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Volumn 6, Issue 8, 2007, Pages 2249-2260

CCG-1423: A small-molecule inhibitor of RhoA transcriptional signaling

Author keywords

[No Author keywords available]

Indexed keywords

CCG 1423; DNA; LYSOPHOSPHATIDIC ACID; RHO FACTOR; RHO KINASE INHIBITOR; SERUM RESPONSE FACTOR; UNCLASSIFIED DRUG;

EID: 34548066554     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0782     Document Type: Article
Times cited : (178)

References (66)
  • 1
    • 1642555578 scopus 로고    scopus 로고
    • Cancer metastasis therapeutic targets and drug discovery: Emerging small-molecule protein kinase inhibitors
    • Sawyer TK. Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors. Expert Opin Investig Drugs 2004;13:1-19.
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 1-19
    • Sawyer, T.K.1
  • 3
    • 17144372934 scopus 로고    scopus 로고
    • Correlation between RhoA overexpression and tumour progression in esophageal squamous cell carcinoma
    • Faried A, Nakajima M, Sohda M, Miyazaki T, Kato H, Kuwano H. Correlation between RhoA overexpression and tumour progression in esophageal squamous cell carcinoma. Eur J Surg Oncol 2005;31:410-4.
    • (2005) Eur J Surg Oncol , vol.31 , pp. 410-414
    • Faried, A.1    Nakajima, M.2    Sohda, M.3    Miyazaki, T.4    Kato, H.5    Kuwano, H.6
  • 4
    • 0035952753 scopus 로고    scopus 로고
    • Rho GTPase-dependent transformation by G protein-coupled receptors
    • Whitehead IP, Zohn IE, Der CJ. Rho GTPase-dependent transformation by G protein-coupled receptors. Oncogene 2001;20:1547-55.
    • (2001) Oncogene , vol.20 , pp. 1547-1555
    • Whitehead, I.P.1    Zohn, I.E.2    Der, C.J.3
  • 5
    • 29844453060 scopus 로고    scopus 로고
    • The role of Rac1 in maintaining malignant phenotype of mouse skin tumor cells
    • Kwei KA, Finch JS, Ranger-Moore J, Bowden GT. The role of Rac1 in maintaining malignant phenotype of mouse skin tumor cells. Cancer Lett 2006;231:326-38.
    • (2006) Cancer Lett , vol.231 , pp. 326-338
    • Kwei, K.A.1    Finch, J.S.2    Ranger-Moore, J.3    Bowden, G.T.4
  • 6
    • 13444292030 scopus 로고    scopus 로고
    • Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues
    • Liang Y, Li C, Guzman VM, et al. Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. FEBS J 2005;272:791-9.
    • (2005) FEBS J , vol.272 , pp. 791-799
    • Liang, Y.1    Li, C.2    Guzman, V.M.3
  • 7
    • 33645742736 scopus 로고    scopus 로고
    • Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42
    • Hirsch DS, Shen Y, Wu WJ. Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42. Cancer Res 2006;66:3523-30.
    • (2006) Cancer Res , vol.66 , pp. 3523-3530
    • Hirsch, D.S.1    Shen, Y.2    Wu, W.J.3
  • 8
    • 34447623358 scopus 로고    scopus 로고
    • Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells
    • Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. Breast Cancer Res 2005;7:R965-74.
    • (2005) Breast Cancer Res , vol.7
    • Baugher, P.J.1    Krishnamoorthy, L.2    Price, J.E.3    Dharmawardhane, S.F.4
  • 9
    • 0032835343 scopus 로고    scopus 로고
    • A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype
    • van Golen KL, Davies S, Wu ZF, et al. A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res 1999;5:2511-9.
    • (1999) Clin Cancer Res , vol.5 , pp. 2511-2519
    • van Golen, K.L.1    Davies, S.2    Wu, Z.F.3
  • 10
    • 0034667370 scopus 로고    scopus 로고
    • RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype
    • van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res 2000;60:5832-8.
    • (2000) Cancer Res , vol.60 , pp. 5832-5838
    • van Golen, K.L.1    Wu, Z.F.2    Qiao, X.T.3    Bao, L.W.4    Merajver, S.D.5
  • 11
    • 33646149996 scopus 로고    scopus 로고
    • GTPase is required for PC-3 prostate cancer cell invasion but not motility
    • Yao H, Dashner EJ, van Golen CM, van Golen KL. Rho C GTPase is required for PC-3 prostate cancer cell invasion but not motility. Oncogene 2006;25:2285-96.
    • (2006) Oncogene , vol.25 , pp. 2285-2296
    • Yao, H.1    Dashner, E.J.2    van Golen, C.M.3    van Golen, K.L.4    Rho, C.5
  • 12
    • 24344486013 scopus 로고    scopus 로고
    • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
    • Hakem A, Sanchez-Sweatman O, You-Ten A, et al. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 2005;19:1974-9.
    • (2005) Genes Dev , vol.19 , pp. 1974-1979
    • Hakem, A.1    Sanchez-Sweatman, O.2    You-Ten, A.3
  • 13
    • 0036827799 scopus 로고    scopus 로고
    • Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho
    • Sawada K, Morishige K, Tahara M, et al. Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho. Cancer Res 2002;62:6015-20.
    • (2002) Cancer Res , vol.62 , pp. 6015-6020
    • Sawada, K.1    Morishige, K.2    Tahara, M.3
  • 14
    • 3543121913 scopus 로고    scopus 로고
    • Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis
    • Shi X, Gangadharan B, Brass LF, Ruf W, Mueller BM. Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol Cancer Res 2004;2:395-402.
    • (2004) Mol Cancer Res , vol.2 , pp. 395-402
    • Shi, X.1    Gangadharan, B.2    Brass, L.F.3    Ruf, W.4    Mueller, B.M.5
  • 15
    • 18144389798 scopus 로고    scopus 로고
    • Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility
    • Lacoste J, Aprikian AG, Chevalier S. Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility. Mol Cell Endocrinol 2005;235:51-61.
    • (2005) Mol Cell Endocrinol , vol.235 , pp. 51-61
    • Lacoste, J.1    Aprikian, A.G.2    Chevalier, S.3
  • 16
    • 0035952680 scopus 로고    scopus 로고
    • RGS-containing RhoGEFs: The missing link between transforming G proteins and Rho?
    • Fukuhara S, Chikumi H, Gutkind JS. RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? Oncogene 2001;20:1661-8.
    • (2001) Oncogene , vol.20 , pp. 1661-1668
    • Fukuhara, S.1    Chikumi, H.2    Gutkind, J.S.3
  • 17
    • 12944262403 scopus 로고    scopus 로고
    • Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia
    • Kourlas PJ, Strout MP, Becknell B, et al. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. Proc Natl Acad Sci U S A 2000;97:2145-50.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2145-2150
    • Kourlas, P.J.1    Strout, M.P.2    Becknell, B.3
  • 18
    • 0032569051 scopus 로고    scopus 로고
    • p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
    • Kozasa T, Jiang X, Hart MJ, et al. p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13. Science 1998;280:2109-11.
    • (1998) Science , vol.280 , pp. 2109-2111
    • Kozasa, T.1    Jiang, X.2    Hart, M.J.3
  • 19
    • 0032568868 scopus 로고    scopus 로고
    • Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13
    • Hart MJ, Jiang X, Kozasa T, et al. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13. Science 1998;280:2112-4.
    • (1998) Science , vol.280 , pp. 2112-2114
    • Hart, M.J.1    Jiang, X.2    Kozasa, T.3
  • 20
    • 0042206775 scopus 로고    scopus 로고
    • Receptor-dependent RhoA activation in G12/G13-deficient cells: Genetic evidence for an involvement of Gq/G11
    • Vogt S, Grosse R, Schultz G, Offermanns S. Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. J Biol Chem 2003;278:28743-9.
    • (2003) J Biol Chem , vol.278 , pp. 28743-28749
    • Vogt, S.1    Grosse, R.2    Schultz, G.3    Offermanns, S.4
  • 21
    • 15744364175 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA
    • Lutz S, Freichel-Blomquist A, Yang Y, et al. The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem 2005;280:11134-9.
    • (2005) J Biol Chem , vol.280 , pp. 11134-11139
    • Lutz, S.1    Freichel-Blomquist, A.2    Yang, Y.3
  • 22
    • 0042354574 scopus 로고    scopus 로고
    • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    • Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 2003;5:711-9.
    • (2003) Nat Cell Biol , vol.5 , pp. 711-719
    • Sahai, E.1    Marshall, C.J.2
  • 23
    • 0042691723 scopus 로고    scopus 로고
    • Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes
    • Cen B, Selvaraj A, Burgess RC, et al. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol Cell Biol 2003;23:6597-608.
    • (2003) Mol Cell Biol , vol.23 , pp. 6597-6608
    • Cen, B.1    Selvaraj, A.2    Burgess, R.C.3
  • 24
    • 0038737042 scopus 로고    scopus 로고
    • Actin dynamics control SRF activity by regulation of its coactivator MAL
    • Miralles F, Posern G, Zaromytidou AI, Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003;113:329-42.
    • (2003) Cell , vol.113 , pp. 329-342
    • Miralles, F.1    Posern, G.2    Zaromytidou, A.I.3    Treisman, R.4
  • 25
    • 0037102445 scopus 로고    scopus 로고
    • Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas
    • Schwartz DR, Kardia SL, Shedden KA, et al. Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas. Cancer Res 2002;62:4722-9.
    • (2002) Cancer Res , vol.62 , pp. 4722-4729
    • Schwartz, D.R.1    Kardia, S.L.2    Shedden, K.A.3
  • 26
    • 8644243021 scopus 로고    scopus 로고
    • Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death
    • Vickers ER, Kasza A, Kurnaz IA, et al. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol Cell Biol 2004;24:10340-51.
    • (2004) Mol Cell Biol , vol.24 , pp. 10340-10351
    • Vickers, E.R.1    Kasza, A.2    Kurnaz, I.A.3
  • 27
    • 1642268839 scopus 로고    scopus 로고
    • RhoC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells
    • Wu M, Wu ZF, Kumar-Sinha C, Chinnaiyan A, Merajver SD. RhoC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells. Breast Cancer Res Treat 2004;84:3-12.
    • (2004) Breast Cancer Res Treat , vol.84 , pp. 3-12
    • Wu, M.1    Wu, Z.F.2    Kumar-Sinha, C.3    Chinnaiyan, A.4    Merajver, S.D.5
  • 28
    • 26444573827 scopus 로고    scopus 로고
    • Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent
    • Selvaraj A, Prywes R. Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent. BMC Mol Biol 2004;5:13.
    • (2004) BMC Mol Biol , vol.5 , pp. 13
    • Selvaraj, A.1    Prywes, R.2
  • 30
    • 34548093299 scopus 로고    scopus 로고
    • Andela VB. Correspondence Re: SS Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14.
    • Andela VB. Correspondence Re: SS Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14.
  • 31
    • 0036827799 scopus 로고    scopus 로고
    • Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho
    • Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho. Cancer Res 2002;62:6015-20.
    • (2002) Cancer Res , vol.62 , pp. 6015-6020
    • Sawada, R.K.1
  • 32
    • 2642526130 scopus 로고    scopus 로고
    • Cancer Res 2004;64:2934-5; author reply 2935-6.
    • Cancer Res 2004;64:2934-5; author reply 2935-6.
  • 33
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 2006;25:4777-86.
    • (2006) Oncogene , vol.25 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 34
    • 33747877145 scopus 로고    scopus 로고
    • Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin
    • Yu YP, Luo JH. Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin. Cancer Res 2006;66:7414-9.
    • (2006) Cancer Res , vol.66 , pp. 7414-7419
    • Yu, Y.P.1    Luo, J.H.2
  • 35
    • 0034647713 scopus 로고    scopus 로고
    • Epiregulin is up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth
    • Zhu Z, Kleeff J, Friess H, et al. Epiregulin is up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth. Biochem Biophys Res Commun 2000;273:1019-24.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 1019-1024
    • Zhu, Z.1    Kleeff, J.2    Friess, H.3
  • 36
    • 33646490271 scopus 로고    scopus 로고
    • Chemical genetics reveals an RGS/G-protein role in the action of a compound
    • Fitzgerald K, Tertyshnikova S, Moore L, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet 2006;2:e57.
    • (2006) PLoS Genet , vol.2
    • Fitzgerald, K.1    Tertyshnikova, S.2    Moore, L.3
  • 37
    • 0038235310 scopus 로고    scopus 로고
    • WF-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility
    • Nakajima M, Katayama K, Tamechika I, et al. WF-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility. Clin Exp Pharmacol Physiol 2003;30:457-63.
    • (2003) Clin Exp Pharmacol Physiol , vol.30 , pp. 457-463
    • Nakajima, M.1    Katayama, K.2    Tamechika, I.3
  • 38
    • 33749347923 scopus 로고    scopus 로고
    • The mobility and invasiveness of metastatic esophageal cancer is potentiated by shear stress in a ROCK and Ras dependent manner
    • Lawler KM, Foran E, O'Sullivan G, Long A, Kenny D. The mobility and invasiveness of metastatic esophageal cancer is potentiated by shear stress in a ROCK and Ras dependent manner. Am J Physiol Cell Physiol 2006;291:C668-77.
    • (2006) Am J Physiol Cell Physiol , vol.291
    • Lawler, K.M.1    Foran, E.2    O'Sullivan, G.3    Long, A.4    Kenny, D.5
  • 39
    • 0242298683 scopus 로고    scopus 로고
    • Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma
    • Nakajima M, Hayashi K, Egi Y, et al. Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma. Cancer Chemother Pharmacol 2003;52:319-24.
    • (2003) Cancer Chemother Pharmacol , vol.52 , pp. 319-324
    • Nakajima, M.1    Hayashi, K.2    Egi, Y.3
  • 40
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    • Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A 2004;101:7618-23.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 41
    • 0037457789 scopus 로고    scopus 로고
    • Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
    • Suzuki N, Nakamura S, Mano H, Kozasa T. Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. Proc Natl Acad Sci U S A 2003;100:733-8.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 733-738
    • Suzuki, N.1    Nakamura, S.2    Mano, H.3    Kozasa, T.4
  • 42
    • 0038100137 scopus 로고    scopus 로고
    • A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein a inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3
    • Subramanian L, Benson MD, Iniguez-Lluhi JA. A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein a inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3. J Biol Chem 2003;278:9134-41.
    • (2003) J Biol Chem , vol.278 , pp. 9134-9141
    • Subramanian, L.1    Benson, M.D.2    Iniguez-Lluhi, J.A.3
  • 43
    • 2342423628 scopus 로고    scopus 로고
    • Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells
    • Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS. Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J Biol Chem 2004;279:17578-86.
    • (2004) J Biol Chem , vol.279 , pp. 17578-17586
    • KL, D.1    Chen, M.2    Li, J.3    Lepore, J.J.4    Mericko, P.5    Parmacek, M.S.6
  • 44
    • 0029794721 scopus 로고    scopus 로고
    • Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
    • Hart MJ, Sharma S, elMasry N, et al. Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. J Biol Chem 1996;271:25452-8.
    • (1996) J Biol Chem , vol.271 , pp. 25452-25458
    • Hart, M.J.1    Sharma, S.2    elMasry, N.3
  • 45
  • 46
    • 18144404319 scopus 로고    scopus 로고
    • A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties
    • Chupreta S, Holmstrom S, Subramanian L, Iniguez-Lluhi JA. A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties. Mol Cell Biol 2005;25:4272-82.
    • (2005) Mol Cell Biol , vol.25 , pp. 4272-4282
    • Chupreta, S.1    Holmstrom, S.2    Subramanian, L.3    Iniguez-Lluhi, J.A.4
  • 47
    • 2442706575 scopus 로고    scopus 로고
    • Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells
    • Collisson EA, Kleer C, Wu M, et al. Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells. Mol Cancer Ther 2003;2:941-8.
    • (2003) Mol Cancer Ther , vol.2 , pp. 941-948
    • Collisson, E.A.1    Kleer, C.2    Wu, M.3
  • 48
    • 0035843169 scopus 로고    scopus 로고
    • Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
    • Soengas MS, Capodieci P, Polsky D, et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 2001;409:207-11.
    • (2001) Nature , vol.409 , pp. 207-211
    • Soengas, M.S.1    Capodieci, P.2    Polsky, D.3
  • 49
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang JH, Chung TD, Oldenburg KR. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999;4:67-73.
    • (1999) J Biomol Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 50
    • 3042523481 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway
    • Bian D, Su S, Mahanivong C, et al. Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway. Cancer Res 2004;64:4209-17.
    • (2004) Cancer Res , vol.64 , pp. 4209-4217
    • Bian, D.1    Su, S.2    Mahanivong, C.3
  • 51
    • 0042887042 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid in cancer
    • Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 2003;3:582-91.
    • (2003) Nat Rev Cancer , vol.3 , pp. 582-591
    • Mills, G.B.1    Moolenaar, W.H.2
  • 52
    • 0037023691 scopus 로고    scopus 로고
    • Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, LARG by tyrosine phosphorylation: Evidence of a role for focal adhesion kinase
    • Chikumi H, Fukuhara S, Gutkind JS. Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. J Biol Chem 2002;277:12463-73.
    • (2002) J Biol Chem , vol.277 , pp. 12463-12473
    • Chikumi, H.1    Fukuhara, S.2    Gutkind, J.S.3
  • 53
    • 3142730924 scopus 로고    scopus 로고
    • Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells
    • Wang Q, Liu M, Kozasa T, Rothstein JD, Sternweis PC, Neubig RR. Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. J Biol Chem 2004;279:28831-4.
    • (2004) J Biol Chem , vol.279 , pp. 28831-28834
    • Wang, Q.1    Liu, M.2    Kozasa, T.3    Rothstein, J.D.4    Sternweis, P.C.5    Neubig, R.R.6
  • 54
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000;406:532-5.
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 55
    • 33748744077 scopus 로고    scopus 로고
    • A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion
    • Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y, Casey PJ. A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem 2006;281:26483-90.
    • (2006) J Biol Chem , vol.281 , pp. 26483-26490
    • Kelly, P.1    Stemmle, L.N.2    Madden, J.F.3    Fields, T.A.4    Daaka, Y.5    Casey, P.J.6
  • 56
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996;56:100-4.
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3
  • 57
    • 0032695910 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
    • Pollack VA, Savage DM, Baker DA, et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 1999;291:739-48.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 739-748
    • Pollack, V.A.1    Savage, D.M.2    Baker, D.A.3
  • 58
    • 33745196731 scopus 로고    scopus 로고
    • 1416Gly) modulates the risk of lung cancer in Mexican Americans
    • 1416Gly) modulates the risk of lung cancer in Mexican Americans. Cancer 2006;106:2716-24.
    • (2006) Cancer , vol.106 , pp. 2716-2724
    • Gu, J.1    Wu, X.2    Dong, Q.3
  • 59
    • 0033546001 scopus 로고    scopus 로고
    • Structure of Giα1.GppNHp, autoinhibition in a ga protein-substrate complex
    • Coleman DE, Sprang SR. Structure of Giα1.GppNHp, autoinhibition in a ga protein-substrate complex. J Biol Chem 1999;274:16669-72.
    • (1999) J Biol Chem , vol.274 , pp. 16669-16672
    • Coleman, D.E.1    Sprang, S.R.2
  • 60
    • 0032537819 scopus 로고    scopus 로고
    • Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
    • Olson MF, Paterson HF, Marshall CJ. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 1998;394:295-9.
    • (1998) Nature , vol.394 , pp. 295-299
    • Olson, M.F.1    Paterson, H.F.2    Marshall, C.J.3
  • 61
    • 33745055712 scopus 로고    scopus 로고
    • The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms
    • Croft DR, Olson MF. The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol 2006;26:4612-27.
    • (2006) Mol Cell Biol , vol.26 , pp. 4612-4627
    • Croft, D.R.1    Olson, M.F.2
  • 62
    • 0347994898 scopus 로고    scopus 로고
    • Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy
    • Holmstrom S, Van Antwerp ME, Iniguez-Lluhi JA. Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy. Proc Natl Acad Sci U S A 2003;100:15758-63.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15758-15763
    • Holmstrom, S.1    Van Antwerp, M.E.2    Iniguez-Lluhi, J.A.3
  • 63
    • 23844533666 scopus 로고    scopus 로고
    • Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification
    • Nakagawa K, Kuzumaki N. Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification. Genes Cells 2005;10:835-50.
    • (2005) Genes Cells , vol.10 , pp. 835-850
    • Nakagawa, K.1    Kuzumaki, N.2
  • 65
    • 30044434455 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits
    • Jimenez-Sainz MC, Murga C, Kavelaars A, et al. G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol Biol Cell 2006;17:25-31.
    • (2006) Mol Biol Cell , vol.17 , pp. 25-31
    • Jimenez-Sainz, M.C.1    Murga, C.2    Kavelaars, A.3
  • 66
    • 1942442183 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1α promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities
    • Bartolome RA, Galvez BG, Longo N, et al. Stromal cell-derived factor-1α promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities. Cancer Res 2004;64:2534-43.
    • (2004) Cancer Res , vol.64 , pp. 2534-2543
    • Bartolome, R.A.1    Galvez, B.G.2    Longo, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.