메뉴 건너뛰기




Volumn 10, Issue 1, 2013, Pages 15-26

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; CYTOSKELETON PROTEIN; DYSTROPHIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 13; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MYOGLOBIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84871796377     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2012.158     Document Type: Review
Times cited : (533)

References (160)
  • 1
    • 0024319420 scopus 로고
    • Cardiac interstitium in health and disease: The fibrillar collagen network
    • Weber, K. T. Cardiac interstitium in health and disease: the fibrillar collagen network. J. Am. Coll. Cardiol. 13, 1637-1652 (1989). (Pubitemid 19145564)
    • (1989) Journal of the American College of Cardiology , vol.13 , Issue.7 , pp. 1637-1652
    • Weber, K.T.1
  • 2
    • 0023092732 scopus 로고
    • Dynamic state of collagen: Pathways of collagen degradation in vivo and their possible role in regulation of collagen mass
    • Laurent, G. J. Dynamic state of collagen: pathways of collagen degradation in vivo and their possible role in regulation of collagen mass. Am. J. Physiol. 252, C1-C9 (1987).
    • (1987) Am. J. Physiol. , vol.252
    • Laurent, G.J.1
  • 3
    • 0028122690 scopus 로고
    • Heterogeneity of myofibroblast phenotypic features: An example of fibroblastic cell plasticity
    • Schmitt-Gräff, A., Desmoulière, A. & Gabbiani, G. Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Arch. 425, 3-24 (1994). (Pubitemid 24295501)
    • (1994) Virchows Archiv , vol.425 , Issue.1 , pp. 3-24
    • Schmitt-Graff, A.1    Desmouliere, A.2    Gabbiani, G.3
  • 5
    • 0642306163 scopus 로고    scopus 로고
    • Aldosteronism and peripheral blood mononuclear cell activation. A neuroendocrine-immune interface
    • Ahokas, R. A. et al. Aldosteronism and peripheral blood mononuclear cell activation. A neuroendocrine-immune interface. Circ. Res. 93, e124-e135 (2003).
    • (2003) Circ. Res. , vol.93
    • Ahokas, R.A.1
  • 8
    • 80054908979 scopus 로고    scopus 로고
    • Myofibroblast-mediated adventitial remodeling: An underestimated player in arterial pathology
    • Coen, M., Gabbiani, G. & Bochaton-Piallat, M. L. Myofibroblast- mediated adventitial remodeling: an underestimated player in arterial pathology. Arterioscler. Thromb. Vasc. Biol. 31, 2391-2396 (2011).
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 2391-2396
    • Coen, M.1    Gabbiani, G.2    Bochaton-Piallat, M.L.3
  • 9
    • 80255123492 scopus 로고    scopus 로고
    • Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of alpha-smooth muscle actin containing stress fibers
    • Rosker, C., Salvarani, N., Schmutz, S., Grand, T. & Rohr, S. Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of alpha-smooth muscle actin containing stress fibers. Circ. Res. 109, 1120-1131 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 1120-1131
    • Rosker, C.1    Salvarani, N.2    Schmutz, S.3    Grand, T.4    Rohr, S.5
  • 10
    • 79951938038 scopus 로고    scopus 로고
    • Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation
    • Yue, L., Xie, J. & Nattel, S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc. Res. 89, 744-753 (2011).
    • (2011) Cardiovasc. Res. , vol.89 , pp. 744-753
    • Yue, L.1    Xie, J.2    Nattel, S.3
  • 11
    • 0024351781 scopus 로고
    • Fibrosis-induced reduction of endomyocardium in the rat after isoproterenol treatment
    • Jalil, J. E., Janicki, J. S., Pick, R., Abrahams, C. & Weber, K. T. Fibrosis-induced reduction of endomyocardium in the rat after isoproterenol treatment. Circ. Res. 65, 258-264 (1989). (Pubitemid 19194611)
    • (1989) Circulation Research , vol.65 , Issue.2 , pp. 258-264
    • Jalil, J.E.1    Janicki, J.S.2    Pick, R.3    Abrahams, C.4    Weber, K.T.5
  • 13
    • 79957933700 scopus 로고    scopus 로고
    • Ubiquitin-proteasome pathway and cellular responses to oxidative stress
    • Shang, F. & Taylor, A. Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic. Biol. Med. 51, 5-16 (2011).
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 5-16
    • Shang, F.1    Taylor, A.2
  • 15
    • 79952217013 scopus 로고    scopus 로고
    • Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner
    • Cosper, P. F. & Leinwand, L. A. Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Res. 71, 1710-1720 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1710-1720
    • Cosper, P.F.1    Leinwand, L.A.2
  • 17
    • 0025893212 scopus 로고
    • Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy
    • Factor, S. M. et al. Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy. J. Am. Coll. Cardiol. 17, 1343-1351 (1991).
    • (1991) J. Am. Coll. Cardiol. , vol.17 , pp. 1343-1351
    • Factor, S.M.1
  • 18
    • 0032054257 scopus 로고    scopus 로고
    • Comparison of clinical and morphologic cardiac findings in patients having cardiac transplantation for ischemic cardiomyopathy, idiopathic dilated cardiomyopathy, and dilated hypertrephic cardiomyopathy
    • DOI 10.1016/S0002-9149(98)00020-4, PII S0002914998000204
    • Waller, T. A., Hiser, W. L., Capehart, J. E. & Roberts, W. C. Comparison of clinical and morphologic cardiac findings in patients having cardiac transplantation for ischemic cardiomyopathy, idiopathic dilated cardiomyopathy, and dilated hypertrophic cardiomyopathy. Am. J. Cardiol. 81, 884-894 (1998). (Pubitemid 28213993)
    • (1998) American Journal of Cardiology , vol.81 , Issue.7 , pp. 884-894
    • Waller, T.A.1    Hiser, W.L.2    Capehart, J.E.3    Roberts, W.C.4
  • 19
    • 0032982831 scopus 로고    scopus 로고
    • The role of apoptosis in dilated cardiomyopathy
    • Schaper, J., Lorenz-Meyer, S. & Suzuki, K. The role of apoptosis in dilated cardiomyopathy. Herz 24, 219-224 (1999). (Pubitemid 29254662)
    • (1999) Herz , vol.24 , Issue.3 , pp. 219-224
    • Schaper, J.1    Lorenz-Meyer, S.2    Suzuki, K.3
  • 21
    • 0026439388 scopus 로고
    • Collagen in dilated cardiomyopathy-scanning electron microscopic and immunohistochemical observations
    • Yoshikane, H. et al. Collagen in dilated cardiomyopathy-scanning electron microscopic and immunohistochemical observations. Jpn Circ. J. 56, 899-910 (1992).
    • (1992) Jpn Circ. J. , vol.56 , pp. 899-910
    • Yoshikane, H.1
  • 22
    • 0028969496 scopus 로고
    • Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ratio: A quantitative assessment
    • Marijianowski, M. M., Teeling, P., Mann, J. & Becker, A. E. Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ratio: a quantitative assessment. J. Am. Coll. Cardiol. 25, 1263-1272 (1995).
    • (1995) J. Am. Coll. Cardiol. , vol.25 , pp. 1263-1272
    • Marijianowski, M.M.1    Teeling, P.2    Mann, J.3    Becker, A.E.4
  • 23
    • 0020067413 scopus 로고
    • Muscle fiber orientation and connective tissue content in the hypertrophied human heart
    • Pearlman, E. S., Weber, K. T., Janicki, J. S., Pietra, G. G. & Fishman, A. P. Muscle fiber orientation and connective tissue content in the hypertrophied human heart. Lab. Invest. 46, 158-164 (1982). (Pubitemid 12181056)
    • (1982) Laboratory Investigation , vol.46 , Issue.2 , pp. 158-164
    • Pearlman, E.S.1    Weber, K.T.2    Janicki, J.S.3
  • 24
    • 0024380218 scopus 로고
    • Changes in nonmyocyte tissue composition associated with pressure overload of hypertrophic human hearts
    • Huysman, J. A. N., Vliegen, H. W., Van der Laarse, A. & Eulderink, F. Changes in nonmyocyte tissue composition associated with pressure overload of hypertrophic human hearts. Pathol. Res. Pract. 184, 577-581 (1989). (Pubitemid 19169093)
    • (1989) Pathology Research and Practice , vol.184 , Issue.6 , pp. 577-581
    • Huysman, J.A.N.1    Vliegen, H.W.2    Van Der Laarse, A.3    Eulderink, F.4
  • 25
    • 0031868917 scopus 로고    scopus 로고
    • Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans
    • DOI 10.1097/00004872-199816070-00018
    • Rossi, M. A. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J. Hypertens. 16, 1031-1041 (1998). (Pubitemid 28367959)
    • (1998) Journal of Hypertension , vol.16 , Issue.7 , pp. 1031-1041
    • Rossi, M.A.1
  • 26
    • 33745280899 scopus 로고    scopus 로고
    • Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure
    • DOI 10.1016/j.jacc.2006.01.077, PII S0735109706009065
    • Lopez, B., Gonzalez, A., Querejeta, R., Larman, M. & Diez, J. Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure. J. Am. Coll. Cardiol. 48, 89-96 (2006). (Pubitemid 43929208)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.1 , pp. 89-96
    • Lopez, B.1    Gonzalez, A.2    Querejeta, R.3    Larman, M.4    Diez, J.5
  • 27
    • 0024510272 scopus 로고
    • Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement
    • Krayenbuehl, H. P. et al. Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement. Circulation 79, 744-755 (1989). (Pubitemid 19100533)
    • (1989) Circulation , vol.79 , Issue.4 , pp. 744-755
    • Krayenbuehl, H.P.1    Hess, O.M.2    Monrad, E.S.3    Schneider, J.4    Mall, G.5    Turina, M.6
  • 28
    • 0017809637 scopus 로고
    • Myocardial structure and function in patients with aortic valve disease and their relation to postoperative results
    • DOI 10.1016/0002-9149(78)90814-7
    • Schwarz, F. et al. Myocardial structure and function in patients with aortic valve disease and their relation to postoperative results. Am. J. Cardiol. 41, 661-669 (1978). (Pubitemid 8311358)
    • (1978) American Journal of Cardiology , vol.41 , Issue.4 , pp. 661-669
    • Schwarz, F.1    Flameng, W.2    Schaper, J.3
  • 29
    • 0037465434 scopus 로고    scopus 로고
    • Progression from compensated hypertrophy to failure in the pressure-overloaded human: Heart structural deterioration and compensatory mechanisms
    • DOI 10.1161/01.CIR.0000051865.66123.B7
    • Hein, S. et al. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107, 984-991 (2003). (Pubitemid 36258721)
    • (2003) Circulation , vol.107 , Issue.7 , pp. 984-991
    • Hein, S.1    Arnon, E.2    Kostin, S.3    Schonburg, M.4    Elsasser, A.5    Polyakova, V.6    Bauer, E.P.7    Klovekorn, W.-P.8    Schaper, J.9
  • 30
    • 75449115350 scopus 로고    scopus 로고
    • Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: Structure, function, and transcript analysis
    • Brooks, W. W., Shen, S. S., Conrad, C. H., Goldstein, R. H. & Bing, O. H. Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: Structure, function, and transcript analysis. Genomics 95, 84-92 (2010).
    • (2010) Genomics , vol.95 , pp. 84-92
    • Brooks, W.W.1    Shen, S.S.2    Conrad, C.H.3    Goldstein, R.H.4    Bing, O.H.5
  • 31
    • 77956343217 scopus 로고    scopus 로고
    • Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy
    • O'Hanlon, R. et al. Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J. Am. Coll. Cardiol. 56, 867-874 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 867-874
    • O'Hanlon, R.1
  • 32
    • 84859592795 scopus 로고    scopus 로고
    • Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy
    • Green, J. J., Berger, J. S., Kramer, C. M. & Salerno, M. Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy. JACC Cardiovasc. Imaging 5, 370-377 (2012).
    • (2012) JACC Cardiovasc. Imaging , vol.5 , pp. 370-377
    • Green, J.J.1    Berger, J.S.2    Kramer, C.M.3    Salerno, M.4
  • 33
    • 0023906624 scopus 로고
    • Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium
    • Weber, K. T. et al. Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium. Circ. Res. 62, 757-765 (1988).
    • (1988) Circ. Res. , vol.62 , pp. 757-765
    • Weber, K.T.1
  • 34
    • 0025168071 scopus 로고
    • Regulation of fibrillar collagen types I and III and basement membrane type IV collagen gene expression in pressure overloaded rat myocardium
    • Chapman, D., Weber, K. T. & Eghbali, M. Regulation of fibrillar collagen types I and III and basement membrane type IV collagen gene expression in pressure overloaded rat myocardium. Circ. Res. 67, 787-794 (1990). (Pubitemid 20315010)
    • (1990) Circulation Research , vol.67 , Issue.4 , pp. 787-794
    • Chapman, D.1    Weber, K.T.2    Eghbali, M.3
  • 35
    • 0020330074 scopus 로고
    • Functional arrangement of connective tissue in striated muscle with emphasis on cardiac muscle
    • Borg, T. K., Sullivan, T. & Ivy, J. Functional arrangement of connective tissue in striated muscle with emphasis on cardiac muscle. Scanning Electron Microsc. 4, 1775-1784 (1982).
    • (1982) Scanning Electron Microsc. , vol.4 , pp. 1775-1784
    • Borg, T.K.1    Sullivan, T.2    Ivy, J.3
  • 36
    • 0020573823 scopus 로고
    • Skeletal framework of mammalian heart muscle. Arrangement of inter- and pericellular connective tissue structures
    • Robinson, T. F., Cohen-Gould, L. & Factor, S. M. Skeletal framework of mammalian heart muscle. Arrangement of inter-and pericellular connective tissue structures. Lab. Invest. 49, 482-498 (1983). (Pubitemid 13021742)
    • (1983) Laboratory Investigation , vol.49 , Issue.4 , pp. 482-498
    • Robinson, T.F.1    Cohen Gould, L.2    Factor, S.M.3
  • 38
    • 33748430214 scopus 로고    scopus 로고
    • Cytoskeletal networks and the regulation of cardiac contractility: Microtubules, hypertrophy, and cardiac dysfunction
    • Cooper, G. Cytoskeletal networks and the regulation of cardiac contractility: microtubules, hypertrophy, and cardiac dysfunction. Am. J. Physiol. Heart Circ. Physiol. 291, H1003-H1014 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291
    • Cooper, G.1
  • 39
    • 33646081053 scopus 로고    scopus 로고
    • Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures
    • Hoshijima, M. Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures. Am. J. Physiol. Heart Circ. Physiol. 290, H1313-H1325 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290
    • Hoshijima, M.1
  • 40
    • 79958838357 scopus 로고    scopus 로고
    • Conformation-regulated mechanosensory control via titin domains in cardiac muscle
    • Voelkel, T. & Linke, W. A. Conformation-regulated mechanosensory control via titin domains in cardiac muscle. Pflügers Arch. 462, 143-154 (2011).
    • (2011) Pflügers Arch. , vol.462 , pp. 143-154
    • Voelkel, T.1    Linke, W.A.2
  • 41
    • 0014478255 scopus 로고
    • Fiber orientation in the canine left ventricle during diastole and systole
    • Streeter, D. D., Spotnitz, H. M., Patel, D. P., Ross, J. & Sonnenblick, E. H. Fiber orientation in the canine left ventricle during diastole and systole. Circ. Res. 24, 339-347 (1969).
    • (1969) Circ. Res. , vol.24 , pp. 339-347
    • Streeter, D.D.1    Spotnitz, H.M.2    Patel, D.P.3    Ross, J.4    Sonnenblick, E.H.5
  • 42
    • 0023739984 scopus 로고
    • Coiled perimysial fibers of papillary muscle in rat heart: Morphology, distribution, and changes in configuration
    • Robinson, T. F., Geraci, M. A., Sonnenblick, E. H. & Factor, S. M. Coiled perimysial fibers of papillary muscle in rat heart: morphology, distribution, and changes in configuration. Circ. Res. 63, 577-592 (1988).
    • (1988) Circ. Res. , vol.63 , pp. 577-592
    • Robinson, T.F.1    Geraci, M.A.2    Sonnenblick, E.H.3    Factor, S.M.4
  • 43
    • 0023920241 scopus 로고
    • Structure and function of connective tissue in cardiac muscle: Collagen types i and III in endomysial struts and pericellular fibers
    • Robinson, T. F., Cohen-Gould, L., Factor, S. M., Eghbali, M. & Blumenfeld, O. O. Structure and function of connective tissue in cardiac muscle: collagen types I and III in endomysial struts and pericellular fibers. Scanning Microsc. 2, 1005-1015 (1988).
    • (1988) Scanning Microsc. , vol.2 , pp. 1005-1015
    • Robinson, T.F.1    Cohen-Gould, L.2    Factor, S.M.3    Eghbali, M.4    Blumenfeld, O.O.5
  • 44
    • 0020602186 scopus 로고
    • Myocardial healing and repair after experimental infarction in the rabbit
    • Lerman, R. H. et al. Myocardial healing and repair after experimental infarction in the rabbit. Circ. Res. 53, 378-388 (1983). (Pubitemid 13012420)
    • (1983) Circulation Research , vol.53 , Issue.3 , pp. 378-388
    • Lerman, R.H.1    Apstein, C.S.2    Kagan, H.M.3
  • 45
    • 0023198061 scopus 로고
    • Left ventricular rupture threshold during the healing phase after myocardial infarction in the dog
    • Jugdutt, B. I. Left ventricular rupture threshold during the healing phase after myocardial infarction in the dog. Can. J. Physiol. Pharmacol. 65, 307-316 (1987). (Pubitemid 17068302)
    • (1987) Canadian Journal of Physiology and Pharmacology , vol.65 , Issue.3 , pp. 307-316
    • Jugdutt, B.I.1
  • 46
    • 0023085856 scopus 로고
    • Alterations of the myocardial skeletal framework in acute myocardial infarction with and without ventricular rupture
    • Factor, S. M., Robinson, T. F., Dominitz, R. & Cho, S. H. Alterations of the myocardial skeletal framework in acute myocardial infarction with and without ventricular rupture. Am. J. Cardiovasc. Pathol. 1, 91-97 (1987).
    • (1987) Am. J. Cardiovasc. Pathol. , vol.1 , pp. 91-97
    • Factor, S.M.1    Robinson, T.F.2    Dominitz, R.3    Cho, S.H.4
  • 47
    • 0037155784 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulation and dysregulation in the failing heart
    • DOI 10.1161/01.RES.0000013290.12884.A3
    • Spinale, F. G. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ. Res. 90, 520-530 (2002). (Pubitemid 34640901)
    • (2002) Circulation Research , vol.90 , Issue.5 , pp. 520-530
    • Spinale, F.G.1
  • 48
    • 0023520907 scopus 로고
    • Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional ("stunned") but viable myocardium
    • Zhao, M. J. et al. Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional ("stunned") but viable myocardium. J. Am. Coll. Cardiol. 10, 1322-1334 (1987).
    • (1987) J. Am. Coll. Cardiol. , vol.10 , pp. 1322-1334
    • Zhao, M.J.1
  • 49
    • 0000730512 scopus 로고
    • The mechanics of ventricular contraction; A cinefluorographic study
    • Rushmer, R. F. & Thal, N. The mechanics of ventricular contraction; a cinefluorographic study. Circulation 4, 219-228 (1951).
    • (1951) Circulation , vol.4 , pp. 219-228
    • Rushmer, R.F.1    Thal, N.2
  • 50
    • 0021013265 scopus 로고
    • Consequences of uncontrolled calcium entry and its prevention with calcium antagonists
    • Fleckenstein, A., Frey, M. & Fleckenstein-Grun, G. Consequences of uncontrolled calcium entry and its prevention with calcium antagonists. Eur. Heart J. 4, 43-50 (1983). (Pubitemid 14211228)
    • (1983) European Heart Journal , vol.4 , Issue.SUPPL. H , pp. 43-50
    • Fleckenstein, A.1    Frey, M.2    Fleckenstein Grun, G.3
  • 51
    • 79961027163 scopus 로고    scopus 로고
    • Cation dyshomeostasis and cardiomyocyte necrosis. The Fleckenstein hypothesis revisited
    • Borkowski, B. J., Cheema, Y., Shahbaz, A. U., Bhattacharya, S. K. & Weber, K. T. Cation dyshomeostasis and cardiomyocyte necrosis. The Fleckenstein hypothesis revisited. Eur. Heart J. 32, 1846-1853 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 1846-1853
    • Borkowski, B.J.1    Cheema, Y.2    Shahbaz, A.U.3    Bhattacharya, S.K.4    Weber, K.T.5
  • 52
    • 84863503744 scopus 로고    scopus 로고
    • Mitochondria play a central role in nonischemic cardiomyocyte necrosis: Common to acute and chronic stressor states
    • Khan, M. U. et al. Mitochondria play a central role in nonischemic cardiomyocyte necrosis: common to acute and chronic stressor states. Pflügers Arch. 464, 123-131 (2012).
    • (2012) Pflügers Arch. , vol.464 , pp. 123-131
    • Khan, M.U.1
  • 56
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • DOI 10.1126/science.1071059
    • Matzinger, P. The danger model: a renewed sense of self. Science 296, 301-305 (2002). (Pubitemid 34303674)
    • (2002) Science , vol.296 , Issue.5566 , pp. 301-305
    • Matzinger, P.1
  • 59
    • 0028147947 scopus 로고
    • Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat
    • Sun, Y., Cleutjens, J. P. M., Diaz-Arias, A. A. & Weber, K. T. Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat. Cardiovasc. Res. 28, 1423-1432 (1994). (Pubitemid 24300449)
    • (1994) Cardiovascular Research , vol.28 , Issue.9 , pp. 1423-1432
    • Sun, Y.1    Cleutjens, J.P.M.2    Diaz-Arias, A.A.3    Weber, K.T.4
  • 60
    • 0343703459 scopus 로고    scopus 로고
    • Cells expressing angiotensin II receptors in fibrous tissue of rat heart
    • DOI 10.1016/0008-6363(95)00232-4
    • Sun, Y. & Weber, K. T. Cells expressing angiotensin II receptors in fibrous tissue of rat heart. Cardiovasc. Res. 31, 518-525 (1996). (Pubitemid 26140062)
    • (1996) Cardiovascular Research , vol.31 , Issue.4 , pp. 518-525
    • Yao, S.1    Weber, K.T.2
  • 62
    • 84866900231 scopus 로고    scopus 로고
    • Matrix control of transforming growth factor-β function
    • Horiguchi, M., Ota, M. & Rifkin, D. B. Matrix control of transforming growth factor-β function. J. Biochem. 152, 321-329 (2012).
    • (2012) J. Biochem. , vol.152 , pp. 321-329
    • Horiguchi, M.1    Ota, M.2    Rifkin, D.B.3
  • 63
    • 0023001706 scopus 로고
    • Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells
    • Filip, D. A., Radu, A. & Simionescu, M. Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells. Circ. Res. 59, 310-320 (1986). (Pubitemid 17178125)
    • (1986) Circulation Research , vol.59 , Issue.3 , pp. 310-320
    • Filip, D.A.1    Radu, A.2    Simionescu, M.3
  • 65
    • 75149174337 scopus 로고    scopus 로고
    • NAD(P)H oxidase mediates TGF-β1-induced activation of kidney myofibroblasts
    • Bondi, C. D. et al. NAD(P)H oxidase mediates TGF-β1-induced activation of kidney myofibroblasts. J. Am. Soc. Nephrol. 21, 93-102 (2010).
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 93-102
    • Bondi, C.D.1
  • 68
    • 0025340067 scopus 로고
    • Expression of fibrillar types I and III and basement membrane collagen type IV genes in myocardium of tight skin mouse
    • Chapman, D. & Eghbali, M. Expression of fibrillar types I and III and basement membrane collagen type IV genes in myocardium of tight skin mouse. Cardiovasc. Res. 24, 578-583 (1990). (Pubitemid 20220921)
    • (1990) Cardiovascular Research , vol.24 , Issue.7 , pp. 578-583
    • Chapman, D.1    Eghbali, M.2
  • 69
    • 85056746741 scopus 로고    scopus 로고
    • Unravelling the mysteries of collagen and cicatrix after myocardial infarction
    • Whittaker, P. Unravelling the mysteries of collagen and cicatrix after myocardial infarction. Cardiovasc. Res. 31, 19-27 (1996).
    • (1996) Cardiovasc. Res. , vol.31 , pp. 19-27
    • Whittaker, P.1
  • 70
    • 84859652373 scopus 로고    scopus 로고
    • Regional mechanics determine collagen fiber structure in healing myocardial infarcts
    • Fomovsky, G. M., Rouillard, A. D. & Holmes, J. W. Regional mechanics determine collagen fiber structure in healing myocardial infarcts. J. Mol. Cell. Cardiol. 52, 1083-1090 (2012).
    • (2012) J. Mol. Cell. Cardiol. , vol.52 , pp. 1083-1090
    • Fomovsky, G.M.1    Rouillard, A.D.2    Holmes, J.W.3
  • 72
    • 76849087987 scopus 로고    scopus 로고
    • Myocardial remodeling after infarction: The role of myofibroblasts
    • van den Borne, S. W. et al. Myocardial remodeling after infarction: the role of myofibroblasts. Nat. Rev. Cardiol. 7, 30-37 (2010).
    • (2010) Nat. Rev. Cardiol. , vol.7 , pp. 30-37
    • Van Den Borne, S.W.1
  • 74
    • 0029690592 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme and wound healing in diverse tissues of the rat
    • Sun, Y. & Weber, K. T. Angiotensin-converting enzyme and wound healing in diverse tissues of the rat. J. Lab. Clin. Med. 127, 94-101 (1996). (Pubitemid 126690992)
    • (1996) Journal of Laboratory and Clinical Medicine , vol.127 , Issue.1 , pp. 94-101
    • Sun, Y.1    Weber, K.T.2
  • 78
    • 0027515656 scopus 로고
    • Angiotensin II and aldosterone receptor binding in rat heart and kidney: Response to chronic angiotensin II or aldosterone administration
    • Sun, Y. & Weber, K. T. Angiotensin II and aldosterone receptor binding in rat heart and kidney: response to chronic angiotensin II or aldosterone administration. J. Lab. Clin. Med. 122, 404-411 (1993). (Pubitemid 23346775)
    • (1993) Journal of Laboratory and Clinical Medicine , vol.122 , Issue.4 , pp. 404-411
    • Sun, Y.1    Weber, K.T.2
  • 80
    • 0031194295 scopus 로고    scopus 로고
    • 1 in cardiac fibroblasts and myofibroblasts
    • DOI 10.1006/jmcc.1997.0435
    • Campbell, S. E. & Katwa, L. C. Angiotensin II stimulated expression of transforming growth factor-beta 1 in cardiac fibroblasts and myofibroblasts. J. Mol. Cell. Cardiol. 29, 1947-1958 (1997). (Pubitemid 27303099)
    • (1997) Journal of Molecular and Cellular Cardiology , vol.29 , Issue.7 , pp. 1947-1958
    • Campbell, S.E.1    Katwa, L.C.2
  • 81
    • 79951713169 scopus 로고    scopus 로고
    • Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease
    • Wang, Q. et al. Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease. Fibrogenesis Tissue Repair 4, 4 (2011).
    • (2011) Fibrogenesis Tissue Repair , vol.4 , pp. 4
    • Wang, Q.1
  • 82
    • 41949091777 scopus 로고    scopus 로고
    • Molecular requirements for induction of CTGF expression by TGF-β1 in primary osteoblasts
    • Arnott, J. A. et al. Molecular requirements for induction of CTGF expression by TGF-β1 in primary osteoblasts. Bone 42, 871-885 (2008).
    • (2008) Bone , vol.42 , pp. 871-885
    • Arnott, J.A.1
  • 83
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • DOI 10.1002/path.2277
    • Wynn, T. A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214, 199-210 (2008). (Pubitemid 351160157)
    • (2008) Journal of Pathology , vol.214 , Issue.2 , pp. 199-210
    • Wynn, T.A.1
  • 84
    • 79955738469 scopus 로고    scopus 로고
    • Transforming growth factor-β1 suppresses the up-regulation of matrix metalloproteinase-2 by lung fibroblasts in response to tumor necrosis factor-α
    • Ye, H., Cai, P. C., Zhou, Q. & Ma, W. L. Transforming growth factor-β1 suppresses the up-regulation of matrix metalloproteinase-2 by lung fibroblasts in response to tumor necrosis factor-α. Wound Repair Regen. 19, 392-399 (2011).
    • (2011) Wound Repair Regen. , vol.19 , pp. 392-399
    • Ye, H.1    Cai, P.C.2    Zhou, Q.3    Ma, W.L.4
  • 85
    • 0028173386 scopus 로고
    • The α-smooth muscle actin-positive cells in healing human myocardial scars
    • Willems, I. E. M. G., Havenith, M. G., De Mey, J. G. R. & Daemen, M. J. A. P. The α-smooth muscle actin-positive cells in healing human myocardial scars. Am. J. Pathol. 145, 868-875 (1994).
    • (1994) Am. J. Pathol. , vol.145 , pp. 868-875
    • Willems, I.E.M.G.1    Havenith, M.G.2    De Mey, J.G.R.3    Daemen, M.J.A.P.4
  • 86
    • 77955056291 scopus 로고    scopus 로고
    • Regulation of myofibroblast activities: Calcium pulls some strings behind the scene
    • Follonier Castella, L., Gabbiani, G., McCulloch, C. A. & Hinz, B. Regulation of myofibroblast activities: calcium pulls some strings behind the scene. Exp. Cell Res. 316, 2390-2401 (2010).
    • (2010) Exp. Cell Res. , vol.316 , pp. 2390-2401
    • Follonier Castella, L.1    Gabbiani, G.2    McCulloch, C.A.3    Hinz, B.4
  • 87
    • 0346995539 scopus 로고
    • eds Cotran, R. S., Kumar, V. & Robbins, S. L., W. B. Saunders, Philadelphia
    • Cotran, R. S., Kumar, V. & Robbins, S. L. in Robbins Pathologic Basis of Disease (eds Cotran, R. S., Kumar, V. & Robbins, S. L.) 597-656 (W. B. Saunders, Philadelphia, 1989).
    • (1989) Robbins Pathologic Basis of Disease , pp. 597-656
    • Cotran, R.S.1    Kumar, V.2    Robbins, S.L.3
  • 89
    • 0018761299 scopus 로고
    • Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries
    • DOI 10.1016/0002-9149(79)90139-5
    • Maron, B. J., Epstein, S. E. & Roberts, W. C. Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries. Am. J. Cardiol. 43, 1086-1102 (1979). (Pubitemid 9190990)
    • (1979) American Journal of Cardiology , vol.43 , Issue.6 , pp. 1086-1102
    • Maron, B.J.1    Epstein, S.E.2    Roberts, W.C.3
  • 90
    • 0037276860 scopus 로고    scopus 로고
    • The heart in human dystrophinopathies
    • DOI 10.1159/000068446
    • Finsterer, J. & Stöllberger, C. The heart in human dystrophinopathies. Cardiology 99, 1-19 (2003). (Pubitemid 36206630)
    • (2003) Cardiology , vol.99 , Issue.1 , pp. 1-19
    • Finsterer, J.1    Stollberger, C.2
  • 92
    • 0024355036 scopus 로고
    • Change in cardiac myocyte size distribution in aortic-constricted neonatal rats
    • Campbell, S. E., Rakusan, K. & Gerdes, A. M. Change in cardiac myocyte size distribution in aortic-constricted neonatal rats. Basic Res. Cardiol. 84, 247-258 (1989). (Pubitemid 19166433)
    • (1989) Basic Research in Cardiology , vol.84 , Issue.3 , pp. 247-258
    • Campbell, S.E.1    Rakusan, K.2    Gerdes, A.M.3
  • 93
  • 94
    • 80052554879 scopus 로고    scopus 로고
    • β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes
    • López, J. E. et al. β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes. Circ. Res. 109, 629-638 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 629-638
    • López, J.E.1
  • 95
    • 84865497468 scopus 로고    scopus 로고
    • Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: Potential role of lysyl oxidase
    • López, B., Querejeta, R., González, A., Larman, M. & Díez, J. Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase. Hypertension 60, 677-683 (2012).
    • (2012) Hypertension , vol.60 , pp. 677-683
    • López, B.1    Querejeta, R.2    González, A.3    Larman, M.4    Díez, J.5
  • 96
    • 0035214269 scopus 로고    scopus 로고
    • Clinical aspects of hypertensive myocardial fibrosis
    • DOI 10.1097/00001573-200111000-00003
    • Diez, J., Lopez, B., Gonzalez, A. & Querejeta, R. Clinical aspects of hypertensive myocardial fibrosis. Curr. Opin. Cardiol. 16, 328-335 (2001). (Pubitemid 33135220)
    • (2001) Current Opinion in Cardiology , vol.16 , Issue.6 , pp. 328-335
    • Diez, J.1    Lopez, B.2    Gonzalez, A.3    Querejeta, R.4
  • 97
    • 85047680324 scopus 로고
    • Myocardial fibrosis: Functional significance and regulatory factors
    • Weber, K. T., Brilla, C. G. & Janicki, J. S. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc. Res. 27, 341-348 (1993). (Pubitemid 23116130)
    • (1993) Cardiovascular Research , vol.27 , Issue.3 , pp. 341-348
    • Weber, K.T.1    Brilla, C.G.2    Janicki, J.S.3
  • 98
    • 0018133166 scopus 로고
    • The effect of the lathyrogen β-amino proprionitrile (BAPN) on the mechanical properties of experimentally hypertrophied rat cardiac muscle
    • Bing, O. H. L., Fanburg, B. L., Brooks, W. W. & Matsushita, S. The effect of the lathyrogen β-amino proprionitrile (BAPN) on the mechanical properties of experimentally hypertrophied rat cardiac muscle. Circ. Res. 43, 632-637 (1978). (Pubitemid 9022308)
    • (1978) Circulation Research , vol.43 , Issue.4 , pp. 632-637
    • Bing, O.H.L.1    Fanburg, B.L.2    Brooks, W.W.3    Matsushita, S.4
  • 99
    • 79952260400 scopus 로고    scopus 로고
    • Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction
    • Westermann, D. et al. Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction. Circ. Heart Fail. 4, 44-52 (2011).
    • (2011) Circ. Heart Fail. , vol.4 , pp. 44-52
    • Westermann, D.1
  • 100
    • 33847105538 scopus 로고    scopus 로고
    • Diastolic heart failure: Evidence of increased myocardial collagen turnover linked to diastolic dysfunction
    • DOI 10.1161/CIRCULATIONAHA.106.638569, PII 0000301720070220000014
    • Martos, R. et al. Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. Circulation 115, 888-895 (2007). (Pubitemid 46294729)
    • (2007) Circulation , vol.115 , Issue.7 , pp. 888-895
    • Martos, R.1    Baugh, J.2    Ledwidge, M.3    O'Loughlin, C.4    Conlon, C.5    Patle, A.6    Donnelly, S.C.7    McDonald, K.8
  • 101
    • 0015225464 scopus 로고
    • Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
    • Gabbiani, G., Ryan, G. B. & Majno, G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27, 549-550 (1971).
    • (1971) Experientia , vol.27 , pp. 549-550
    • Gabbiani, G.1    Ryan, G.B.2    Majno, G.3
  • 102
    • 0027096671 scopus 로고
    • Diastolic dysfunction in pressure-overload hypertrophy and its modification by angiotensin II: Current concepts
    • Lorell, B. H. Diastolic dysfunction in pressure-overload hypertrophy and its modification by angiotensin II: current concepts. Basic Res. Cardiol. 87 (Suppl. 2), 163-172 (1992). (Pubitemid 23081266)
    • (1992) Basic Research in Cardiology , vol.87 , Issue.SUPPL. 2 , pp. 163-172
    • Lorell, B.H.1
  • 103
    • 0028609776 scopus 로고
    • Intracardiac angiotensin-converting enzyme inhibition improves diastolic function in patients with left ventricular hypertrophy due to aortic stenosis
    • Friedrich, S. P. et al. Intracardiac angiotensin-converting enzyme inhibition improves diastolic function in patients with left ventricular hypertrophy due to aortic stenosis. Circulation 90, 2761-2771 (1994).
    • (1994) Circulation , vol.90 , pp. 2761-2771
    • Friedrich, S.P.1
  • 104
    • 84861787843 scopus 로고    scopus 로고
    • Targeting cardiac fibrosis: A new frontier in antiarrhythmic therapy?
    • Karagueuzian, H. S. Targeting cardiac fibrosis: a new frontier in antiarrhythmic therapy? Am. J. Cardiovasc. Dis. 1, 101-109 (2011).
    • (2011) Am. J. Cardiovasc. Dis. , vol.1 , pp. 101-109
    • Karagueuzian, H.S.1
  • 105
    • 56649083642 scopus 로고    scopus 로고
    • Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart
    • Hothi, S. S. et al. Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart. Pflügers Arch. 457, 253-270 (2008).
    • (2008) Pflügers Arch. , vol.457 , pp. 253-270
    • Hothi, S.S.1
  • 106
    • 65649095952 scopus 로고    scopus 로고
    • Myofibroblasts in diseased hearts: New players in cardiac arrhythmias?
    • Rohr, S. Myofibroblasts in diseased hearts: new players in cardiac arrhythmias? Heart Rhythm 6, 848-856 (2009).
    • (2009) Heart Rhythm , vol.6 , pp. 848-856
    • Rohr, S.1
  • 107
    • 41149136780 scopus 로고    scopus 로고
    • Atrial extracellular matrix remodelling in patients with atrial fibrillation
    • Polyakova, V., Miyagawa, S., Szalay, Z., Risteli, J. & Kostin, S. Atrial extracellular matrix remodelling in patients with atrial fibrillation. J. Cell. Mol. Med. 12, 189-208 (2008).
    • (2008) J. Cell. Mol. Med. , vol.12 , pp. 189-208
    • Polyakova, V.1    Miyagawa, S.2    Szalay, Z.3    Risteli, J.4    Kostin, S.5
  • 109
    • 0018827893 scopus 로고
    • Aerobic limit of the heart perfused at constant pressure
    • Weber, K. T., Janicki, J. S. & Fishman, A. P. Aerobic limit of the heart perfused at constant pressure. Am. J. Physiol. 238, H118-H125 (1980).
    • (1980) Am. J. Physiol. , vol.238
    • Weber, K.T.1    Janicki, J.S.2    Fishman, A.P.3
  • 110
    • 0025729459 scopus 로고
    • Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy
    • Brilla, C. G., Janicki, J. S. & Weber, K. T. Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy. Circulation 83, 1771-1779 (1991).
    • (1991) Circulation , vol.83 , pp. 1771-1779
    • Brilla, C.G.1    Janicki, J.S.2    Weber, K.T.3
  • 111
    • 33645927315 scopus 로고    scopus 로고
    • Relation between flow reserve capacity of penetrating intramyocardial coronary arteries and myocardial fibrosis in hypertension: Study using transthoracic Doppler echocardiography
    • Youn, H. J. et al. Relation between flow reserve capacity of penetrating intramyocardial coronary arteries and myocardial fibrosis in hypertension: study using transthoracic Doppler echocardiography. J. Am. Soc. Echocardiogr. 19, 373-378 (2006).
    • (2006) J. Am. Soc. Echocardiogr. , vol.19 , pp. 373-378
    • Youn, H.J.1
  • 112
    • 0021741951 scopus 로고
    • Massive cardiac ventricular scarring in first-degree relatives with hypertrophic cardiomyopathy
    • DOI 10.1016/S0002-9149(84)80108-3
    • Warnes, C. A., Maron, B. J. & Roberts, W. C. Massive cardiac ventricular scarring in first-degree relatives with hypertrophic cardiomyopathy. Am. J. Cardiol. 54, 1377-1379 (1984). (Pubitemid 15220579)
    • (1984) American Journal of Cardiology , vol.54 , Issue.10 , pp. 1377-1379
    • Warnes, C.A.1    Maron, B.J.2    Roberts, W.C.3
  • 114
    • 80051623476 scopus 로고    scopus 로고
    • Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations
    • Olivotto, I. et al. Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations. J. Am. Coll. Cardiol. 58, 839-48 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.58 , pp. 839-848
    • Olivotto, I.1
  • 115
    • 0024840101 scopus 로고
    • Myocardial collagen remodeling in pressure overload hypertrophy. A case for interstitial heart disease
    • Weber, K. T., Jalil, J. E., Janicki, J. S. & Pick, R. Myocardial collagen remodeling in pressure overload hypertrophy: a case for interstitial heart disease. Am. J. Hypertens. 2, 931-940 (1989). (Pubitemid 20046711)
    • (1989) American Journal of Hypertension , vol.2 , Issue.12 , pp. 931-940
    • Weber, K.T.1    Jalil, J.E.2    Janicki, J.S.3    Pick, R.4
  • 116
    • 84865126681 scopus 로고    scopus 로고
    • Diagnostics and therapeutic interventions in myocardial interstitial disease, a previously neglected pathology
    • Collier, P., Ledwidge, M. & McDonald, K. Diagnostics and therapeutic interventions in myocardial interstitial disease, a previously neglected pathology. QJM 105, 721-724 (2012).
    • (2012) QJM , vol.105 , pp. 721-724
    • Collier, P.1    Ledwidge, M.2    McDonald, K.3
  • 117
    • 84859912642 scopus 로고    scopus 로고
    • Mitochondria and heart disease
    • Griffiths, E. J. Mitochondria and heart disease. Adv. Exp. Med. Biol. 942, 249-267 (2012).
    • (2012) Adv. Exp. Med. Biol. , vol.942 , pp. 249-267
    • Griffiths, E.J.1
  • 118
    • 79959525058 scopus 로고    scopus 로고
    • Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy
    • Dai, D. F. et al. Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy. J. Am. Coll. Cardiol. 58, 73-82 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.58 , pp. 73-82
    • Dai, D.F.1
  • 119
    • 78951482658 scopus 로고    scopus 로고
    • Mitochondria-targeted cardioprotection in aldosteronism
    • Shahbaz, A. U. et al. Mitochondria-targeted cardioprotection in aldosteronism. J. Cardiovasc. Pharmacol. 57, 37-43 (2011).
    • (2011) J. Cardiovasc. Pharmacol. , vol.57 , pp. 37-43
    • Shahbaz, A.U.1
  • 120
    • 79960413043 scopus 로고    scopus 로고
    • Mitochondriocentric pathway to cardiomyocyte necrosis in aldosteronism: Cardioprotective responses to carvedilol and nebivolol
    • Cheema, Y. et al. Mitochondriocentric pathway to cardiomyocyte necrosis in aldosteronism: cardioprotective responses to carvedilol and nebivolol. J. Cardiovasc. Pharmacol. 58, 80-86 (2011).
    • (2011) J. Cardiovasc. Pharmacol. , vol.58 , pp. 80-86
    • Cheema, Y.1
  • 121
    • 84864459708 scopus 로고    scopus 로고
    • ATP channels and permeability transition pores of mitochondria in dogs
    • ATP channels and permeability transition pores of mitochondria in dogs. Cardiovasc. Drugs Ther. 26, 217-226 (2012).
    • (2012) Cardiovasc. Drugs Ther. , vol.26 , pp. 217-226
    • Yoshida, A.1
  • 122
    • 84859720170 scopus 로고    scopus 로고
    • 2+ overload and cell death
    • 2+ overload and cell death. J. Clin. Invest. 122, 1222-1232 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1222-1232
    • Aurora, A.B.1
  • 123
    • 78650170396 scopus 로고    scopus 로고
    • Regulation of myocardial fibrosis by MicroRNAs
    • Bauersachs, J. Regulation of myocardial fibrosis by MicroRNAs. J. Cardiovasc. Pharmacol. 56, 454-459 (2010).
    • (2010) J. Cardiovasc. Pharmacol. , vol.56 , pp. 454-459
    • Bauersachs, J.1
  • 124
    • 84865273299 scopus 로고    scopus 로고
    • Cardiac fibrosis revisited by microRNA therapeutics
    • Thum, T. & Lorenzen, J. M. Cardiac fibrosis revisited by microRNA therapeutics. Circulation 126, 800-802 (2012).
    • (2012) Circulation , vol.126 , pp. 800-802
    • Thum, T.1    Lorenzen, J.M.2
  • 125
    • 54949128696 scopus 로고    scopus 로고
    • Fibrosis and cirrhosis reversibility-molecular mechanisms
    • Gieling, R. G., Burt, A. D. & Mann, D. A. Fibrosis and cirrhosis reversibility-molecular mechanisms. Clin. Liver Dis. 12, 915-937 (2008).
    • (2008) Clin. Liver Dis. , vol.12 , pp. 915-937
    • Gieling, R.G.1    Burt, A.D.2    Mann, D.A.3
  • 126
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • DOI 10.1007/s10495-005-1055-4
    • Elsharkawy, A. M., Oakley, F. & Mann, D. A. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 10, 927-939 (2005). (Pubitemid 41285572)
    • (2005) Apoptosis , vol.10 , Issue.5 , pp. 927-939
    • Elsharkawy, A.M.1    Oakley, F.2    Mann, D.A.3
  • 127
    • 33847622043 scopus 로고    scopus 로고
    • Resolving fibrosis in the diseased liver: Translating the scientific promise to the clinic
    • DOI 10.1016/j.biocel.2006.10.006, PII S1357272506002809
    • Muddu, A. K., Guha, I. N., Elsharkawy, A. M. & Mann, D. A. Resolving fibrosis in the diseased liver: translating the scientific promise to the clinic. Int. J. Biochem. Cell Biol. 39, 695-714 (2007). (Pubitemid 46366796)
    • (2007) International Journal of Biochemistry and Cell Biology , vol.39 , Issue.4 , pp. 695-714
    • Muddu, A.K.1    Guha, I.N.2    Elsharkawy, A.M.3    Mann, D.A.4
  • 128
    • 0026667436 scopus 로고
    • Angiotensin II receptor blockade after myocardial infarction in rats: Effects on hemodynamics, myocardial DNA synthesis, and interstitial collagen content
    • Smits, J. F. M., van Krimpen, C., Schoemaker, R. G., Cleutjens, J. P. M. & Daemen, M. J. A. P. Angiotensin II receptor blockade after myocardial infarction in rats: effects on hemodynamics, myocardial DNA synthesis, and interstitial collagen content. J. Cardiovasc. Pharmacol. 20, 772-778 (1992).
    • (1992) J. Cardiovasc. Pharmacol. , vol.20 , pp. 772-778
    • Smits, J.F.M.1    Van Krimpen, C.2    Schoemaker, R.G.3    Cleutjens, J.P.M.4    Daemen, M.J.A.P.5
  • 130
    • 33749826834 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction
    • DOI 10.1097/01.fjc.0000245405.41317.60, PII 0000534420060900000004
    • Matsusaka, H. et al. Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction. J. Cardiovasc. Pharmacol. 48, 95-102 (2006). (Pubitemid 44562948)
    • (2006) Journal of Cardiovascular Pharmacology , vol.48 , Issue.3 , pp. 95-102
    • Matsusaka, H.1    Kinugawa, S.2    Ide, T.3    Matsushima, S.4    Shiomi, T.5    Kubota, T.6    Sunagawa, K.7    Tsutsui, H.8
  • 131
    • 78649813439 scopus 로고    scopus 로고
    • Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan
    • Iwamoto, M. et al. Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan. Hypertens. Res. 33, 1305-1311 (2010).
    • (2010) Hypertens. Res. , vol.33 , pp. 1305-1311
    • Iwamoto, M.1
  • 132
    • 61949197524 scopus 로고    scopus 로고
    • Regulation of T-cell function by endogenously produced angiotensin II
    • Hoch, N. E. et al. Regulation of T-cell function by endogenously produced angiotensin II. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R208-R216 (2009).
    • (2009) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.296
    • Hoch, N.E.1
  • 133
    • 22144435873 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: Role of angiotensin II
    • DOI 10.1113/expphysiol.2005.030080
    • Touyz, R. M. Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II. Exp. Physiol. 90, 449-55 (2005). (Pubitemid 40980144)
    • (2005) Experimental Physiology , vol.90 , Issue.4 , pp. 449-455
    • Touyz, R.M.1
  • 134
    • 65449116497 scopus 로고    scopus 로고
    • Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan
    • Fujiwara, Y. et al. Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan. Int. J. Mol. Med. 22, 703-708 (2008).
    • (2008) Int. J. Mol. Med. , vol.22 , pp. 703-708
    • Fujiwara, Y.1
  • 135
    • 33645672459 scopus 로고    scopus 로고
    • Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    • Habashi, J. P. et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312, 117-121 (2006).
    • (2006) Science , vol.312 , pp. 117-121
    • Habashi, J.P.1
  • 136
    • 79961221183 scopus 로고    scopus 로고
    • 1) receptor blockade
    • 1) receptor blockade. PLoS ONE 6, e23411 (2011).
    • (2011) PLoS ONE , vol.6
    • Moltzer, E.1
  • 138
    • 78649647608 scopus 로고    scopus 로고
    • Pathobiological aspects of the local bone marrow renin-angiotensin system: A review
    • Haznedaroglu, I. C. & Beyazit, Y. Pathobiological aspects of the local bone marrow renin-angiotensin system: a review. J. Renin Angiotensin. Aldosterone Syst. 11, 205-213 (2010).
    • (2010) J. Renin Angiotensin. Aldosterone Syst. , vol.11 , pp. 205-213
    • Haznedaroglu, I.C.1    Beyazit, Y.2
  • 139
    • 77950849253 scopus 로고    scopus 로고
    • ANG II receptor antagonists as modulators of macrophages polarization
    • Garcia, G. E. ANG II receptor antagonists as modulators of macrophages polarization. Am. J. Physiol. Renal Physiol. 298, F868-F869 (2010).
    • (2010) Am. J. Physiol. Renal Physiol. , vol.298
    • Garcia, G.E.1
  • 140
    • 84856120678 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats
    • Rehman, A. et al. Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 59, 291-299 (2012).
    • (2012) Hypertension , vol.59 , pp. 291-299
    • Rehman, A.1
  • 141
    • 33846256550 scopus 로고    scopus 로고
    • ACE2 of the heart: From angiotensin I to angiotensin (1-7)
    • DOI 10.1016/j.cardiores.2006.09.006, PII S0008636306004056
    • Keidar, S., Kaplan, M. & Gamliel-Lazarovich, A. ACE2 of the heart: from angiotensin I to angiotensin (1-7). Cardiovasc. Res. 73, 463-469 (2007). (Pubitemid 46091776)
    • (2007) Cardiovascular Research , vol.73 , Issue.3 , pp. 463-469
    • Keidar, S.1    Kaplan, M.2    Gamliel-Lazarovich, A.3
  • 142
    • 0141988865 scopus 로고    scopus 로고
    • Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: Evidence for upregulation of the angiotensin-converting enzyme homologue ACE2
    • DOI 10.1161/01.CIR.0000094734.67990.99
    • Zisman, L. S. et al. Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2. Circulation 108, 1707-1712 (2003). (Pubitemid 37243658)
    • (2003) Circulation , vol.108 , Issue.14 , pp. 1707-1712
    • Zisman, L.S.1    Keller, R.S.2    Weaver, B.3    Lin, Q.4    Speth, R.5    Bristow, M.R.6    Canver, C.C.7
  • 144
    • 34548822986 scopus 로고    scopus 로고
    • Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in dahl salt-sensitive hypertensive rats
    • DOI 10.1016/j.amjhyper.2007.05.008, PII S0895706107003111
    • Takeda, Y. et al. Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats. Am. J. Hypertens. 20, 1119-1124 (2007). (Pubitemid 47446168)
    • (2007) American Journal of Hypertension , vol.20 , Issue.10 , pp. 1119-1124
    • Takeda, Y.1    Zhu, A.2    Yoneda, T.3    Usukura, M.4    Takata, H.5    Yamagishi, M.6
  • 145
    • 80052693325 scopus 로고    scopus 로고
    • Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis
    • Sukumaran, V. et al. Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis. Int. J. Biol. Sci. 7, 1077-1092 (2011).
    • (2011) Int. J. Biol. Sci. , vol.7 , pp. 1077-1092
    • Sukumaran, V.1
  • 146
    • 70350457666 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
    • Kassiri, Z. et al. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ. Heart Fail. 2, 446-455 (2009).
    • (2009) Circ. Heart Fail. , vol.2 , pp. 446-455
    • Kassiri, Z.1
  • 147
    • 78649337583 scopus 로고    scopus 로고
    • ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction
    • Zhao, Y. X. et al. ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction. Hum. Gene Ther. 21, 1545-1554 (2010).
    • (2010) Hum. Gene Ther. , vol.21 , pp. 1545-1554
    • Zhao, Y.X.1
  • 148
    • 84863116259 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy
    • Dong, B. et al. Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. J. Am. Coll. Cardiol. 59, 739-747 (2012).
    • (2012) J. Am. Coll. Cardiol. , vol.59 , pp. 739-747
    • Dong, B.1
  • 149
    • 77952511816 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    • Trask, A. J. et al. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am. J. Hypertens. 23, 687-693 (2010).
    • (2010) Am. J. Hypertens. , vol.23 , pp. 687-693
    • Trask, A.J.1
  • 150
    • 33645960124 scopus 로고    scopus 로고
    • Therapeutic strategies against TGF-β signaling pathway in hepatic fibrosis
    • Liu, X., Hu, H. & Yin, J. Q. Therapeutic strategies against TGF-β signaling pathway in hepatic fibrosis. Liver Int. 26, 8-22 (2006).
    • (2006) Liver Int , vol.26 , pp. 8-22
    • Liu, X.1    Hu, H.2    Yin, J.Q.3
  • 151
    • 70349659185 scopus 로고    scopus 로고
    • Angiotensin II induces connective tissue growth factor and collagen i expression via transforming growth factor-β-dependent and-independent Smad pathways: The role of Smad3
    • Yang, F., Chung, A. C., Huang, X. R. & Lan, H. Y. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-β-dependent and-independent Smad pathways: the role of Smad3. Hypertension 54, 877-884 (2009).
    • (2009) Hypertension , vol.54 , pp. 877-884
    • Yang, F.1    Chung, A.C.2    Huang, X.R.3    Lan, H.Y.4
  • 152
    • 84864312353 scopus 로고    scopus 로고
    • Transforming growth factor-β/Smad signalling in diabetic nephropathy
    • Lan, H. Y. Transforming growth factor-β/Smad signalling in diabetic nephropathy. Clin. Exp. Pharmacol. Physiol. 39, 731-738 (2012).
    • (2012) Clin. Exp. Pharmacol. Physiol. , vol.39 , pp. 731-738
    • Lan, H.Y.1
  • 153
    • 84859073207 scopus 로고    scopus 로고
    • Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling
    • Hinz, B. et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am. J. Pathol. 180, 1340-1355 (2012).
    • (2012) Am. J. Pathol. , vol.180 , pp. 1340-1355
    • Hinz, B.1
  • 154
    • 79960364782 scopus 로고    scopus 로고
    • Exploring anti-TGF-β therapies in cancer and fibrosis
    • Hawinkels, L. J. & Ten Dijke, P. Exploring anti-TGF-β therapies in cancer and fibrosis. Growth Factors 29, 140-152 (2011).
    • (2011) Growth Factors , vol.29 , pp. 140-152
    • Hawinkels, L.J.1    Ten Dijke, P.2
  • 155
    • 78650170396 scopus 로고    scopus 로고
    • Regulation of myocardial fibrosis by MicroRNAs
    • Bauersachs, J. Regulation of myocardial fibrosis by MicroRNAs. J. Cardiovasc. Pharmacol. 56, 454-459 (2010).
    • (2010) J. Cardiovasc. Pharmacol. , vol.56 , pp. 454-459
    • Bauersachs, J.1
  • 157
    • 78049322513 scopus 로고    scopus 로고
    • Prevention of liver fibrosis by triple helix-forming oligodeoxyribonucleotides targeted to the promoter region of type i collagen gene
    • Koilan, S. et al. Prevention of liver fibrosis by triple helix-forming oligodeoxyribonucleotides targeted to the promoter region of type I collagen gene. Oligonucleotides 20, 231-237 (2010).
    • (2010) Oligonucleotides , vol.20 , pp. 231-237
    • Koilan, S.1
  • 158
    • 0034687149 scopus 로고    scopus 로고
    • Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease
    • Brilla, C. G., Funck, R. C. & Rupp, H. Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation 102, 1388-1393 (2000).
    • (2000) Circulation , vol.102 , pp. 1388-1393
    • Brilla, C.G.1    Funck, R.C.2    Rupp, H.3
  • 159
    • 0034083871 scopus 로고    scopus 로고
    • 1 blockade stimulates extracellular collagen type I degradation and reverses myocardial fibrosis in spontaneously hypertensive rats
    • 1 blockade stimulates extracellular collagen type I degradation and reverses myocardial fibrosis in spontaneously hypertensive rats. Hypertension 35, 1197-1202 (2000). (Pubitemid 30413650)
    • (2000) Hypertension , vol.35 , Issue.6 , pp. 1197-1202
    • Varo, N.1    Iraburu, M.J.2    Varela, M.3    Lopez, B.4    Etayo, J.C.5    Diez, J.6
  • 160
    • 0037188574 scopus 로고    scopus 로고
    • Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients
    • DOI 10.1161/01.CIR.0000017264.66561.3D
    • Díez, J. et al. Losar tan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients. Circulation 105, 2512-2517 (2002). (Pubitemid 34568973)
    • (2002) Circulation , vol.105 , Issue.21 , pp. 2512-2517
    • Diez, J.1    Querejeta, R.2    Lopez, B.3    Gonzalez, A.4    Larman, M.5    Martinez Ubago, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.