Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway.

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Volumn 16, Issue 14, 2002, Pages 1949-1951

  Stratton, Richard ^a   Rajkumar, Vineeth ^a   Ponticos, Markella ^a   Nichols, Blake ^a   Shiwen, X ^a   Black, Carol M ^a   Abraham, David J ^a   Leask, Andrew ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA BINDING PROTEIN; ILOPROST; IMMEDIATE EARLY PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN P21; SIGNAL PEPTIDE; SMAD PROTEIN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; FIBROSIS; GENETICS; METABOLISM; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; FIBROBLASTS; FIBROSIS; ILOPROST; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; RNA, MESSENGER; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036883881     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.02-0204fje     Document Type: Article

References (0)