarcomeric gene expression and contractility in myofibroblasts
    • Mayer D.C., Leinwand L.A. Sarcomeric gene expression and contractility in myofibroblasts. J. Cell Biol. 1997, 139(6):1477-1484.
    • (1997) J. Cell Biol. , vol.139 , Issue.6 , pp. 1477-1484
    • Mayer, D.C.1    Leinwand, L.A.2
  • 32
    • 0142089586 scopus 로고    scopus 로고
    • Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling
    • Hinz B., Gabbiani G. Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling. Thromb. Haemost. 2003, 90(6):993-1002.
    • (2003) Thromb. Haemost. , vol.90 , Issue.6 , pp. 993-1002
    • Hinz, B.1    Gabbiani, G.2
  • 34
    • 34548371401 scopus 로고    scopus 로고
    • Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    • Oka T., Xu J., Kaiser R.A., Melendez J., Hambleton M., Sargent M.A., et al. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ. Res. 2007, 101(3):313-321.
    • (2007) Circ. Res. , vol.101 , Issue.3 , pp. 313-321
    • Oka, T.1    Xu, J.2    Kaiser, R.A.3    Melendez, J.4    Hambleton, M.5    Sargent, M.A.6
  • 35
    • 0023025366 scopus 로고
    • Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
    • Ignotz R.A., Massague J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 1986, 261(9):4337-4345.
    • (1986) J. Biol. Chem. , vol.261 , Issue.9 , pp. 4337-4345
    • Ignotz, R.A.1    Massague, J.2
  • 37
    • 0024416745 scopus 로고
    • Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis
    • Benjamin I.J., Jalil J.E., Tan L.B., Cho K., Weber K.T., Clark W.A. Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ. Res. 1989, 65(3):657-670.
    • (1989) Circ. Res. , vol.65 , Issue.3 , pp. 657-670
    • Benjamin, I.J.1    Jalil, J.E.2    Tan, L.B.3    Cho, K.4    Weber, K.T.5    Clark, W.A.6
  • 38
    • 33751004679 scopus 로고    scopus 로고
    • Liver regeneration in acute severe liver impairment: a clinicopathological correlation study
    • Katoonizadeh A., Nevens F., Verslype C., Pirenne J., Roskams T. Liver regeneration in acute severe liver impairment: a clinicopathological correlation study. Liver Int. 2006, 26(10):1225-1233.
    • (2006) Liver Int. , vol.26 , Issue.10 , pp. 1225-1233
    • Katoonizadeh, A.1    Nevens, F.2    Verslype, C.3    Pirenne, J.4    Roskams, T.5
  • 40
    • 84905869926 scopus 로고    scopus 로고
    • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function
    • Hogan B.L., Barkauskas C.E., Chapman H.A., Epstein J.A., Jain R., Hsia C.C., et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell 2014, 15(2):123-138.
    • (2014) Cell Stem Cell , vol.15 , Issue.2 , pp. 123-138
    • Hogan, B.L.1    Barkauskas, C.E.2    Chapman, H.A.3    Epstein, J.A.4    Jain, R.5    Hsia, C.C.6
  • 41
    • 0037073890 scopus 로고    scopus 로고
    • Heart regeneration in zebrafish
    • Poss K.D., Wilson L.G., Keating M.T. Heart regeneration in zebrafish. Science 2002, 298(5601):2188-2190.
    • (2002) Science , vol.298 , Issue.5601 , pp. 2188-2190
    • Poss, K.D.1    Wilson, L.G.2    Keating, M.T.3
  • 43
    • 85047678603 scopus 로고
    • Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy
    • Doering C.W., Jalil J.E., Janicki J.S., Pick R., Aghili S., Abrahams C., et al. Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy. Cardiovasc. Res. 1988, 22(10):686-695.
    • (1988) Cardiovasc. Res. , vol.22 , Issue.10 , pp. 686-695
    • Doering, C.W.1    Jalil, J.E.2    Janicki, J.S.3    Pick, R.4    Aghili, S.5    Abrahams, C.6
  • 44
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • Elsharkawy A.M., Oakley F., Mann D.A. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 2005, 10(5):927-939.
    • (2005) Apoptosis , vol.10 , Issue.5 , pp. 927-939
    • Elsharkawy, A.M.1    Oakley, F.2    Mann, D.A.3
  • 45
    • 84928898387 scopus 로고    scopus 로고
    • Pathobiology of liver fibrosis: a translational success story
    • Lee Y.A., Wallace M.C., Friedman S.L. Pathobiology of liver fibrosis: a translational success story. Gut 2015, 64(5):830-841.
    • (2015) Gut , vol.64 , Issue.5 , pp. 830-841
    • Lee, Y.A.1    Wallace, M.C.2    Friedman, S.L.3
  • 46
    • 84893797280 scopus 로고    scopus 로고
    • The epithelium in idiopathic pulmonary fibrosis: breaking the barrier
    • Camelo A., Dunmore R., Sleeman M.A., Clarke D.L. The epithelium in idiopathic pulmonary fibrosis: breaking the barrier. Front. Pharmacol. 2014, 4:173.
    • (2014) Front. Pharmacol. , vol.4 , pp. 173
    • Camelo, A.1    Dunmore, R.2    Sleeman, M.A.3    Clarke, D.L.4
  • 47
    • 30944452186 scopus 로고    scopus 로고
    • Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers
    • Goffin J.M., Pittet P., Csucs G., Lussi J.W., Meister J.J., Hinz B. Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J. Cell Biol. 2006, 172(2):259-268.
    • (2006) J. Cell Biol. , vol.172 , Issue.2 , pp. 259-268
    • Goffin, J.M.1    Pittet, P.2    Csucs, G.3    Lussi, J.W.4    Meister, J.J.5    Hinz, B.6
  • 50
    • 84899897293 scopus 로고    scopus 로고
    • Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
    • Furtado M.B., Costa M.W., Pranoto E.A., Salimova E., Pinto A.R., Lam N.T., et al. Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ. Res. 2014, 114(9):1422-1434.
    • (2014) Circ. Res. , vol.114 , Issue.9 , pp. 1422-1434
    • Furtado, M.B.1    Costa, M.W.2    Pranoto, E.A.3    Salimova, E.4    Pinto, A.R.5    Lam, N.T.6
  • 51
    • 0031966326 scopus 로고    scopus 로고
    • Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries
    • Hidai H., Bardales R., Goodwin R., Quertermous T., Quertermous E.E. Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries. Mech. Dev. 1998, 73(1):33-43.
    • (1998) Mech. Dev. , vol.73 , Issue.1 , pp. 33-43
    • Hidai, H.1    Bardales, R.2    Goodwin, R.3    Quertermous, T.4    Quertermous, E.E.5
  • 52
    • 84871439217 scopus 로고    scopus 로고
    • C/EBP transcription factors mediate epicardial activation during heart development and injury
    • Huang G.N., Thatcher J.E., McAnally J., Kong Y., Qi X., Tan W., et al. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science 2012, 338(6114):1599-1603.
    • (2012) Science , vol.338 , Issue.6114 , pp. 1599-1603
    • Huang, G.N.1    Thatcher, J.E.2    McAnally, J.3    Kong, Y.4    Qi, X.5    Tan, W.6
  • 53
    • 0031980818 scopus 로고    scopus 로고
    • Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs
    • Lu J., Richardson J.A., Olson E.N. Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs. Mech. Dev. 1998, 73(1):23-32.
    • (1998) Mech. Dev. , vol.73 , Issue.1 , pp. 23-32
    • Lu, J.1    Richardson, J.A.2    Olson, E.N.3
  • 54
    • 0032126758 scopus 로고    scopus 로고
    • Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart
    • Moss J.B., Xavier-Neto J., Shapiro M.D., Nayeem S.M., McCaffery P., Drager U.C., et al. Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. Dev. Biol. 1998, 199(1):55-71.
    • (1998) Dev. Biol. , vol.199 , Issue.1 , pp. 55-71
    • Moss, J.B.1    Xavier-Neto, J.2    Shapiro, M.D.3    Nayeem, S.M.4    McCaffery, P.5    Drager, U.C.6
  • 55
    • 0033005665 scopus 로고    scopus 로고
    • YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    • Moore A.W., McInnes L., Kreidberg J., Hastie N.D., Schedl A. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 1999, 126(9):1845-1857.
    • (1999) Development , vol.126 , Issue.9 , pp. 1845-1857
    • Moore, A.W.1    McInnes, L.2    Kreidberg, J.3    Hastie, N.D.4    Schedl, A.5
  • 56
    • 79954946130 scopus 로고    scopus 로고
    • Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development
    • Barnes R.M., Firulli B.A., VanDusen N.J., Morikawa Y., Conway S.J., Cserjesi P., et al. Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ. Res. 2011, 108(8):940-949.
    • (2011) Circ. Res. , vol.108 , Issue.8 , pp. 940-949
    • Barnes, R.M.1    Firulli, B.A.2    VanDusen, N.J.3    Morikawa, Y.4    Conway, S.J.5    Cserjesi, P.6
  • 57
    • 84918515802 scopus 로고    scopus 로고
    • Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels
    • Trembley M.A., Velasquez L.S., de Mesy Bentley K.L., Small E.M. Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development 2015, 142(1):21-30.
    • (2015) Development , vol.142 , Issue.1 , pp. 21-30
    • Trembley, M.A.1    Velasquez, L.S.2    de Mesy Bentley, K.L.3    Small, E.M.4
  • 58
    • 84864067904 scopus 로고    scopus 로고
    • Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart
    • Braitsch C.M., Combs M.D., Quaggin S.E., Yutzey K.E. Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev. Biol. 2012, 368(2):345-357.
    • (2012) Dev. Biol. , vol.368 , Issue.2 , pp. 345-357
    • Braitsch, C.M.1    Combs, M.D.2    Quaggin, S.E.3    Yutzey, K.E.4
  • 59
    • 84861394103 scopus 로고    scopus 로고
    • The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors
    • Acharya A., Baek S.T., Huang G., Eskiocak B., Goetsch S., Sung C.Y., et al. The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development 2012, 139(12):2139-2149.
    • (2012) Development , vol.139 , Issue.12 , pp. 2139-2149
    • Acharya, A.1    Baek, S.T.2    Huang, G.3    Eskiocak, B.4    Goetsch, S.5    Sung, C.Y.6
  • 60
    • 84930789026 scopus 로고    scopus 로고
    • Characterization of TCF21 downstream target regions identifies a transcriptional network linking multiple independent coronary artery disease loci
    • Sazonova O., Zhao Y., Nurnberg S., Miller C., Pjanic M., Castano V.G., et al. Characterization of TCF21 downstream target regions identifies a transcriptional network linking multiple independent coronary artery disease loci. PLoS Genet. 2015, 11(5).
    • (2015) PLoS Genet. , vol.11 , Issue.5
    • Sazonova, O.1    Zhao, Y.2    Nurnberg, S.3    Miller, C.4    Pjanic, M.5    Castano, V.G.6
  • 61
    • 70449704621 scopus 로고    scopus 로고
    • JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction
    • Ponticos M., Harvey C., Ikeda T., Abraham D., Bou-Gharios G. JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction. Nucleic Acids Res. 2009, 37(16):5378-5389.
    • (2009) Nucleic Acids Res. , vol.37 , Issue.16 , pp. 5378-5389
    • Ponticos, M.1    Harvey, C.2    Ikeda, T.3    Abraham, D.4    Bou-Gharios, G.5
  • 62
    • 84919913137 scopus 로고    scopus 로고
    • Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis
    • Ponticos M., Papaioannou I., Xu S., Holmes A.M., Khan K., Denton C.P., et al. Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum. 2015, 67(1):243-253.
    • (2015) Arthritis Rheum. , vol.67 , Issue.1 , pp. 243-253
    • Ponticos, M.1    Papaioannou, I.2    Xu, S.3    Holmes, A.M.4    Khan, K.5    Denton, C.P.6
  • 63
    • 34047148354 scopus 로고    scopus 로고
    • The role of TGF-beta signaling in myocardial infarction and cardiac remodeling
    • Bujak M., Frangogiannis N.G. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc. Res. 2007, 74(2):184-195.
    • (2007) Cardiovasc. Res. , vol.74 , Issue.2 , pp. 184-195
    • Bujak, M.1    Frangogiannis, N.G.2
  • 64
    • 0028138619 scopus 로고
    • The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta
    • Schultz-Cherry S., Lawler J., Murphy-Ullrich J.E. The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J. Biol. Chem. 1994, 269(43):26783-26788.
    • (1994) J. Biol. Chem. , vol.269 , Issue.43 , pp. 26783-26788
    • Schultz-Cherry, S.1    Lawler, J.2    Murphy-Ullrich, J.E.3
  • 65
    • 84901440560 scopus 로고    scopus 로고
    • Integrins alphavbeta5 and alphavbeta3 promote latent TGF-beta1 activation by human cardiac fibroblast contraction
    • Sarrazy V., Koehler A., Chow M.L., Zimina E., Li C.X., Kato H., et al. Integrins alphavbeta5 and alphavbeta3 promote latent TGF-beta1 activation by human cardiac fibroblast contraction. Cardiovasc. Res. 2014, 102(3):407-417.
    • (2014) Cardiovasc. Res. , vol.102 , Issue.3 , pp. 407-417
    • Sarrazy, V.1    Koehler, A.2    Chow, M.L.3    Zimina, E.4    Li, C.X.5    Kato, H.6
  • 66
    • 0037439630 scopus 로고    scopus 로고
    • Making sense of latent TGFbeta activation
    • Annes J.P., Munger J.S., Rifkin D.B. Making sense of latent TGFbeta activation. J. Cell Sci. 2003, 116(Pt 2):217-224.
    • (2003) J. Cell Sci. , vol.116 , pp. 217-224
    • Annes, J.P.1    Munger, J.S.2    Rifkin, D.B.3
  • 67
    • 35848951385 scopus 로고    scopus 로고
    • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling
    • Bujak M., Ren G., Kweon H.J., Dobaczewski M., Reddy A., Taffet G., et al. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation 2007, 116(19):2127-2138.
    • (2007) Circulation , vol.116 , Issue.19 , pp. 2127-2138
    • Bujak, M.1    Ren, G.2    Kweon, H.J.3    Dobaczewski, M.4    Reddy, A.5    Taffet, G.6
  • 68
    • 84899650478 scopus 로고    scopus 로고
    • The inflammatory response in myocardial injury, repair, and remodelling
    • Frangogiannis N.G. The inflammatory response in myocardial injury, repair, and remodelling. Nat. Rev. Cardiol. 2014, 11(5):255-265.
    • (2014) Nat. Rev. Cardiol. , vol.11 , Issue.5 , pp. 255-265
    • Frangogiannis, N.G.1
  • 69
    • 0032566046 scopus 로고    scopus 로고
    • SMAD proteins and mammalian anatomy
    • Derynck R. SMAD proteins and mammalian anatomy. Nature 1998, 393(6687):737-739.
    • (1998) Nature , vol.393 , Issue.6687 , pp. 737-739
    • Derynck, R.1
  • 70
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • Massague J., Seoane J., Wotton D. Smad transcription factors. Genes Dev. 2005, 19(23):2783-2810.
    • (2005) Genes Dev. , vol.19 , Issue.23 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 71
    • 0032014216 scopus 로고    scopus 로고
    • Human Smad3 and Smad4 are sequence-specific transcription activators
    • Zawel L., Dai J.L., Buckhaults P., Zhou S., Kinzler K.W., Vogelstein B., et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1998, 1(4):611-617.
    • (1998) Mol. Cell , vol.1 , Issue.4 , pp. 611-617
    • Zawel, L.1    Dai, J.L.2    Buckhaults, P.3    Zhou, S.4    Kinzler, K.W.5    Vogelstein, B.6
  • 72
    • 0027212686 scopus 로고
    • Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmouliere A., Geinoz A., Gabbiani F., Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 1993, 122(1):103-111.
    • (1993) J. Cell Biol. , vol.122 , Issue.1 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 73
    • 27944445459 scopus 로고    scopus 로고
    • Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: smad-binding element is an important cis element for SM22alpha transcription in vivo
    • Qiu P., Ritchie R.P., Fu Z., Cao D., Cumming J., Miano J.M., et al. Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ. Res. 2005, 97(10):983-991.
    • (2005) Circ. Res. , vol.97 , Issue.10 , pp. 983-991
    • Qiu, P.1    Ritchie, R.P.2    Fu, Z.3    Cao, D.4    Cumming, J.5    Miano, J.M.6
  • 74
    • 17844386070 scopus 로고    scopus 로고
    • Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element
    • Tomasek J.J., McRae J., Owens G.K., Haaksma C.J. Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element. Am. J. Pathol. 2005, 166(5):1343-1351.
    • (2005) Am. J. Pathol. , vol.166 , Issue.5 , pp. 1343-1351
    • Tomasek, J.J.1    McRae, J.2    Owens, G.K.3    Haaksma, C.J.4
  • 75
    • 37349043944 scopus 로고    scopus 로고
    • Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression
    • Gan Q., Yoshida T., Li J., Owens G.K. Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression. Circ. Res. 2007, 101(9):883-892.
    • (2007) Circ. Res. , vol.101 , Issue.9 , pp. 883-892
    • Gan, Q.1    Yoshida, T.2    Li, J.3    Owens, G.K.4
  • 76
    • 0030765945 scopus 로고    scopus 로고
    • Smad6 inhibits signalling by the TGF-beta superfamily
    • Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., et al. Smad6 inhibits signalling by the TGF-beta superfamily. Nature 1997, 389(6651):622-626.
    • (1997) Nature , vol.389 , Issue.6651 , pp. 622-626
    • Imamura, T.1    Takase, M.2    Nishihara, A.3    Oeda, E.4    Hanai, J.5    Kawabata, M.6
  • 77
    • 0030611757 scopus 로고    scopus 로고
    • Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
    • Nakao A., Afrakhte M., Moren A., Nakayama T., Christian J.L., Heuchel R., et al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 1997, 389(6651):631-635.
    • (1997) Nature , vol.389 , Issue.6651 , pp. 631-635
    • Nakao, A.1    Afrakhte, M.2    Moren, A.3    Nakayama, T.4    Christian, J.L.5    Heuchel, R.6
  • 78
    • 77956627158 scopus 로고    scopus 로고
    • Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction
    • Dobaczewski M., Bujak M., Li N., Gonzalez-Quesada C., Mendoza L.H., Wang X.F., et al. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ. Res. 2010, 107(3):418-428.
    • (2010) Circ. Res. , vol.107 , Issue.3 , pp. 418-428
    • Dobaczewski, M.1    Bujak, M.2    Li, N.3    Gonzalez-Quesada, C.4    Mendoza, L.H.5    Wang, X.F.6
  • 79
    • 84942936191 scopus 로고    scopus 로고
    • Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice
    • Biernacka A., Cavalera M., Wang J., Russo I., Shinde A., Kong P., et al. Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice. Circ. Heart Fail. 2015, 8(4):788-798.
    • (2015) Circ. Heart Fail. , vol.8 , Issue.4 , pp. 788-798
    • Biernacka, A.1    Cavalera, M.2    Wang, J.3    Russo, I.4    Shinde, A.5    Kong, P.6
  • 82
    • 84883303964 scopus 로고    scopus 로고
    • Overexpression of Smad7 suppressed ROS/MMP9-dependent collagen synthesis through regulation of heme oxygenase-1
    • Yu H., Huang J., Wang S., Zhao G., Jiao X., Zhu L. Overexpression of Smad7 suppressed ROS/MMP9-dependent collagen synthesis through regulation of heme oxygenase-1. Mol. Biol. Rep. 2013, 40(9):5307-5314.
    • (2013) Mol. Biol. Rep. , vol.40 , Issue.9 , pp. 5307-5314
    • Yu, H.1    Huang, J.2    Wang, S.3    Zhao, G.4    Jiao, X.5    Zhu, L.6
  • 83
    • 84883239076 scopus 로고    scopus 로고
    • Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling
    • Wei L.H., Huang X.R., Zhang Y., Li Y.Q., Chen H.Y., Yan B.P., et al. Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling. Cardiovasc. Res. 2013, 99(4):665-673.
    • (2013) Cardiovasc. Res. , vol.99 , Issue.4 , pp. 665-673
    • Wei, L.H.1    Huang, X.R.2    Zhang, Y.3    Li, Y.Q.4    Chen, H.Y.5    Yan, B.P.6
  • 84
    • 0036347210 scopus 로고    scopus 로고
    • Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
    • Shindo T., Manabe I., Fukushima Y., Tobe K., Aizawa K., Miyamoto S., et al. Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat. Med. 2002, 8(8):856-863.
    • (2002) Nat. Med. , vol.8 , Issue.8 , pp. 856-863
    • Shindo, T.1    Manabe, I.2    Fukushima, Y.3    Tobe, K.4    Aizawa, K.5    Miyamoto, S.6
  • 85
    • 74949131620 scopus 로고    scopus 로고
    • Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
    • Takeda N., Manabe I., Uchino Y., Eguchi K., Matsumoto S., Nishimura S., et al. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J. Clin. Invest. 2010, 120(1):254-265.
    • (2010) J. Clin. Invest. , vol.120 , Issue.1 , pp. 254-265
    • Takeda, N.1    Manabe, I.2    Uchino, Y.3    Eguchi, K.4    Matsumoto, S.5    Nishimura, S.6
  • 86
    • 48849101093 scopus 로고    scopus 로고
    • The kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts
    • Wang B., Haldar S.M., Lu Y., Ibrahim O.A., Fisch S., Gray S., et al. The kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J. Mol. Cell. Cardiol. 2008, 45(2):193-197.
    • (2008) J. Mol. Cell. Cardiol. , vol.45 , Issue.2 , pp. 193-197
    • Wang, B.1    Haldar, S.M.2    Lu, Y.3    Ibrahim, O.A.4    Fisch, S.5    Gray, S.6
  • 88
    • 84864959226 scopus 로고    scopus 로고
    • Synergistic roles of scleraxis and Smads in the regulation of collagen 1alpha2 gene expression
    • Bagchi R.A., Czubryt M.P. Synergistic roles of scleraxis and Smads in the regulation of collagen 1alpha2 gene expression. Biochim. Biophys. Acta 2012, 1823(10):1936-1944.
    • (2012) Biochim. Biophys. Acta , vol.1823 , Issue.10 , pp. 1936-1944
    • Bagchi, R.A.1    Czubryt, M.P.2
  • 89
    • 84864120935 scopus 로고    scopus 로고
    • TGF-beta signaling via TAK1 pathway: role in kidney fibrosis
    • Choi M.E., Ding Y., Kim S.I. TGF-beta signaling via TAK1 pathway: role in kidney fibrosis. Semin. Nephrol. 2012, 32(3):244-252.
    • (2012) Semin. Nephrol. , vol.32 , Issue.3 , pp. 244-252
    • Choi, M.E.1    Ding, Y.2    Kim, S.I.3
  • 90
    • 0036674213 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
    • Bakin A.V., Rinehart C., Tomlinson A.K., Arteaga C.L. p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J. Cell Sci. 2002, 115(Pt 15):3193-3206.
    • (2002) J. Cell Sci. , vol.115 , pp. 3193-3206
    • Bakin, A.V.1    Rinehart, C.2    Tomlinson, A.K.3    Arteaga, C.L.4
  • 91
    • 44249083229 scopus 로고    scopus 로고
    • Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction
    • Kompa A.R., See F., Lewis D.A., Adrahtas A., Cantwell D.M., Wang B.H., et al. Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction. J. Pharmacol. Exp. Ther. 2008, 325(3):741-750.
    • (2008) J. Pharmacol. Exp. Ther. , vol.325 , Issue.3 , pp. 741-750
    • Kompa, A.R.1    See, F.2    Lewis, D.A.3    Adrahtas, A.4    Cantwell, D.M.5    Wang, B.H.6
  • 93
    • 5644285411 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat
    • See F., Thomas W., Way K., Tzanidis A., Kompa A., Lewis D., et al. p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat. J. Am. Coll. Cardiol. 2004, 44(8):1679-1689.
    • (2004) J. Am. Coll. Cardiol. , vol.44 , Issue.8 , pp. 1679-1689
    • See, F.1    Thomas, W.2    Way, K.3    Tzanidis, A.4    Kompa, A.5    Lewis, D.6
  • 94
    • 84874575262 scopus 로고    scopus 로고
    • TGF-beta-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between Smad3, p38alpha, and ERK1/2
    • Leivonen S.K., Lazaridis K., Decock J., Chantry A., Edwards D.R., Kahari V.M. TGF-beta-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between Smad3, p38alpha, and ERK1/2. PLoS One 2013, 8(2).
    • (2013) PLoS One , vol.8 , Issue.2
    • Leivonen, S.K.1    Lazaridis, K.2    Decock, J.3    Chantry, A.4    Edwards, D.R.5    Kahari, V.M.6
  • 95
    • 0036883881 scopus 로고    scopus 로고
    • Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway
    • Stratton R., Rajkumar V., Ponticos M., Nichols B., Shiwen X., Black C.M., et al. Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway. FASEB J. 2002, 16(14):1949-1951.
    • (2002) FASEB J. , vol.16 , Issue.14 , pp. 1949-1951
    • Stratton, R.1    Rajkumar, V.2    Ponticos, M.3    Nichols, B.4    Shiwen, X.5    Black, C.M.6
  • 96
    • 84927728714 scopus 로고    scopus 로고
    • PKC delta and betaII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension
    • Chichger H., Vang A., O'Connell K.A., Zhang P., Mende U., Harrington E.O., et al. PKC delta and betaII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 2015, 308(8):L827-L836.
    • (2015) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.308 , Issue.8 , pp. L827-L836
    • Chichger, H.1    Vang, A.2    O'Connell, K.A.3    Zhang, P.4    Mende, U.5    Harrington, E.O.6
  • 97
    • 84884981103 scopus 로고    scopus 로고
    • The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation
    • Rustad K.C., Wong V.W., Gurtner G.C. The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation. Differentiation 2013, 86(3):87-91.
    • (2013) Differentiation , vol.86 , Issue.3 , pp. 87-91
    • Rustad, K.C.1    Wong, V.W.2    Gurtner, G.C.3
  • 98
    • 84855555498 scopus 로고    scopus 로고
    • Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling
    • Wong V.W., Rustad K.C., Akaishi S., Sorkin M., Glotzbach J.P., Januszyk M., et al. Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat. Med. 2012, 18(1):148-152.
    • (2012) Nat. Med. , vol.18 , Issue.1 , pp. 148-152
    • Wong, V.W.1    Rustad, K.C.2    Akaishi, S.3    Sorkin, M.4    Glotzbach, J.P.5    Januszyk, M.6
  • 99
    • 0024206625 scopus 로고
    • Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
    • Norman C., Runswick M., Pollock R., Treisman R. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell 1988, 55(6):989-1003.
    • (1988) Cell , vol.55 , Issue.6 , pp. 989-1003
    • Norman, C.1    Runswick, M.2    Pollock, R.3    Treisman, R.4
  • 100
    • 0022727606 scopus 로고
    • Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif
    • Minty A., Kedes L. Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif. Mol. Cell. Biol. 1986, 6(6):2125-2136.
    • (1986) Mol. Cell. Biol. , vol.6 , Issue.6 , pp. 2125-2136
    • Minty, A.1    Kedes, L.2
  • 102
    • 80053153925 scopus 로고    scopus 로고
    • Identifying functional single nucleotide polymorphisms in the human CArGome
    • Benson C.C., Zhou Q., Long X., Miano J.M. Identifying functional single nucleotide polymorphisms in the human CArGome. Physiol. Genomics 2011, 43(18):1038-1048.
    • (2011) Physiol. Genomics , vol.43 , Issue.18 , pp. 1038-1048
    • Benson, C.C.1    Zhou, Q.2    Long, X.3    Miano, J.M.4
  • 103
    • 84899734505 scopus 로고    scopus 로고
    • Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
    • Esnault C., Stewart A., Gualdrini F., East P., Horswell S., Matthews N., et al. Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. Genes Dev. 2014, 28(9):943-958.
    • (2014) Genes Dev. , vol.28 , Issue.9 , pp. 943-958
    • Esnault, C.1    Stewart, A.2    Gualdrini, F.3    East, P.4    Horswell, S.5    Matthews, N.6
  • 104
    • 0037870478 scopus 로고    scopus 로고
    • Serum response factor: toggling between disparate programs of gene expression
    • Miano J.M. Serum response factor: toggling between disparate programs of gene expression. J. Mol. Cell. Cardiol. 2003, 35(6):577-593.
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , Issue.6 , pp. 577-593
    • Miano, J.M.1
  • 105
    • 77951582061 scopus 로고    scopus 로고
    • Linking actin dynamics and gene transcription to drive cellular motile functions
    • Olson E.N., Nordheim A. Linking actin dynamics and gene transcription to drive cellular motile functions. Nat. Rev. Mol. Cell Biol. 2010, 11(5):353-365.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , Issue.5 , pp. 353-365
    • Olson, E.N.1    Nordheim, A.2
  • 106
    • 0037379178 scopus 로고    scopus 로고
    • Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation
    • Du K.L., Ip H.S., Li J., Chen M., Dandre F., Yu W., et al. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol. Cell. Biol. 2003, 23(7):2425-2437.
    • (2003) Mol. Cell. Biol. , vol.23 , Issue.7 , pp. 2425-2437
    • Du, K.L.1    Ip, H.S.2    Li, J.3    Chen, M.4    Dandre, F.5    Yu, W.6
  • 107
    • 38849110886 scopus 로고    scopus 로고
    • Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice
    • Huang J., Cheng L., Li J., Chen M., Zhou D., Lu M.M., et al. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J. Clin. Invest. 2008, 118(2):515-525.
    • (2008) J. Clin. Invest. , vol.118 , Issue.2 , pp. 515-525
    • Huang, J.1    Cheng, L.2    Li, J.3    Chen, M.4    Zhou, D.5    Lu, M.M.6
  • 108
    • 0041422285 scopus 로고    scopus 로고
    • The serum response factor coactivator myocardin is required for vascular smooth muscle development
    • Li S., Wang D.Z., Wang Z., Richardson J.A., Olson E.N. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(16):9366-9370.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.16 , pp. 9366-9370
    • Li, S.1    Wang, D.Z.2    Wang, Z.3    Richardson, J.A.4    Olson, E.N.5
  • 110
    • 0035967868 scopus 로고    scopus 로고
    • Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
    • Wang D., Chang P.S., Wang Z., Sutherland L., Richardson J.A., Small E., et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 2001, 105(7):851-862.
    • (2001) Cell , vol.105 , Issue.7 , pp. 851-862
    • Wang, D.1    Chang, P.S.2    Wang, Z.3    Sutherland, L.4    Richardson, J.A.5    Small, E.6
  • 111
    • 33745152386 scopus 로고    scopus 로고
    • The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis
    • Pipes G.C., Creemers E.E., Olson E.N. The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev. 2006, 20(12):1545-1556.
    • (2006) Genes Dev. , vol.20 , Issue.12 , pp. 1545-1556
    • Pipes, G.C.1    Creemers, E.E.2    Olson, E.N.3
  • 112
    • 0037069365 scopus 로고    scopus 로고
    • Potentiation of serum response factor activity by a family of myocardin-related transcription factors
    • Wang D.Z., Li S., Hockemeyer D., Sutherland L., Wang Z., Schratt G., et al. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(23):14855-14860.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , Issue.23 , pp. 14855-14860
    • Wang, D.Z.1    Li, S.2    Hockemeyer, D.3    Sutherland, L.4    Wang, Z.5    Schratt, G.6
  • 113
    • 37849015440 scopus 로고    scopus 로고
    • RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding
    • Guettler S., Vartiainen M.K., Miralles F., Larijani B., Treisman R. RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding. Mol. Cell. Biol. 2008, 28(2):732-742.
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.2 , pp. 732-742
    • Guettler, S.1    Vartiainen, M.K.2    Miralles, F.3    Larijani, B.4    Treisman, R.5
  • 114
    • 0038737042 scopus 로고    scopus 로고
    • Actin dynamics control SRF activity by regulation of its coactivator MAL
    • Miralles F., Posern G., Zaromytidou A.I., Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003, 113(3):329-342.
    • (2003) Cell , vol.113 , Issue.3 , pp. 329-342
    • Miralles, F.1    Posern, G.2    Zaromytidou, A.I.3    Treisman, R.4
  • 115
    • 79959259657 scopus 로고    scopus 로고
    • Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator
    • Mouilleron S., Langer C.A., Guettler S., McDonald N.Q., Treisman R. Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator. Sci. Signal. 2011, 4(177).
    • (2011) Sci. Signal. , vol.4 , Issue.177
    • Mouilleron, S.1    Langer, C.A.2    Guettler, S.3    McDonald, N.Q.4    Treisman, R.5
  • 116
    • 0042691723 scopus 로고    scopus 로고
    • Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes
    • Cen B., Selvaraj A., Burgess R.C., Hitzler J.K., Ma Z., Morris S.W., et al. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol. 2003, 23(18):6597-6608.
    • (2003) Mol. Cell. Biol. , vol.23 , Issue.18 , pp. 6597-6608
    • Cen, B.1    Selvaraj, A.2    Burgess, R.C.3    Hitzler, J.K.4    Ma, Z.5    Morris, S.W.6
  • 117
    • 33846991973 scopus 로고    scopus 로고
    • Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors
    • Hinson J.S., Medlin M.D., Lockman K., Taylor J.M., Mack C.P. Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors. Am. J. Physiol. Heart Circ. Physiol. 2007, 292(2):H1170-H1180.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292 , Issue.2 , pp. H1170-H1180
    • Hinson, J.S.1    Medlin, M.D.2    Lockman, K.3    Taylor, J.M.4    Mack, C.P.5
  • 118
    • 26444573827 scopus 로고    scopus 로고
    • Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent
    • Selvaraj A., Prywes R. Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent. BMC Mol. Biol. 2004, 5:13.
    • (2004) BMC Mol. Biol. , vol.5 , pp. 13
    • Selvaraj, A.1    Prywes, R.2
  • 119
    • 16244382549 scopus 로고    scopus 로고
    • Muscle-specific signaling mechanism that links actin dynamics to serum response factor
    • Kuwahara K., Barrientos T., Pipes G.C., Li S., Olson E.N. Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol. Cell. Biol. 2005, 25(8):3173-3181.
    • (2005) Mol. Cell. Biol. , vol.25 , Issue.8 , pp. 3173-3181
    • Kuwahara, K.1    Barrientos, T.2    Pipes, G.C.3    Li, S.4    Olson, E.N.5
  • 120
    • 69449104522 scopus 로고    scopus 로고
    • Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta
    • Sandbo N., Kregel S., Taurin S., Bhorade S., Dulin N.O. Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Am. J. Respir. Cell Mol. Biol. 2009, 41(3):332-338.
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.41 , Issue.3 , pp. 332-338
    • Sandbo, N.1    Kregel, S.2    Taurin, S.3    Bhorade, S.4    Dulin, N.O.5
  • 121
    • 33750343214 scopus 로고    scopus 로고
    • Actin' together: serum response factor, its cofactors and the link to signal transduction
    • Posern G., Treisman R. Actin' together: serum response factor, its cofactors and the link to signal transduction. Trends Cell Biol. 2006, 16(11):588-596.
    • (2006) Trends Cell Biol. , vol.16 , Issue.11 , pp. 588-596
    • Posern, G.1    Treisman, R.2
  • 122
    • 84878193974 scopus 로고    scopus 로고
    • The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation
    • Small E.M. The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation. J. Cardiovasc. Transl. Res. 2012, 5(6):794-804.
    • (2012) J. Cardiovasc. Transl. Res. , vol.5 , Issue.6 , pp. 794-804
    • Small, E.M.1
  • 123
    • 43149111791 scopus 로고    scopus 로고
    • Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling
    • Busche S., Descot A., Julien S., Genth H., Posern G. Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling. J. Cell Sci. 2008, 121(Pt 7):1025-1035.
    • (2008) J. Cell Sci. , vol.121 , pp. 1025-1035
    • Busche, S.1    Descot, A.2    Julien, S.3    Genth, H.4    Posern, G.5
  • 124
    • 45149112555 scopus 로고    scopus 로고
    • MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells
    • Elberg G., Chen L., Elberg D., Chan M.D., Logan C.J., Turman M.A. MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells. Am. J. Physiol. Ren. Physiol. 2008, 294(5):F1116-F1128.
    • (2008) Am. J. Physiol. Ren. Physiol. , vol.294 , Issue.5 , pp. F1116-F1128
    • Elberg, G.1    Chen, L.2    Elberg, D.3    Chan, M.D.4    Logan, C.J.5    Turman, M.A.6
  • 125
    • 84856908842 scopus 로고    scopus 로고
    • MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins
    • Leitner L., Shaposhnikov D., Mengel A., Descot A., Julien S., Hoffmann R., et al. MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins. J. Cell Sci. 2011, 124(Pt 24):4318-4331.
    • (2011) J. Cell Sci. , vol.124 , pp. 4318-4331
    • Leitner, L.1    Shaposhnikov, D.2    Mengel, A.3    Descot, A.4    Julien, S.5    Hoffmann, R.6
  • 126
    • 84892404296 scopus 로고    scopus 로고
    • Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling
    • O'Connor J.W., Gomez E.W. Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling. PLoS One 2013, 8(12).
    • (2013) PLoS One , vol.8 , Issue.12
    • O'Connor, J.W.1    Gomez, E.W.2
  • 127
    • 33745544013 scopus 로고    scopus 로고
    • Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity
    • Tomasek J.J., Vaughan M.B., Kropp B.P., Gabbiani G., Martin M.D., Haaksma C.J., et al. Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity. Wound Repair Regen. 2006, 14(3):313-320.
    • (2006) Wound Repair Regen. , vol.14 , Issue.3 , pp. 313-320
    • Tomasek, J.J.1    Vaughan, M.B.2    Kropp, B.P.3    Gabbiani, G.4    Martin, M.D.5    Haaksma, C.J.6
  • 128
    • 79960834633 scopus 로고    scopus 로고
    • Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
    • Copaja M., Venegas D., Aranguiz P., Canales J., Vivar R., Catalan M., et al. Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts. Toxicol. Appl. Pharmacol. 2011, 255(1):57-64.
    • (2011) Toxicol. Appl. Pharmacol. , vol.255 , Issue.1 , pp. 57-64
    • Copaja, M.1    Venegas, D.2    Aranguiz, P.3    Canales, J.4    Vivar, R.5    Catalan, M.6
  • 129
    • 84874609382 scopus 로고    scopus 로고
    • Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
    • Zhou Y., Huang X., Hecker L., Kurundkar D., Kurundkar A., Liu H., et al. Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J. Clin. Invest. 2013, 123(3):1096-1108.
    • (2013) J. Clin. Invest. , vol.123 , Issue.3 , pp. 1096-1108
    • Zhou, Y.1    Huang, X.2    Hecker, L.3    Kurundkar, D.4    Kurundkar, A.5    Liu, H.6
  • 130
    • 77955173404 scopus 로고    scopus 로고
    • Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction
    • Small E.M., Thatcher J.E., Sutherland L.B., Kinoshita H., Gerard R.D., Richardson J.A., et al. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ. Res. 2010, 107(2):294-304.
    • (2010) Circ. Res. , vol.107 , Issue.2 , pp. 294-304
    • Small, E.M.1    Thatcher, J.E.2    Sutherland, L.B.3    Kinoshita, H.4    Gerard, R.D.5    Richardson, J.A.6
  • 131
    • 74749102175 scopus 로고    scopus 로고
    • Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice
    • Kagiyama S., Matsumura K., Goto K., Otsubo T., Iida M. Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice. Regul. Pept. 2010, 160(1-3):133-139.
    • (2010) Regul. Pept. , vol.160 , Issue.1-3 , pp. 133-139
    • Kagiyama, S.1    Matsumura, K.2    Goto, K.3    Otsubo, T.4    Iida, M.5
  • 132
    • 84885710467 scopus 로고    scopus 로고
    • Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing
    • Velasquez L.S., Sutherland L.B., Liu Z., Grinnell F., Kamm K.E., Schneider J.W., et al. Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(42):16850-16855.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.42 , pp. 16850-16855
    • Velasquez, L.S.1    Sutherland, L.B.2    Liu, Z.3    Grinnell, F.4    Kamm, K.E.5    Schneider, J.W.6
  • 133
    • 80855143589 scopus 로고    scopus 로고
    • Myocardin-related transcription factors A and B are key regulators of TGF-beta1-induced fibroblast to myofibroblast differentiation
    • Crider B.J., Risinger G.M., Haaksma C.J., Howard E.W., Tomasek J.J. Myocardin-related transcription factors A and B are key regulators of TGF-beta1-induced fibroblast to myofibroblast differentiation. J. Investig. Dermatol. 2011, 131(12):2378-2385.
    • (2011) J. Investig. Dermatol. , vol.131 , Issue.12 , pp. 2378-2385
    • Crider, B.J.1    Risinger, G.M.2    Haaksma, C.J.3    Howard, E.W.4    Tomasek, J.J.5
  • 134
    • 83755162557 scopus 로고    scopus 로고
    • Myocardin-related transcription factor-a complexes activate type I collagen expression in lung fibroblasts
    • Luchsinger L.L., Patenaude C.A., Smith B.D., Layne M.D. Myocardin-related transcription factor-a complexes activate type I collagen expression in lung fibroblasts. J Biol Chem. 2011, 286(51):44116-44125.
    • (2011) J Biol Chem. , vol.286 , Issue.51 , pp. 44116-44125
    • Luchsinger, L.L.1    Patenaude, C.A.2    Smith, B.D.3    Layne, M.D.4
  • 135
    • 0344924879 scopus 로고    scopus 로고
    • Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation
    • Qiu P., Feng X.H., Li L. Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation. J. Mol. Cell. Cardiol. 2003, 35(12):1407-1420.
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , Issue.12 , pp. 1407-1420
    • Qiu, P.1    Feng, X.H.2    Li, L.3
  • 136
    • 34548624377 scopus 로고    scopus 로고
    • Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)
    • Morita T., Mayanagi T., Sobue K. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs). Exp. Cell Res. 2007, 313(16):3432-3445.
    • (2007) Exp. Cell Res. , vol.313 , Issue.16 , pp. 3432-3445
    • Morita, T.1    Mayanagi, T.2    Sobue, K.3
  • 137
    • 84887212494 scopus 로고    scopus 로고
    • Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools
    • Kam Y., Quaranta V. Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. PLoS One 2009, 4(2).
    • (2009) PLoS One , vol.4 , Issue.2
    • Kam, Y.1    Quaranta, V.2
  • 138
    • 8744250147 scopus 로고    scopus 로고
    • Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts
    • El Sayegh T.Y., Arora P.D., Laschinger C.A., Lee W., Morrison C., Overall C.M., et al. Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts. J. Cell Sci. 2004, 117(Pt 21):5117-5131.
    • (2004) J. Cell Sci. , vol.117 , pp. 5117-5131
    • El Sayegh, T.Y.1    Arora, P.D.2    Laschinger, C.A.3    Lee, W.4    Morrison, C.5    Overall, C.M.6
  • 139
    • 0035955728 scopus 로고    scopus 로고
    • MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function
    • Ho A.T., Voura E.B., Soloway P.D., Watson K.L., Khokha R. MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function. J. Biol. Chem. 2001, 276(43):40215-40224.
    • (2001) J. Biol. Chem. , vol.276 , Issue.43 , pp. 40215-40224
    • Ho, A.T.1    Voura, E.B.2    Soloway, P.D.3    Watson, K.L.4    Khokha, R.5
  • 140
    • 33845654352 scopus 로고    scopus 로고
    • Dynamic interactions between myocytes, fibroblasts, and extracellular matrix
    • Banerjee I., Yekkala K., Borg T.K., Baudino T.A. Dynamic interactions between myocytes, fibroblasts, and extracellular matrix. Ann. N. Y. Acad. Sci. 2006, 1080:76-84.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1080 , pp. 76-84
    • Banerjee, I.1    Yekkala, K.2    Borg, T.K.3    Baudino, T.A.4
  • 141
    • 9644274187 scopus 로고    scopus 로고
    • Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin
    • Masszi A., Fan L., Rosivall L., McCulloch C.A., Rotstein O.D., Mucsi I., et al. Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin. Am. J. Pathol. 2004, 165(6):1955-1967.
    • (2004) Am. J. Pathol. , vol.165 , Issue.6 , pp. 1955-1967
    • Masszi, A.1    Fan, L.2    Rosivall, L.3    McCulloch, C.A.4    Rotstein, O.D.5    Mucsi, I.6
  • 142
    • 0037405501 scopus 로고    scopus 로고
    • Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition
    • Masszi A., Di Ciano C., Sirokmany G., Arthur W.T., Rotstein O.D., Wang J., et al. Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am. J. Physiol. Ren. Physiol. 2003, 284(5):F911-F924.
    • (2003) Am. J. Physiol. Ren. Physiol. , vol.284 , Issue.5 , pp. F911-F924
    • Masszi, A.1    Di Ciano, C.2    Sirokmany, G.3    Arthur, W.T.4    Rotstein, O.D.5    Wang, J.6
  • 143
    • 33947099459 scopus 로고    scopus 로고
    • Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway
    • Fan L., Sebe A., Peterfi Z., Masszi A., Thirone A.C., Rotstein O.D., et al. Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway. Mol. Biol. Cell 2007, 18(3):1083-1097.
    • (2007) Mol. Biol. Cell , vol.18 , Issue.3 , pp. 1083-1097
    • Fan, L.1    Sebe, A.2    Peterfi, Z.3    Masszi, A.4    Thirone, A.C.5    Rotstein, O.D.6
  • 144
    • 84887087639 scopus 로고    scopus 로고
    • Differential topical susceptibility to TGFbeta in intact and injured regions of the epithelium: key role in myofibroblast transition
    • Speight P., Nakano H., Kelley T.J., Hinz B., Kapus A. Differential topical susceptibility to TGFbeta in intact and injured regions of the epithelium: key role in myofibroblast transition. Mol. Biol. Cell 2013, 24(21):3326-3336.
    • (2013) Mol. Biol. Cell , vol.24 , Issue.21 , pp. 3326-3336
    • Speight, P.1    Nakano, H.2    Kelley, T.J.3    Hinz, B.4    Kapus, A.5
  • 145
    • 82655173709 scopus 로고    scopus 로고
    • Beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition
    • Charbonney E., Speight P., Masszi A., Nakano H., Kapus A. Beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition. Mol. Biol. Cell 2011, 22(23):4472-4485.
    • (2011) Mol. Biol. Cell , vol.22 , Issue.23 , pp. 4472-4485
    • Charbonney, E.1    Speight, P.2    Masszi, A.3    Nakano, H.4    Kapus, A.5
  • 146
    • 34248363982 scopus 로고    scopus 로고
    • Beta-catenin downregulation is required for adaptive cardiac remodeling
    • Baurand A., Zelarayan L., Betney R., Gehrke C., Dunger S., Noack C., et al. Beta-catenin downregulation is required for adaptive cardiac remodeling. Circ. Res. 2007, 100(9):1353-1362.
    • (2007) Circ. Res. , vol.100 , Issue.9 , pp. 1353-1362
    • Baurand, A.1    Zelarayan, L.2    Betney, R.3    Gehrke, C.4    Dunger, S.5    Noack, C.6
  • 147
    • 84857192566 scopus 로고    scopus 로고
    • Wnt1/betacatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
    • Duan J., Gherghe C., Liu D., Hamlett E., Srikantha L., Rodgers L., et al. Wnt1/betacatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 2012, 31(2):429-442.
    • (2012) EMBO J. , vol.31 , Issue.2 , pp. 429-442
    • Duan, J.1    Gherghe, C.2    Liu, D.3    Hamlett, E.4    Srikantha, L.5    Rodgers, L.6
  • 148
    • 77954763443 scopus 로고    scopus 로고
    • Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts
    • Laeremans H., Rensen S.S., Ottenheijm H.C., Smits J.F., Blankesteijn W.M. Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts. Cardiovasc. Res. 2010, 87(3):514-523.
    • (2010) Cardiovasc. Res. , vol.87 , Issue.3 , pp. 514-523
    • Laeremans, H.1    Rensen, S.S.2    Ottenheijm, H.C.3    Smits, J.F.4    Blankesteijn, W.M.5
  • 149
    • 53549120639 scopus 로고    scopus 로고
    • Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization
    • Muehlich S., Wang R., Lee S.M., Lewis T.C., Dai C., Prywes R. Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization. Mol. Cell. Biol. 2008, 28(20):6302-6313.
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.20 , pp. 6302-6313
    • Muehlich, S.1    Wang, R.2    Lee, S.M.3    Lewis, T.C.4    Dai, C.5    Prywes, R.6
  • 150
    • 23844533666 scopus 로고    scopus 로고
    • Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification
    • Nakagawa K., Kuzumaki N. Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification. Genes Cells 2005, 10(8):835-850.
    • (2005) Genes Cells , vol.10 , Issue.8 , pp. 835-850
    • Nakagawa, K.1    Kuzumaki, N.2
  • 152
  • 153
    • 84894116346 scopus 로고    scopus 로고
    • The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis
    • Alnajar A., Nordhoff C., Schied T., Chiquet-Ehrismann R., Loser K., Vogl T., et al. The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis. PLoS One 2013, 8(11).
    • (2013) PLoS One , vol.8 , Issue.11
    • Alnajar, A.1    Nordhoff, C.2    Schied, T.3    Chiquet-Ehrismann, R.4    Loser, K.5    Vogl, T.6
  • 154
    • 0032476590 scopus 로고    scopus 로고
    • Serum response factor is essential for mesoderm formation during mouse embryogenesis
    • Arsenian S., Weinhold B., Oelgeschlager M., Ruther U., Nordheim A. Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 1998, 17(21):6289-6299.
    • (1998) EMBO J. , vol.17 , Issue.21 , pp. 6289-6299
    • Arsenian, S.1    Weinhold, B.2    Oelgeschlager, M.3    Ruther, U.4    Nordheim, A.5
  • 155
    • 21144455710 scopus 로고    scopus 로고
    • Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development
    • Li J., Zhu X., Chen M., Cheng L., Zhou D., Lu M.M., et al. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(25):8916-8921.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.25 , pp. 8916-8921
    • Li, J.1    Zhu, X.2    Chen, M.3    Cheng, L.4    Zhou, D.5    Lu, M.M.6
  • 156
    • 33745170559 scopus 로고    scopus 로고
    • Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells
    • Li S., Chang S., Qi X., Richardson J.A., Olson E.N. Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells. Mol. Cell. Biol. 2006, 26(15):5797-5808.
    • (2006) Mol. Cell. Biol. , vol.26 , Issue.15 , pp. 5797-5808
    • Li, S.1    Chang, S.2    Qi, X.3    Richardson, J.A.4    Olson, E.N.5
  • 157
    • 84927777902 scopus 로고    scopus 로고
    • Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis
    • Bernau K., Ngam C., Torr E.E., Acton B., Kach J., Dulin N.O., et al. Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis. Respir. Res. 2015, 16:45.
    • (2015) Respir. Res. , vol.16 , pp. 45
    • Bernau, K.1    Ngam, C.2    Torr, E.E.3    Acton, B.4    Kach, J.5    Dulin, N.O.6
  • 159
    • 84895870226 scopus 로고    scopus 로고
    • RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling
    • Hayashi K., Watanabe B., Nakagawa Y., Minami S., Morita T. RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling. PLoS One 2014, 9(2).
    • (2014) PLoS One , vol.9 , Issue.2
    • Hayashi, K.1    Watanabe, B.2    Nakagawa, Y.3    Minami, S.4    Morita, T.5
  • 160
    • 84901218345 scopus 로고    scopus 로고
    • Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury
    • Haak A.J., Tsou P.S., Amin M.A., Ruth J.H., Campbell P., Fox D.A., et al. Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J. Pharmacol. Exp. Ther. 2014, 349(3):480-486.
    • (2014) J. Pharmacol. Exp. Ther. , vol.349 , Issue.3 , pp. 480-486
    • Haak, A.J.1    Tsou, P.S.2    Amin, M.A.3    Ruth, J.H.4    Campbell, P.5    Fox, D.A.6
  • 161
    • 84893643399 scopus 로고    scopus 로고
    • Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts
    • Johnson L.A., Rodansky E.S., Haak A.J., Larsen S.D., Neubig R.R., Higgins P.D. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts. Inflamm. Bowel Dis. 2014, 20(1):154-165.
    • (2014) Inflamm. Bowel Dis. , vol.20 , Issue.1 , pp. 154-165
    • Johnson, L.A.1    Rodansky, E.S.2    Haak, A.J.3    Larsen, S.D.4    Neubig, R.R.5    Higgins, P.D.6
  • 162
    • 72249108943 scopus 로고    scopus 로고
    • Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423
    • Evelyn C.R., Bell J.L., Ryu J.G., Wade S.M., Kocab A., Harzdorf N.L., et al. Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorg. Med. Chem. Lett. 2010, 20(2):665-672.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , Issue.2 , pp. 665-672
    • Evelyn, C.R.1    Bell, J.L.2    Ryu, J.G.3    Wade, S.M.4    Kocab, A.5    Harzdorf, N.L.6
  • 163
    • 4444382387 scopus 로고    scopus 로고
    • Calcium-calcineurin signaling in the regulation of cardiac hypertrophy
    • Wilkins B.J., Molkentin J.D. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem. Biophys. Res. Commun. 2004, 322(4):1178-1191.
    • (2004) Biochem. Biophys. Res. Commun. , vol.322 , Issue.4 , pp. 1178-1191
    • Wilkins, B.J.1    Molkentin, J.D.2
  • 164
    • 84871836123 scopus 로고    scopus 로고
    • Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress
    • Herum K.M., Lunde I.G., Skrbic B., Florholmen G., Behmen D., Sjaastad I., et al. Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress. J. Mol. Cell. Cardiol. 2013, 54:73-81.
    • (2013) J. Mol. Cell. Cardiol. , vol.54 , pp. 73-81
    • Herum, K.M.1    Lunde, I.G.2    Skrbic, B.3    Florholmen, G.4    Behmen, D.5    Sjaastad, I.6
  • 165
    • 22544437015 scopus 로고    scopus 로고
    • Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer
    • Gonzalez Bosc L.V., Layne J.J., Nelson M.T., Hill-Eubanks D.C. Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer. J. Biol. Chem. 2005, 280(28):26113-26120.
    • (2005) J. Biol. Chem. , vol.280 , Issue.28 , pp. 26113-26120
    • Gonzalez Bosc, L.V.1    Layne, J.J.2    Nelson, M.T.3    Hill-Eubanks, D.C.4
  • 166
    • 84867732495 scopus 로고    scopus 로고
    • A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo
    • Davis J., Burr A.R., Davis G.F., Birnbaumer L., Molkentin J.D. A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Dev. Cell 2012, 23(4):705-715.
    • (2012) Dev. Cell , vol.23 , Issue.4 , pp. 705-715
    • Davis, J.1    Burr, A.R.2    Davis, G.F.3    Birnbaumer, L.4    Molkentin, J.D.5
  • 167
    • 0032540267 scopus 로고    scopus 로고
    • A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    • Molkentin J.D., Lu J.R., Antos C.L., Markham B., Richardson J., Robbins J., et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998, 93(2):215-228.
    • (1998) Cell , vol.93 , Issue.2 , pp. 215-228
    • Molkentin, J.D.1    Lu, J.R.2    Antos, C.L.3    Markham, B.4    Richardson, J.5    Robbins, J.6
  • 171
    • 33845317604 scopus 로고    scopus 로고
    • TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
    • Kuwahara K., Wang Y., McAnally J., Richardson J.A., Bassel-Duby R., Hill J.A., et al. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J. Clin. Invest. 2006, 116(12):3114-3126.
    • (2006) J. Clin. Invest. , vol.116 , Issue.12 , pp. 3114-3126
    • Kuwahara, K.1    Wang, Y.2    McAnally, J.3    Richardson, J.A.4    Bassel-Duby, R.5    Hill, J.A.6
  • 172
    • 33749338744 scopus 로고    scopus 로고
    • Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart
    • Nakayama H., Wilkin B.J., Bodi I., Molkentin J.D. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J. 2006, 20(10):1660-1670.
    • (2006) FASEB J. , vol.20 , Issue.10 , pp. 1660-1670
    • Nakayama, H.1    Wilkin, B.J.2    Bodi, I.3    Molkentin, J.D.4
  • 173
    • 84907140944 scopus 로고    scopus 로고
    • Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction
    • Makarewich C.A., Zhang H., Davis J., Correll R.N., Trappanese D.M., Hoffman N.E., et al. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circ. Res. 2014, 115(6):567-580.
    • (2014) Circ. Res. , vol.115 , Issue.6 , pp. 567-580
    • Makarewich, C.A.1    Zhang, H.2    Davis, J.3    Correll, R.N.4    Trappanese, D.M.5    Hoffman, N.E.6
  • 174
    • 84867767699 scopus 로고    scopus 로고
    • Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
    • Harada M., Luo X., Qi X.Y., Tadevosyan A., Maguy A., Ordog B., et al. Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation 2012, 126(17):2051-2064.
    • (2012) Circulation , vol.126 , Issue.17 , pp. 2051-2064
    • Harada, M.1    Luo, X.2    Qi, X.Y.3    Tadevosyan, A.4    Maguy, A.5    Ordog, B.6
  • 175
    • 84938922666 scopus 로고    scopus 로고
    • Evidence of a role for fibroblast transient receptor potential canonical 3 Ca2+ channel in renal fibrosis
    • Saliba Y., Karam R., Smayra V., Aftimos G., Abramowitz J., Birnbaumer L., et al. Evidence of a role for fibroblast transient receptor potential canonical 3 Ca2+ channel in renal fibrosis. J. Am. Soc. Nephrol. 2015, 26(8):1855-1876.
    • (2015) J. Am. Soc. Nephrol. , vol.26 , Issue.8 , pp. 1855-1876
    • Saliba, Y.1    Karam, R.2    Smayra, V.3    Aftimos, G.4    Abramowitz, J.5    Birnbaumer, L.6
  • 176
    • 0028173386 scopus 로고
    • The alpha-smooth muscle actin-positive cells in healing human myocardial scars
    • Willems I.E., Havenith M.G., De Mey J.G., Daemen M.J. The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am. J. Pathol. 1994, 145(4):868-875.
    • (1994) Am. J. Pathol. , vol.145 , Issue.4 , pp. 868-875
    • Willems, I.E.1    Havenith, M.G.2    De Mey, J.G.3    Daemen, M.J.4
  • 178
    • 84875062824 scopus 로고    scopus 로고
    • TGF-beta1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
    • Vivar R., Humeres C., Ayala P., Olmedo I., Catalan M., Garcia L., et al. TGF-beta1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways. Biochim. Biophys. Acta 2013, 1832(6):754-762.
    • (2013) Biochim. Biophys. Acta , vol.1832 , Issue.6 , pp. 754-762
    • Vivar, R.1    Humeres, C.2    Ayala, P.3    Olmedo, I.4    Catalan, M.5    Garcia, L.6
  • 179
    • 85014604198 scopus 로고    scopus 로고
    • Persistent phenotypic shift in cardiac fibroblasts: impact of transient renin angiotensin system inhibition
    • Hale T.M. Persistent phenotypic shift in cardiac fibroblasts: impact of transient renin angiotensin system inhibition. J. Mol. Cell. Cardiol. 2015.
    • (2015) J. Mol. Cell. Cardiol.
    • Hale, T.M.1
  • 181
    • 77955321344 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    • Ieda M., Fu J.D., Delgado-Olguin P., Vedantham V., Hayashi Y., Bruneau B.G., et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010, 142(3):375-386.
    • (2010) Cell , vol.142 , Issue.3 , pp. 375-386
    • Ieda, M.1    Fu, J.D.2    Delgado-Olguin, P.3    Vedantham, V.4    Hayashi, Y.5    Bruneau, B.G.6
  • 182
    • 84863626782 scopus 로고    scopus 로고
    • Heart repair by reprogramming non-myocytes with cardiac transcription factors
    • Song K., Nam Y.J., Luo X., Qi X., Tan W., Huang G.N., et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 2012, 485(7400):599-604.
    • (2012) Nature , vol.485 , Issue.7400 , pp. 599-604
    • Song, K.1    Nam, Y.J.2    Luo, X.3    Qi, X.4    Tan, W.5    Huang, G.N.6
  • 183
    • 84908431264 scopus 로고    scopus 로고
    • Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors
    • Nam Y.J., Lubczyk C., Bhakta M., Zang T., Fernandez-Perez A., McAnally J., et al. Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors. Development 2014, 141(22):4267-4278.
    • (2014) Development , vol.141 , Issue.22 , pp. 4267-4278
    • Nam, Y.J.1    Lubczyk, C.2    Bhakta, M.3    Zang, T.4    Fernandez-Perez, A.5    McAnally, J.6
  • 184
    • 84941595669 scopus 로고    scopus 로고
    • High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling
    • Zhao Y., Londono P., Cao Y., Sharpe E.J., Proenza C., O'Rourke R., et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat. Commun. 2015, 6:8243.
    • (2015) Nat. Commun. , vol.6 , pp. 8243
    • Zhao, Y.1    Londono, P.2    Cao, Y.3    Sharpe, E.J.4    Proenza, C.5    O'Rourke, R.6
  • 185
    • 84940892376 scopus 로고    scopus 로고
    • Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails
    • Fu Y., Huang C., Xu X., Gu H., Ye Y., Jiang C., et al. Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Res. 2015, 25(9):1013-1024.
    • (2015) Cell Res. , vol.25 , Issue.9 , pp. 1013-1024
    • Fu, Y.1    Huang, C.2    Xu, X.3    Gu, H.4    Ye, Y.5    Jiang, C.6
  • 186
    • 84895921071 scopus 로고    scopus 로고
    • Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4
    • Wang H., Cao N., Spencer C.I., Nie B., Ma T., Xu T., et al. Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. Cell Rep. 2014, 6(5):951-960.
    • (2014) Cell Rep. , vol.6 , Issue.5 , pp. 951-960
    • Wang, H.1    Cao, N.2    Spencer, C.I.3    Nie, B.4    Ma, T.5    Xu, T.6
  • 187
    • 84908241553 scopus 로고    scopus 로고
    • "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors
    • Mathison M., Singh V.P., Gersch R.P., Ramirez M.O., Cooney A., Kaminsky S.M., et al. "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. J. Thorac. Cardiovasc. Surg. 2014, 148(4):1656-1664.
    • (2014) J. Thorac. Cardiovasc. Surg. , vol.148 , Issue.4 , pp. 1656-1664
    • Mathison, M.1    Singh, V.P.2    Gersch, R.P.3    Ramirez, M.O.4    Cooney, A.5    Kaminsky, S.M.6
  • 188
    • 84863629484 scopus 로고    scopus 로고
    • In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
    • Qian L., Huang Y., Spencer C.I., Foley A., Vedantham V., Liu L., et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 2012, 485(7400):593-598.
    • (2012) Nature , vol.485 , Issue.7400 , pp. 593-598
    • Qian, L.1    Huang, Y.2    Spencer, C.I.3    Foley, A.4    Vedantham, V.5    Liu, L.6
  • 189
    • 85018222836 scopus 로고    scopus 로고
    • Gaining myocytes or losing fibroblasts: challenges in cardiac fibroblast reprogramming for infarct repair
    • Nagalingam R.S., Safi H.A., Czubryt M.P. Gaining myocytes or losing fibroblasts: challenges in cardiac fibroblast reprogramming for infarct repair. J. Mol. Cell. Cardiol. 2015.
    • (2015) J. Mol. Cell. Cardiol.
    • Nagalingam, R.S.1    Safi, H.A.2    Czubryt, M.P.3


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