The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts

Journal of Molecular and Cellular Cardiology

Volumn 45, Issue 2, 2008, Pages 193-197

  Wang, Baiqiu ^a   Haldar, Saptarsi M ^a   Lu, Yuan ^a   Ibrahim, Osama A ^a   Fisch, Sudeshna ^b   Gray, Susan ^b   Leask, Andrew ^c   Jain, Mukesh K ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c WESTERN UNIVERSITY   (Canada)

Author keywords

CTGF; Fibroblast; Fibrosis; Kruppel; P CAF; TGF; Transcription

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 15; SMAD3 PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; DOWN REGULATION; FIBROBLAST; HEART MUSCLE FIBROSIS; HEART VENTRICLE OVERLOAD; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANIMALS, NEWBORN; CELL LINE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS;

MUS; RATTUS;

EID: 48849101093     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2008.05.005     Document Type: Article

References (15)

1. Sun Y., Zhang J.Q., Zhang J., and Lamparter S. Cardiac remodeling by fibrous tissue after infarction in rats. J Lab Clin Med 135 (2000) 316-323
2. Chen M.M., Lam A., Abraham J.A., Schreiner G.F., and Joly A.H. CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J Mol Cell Cardio 32 (2000) 1805-1819
3. Oemar B.S., Werner A., Garnier J.M., Do D.D., Godoy N., Nauck M., et al. Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. Circulation 95 (1997) 831-839
4. Khan R., and Sheppard R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118 (2006) 10-24
5. Grotendorst G.R., Okochi H., and Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 7 (1996) 469-480
6. Chen Y., Blom I.E., Sa S., Goldschmeding R., Abraham D.J., and Leask A. CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int 62 (2002) 1149-1159
7. Haldar S.M., Ibrahim O.A., and Jain M.K. Kruppel-like Factors (KLFs) in muscle biology. J Mol Cell Cardiol 43 (2007) 1-10
8. Gray S., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., et al. The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem 277 (2002) 34322-34328
9. Fisch S., Gray S., Heymans S., Haldar S.M., Wang B., Pfister O., et al. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A 104 (2007) 7074-7079
10. Leask A., and Abraham D.J. TGF-beta signaling and the fibrotic response. FASEB J 18 (2004) 816-827
11. Feinberg M.W., Cao Z., Wara A.K., Lebedeva M.A., Senbanerjee S., and Jain M.K. Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J Biol Chem 280 (2005) 38247-38258
12. Kumar A., Lin Z., SenBanerjee S., and Jain M.K. Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol 25 (2005) 5893-5903
13. Katsuma S., Ruike Y., Yano T., Kimura M., Hirasawa A., and Tsujimoto G. Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. FEBS Lett 579 (2005) 2576-2582
14. Flanders K.C., Major C.D., Arabshahi A., Aburime E.E., Okada M.H., Fujii M., et al. Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol 163 (2003) 2247-2257
15. Itoh S., Ericsson J., Nishikawa J., Heldin C.H., and ten Dijke P. The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling. Nucleic Acids Res 28 (2000) 4291-4298