Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction

Cardiovascular Research

Volumn 102, Issue 3, 2014, Pages 407-417

  Sarrazy, Vincent ^a   Koehler, Anne ^a   Chow, Melissa L ^a   Zimina, Elena ^a   Li, Chen X ^a   Kato, Hideyuki ^a,b   Caldarone, Christopher A ^a,b   Hinz, Boris ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Cardiac fibrosis; Cardiac repair; Mechanical stress; Myofibroblast

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ALPHAVBETA5 INTEGRIN; CILENGITIDE; TRANSFORMING GROWTH FACTOR BETA1; VITRONECTIN RECEPTOR; ACTA2 PROTEIN, HUMAN; ACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC FIBROBLAST; CELL ACTIVATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE COURSE; FIBROBLAST; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RIGHT VENTRICULAR FIBROSIS; UPREGULATION; VASCULAR SMOOTH MUSCLE; ADULT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; FIBROSIS; HEART MUSCLE; MALE; PATHOLOGY; PHYSIOLOGY; SWINE;

ACTINS; ADULT; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; FIBROSIS; HUMANS; INTEGRIN ALPHAVBETA3; MALE; MYOCARDIUM; MYOFIBROBLASTS; RECEPTORS, VITRONECTIN; SWINE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84901440560     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu053     Document Type: Article

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