Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 42, 2013, Pages 16850-16855

  Velasquez, Lissette S ^a   Sutherland, Lillian B ^b   Liu, Zhenan ^b   Grinnell, Frederick ^b   Kamm, Kristine E ^c   Schneider, Jay W ^c   Olson, Eric N ^b   Small, Eric M ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Dermal injury; Fibrosis; Granulation tissue; MAP kinase signaling

Indexed keywords

ALPHA ACTIN; COLLAGEN; ISOXAZOLE; MYOCARDIN; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MOTILITY; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GRANULATION TISSUE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SKIN BIOPSY; SKIN FIBROBLAST; SKIN INJURY; STEM CELL; WOUND CLOSURE; WOUND HEALING;

DERMAL INJURY; FIBROSIS; GRANULATION TISSUE; MAP KINASE SIGNALING;

ANDROSTENOLS; ANIMALS; CELL DIFFERENTIATION; DERMIS; GENE EXPRESSION REGULATION; MICE; MYOFIBROBLASTS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 84885710467     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1316764110     Document Type: Article

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