Reversibility of liver fibrosis

Clinics and Research in Hepatology and Gastroenterology

Volumn 39, Issue , 2015, Pages S60-S63

  Sun, Mengxi ^a   Kisseleva, Tatiana ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL RESEARCH; HUMAN; LIVER FIBROSIS; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; SHORT SURVEY; STELLATE CELL; EXTRACELLULAR MATRIX; LIVER CIRRHOSIS; MACROPHAGE; METABOLISM; PATHOPHYSIOLOGY; REMISSION;

EXTRACELLULAR MATRIX; HUMANS; LIVER CIRRHOSIS; MACROPHAGES; MYOFIBROBLASTS; REMISSION INDUCTION;

EID: 84942821320     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2015.06.015     Document Type: Short Survey

References (25)

1. Bataller R., Brenner D.A. Liver fibrosis. J Clin Invest 2005, 115:1100.
2. Kisseleva T., Brenner D.A. Mechanisms of fibrogenesis. Exp Biol Med 2008, 233:109-122.
3. Puche J.E., et al. A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice. Hepatology 2013, 57:340-350.
4. Iwaisako K., Brenner D.A., Kisseleva T. What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis. J Gastroenterol Hepatol 27 Suppl 2012, 2:65-68.
5. Iwaisako K., et al. Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci U S A 2014, 111:E3297-E3305.
6. Kisseleva T., Brenner D.A. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol 21 Suppl 2006, 3:S84-S87.
7. Geerts A., History heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis 2001, 21:311-335.
8. Krizhanovsky V., et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008, 134:657-667.
9. Hernandez-Gea V., et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 2012, 142:938-946.
10. Kluwe J., et al. Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis. Gut 2011, 60:1260-1268.
11. Alcolado R., Arthur M.J., Iredale J.P. Pathogenesis of liver fibrosis. Clin Sci (Lond) 1997, 92:103-112.
12. Iredale J.P., et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998, 102:538-549.
13. Issa R., et al. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 2001, 48:548-557.
14. Iredale J.P. Hepatic stellate cell behavior during resolution of liver injury. Semin Liver Dis 2001, 21:427-436.
15. Gao B., Radaeva S., Park O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol 2009, 86:513-528.
16. Kisseleva T., et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A 2012, 109:9448-9453.
17. Troeger J.S., et al. Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology 2012, 143. 1073-1083 e1022.
18. She H., Xiong S., Hazra S., Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem 2005, 280:4959-4967.
19. Liu X., Xu J., Brenner D.A., Kisseleva T. Reversibility of liver fibrosis and inactivation of fibrogenic myofibroblasts. Curr Pathobiol Rep 2013, 1:209-214.
20. Baeck C., et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 2012, 61:416-426.
21. Duffield J.S., et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 2005, 115:56-65.
22. Ramachandran P., et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A 2012, 109:E3186-E3195.
23. Issa R., et al. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology 2004, 126:1795-1808.
24. Pellicoro A., Ramachandran P., Iredale J.P., Fallowfield J.A. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol 2014, 14:181-194.
25. Lee Y.A., Wallace M.C., Friedman S.L. Pathobiology of liver fibrosis: a translational success story. Gut 2015, 64:830-841.