Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice

Regulatory Peptides

Volumn 160, Issue 1-3, 2010, Pages 133-139

  Kagiyama, Shuntaro ^a   Matsumura, Kiyoshi ^a   Goto, Kenichi ^a   Otsubo, Toshio ^a   Iida, Mitsuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Aldosterone; AT1 knockout mice; Eplerenone; Rho kinase

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ALDOSTERONE; ANGIOTENSIN 1A RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; EPLERENONE; EZRIN; FASUDIL; MINERALOCORTICOID RECEPTOR; MOESIN; P22PHOX PROTEIN; P47PHOX PROTEIN; P67PHOX PROTEIN; RADIXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RHO KINASE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; GENE EXPRESSION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE FIBROSIS; KNOCKOUT MOUSE; LOW DRUG DOSE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SYSTOLIC BLOOD PRESSURE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ALDOSTERONE; ALDOSTERONE ANTAGONISTS; ANIMALS; BLOOD PRESSURE; FIBROSIS; HEART; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MYOCARDIUM; OXIDATIVE STRESS; RECEPTOR, ANGIOTENSIN, TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO-ASSOCIATED KINASES; SODIUM CHLORIDE; SPIRONOLACTONE;

MUS; RATTUS;

EID: 74749102175     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2009.12.002     Document Type: Article

References (28)

1. Pitt B., Remme W., Zannad F., Neaton J., Martinez F., Roniker B., et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348 (2003) 1309-1321
2. Xiao F., Puddefoot J.R., Barker S., and Vinson G.P. Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation. Hypertension 44 (2004) 340-345
3. Kagiyama S., Matsumura K., Fukuhara M., Sakagami K., Fujii K., and Iida M. Aldosterone-and-salt-induced cardiac fibrosis is independent from angiotensin II type 1a receptor signaling in mice. Hypertens Res 30 (2007) 979-989
4. Somlyo A.P., and Somlyo A.V. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83 (2003) 1325-1358
5. Shibuya M., Suzuki Y., Sugita K., Saito I., Sasaki T., Takakura K., et al. Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg 76 (1992) 571-577
6. Shimokawa H., and Takeshita A. Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25 (2005) 1767-1775
7. Nishikimi T., Akimoto K., Wang X., Mori Y., Tadokoro K., Ishikawa Y., et al. Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats. J Hypertens 22 (2004) 1787-1796
8. Koshikawa S., Nishikimi T., Inaba C., Akimoto K., and Matsuoka H. Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. J Hypertens 26 (2008) 1837-1848
9. Brilla C.G., and Weber K.T. Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med 120 (1992) 893-901
10. Robert V., Silvestre J.S., Charlemagne D., Sabri A., Trouve P., Wassef M., et al. Biological determinants of aldosterone-induced cardiac fibrosis in rats. Hypertension 26 (1995) 971-978
11. Rocha R., Rudolph A.E., Frierdich G.E., Nachowiak D.A., Kekec B.K., Blomme E.A., et al. Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol Heart Circ Physiol 283 (2002) H1802-H1810
12. Maeda A., Amano M., Fukata Y., and Kaibuchi K. Translocation of Na(+), K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells. Biochem Biophys Res Commun 297 (2002) 1231-1237
13. Hooley R., Yu C.Y., Symons M., and Barber D.L. G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J Biol Chem 271 (1996) 6152-6158
14. Wu K.L., Khan S., Lakhe-Reddy S., Jarad G., Mukherjee A., Obejero-Paz C.A., et al. The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J Biol Chem 279 (2004) 26280-26286
15. Hiroki J., Shimokawa H., Higashi M., Morikawa K., Kandabashi T., Kawamura N., et al. Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells. J Mol Cell Cardiol 37 (2004) 537-546
16. Hattori T., Shimokawa H., Higashi M., Hiroki J., Mukai Y., Tsutsui H., et al. Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109 (2004) 2234-2239
17. Sun G.P., Kohno M., Guo P., Nagai Y., Miyata K., Fan Y.Y., et al. Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury. J Am Soc Nephrol 17 (2006) 2193-2201
18. Shibata S., Nagase M., Yoshida S., Kawarazaki W., Kurihara H., Tanaka H., et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med 14 (2008) 1370-1376
19. Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389 (1997) 990-994
20. Nishikimi T., Koshikawa S., Ishikawa Y., Akimoto K., Inaba C., Ishimura K., et al. Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. J Hypertens 25 (2007) 1053-1063
21. Ishikawa Y., Nishikimi T., Akimoto K., Ishimura K., Ono H., and Matsuoka H. Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats. Hypertension 47 (2006) 1075-1083
22. Kanda T., Wakino S., Hayashi K., Homma K., Ozawa Y., and Saruta T. Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats. Kidney Int 64 (2003) 2009-2019
23. Fukui S., Fukumoto Y., Suzuki J., Saji K., Nawata J., Tawara S., et al. Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats. J Cardiovasc Pharmacol 51 (2008) 317-326
24. Ishimaru K., Ueno H., Kagitani S., Takabayashi D., Takata M., and Inoue H. Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats. J Cardiovasc Pharmacol 50 (2007) 187-194
25. Onorato J.M., Thorpe S.R., and Baynes J.W. Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. Ann NY Acad Sci 854 (1998) 277-290
26. Shibata S., Nagase M., Yoshida S., Kawachi H., and Fujita T. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 49 (2007) 355-364
27. Nishiyama A., Yao L., Nagai Y., Miyata K., Yoshizumi M., Kagami S., et al. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 43 (2004) 841-848
28. Virdis A., Neves M.F., Amiri F., Viel E., Touyz R.M., and Schiffrin E.L. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 40 (2002) 504-510