메뉴 건너뛰기




Volumn 1353, Issue 1, 2015, Pages 1-20

Insulin resistance in clinical and experimental alcoholic liver disease

Author keywords

Alcoholic liver disease; Insulin resistance; Metabolic syndrome; NAFLD NASH; Steatohepatitis

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADIPONECTIN; ALCOHOL; GLITAZONE DERIVATIVE; GLUCAGON; GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LEPTIN; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PIOGLITAZONE; PIRINIXIC ACID; PROTEIN KINASE B; RESVERATROL; ROSIGLITAZONE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR FKHR; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; TUROFEXORATE ISOPROPYL; UNINDEXED DRUG;

EID: 84945484423     PISSN: 00778923     EISSN: 17496632     Source Type: Journal    
DOI: 10.1111/nyas.12787     Document Type: Article
Times cited : (46)

References (176)
  • 3
    • 80053581540 scopus 로고    scopus 로고
    • Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States
    • Charlton, M.R. et al. 2011. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology 141: 1249-1253.
    • (2011) Gastroenterology , vol.141 , pp. 1249-1253
    • Charlton, M.R.1
  • 4
    • 0030998305 scopus 로고    scopus 로고
    • Alcoholic liver disease: natural history
    • Diehl, A.M. 1997. Alcoholic liver disease: natural history. Liver Transpl. Surg. 3: 206-211.
    • (1997) Liver Transpl. Surg. , vol.3 , pp. 206-211
    • Diehl, A.M.1
  • 5
    • 0036185832 scopus 로고    scopus 로고
    • Risk factors of fibrosis in alcohol-induced liver disease
    • Raynard, B. et al. 2002. Risk factors of fibrosis in alcohol-induced liver disease. Hepatology 35: 635-638.
    • (2002) Hepatology , vol.35 , pp. 635-638
    • Raynard, B.1
  • 6
    • 67349260732 scopus 로고    scopus 로고
    • Alcohol consumption and the prevalence of metabolic syndrome: a meta-analysis of observational studies
    • Alkerwi, A. et al. 2009. Alcohol consumption and the prevalence of metabolic syndrome: a meta-analysis of observational studies. Atherosclerosis 204: 624-635.
    • (2009) Atherosclerosis , vol.204 , pp. 624-635
    • Alkerwi, A.1
  • 7
    • 0033983645 scopus 로고    scopus 로고
    • Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease
    • Zein, N.N. et al. 2000. Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease. J. Hepatol. 32: 209-217.
    • (2000) J. Hepatol. , vol.32 , pp. 209-217
    • Zein, N.N.1
  • 8
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • Perry, R.J. et al. 2014. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510: 84-91.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1
  • 9
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • Muoio, D.M. & C.B. Newgard . 2008. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9: 193-205.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 10
    • 81555230504 scopus 로고    scopus 로고
    • Selection of the appropriate method for the assessment of insulin resistance
    • Borai, A. et al. 2011. Selection of the appropriate method for the assessment of insulin resistance. BMC Med. Res. Methodol. 11: 158.
    • (2011) BMC Med. Res. Methodol. , vol.11 , pp. 158
    • Borai, A.1
  • 11
    • 84879887196 scopus 로고    scopus 로고
    • Temporal effects of ethanol consumption on energy homeostasis, hepatic steatosis, and insulin sensitivity in mice
    • Carr, R.M. et al. 2013. Temporal effects of ethanol consumption on energy homeostasis, hepatic steatosis, and insulin sensitivity in mice. Alcohol Clin. Exp. Res. 37: 1091-1099.
    • (2013) Alcohol Clin. Exp. Res. , vol.37 , pp. 1091-1099
    • Carr, R.M.1
  • 12
    • 0021141204 scopus 로고
    • Kinetics of glucose metabolism in relation to insulin concentrations in patients with alcoholic cirrhosis and in healthy persons
    • Iversen, J., H. Vilstrup, & N. Tygstrup . 1984. Kinetics of glucose metabolism in relation to insulin concentrations in patients with alcoholic cirrhosis and in healthy persons. Gastroenterology 87: 1138-1143.
    • (1984) Gastroenterology , vol.87 , pp. 1138-1143
    • Iversen, J.1    Vilstrup, H.2    Tygstrup, N.3
  • 13
    • 0027153970 scopus 로고
    • Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis
    • Shmueli, E. et al. 1993. Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis. Hepatology 18: 86-95.
    • (1993) Hepatology , vol.18 , pp. 86-95
    • Shmueli, E.1
  • 14
    • 75549085755 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
    • DeFronzo, R.A. & D. Tripathy . 2009. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32: S157-S163.
    • (2009) Diabetes Care , vol.32 , pp. S157-S163
    • DeFronzo, R.A.1    Tripathy, D.2
  • 15
    • 0023124359 scopus 로고
    • Impaired early insulin response to intravenous glucose in alcoholic liver cirrhosis
    • Magnusson, J. & K.G. Tranberg . 1987. Impaired early insulin response to intravenous glucose in alcoholic liver cirrhosis. Scand. J. Gastroenterol. 22: 301-307.
    • (1987) Scand. J. Gastroenterol. , vol.22 , pp. 301-307
    • Magnusson, J.1    Tranberg, K.G.2
  • 16
    • 0032006528 scopus 로고    scopus 로고
    • Insulin secretory capacity and the regulation of glucagon secretion in diabetic and non-diabetic alcoholic cirrhotic patients
    • Kruszynska, Y.T. et al. 1998. Insulin secretory capacity and the regulation of glucagon secretion in diabetic and non-diabetic alcoholic cirrhotic patients. J. Hepatol. 28: 280-291.
    • (1998) J. Hepatol. , vol.28 , pp. 280-291
    • Kruszynska, Y.T.1
  • 17
    • 27544457323 scopus 로고    scopus 로고
    • Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity
    • Donohue, T.M., N.A. Osna, & D.L. Clemens . 2006. Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. Int. J. Biochem. Cell Biol. 38: 92-101.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 92-101
    • Donohue, T.M.1    Osna, N.A.2    Clemens, D.L.3
  • 18
    • 0023920996 scopus 로고
    • Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone
    • Wolfla, C.E., R.A. Ross, & D.W. Crabb . 1988. Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone. Arch. Biochem. Biophys. 263: 69-76.
    • (1988) Arch. Biochem. Biophys. , vol.263 , pp. 69-76
    • Wolfla, C.E.1    Ross, R.A.2    Crabb, D.W.3
  • 19
    • 0027408090 scopus 로고
    • Regulation of gene expression in hepatomas
    • Lea, M.A. 1993. Regulation of gene expression in hepatomas. Int. J. Biochem. 25: 457-469.
    • (1993) Int. J. Biochem. , vol.25 , pp. 457-469
    • Lea, M.A.1
  • 20
    • 42949170007 scopus 로고    scopus 로고
    • Ethanol-induced JNK activation suppressed via active Akt in hepatocytes
    • Nishitani, Y. et al. 2008. Ethanol-induced JNK activation suppressed via active Akt in hepatocytes. Nihon Arukoru Yakubutsu Igakkai Zasshi 43: 35-43.
    • (2008) Nihon Arukoru Yakubutsu Igakkai Zasshi , vol.43 , pp. 35-43
    • Nishitani, Y.1
  • 21
    • 0023915349 scopus 로고
    • Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes
    • Hoek, J.B., R. Rubin, & A.P. Thomas . 1988. Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes. Biochem. J. 251: 865-871.
    • (1988) Biochem. J. , vol.251 , pp. 865-871
    • Hoek, J.B.1    Rubin, R.2    Thomas, A.P.3
  • 22
    • 0020696022 scopus 로고
    • Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat
    • Leo, M.A. & C.S. Lieber . 1983. Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat. Hepatology 3: 1-11.
    • (1983) Hepatology , vol.3 , pp. 1-11
    • Leo, M.A.1    Lieber, C.S.2
  • 23
    • 0029160569 scopus 로고
    • Experimental liver cirrhosis induced by alcohol and iron
    • Tsukamoto, H. et al. 1995. Experimental liver cirrhosis induced by alcohol and iron. J. Clin. Invest. 96: 620-630.
    • (1995) J. Clin. Invest. , vol.96 , pp. 620-630
    • Tsukamoto, H.1
  • 24
    • 84900821567 scopus 로고    scopus 로고
    • Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges
    • Mathews, S. et al. 2014. Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges. Am. J. Physiol. Gastrointest. Liver Physiol. 306: G819-G823.
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.306 , pp. G819-G823
    • Mathews, S.1
  • 25
    • 79251477852 scopus 로고    scopus 로고
    • Alcoholic liver disease and exacerbation by malnutrition and infections: what animal models are currently available?
    • Bergheim, I. et al. 2011. Alcoholic liver disease and exacerbation by malnutrition and infections: what animal models are currently available? Ann. N. Y. Acad. Sci. 1216: 41-49.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1216 , pp. 41-49
    • Bergheim, I.1
  • 26
    • 0000156898 scopus 로고
    • Effects of prolonged ethanol intake: production of fatty liver despite adequate diets
    • Lieber, C.S., D.P. Jones, & L.M. Decarli . 1965. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J. Clin. Invest. 44: 1009-1021.
    • (1965) J. Clin. Invest. , vol.44 , pp. 1009-1021
    • Lieber, C.S.1    Jones, D.P.2    Decarli, L.M.3
  • 27
    • 0028364431 scopus 로고
    • Animal models of chronic ethanol toxicity
    • Lieber, C.S. & L.M. DeCarli . 1994. Animal models of chronic ethanol toxicity. Methods Enzymol. 233: 585-594.
    • (1994) Methods Enzymol. , vol.233 , pp. 585-594
    • Lieber, C.S.1    DeCarli, L.M.2
  • 28
    • 84863166688 scopus 로고    scopus 로고
    • Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice
    • Liangpunsakul, S. et al. 2012. Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice. Am. J. Physiol. Gastrointest. Liver Physiol. 302: G515-G523.
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.302 , pp. G515-G523
    • Liangpunsakul, S.1
  • 29
    • 0344211825 scopus 로고    scopus 로고
    • Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation
    • Onishi, Y. et al. 2003. Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation. Biochem. Biophys. Res. Commun. 303: 788-794.
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 788-794
    • Onishi, Y.1
  • 30
    • 48549100951 scopus 로고    scopus 로고
    • Insulin resistance in experimental alcohol-induced liver disease
    • de la Monte, S.M. et al. 2008. Insulin resistance in experimental alcohol-induced liver disease. J. Gastroenterol. Hepatol. 23: e477-486.
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , pp. e477-e486
    • de la Monte, S.M.1
  • 31
    • 34948831425 scopus 로고    scopus 로고
    • Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health
    • He, L. et al. 2007. Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol. Endocrinol. 21: 2541-2550.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 2541-2550
    • He, L.1
  • 32
    • 84898024176 scopus 로고    scopus 로고
    • Strain-dependent differences for suppression of insulin-stimulated glucose uptake in skeletal and cardiac muscle by ethanol
    • Lang, C.H., Z. Derdak, & J.R. Wands . 2014. Strain-dependent differences for suppression of insulin-stimulated glucose uptake in skeletal and cardiac muscle by ethanol. Alcohol Clin. Exp. Res. 38: 897-910.
    • (2014) Alcohol Clin. Exp. Res. , vol.38 , pp. 897-910
    • Lang, C.H.1    Derdak, Z.2    Wands, J.R.3
  • 33
    • 0032835529 scopus 로고    scopus 로고
    • Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
    • Yin, M. et al. 1999. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 117: 942-952.
    • (1999) Gastroenterology , vol.117 , pp. 942-952
    • Yin, M.1
  • 34
    • 84861777658 scopus 로고    scopus 로고
    • Mouse intragastric infusion (iG) model
    • Ueno, A. et al. 2012. Mouse intragastric infusion (iG) model. Nat. Protoc. 7: 771-781.
    • (2012) Nat. Protoc. , vol.7 , pp. 771-781
    • Ueno, A.1
  • 35
    • 0011057855 scopus 로고
    • Long-term cannulation model for blood sampling and intragastric infusion in the rat
    • Tsukamoto, H. et al. 1984. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am. J. Physiol. 247: R595-R599.
    • (1984) Am. J. Physiol. , vol.247 , pp. R595-R599
    • Tsukamoto, H.1
  • 36
    • 67649419157 scopus 로고    scopus 로고
    • The diabetogenic effects of excessive ethanol: reducing beta-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats
    • Zhao, L.N. et al. 2009. The diabetogenic effects of excessive ethanol: reducing beta-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats. Br. J. Nutr. 101: 1467-1473.
    • (2009) Br. J. Nutr. , vol.101 , pp. 1467-1473
    • Zhao, L.N.1
  • 37
    • 84874104450 scopus 로고    scopus 로고
    • Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action
    • 170ra14
    • Lindtner, C. et al. 2013. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Sci. Transl. Med. 5: 170ra14.
    • (2013) Sci. Transl. Med. , vol.5
    • Lindtner, C.1
  • 38
    • 67349255861 scopus 로고    scopus 로고
    • PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair
    • Pang, M. et al. 2009. PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair. J. Hepatol. 50: 1192-1201.
    • (2009) J. Hepatol. , vol.50 , pp. 1192-1201
    • Pang, M.1
  • 39
    • 77956797226 scopus 로고    scopus 로고
    • Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance
    • DeNucci, S.M. et al. 2010. Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. Gastroenterol. Res. Pract. 2010: 312790.
    • (2010) Gastroenterol. Res. Pract. , vol.2010 , pp. 312790
    • DeNucci, S.M.1
  • 40
    • 0026064733 scopus 로고
    • Chronic ethanol-induced impairments in receptor-mediated endocytosis of insulin in rat hepatocytes
    • Tuma, D.J., C.A. Casey, & M.F. Sorrell . 1991. Chronic ethanol-induced impairments in receptor-mediated endocytosis of insulin in rat hepatocytes. Alcohol Clin. Exp. Res. 15: 808-813.
    • (1991) Alcohol Clin. Exp. Res. , vol.15 , pp. 808-813
    • Tuma, D.J.1    Casey, C.A.2    Sorrell, M.F.3
  • 41
    • 0025940396 scopus 로고
    • Impairment of hepatic insulin receptors during chronic ethanol administration
    • Patel, B.C. et al. 1991. Impairment of hepatic insulin receptors during chronic ethanol administration. Am. J. Physiol. 261: G199-G205.
    • (1991) Am. J. Physiol. , vol.261 , pp. G199-G205
    • Patel, B.C.1
  • 42
    • 0027510514 scopus 로고
    • Acute effects of ethanol on hepatic endocytosis and processing of insulin in perfused rat liver
    • Fawcett, J., B. Hammond, & G.D. Smith . 1993. Acute effects of ethanol on hepatic endocytosis and processing of insulin in perfused rat liver. Am. J. Physiol. 264: E420-E427.
    • (1993) Am. J. Physiol. , vol.264 , pp. E420-E427
    • Fawcett, J.1    Hammond, B.2    Smith, G.D.3
  • 43
    • 0032407769 scopus 로고    scopus 로고
    • Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells
    • Banerjee, K. et al. 1998. Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells. Alcohol Clin. Exp. Res. 22: 2093-2101.
    • (1998) Alcohol Clin. Exp. Res. , vol.22 , pp. 2093-2101
    • Banerjee, K.1
  • 44
    • 84871565729 scopus 로고    scopus 로고
    • Insulin resistance, ceramide accumulation and endoplasmic reticulum stress in experimental chronic alcohol-induced steatohepatitis
    • Ramirez, T. et al. 2013. Insulin resistance, ceramide accumulation and endoplasmic reticulum stress in experimental chronic alcohol-induced steatohepatitis. Alcohol Alcohol 48: 39-52.
    • (2013) Alcohol Alcohol , vol.48 , pp. 39-52
    • Ramirez, T.1
  • 45
    • 84905453839 scopus 로고    scopus 로고
    • Combination of alcohol and fructose exacerbates metabolic imbalance in terms of hepatic damage, dyslipidemia, and insulin resistance in rats
    • Alwahsh, S.M. et al. 2014. Combination of alcohol and fructose exacerbates metabolic imbalance in terms of hepatic damage, dyslipidemia, and insulin resistance in rats. PLoS One 9: e104220.
    • (2014) PLoS One , vol.9 , pp. e104220
    • Alwahsh, S.M.1
  • 46
    • 0028958453 scopus 로고
    • Effect of ethanol on p36 protein kinase substrate and insulin receptor substrate 1 expression and tyrosyl phosphorylation in human hepatocellular carcinoma cells
    • Bhavani, K. et al. 1995. Effect of ethanol on p36 protein kinase substrate and insulin receptor substrate 1 expression and tyrosyl phosphorylation in human hepatocellular carcinoma cells. Alcohol Clin. Exp. Res. 19: 441-446.
    • (1995) Alcohol Clin. Exp. Res. , vol.19 , pp. 441-446
    • Bhavani, K.1
  • 47
    • 15444375341 scopus 로고    scopus 로고
    • Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling
    • Schattenberg, J.M. et al. 2005. Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. J. Biol. Chem. 280: 9887-9894.
    • (2005) J. Biol. Chem. , vol.280 , pp. 9887-9894
    • Schattenberg, J.M.1
  • 48
    • 37749020003 scopus 로고    scopus 로고
    • Acute ethanol exposure inhibits insulin signaling in the liver
    • He, J., S. de la Monte, & J.R. Wands . 2007. Acute ethanol exposure inhibits insulin signaling in the liver. Hepatology 46: 1791-1800.
    • (2007) Hepatology , vol.46 , pp. 1791-1800
    • He, J.1    de la Monte, S.2    Wands, J.R.3
  • 49
    • 84857934301 scopus 로고    scopus 로고
    • Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
    • Lu, M. et al. 2012. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat. Med. 18: 388-395.
    • (2012) Nat. Med. , vol.18 , pp. 388-395
    • Lu, M.1
  • 50
    • 33744955437 scopus 로고    scopus 로고
    • Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation
    • He, L. et al. 2006. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. J. Biol. Chem. 281: 11126-11134.
    • (2006) J. Biol. Chem. , vol.281 , pp. 11126-11134
    • He, L.1
  • 51
    • 46049084164 scopus 로고    scopus 로고
    • Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function
    • Lieber, C.S. et al. 2008. Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function. Biochem. Biophys. Res. Commun. 373: 246-252.
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 246-252
    • Lieber, C.S.1
  • 52
    • 84880329966 scopus 로고    scopus 로고
    • Elevated expression of forkhead box protein O1 (FoxO1) in alcohol-induced intestinal barrier dysfunction
    • Wang, Y. et al. 2013. Elevated expression of forkhead box protein O1 (FoxO1) in alcohol-induced intestinal barrier dysfunction. Acta Histochem. 115: 557-563.
    • (2013) Acta Histochem. , vol.115 , pp. 557-563
    • Wang, Y.1
  • 53
    • 34247198341 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells
    • Adachi, M. et al. 2007. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology 132: 1434-1446.
    • (2007) Gastroenterology , vol.132 , pp. 1434-1446
    • Adachi, M.1
  • 54
    • 34547691071 scopus 로고    scopus 로고
    • The role of GSK3 in glucose homeostasis and the development of insulin resistance
    • Lee, J. & M.S. Kim . 2007. The role of GSK3 in glucose homeostasis and the development of insulin resistance. Diabetes Res. Clin. Pract. 77(Suppl. 1): S49-S57.
    • (2007) Diabetes Res. Clin. Pract. , vol.77 , pp. S49-S57
    • Lee, J.1    Kim, M.S.2
  • 55
    • 84879422664 scopus 로고    scopus 로고
    • Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats
    • Bourogaa, E. et al. 2013. Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats. J. Physiol. Biochem. 69: 227-237.
    • (2013) J. Physiol. Biochem. , vol.69 , pp. 227-237
    • Bourogaa, E.1
  • 56
    • 84879335362 scopus 로고    scopus 로고
    • Alteration of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor by ethanol in rat liver and mouse hepatoma cells
    • Meng, Z. et al. 2013. Alteration of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor by ethanol in rat liver and mouse hepatoma cells. J. Diabetes Res. 2013: 218102.
    • (2013) J. Diabetes Res. , vol.2013 , pp. 218102
    • Meng, Z.1
  • 57
    • 0014866919 scopus 로고
    • Effect of ethanol on ketone metabolism
    • Lefevre, A., H. Adler, & C.S. Lieber . 1970. Effect of ethanol on ketone metabolism. J. Clin. Invest. 49: 1775-1782.
    • (1970) J. Clin. Invest. , vol.49 , pp. 1775-1782
    • Lefevre, A.1    Adler, H.2    Lieber, C.S.3
  • 58
    • 84901302133 scopus 로고    scopus 로고
    • Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice
    • Carr, R.M. et al. 2014. Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice. PLoS One 9: e97118.
    • (2014) PLoS One , vol.9 , pp. e97118
    • Carr, R.M.1
  • 59
    • 84910646076 scopus 로고    scopus 로고
    • Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver
    • Liu, J. 2014. Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver. World J. Gastroenterol. 20: 14672-14685.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 14672-14685
    • Liu, J.1
  • 60
    • 12744267804 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins
    • You, M. & D.W. Crabb . 2004. Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins. Alcohol 34: 39-43.
    • (2004) Alcohol , vol.34 , pp. 39-43
    • You, M.1    Crabb, D.W.2
  • 61
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: a pathogenic paradox
    • Brown, M.S. & J.L. Goldstein . 2008. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 7: 95-96.
    • (2008) Cell Metab. , vol.7 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 63
    • 84875653241 scopus 로고    scopus 로고
    • Human adipose dynamics and metabolic health
    • Feng, B., T. Zhang, & H. Xu . 2013. Human adipose dynamics and metabolic health. Ann. N. Y. Acad. Sci. 1281: 160-177.
    • (2013) Ann. N. Y. Acad. Sci. , vol.1281 , pp. 160-177
    • Feng, B.1    Zhang, T.2    Xu, H.3
  • 64
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • Marra, F. & C. Bertolani . 2009. Adipokines in liver diseases. Hepatology 50: 957-969.
    • (2009) Hepatology , vol.50 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 66
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter, M.A. et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1
  • 67
    • 84866488176 scopus 로고    scopus 로고
    • Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice
    • Tan, X. et al. 2012. Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice. Am. J. Pathol. 181: 1279-1286.
    • (2012) Am. J. Pathol. , vol.181 , pp. 1279-1286
    • Tan, X.1
  • 68
    • 12844276509 scopus 로고    scopus 로고
    • MELD accurately predicts mortality in patients with alcoholic hepatitis
    • Dunn, W. et al. 2005. MELD accurately predicts mortality in patients with alcoholic hepatitis. Hepatology 41: 353-358.
    • (2005) Hepatology , vol.41 , pp. 353-358
    • Dunn, W.1
  • 69
    • 84911432449 scopus 로고    scopus 로고
    • Stratification of risk of death in severe acute alcoholic hepatitis using a panel of adipokines and cytokines
    • Rachakonda, V. et al. 2014. Stratification of risk of death in severe acute alcoholic hepatitis using a panel of adipokines and cytokines. Alcohol. Clin. Exp. Res. 38: 2712-2721.
    • (2014) Alcohol. Clin. Exp. Res. , vol.38 , pp. 2712-2721
    • Rachakonda, V.1
  • 70
    • 10744224100 scopus 로고    scopus 로고
    • Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
    • Shklyaev, S. et al. 2003. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc. Natl. Acad. Sci. U.S.A. 100: 14217-14222.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 14217-14222
    • Shklyaev, S.1
  • 71
    • 59649097669 scopus 로고    scopus 로고
    • Adiponectin and alcoholic fatty liver disease
    • Rogers, C.Q., J.M. Ajmo, & M. You . 2008. Adiponectin and alcoholic fatty liver disease. IUBMB Life 60: 790-797.
    • (2008) IUBMB Life , vol.60 , pp. 790-797
    • Rogers, C.Q.1    Ajmo, J.M.2    You, M.3
  • 72
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki, T. & T. Yamauchi . 2005. Adiponectin and adiponectin receptors. Endocr. Rev. 26: 439-451.
    • (2005) Endocr. Rev. , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 73
    • 24144496133 scopus 로고    scopus 로고
    • Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    • You, M. et al. 2005. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42: 568-577.
    • (2005) Hepatology , vol.42 , pp. 568-577
    • You, M.1
  • 74
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu, A. et al. 2003. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 112: 91-100.
    • (2003) J. Clin. Invest. , vol.112 , pp. 91-100
    • Xu, A.1
  • 75
    • 33846883075 scopus 로고    scopus 로고
    • Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes
    • Chen, X., B.M. Sebastian, & L.E. Nagy . 2007. Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes. Am. J. Physiol. Endocrinol. Metab. 292: E621-E628.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292 , pp. E621-E628
    • Chen, X.1    Sebastian, B.M.2    Nagy, L.E.3
  • 76
    • 40949119415 scopus 로고    scopus 로고
    • Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease
    • Song, Z. et al. 2008. Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease. Hepatology 47: 867-879.
    • (2008) Hepatology , vol.47 , pp. 867-879
    • Song, Z.1
  • 77
    • 34250679654 scopus 로고    scopus 로고
    • S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet
    • Esfandiari, F. et al. 2007. S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet. Alcohol Clin. Exp. Res. 31: 1231-1239.
    • (2007) Alcohol Clin. Exp. Res. , vol.31 , pp. 1231-1239
    • Esfandiari, F.1
  • 78
    • 57349114641 scopus 로고    scopus 로고
    • Resveratrol alleviates alcoholic fatty liver in mice
    • Ajmo, J.M. et al. 2008. Resveratrol alleviates alcoholic fatty liver in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G833-G842.
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.295 , pp. G833-G842
    • Ajmo, J.M.1
  • 79
    • 84860389258 scopus 로고    scopus 로고
    • Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
    • Xu, J. et al. 2011. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J. Hepatol. 55: 673-682.
    • (2011) J. Hepatol. , vol.55 , pp. 673-682
    • Xu, J.1
  • 80
    • 84901708592 scopus 로고    scopus 로고
    • Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice
    • Correnti, J.M. et al. 2014. Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice. Am. J. Physiol. Gastrointest. Liver Physiol. 306: G959-G973.
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.306 , pp. G959-G973
    • Correnti, J.M.1
  • 81
    • 63849211696 scopus 로고    scopus 로고
    • Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal
    • Buechler, C. et al. 2009. Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal. J. Gastroenterol. Hepatol. 24: 558-563.
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , pp. 558-563
    • Buechler, C.1
  • 82
    • 84887325857 scopus 로고    scopus 로고
    • Association of serum adiponectin, leptin, and resistin concentrations with the severity of liver dysfunction and the disease complications in alcoholic liver disease
    • Kasztelan-Szczerbinska, B. et al. 2013. Association of serum adiponectin, leptin, and resistin concentrations with the severity of liver dysfunction and the disease complications in alcoholic liver disease. Mediators Inflamm. 2013: 148526.
    • (2013) Mediators Inflamm. , vol.2013 , pp. 148526
    • Kasztelan-Szczerbinska, B.1
  • 83
    • 0032986374 scopus 로고    scopus 로고
    • 2+-independent protein kinase C activation in cultured rat hepatic stellate cells
    • 2+-independent protein kinase C activation in cultured rat hepatic stellate cells. Alcohol Clin. Exp. Res. 23: 279-284.
    • (1999) Alcohol Clin. Exp. Res. , vol.23 , pp. 279-284
    • Anania, F.A.1
  • 84
    • 0022390448 scopus 로고
    • Effect of ethanol on fatty acid metabolism in cultured hepatocytes: dependency on incubation time and fatty acid concentration
    • Grunnet, N. et al. 1985. Effect of ethanol on fatty acid metabolism in cultured hepatocytes: dependency on incubation time and fatty acid concentration. Alcohol 2: 157-161.
    • (1985) Alcohol , vol.2 , pp. 157-161
    • Grunnet, N.1
  • 86
    • 80555124939 scopus 로고    scopus 로고
    • Ceramides as modulators of cellular and whole-body metabolism
    • Bikman, B.T. & S.A. Summers . 2011. Ceramides as modulators of cellular and whole-body metabolism. J. Clin. Invest. 121: 4222-4230.
    • (2011) J. Clin. Invest. , vol.121 , pp. 4222-4230
    • Bikman, B.T.1    Summers, S.A.2
  • 87
    • 78651376861 scopus 로고    scopus 로고
    • Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance
    • Turban, S. & E. Hajduch, 2011. Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance. FEBS Lett. 585: 269-274.
    • (2011) FEBS Lett. , vol.585 , pp. 269-274
    • Turban, S.1    Hajduch, E.2
  • 88
    • 0142091454 scopus 로고    scopus 로고
    • Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism
    • Powell, D.J. et al. 2003. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol. Cell. Biol. 23: 7794-7808.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7794-7808
    • Powell, D.J.1
  • 89
    • 0027202552 scopus 로고
    • Ceramide activates heterotrimeric protein phosphatase 2A
    • Dobrowsky, R.T. et al. 1993. Ceramide activates heterotrimeric protein phosphatase 2A. J. Biol. Chem. 268: 15523-15530.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15523-15530
    • Dobrowsky, R.T.1
  • 90
    • 0033772936 scopus 로고    scopus 로고
    • Apoptosis and dysregulated ceramide metabolism in a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity
    • Deaciuc, I.V. et al. 2000. Apoptosis and dysregulated ceramide metabolism in a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity. Alcohol Clin. Exp. Res. 24: 1557-1565.
    • (2000) Alcohol Clin. Exp. Res. , vol.24 , pp. 1557-1565
    • Deaciuc, I.V.1
  • 91
    • 77952739878 scopus 로고    scopus 로고
    • Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels
    • Liangpunsakul, S. et al. 2010. Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. Am. J. Physiol. Gastrointest. Liver Physiol. 298: G1004-G1012.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.298 , pp. G1004-G1012
    • Liangpunsakul, S.1
  • 92
    • 80054113765 scopus 로고    scopus 로고
    • Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study
    • Clugston, R.D. et al. 2011. Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. J. Lipid Res. 52: 2021-2031.
    • (2011) J. Lipid Res. , vol.52 , pp. 2021-2031
    • Clugston, R.D.1
  • 93
    • 78851468901 scopus 로고    scopus 로고
    • Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice
    • Zhao, Z. et al. 2011. Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice. Alcohol Clin. Exp. Res. 35: 229-234.
    • (2011) Alcohol Clin. Exp. Res. , vol.35 , pp. 229-234
    • Zhao, Z.1
  • 94
    • 84897594451 scopus 로고    scopus 로고
    • Ceramide inhibitor myriocin restores insulin/insulin growth factor signaling for liver remodeling in experimental alcohol-related steatohepatitis
    • Lizarazo, D. et al. 2013. Ceramide inhibitor myriocin restores insulin/insulin growth factor signaling for liver remodeling in experimental alcohol-related steatohepatitis. J. Gastroenterol. Hepatol. 28: 1660-1668.
    • (2013) J. Gastroenterol. Hepatol. , vol.28 , pp. 1660-1668
    • Lizarazo, D.1
  • 95
    • 35348942255 scopus 로고    scopus 로고
    • Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation
    • Kang, L. et al. 2007. Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation. J. Biol. Chem. 282: 28465-28473.
    • (2007) J. Biol. Chem. , vol.282 , pp. 28465-28473
    • Kang, L.1
  • 96
    • 59849098608 scopus 로고    scopus 로고
    • Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells
    • Watson, M.L., M. Coghlan, & H.S. Hundal . 2009. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem. J. 417: 791-801.
    • (2009) Biochem. J. , vol.417 , pp. 791-801
    • Watson, M.L.1    Coghlan, M.2    Hundal, H.S.3
  • 97
    • 53449099325 scopus 로고    scopus 로고
    • Inhibition of ADRP prevents diet-induced insulin resistance
    • Varela, G.M. et al. 2008. Inhibition of ADRP prevents diet-induced insulin resistance. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G621-G628.
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.295 , pp. G621-G628
    • Varela, G.M.1
  • 98
    • 78651260799 scopus 로고    scopus 로고
    • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    • Holland, W.L. et al. 2011. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat. Med. 17: 55-63.
    • (2011) Nat. Med. , vol.17 , pp. 55-63
    • Holland, W.L.1
  • 99
    • 84918817256 scopus 로고    scopus 로고
    • Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways
    • Garcia-Ruiz, C. et al. 2015. Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways. J. Hepatol. 62: 219-233.
    • (2015) J. Hepatol. , vol.62 , pp. 219-233
    • Garcia-Ruiz, C.1
  • 100
    • 84904353675 scopus 로고    scopus 로고
    • PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival
    • Friedrich, K. et al. 2014. PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival. J. Gastroenterol. Hepatol. 29: 1477-1484.
    • (2014) J. Gastroenterol. Hepatol , vol.29 , pp. 1477-1484
    • Friedrich, K.1
  • 101
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo, S. et al. 2008. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40: 1461-1465.
    • (2008) Nat. Genet. , vol.40 , pp. 1461-1465
    • Romeo, S.1
  • 102
    • 84887553152 scopus 로고    scopus 로고
    • PNPLA3 I148M polymorphism and progressive liver disease
    • Dongiovanni, P. et al. 2013. PNPLA3 I148M polymorphism and progressive liver disease. World J. Gastroenterol. 19: 6969-6978.
    • (2013) World J. Gastroenterol. , vol.19 , pp. 6969-6978
    • Dongiovanni, P.1
  • 103
    • 73349111259 scopus 로고    scopus 로고
    • Variant in PNPLA3 is associated with alcoholic liver disease
    • Tian, C. et al. 2010. Variant in PNPLA3 is associated with alcoholic liver disease. Nat. Genet. 42: 21-23.
    • (2010) Nat. Genet. , vol.42 , pp. 21-23
    • Tian, C.1
  • 104
    • 78751536418 scopus 로고    scopus 로고
    • Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
    • Stickel, F. et al. 2011. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology 53: 86-95.
    • (2011) Hepatology , vol.53 , pp. 86-95
    • Stickel, F.1
  • 105
    • 77952409634 scopus 로고    scopus 로고
    • A feed-forward loop amplifies nutritional regulation of PNPLA3
    • Huang, Y. et al. 2010. A feed-forward loop amplifies nutritional regulation of PNPLA3. Proc. Natl. Acad. Sci. U.S.A. 107: 7892-7897.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 7892-7897
    • Huang, Y.1
  • 106
    • 33748745960 scopus 로고    scopus 로고
    • Characterization of the human patatin-like phospholipase family
    • Wilson, P.A. et al. 2006. Characterization of the human patatin-like phospholipase family. J. Lipid Res. 47: 1940-1949.
    • (2006) J. Lipid Res. , vol.47 , pp. 1940-1949
    • Wilson, P.A.1
  • 107
    • 83455259910 scopus 로고    scopus 로고
    • Genetic determinants of alcoholic liver disease
    • Stickel, F. & J. Hampe . 2012. Genetic determinants of alcoholic liver disease. Gut 61: 150-159.
    • (2012) Gut , vol.61 , pp. 150-159
    • Stickel, F.1    Hampe, J.2
  • 108
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • He, S. et al.2010. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J. Biol. Chem. 285: 6706-6715.
    • (2010) J. Biol. Chem. , vol.285 , pp. 6706-6715
    • He, S.1
  • 109
    • 79960729651 scopus 로고    scopus 로고
    • Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
    • Qiao, A. et al. 2011. Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis. Hepatology 54: 509-521.
    • (2011) Hepatology , vol.54 , pp. 509-521
    • Qiao, A.1
  • 110
    • 77956625538 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    • Chen, W. et al. 2010. Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. Hepatology 52: 1134-1142.
    • (2010) Hepatology , vol.52 , pp. 1134-1142
    • Chen, W.1
  • 111
    • 78751489992 scopus 로고    scopus 로고
    • Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
    • Basantani, M.K. et al. 2011. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J. Lipid Res. 52: 318-329.
    • (2011) J. Lipid Res. , vol.52 , pp. 318-329
    • Basantani, M.K.1
  • 112
    • 84883241741 scopus 로고    scopus 로고
    • Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent
    • Palmer, N.D. et al. 2013. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology 58: 966-975.
    • (2013) Hepatology , vol.58 , pp. 966-975
    • Palmer, N.D.1
  • 113
    • 84896542255 scopus 로고    scopus 로고
    • Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis
    • Dupont, N. et al. 2014. Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Curr. Biol. 24: 609-620.
    • (2014) Curr. Biol , vol.24 , pp. 609-620
    • Dupont, N.1
  • 114
    • 84926660045 scopus 로고    scopus 로고
    • PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
    • Peter, A. et al. 2014. PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans. Diabetologia 57: 2103-2107.
    • (2014) Diabetologia , vol.57 , pp. 2103-2107
    • Peter, A.1
  • 115
    • 0342699553 scopus 로고    scopus 로고
    • Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
    • Parlesak, A. et al. 2000. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J. Hepatol. 32: 742-747.
    • (2000) J. Hepatol. , vol.32 , pp. 742-747
    • Parlesak, A.1
  • 116
    • 33645804223 scopus 로고    scopus 로고
    • Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding
    • Thakur, V. et al. 2006. Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G998-G1007.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290 , pp. G998-G1007
    • Thakur, V.1
  • 118
    • 70349335851 scopus 로고    scopus 로고
    • Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats
    • Mutlu, E. et al. 2009. Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol. Clin. Exp. Res. 33: 1836-1846.
    • (2009) Alcohol. Clin. Exp. Res. , vol.33 , pp. 1836-1846
    • Mutlu, E.1
  • 119
    • 79960714764 scopus 로고    scopus 로고
    • Characterization of fecal microbial communities in patients with liver cirrhosis
    • Chen, Y. et al. 2011. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 54: 562-572.
    • (2011) Hepatology , vol.54 , pp. 562-572
    • Chen, Y.1
  • 120
    • 0034757037 scopus 로고    scopus 로고
    • Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats
    • Keshavarzian, A. et al. 2001. Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats. J. Pharmacol. Exp. Ther., 299: 442-448.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 442-448
    • Keshavarzian, A.1
  • 121
    • 66749115646 scopus 로고    scopus 로고
    • Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage
    • Tang, Y. et al. 2009. Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage. J. Pharmacol. Exp. Ther. 329: 952-958.
    • (2009) J. Pharmacol. Exp. Ther. , vol.329 , pp. 952-958
    • Tang, Y.1
  • 122
    • 61349161828 scopus 로고    scopus 로고
    • Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    • Forsyth, C.B. et al. 2009. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 43: 163-172.
    • (2009) Alcohol , vol.43 , pp. 163-172
    • Forsyth, C.B.1
  • 123
    • 84914693446 scopus 로고    scopus 로고
    • Serum metabolomic profiling in acute alcoholic hepatitis identifies multiple dysregulated pathways
    • Rachakonda, V. et al. 2014. Serum metabolomic profiling in acute alcoholic hepatitis identifies multiple dysregulated pathways. PLoS One 9: e113860.
    • (2014) PLoS One , vol.9 , pp. e113860
    • Rachakonda, V.1
  • 124
    • 84945437206 scopus 로고    scopus 로고
    • Alcohol Alert.
    • National Institute on Alcohol Abuse and Alcoholism (U.S.). 2005. Alcohol Alert. 66.
    • (2005) , vol.66
  • 125
    • 0023266508 scopus 로고
    • Recidivism in "controlled drinker" alcoholics: a longitudinal study
    • Watson, C.G. 1987. Recidivism in "controlled drinker" alcoholics: a longitudinal study. J. Clin. Psychol. 43: 404-412.
    • (1987) J. Clin. Psychol. , vol.43 , pp. 404-412
    • Watson, C.G.1
  • 126
    • 84911999849 scopus 로고    scopus 로고
    • Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes
    • Zhang, X. et al. 2014. Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes. Hepatology 60: 2008-2016.
    • (2014) Hepatology , vol.60 , pp. 2008-2016
    • Zhang, X.1
  • 127
    • 77957768686 scopus 로고    scopus 로고
    • AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner
    • Lee, J.M. et al. 2010. AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner. J. Biol. Chem. 285: 32182-32191.
    • (2010) J. Biol. Chem. , vol.285 , pp. 32182-32191
    • Lee, J.M.1
  • 128
    • 84901923852 scopus 로고    scopus 로고
    • Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury
    • Zhu, Z. et al. 2014. Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. Alcohol. Clin. Exp. Res. 38: 1510-1519.
    • (2014) Alcohol. Clin. Exp. Res. , vol.38 , pp. 1510-1519
    • Zhu, Z.1
  • 129
    • 33744537874 scopus 로고    scopus 로고
    • Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1
    • Bergheim, I. et al. 2006. Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1. Gastroenterology 130: 2099-2112.
    • (2006) Gastroenterology , vol.130 , pp. 2099-2112
    • Bergheim, I.1
  • 130
    • 9644290860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the action of ethanol in the liver
    • You, M. et al. 2004. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127: 1798-1808.
    • (2004) Gastroenterology , vol.127 , pp. 1798-1808
    • You, M.1
  • 131
    • 30144445780 scopus 로고    scopus 로고
    • AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats
    • Tomita, K. et al. 2005. AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. Alcohol Clin. Exp. Res. 29: 240S-245S.
    • (2005) Alcohol Clin. Exp. Res. , vol.29 , pp. 240S-245S
    • Tomita, K.1
  • 132
    • 0041430945 scopus 로고    scopus 로고
    • Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptor-gamma, pioglitazone
    • Enomoto, N. et al. 2003. Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptor-gamma, pioglitazone. J. Pharmacol. Exp. Ther. 306: 846-854.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 846-854
    • Enomoto, N.1
  • 133
    • 13844289492 scopus 로고    scopus 로고
    • Pioglitazone prevents acute liver injury induced by ethanol and lipopolysaccharide through the suppression of tumor necrosis factor-alpha
    • Ohata, M. et al. 2004. Pioglitazone prevents acute liver injury induced by ethanol and lipopolysaccharide through the suppression of tumor necrosis factor-alpha. Alcohol Clin. Exp. Res. 28: 139S-144S.
    • (2004) Alcohol Clin. Exp. Res. , vol.28 , pp. 139S-144S
    • Ohata, M.1
  • 134
    • 10744221756 scopus 로고    scopus 로고
    • Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met
    • Tomita, K. et al. 2004. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Gastroenterology 126: 873-885.
    • (2004) Gastroenterology , vol.126 , pp. 873-885
    • Tomita, K.1
  • 135
    • 77249094005 scopus 로고    scopus 로고
    • Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
    • Shen, Z. et al. 2010. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 298: G364-G374.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.298 , pp. G364-G374
    • Shen, Z.1
  • 136
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten, S. et al. 1999. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103: 1489-1498.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1489-1498
    • Kersten, S.1
  • 137
    • 84855177721 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice
    • Kong, L. et al. 2011. Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice. Lipids Health Dis. 10: 246.
    • (2011) Lipids Health Dis. , vol.10 , pp. 246
    • Kong, L.1
  • 138
    • 79952856967 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor agonist treatment of alcohol-induced hepatic insulin resistance
    • de la Monte, S.M. et al. 2011. Peroxisome proliferator-activated receptor agonist treatment of alcohol-induced hepatic insulin resistance. Hepatol. Res. 41: 386-398.
    • (2011) Hepatol. Res. , vol.41 , pp. 386-398
    • de la Monte, S.M.1
  • 139
    • 84871659091 scopus 로고    scopus 로고
    • Chronic alcohol-induced hepatic insulin resistance and endoplasmic reticulum stress ameliorated by peroxisome-proliferator activated receptor-delta agonist treatment
    • Ramirez, T. et al. 2013. Chronic alcohol-induced hepatic insulin resistance and endoplasmic reticulum stress ameliorated by peroxisome-proliferator activated receptor-delta agonist treatment. J. Gastroenterol. Hepatol. 28: 179-187.
    • (2013) J. Gastroenterol. Hepatol. , vol.28 , pp. 179-187
    • Ramirez, T.1
  • 140
    • 84890854373 scopus 로고    scopus 로고
    • Cell biology. Ronning after the adiponectin receptors
    • Holland, W.L. & P.E. Scherer . 2013. Cell biology. Ronning after the adiponectin receptors. Science 342: 1460-1461.
    • (2013) Science , vol.342 , pp. 1460-1461
    • Holland, W.L.1    Scherer, P.E.2
  • 141
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • Yamauchi, T. et al. 2003. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423: 762-769.
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1
  • 142
    • 84888639952 scopus 로고    scopus 로고
    • A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
    • Okada-Iwabu, M. et al. 2013. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503: 493-499.
    • (2013) Nature , vol.503 , pp. 493-499
    • Okada-Iwabu, M.1
  • 143
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar, S. et al. 2013. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 145: 574-582.e1.
    • (2013) Gastroenterology , vol.145 , pp. 574-582e1
    • Mudaliar, S.1
  • 144
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri, B.A. et al. 2015. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 385: 956-965.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1
  • 145
    • 84923066154 scopus 로고    scopus 로고
    • FXR Agonists as therapeutic agents for non-alcoholic fatty liver disease
    • Carr, R.M. & A.E. Reid . 2015. FXR Agonists as therapeutic agents for non-alcoholic fatty liver disease. Curr. Atheroscler. Rep. 17: 500.
    • (2015) Curr. Atheroscler. Rep. , vol.17 , pp. 500
    • Carr, R.M.1    Reid, A.E.2
  • 146
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre, P. et al. 2009. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89: 147-191.
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1
  • 147
    • 84890857617 scopus 로고    scopus 로고
    • Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease
    • Wu, W. et al. 2014. Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease. Biochem. Biophys. Res. Commun. 443: 68-73.
    • (2014) Biochem. Biophys. Res. Commun. , vol.443 , pp. 68-73
    • Wu, W.1
  • 148
    • 84899841383 scopus 로고    scopus 로고
    • The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice
    • Livero, F.A. et al. 2014. The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice. Chem. Biol. Interact. 217: 19-27.
    • (2014) Chem. Biol. Interact. , vol.217 , pp. 19-27
    • Livero, F.A.1
  • 149
    • 84945463854 scopus 로고    scopus 로고
    • Cited March 25, 2015.
    • 2015. Cited March 25, 2015. www.clinicaltrials.gov/ct2/show/NCT02039219.
    • (2015)
  • 151
    • 77957196987 scopus 로고    scopus 로고
    • Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study
    • Stepanova, M., N. Rafiq, & Z.M. Younossi . 2010. Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study. Gut 59: 1410-1415.
    • (2010) Gut , vol.59 , pp. 1410-1415
    • Stepanova, M.1    Rafiq, N.2    Younossi, Z.M.3
  • 152
    • 84861329163 scopus 로고    scopus 로고
    • Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population
    • Stepanova, M. & Z.M. Younossi . 2012. Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population. Clin. Gastroenterol. Hepatol. 10: 646-650.
    • (2012) Clin. Gastroenterol. Hepatol. , vol.10 , pp. 646-650
    • Stepanova, M.1    Younossi, Z.M.2
  • 153
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani, N. et al. 2012. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 55: 2005-2023.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1
  • 154
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: pathogenesis and new therapeutic targets
    • Gao, B. & R. Bataller 2011. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141: 1572-1585.
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 155
    • 0031012322 scopus 로고    scopus 로고
    • Excess weight risk factor for alcoholic liver disease
    • Naveau, S. et al. 1997. Excess weight risk factor for alcoholic liver disease. Hepatology 25: 108-111.
    • (1997) Hepatology , vol.25 , pp. 108-111
    • Naveau, S.1
  • 156
    • 77949751643 scopus 로고    scopus 로고
    • Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies
    • Hart, C.L. et al. 2010. Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies. BMJ 340: c1240.
    • (2010) BMJ , vol.340 , pp. c1240
    • Hart, C.L.1
  • 157
    • 0023902215 scopus 로고
    • Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics
    • Iturriaga, H. et al. 1988. Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics. Am. J. Clin. Nutr. 47: 235-238.
    • (1988) Am. J. Clin. Nutr. , vol.47 , pp. 235-238
    • Iturriaga, H.1
  • 158
    • 70350752461 scopus 로고    scopus 로고
    • Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo Study
    • Loomba, R., R. Bettencourt, & E. Barrett-Connor . 2009. Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo Study. Aliment. Pharmacol. Ther. 30: 1137-1149.
    • (2009) Aliment. Pharmacol. Ther. , vol.30 , pp. 1137-1149
    • Loomba, R.1    Bettencourt, R.2    Barrett-Connor, E.3
  • 159
    • 84921061696 scopus 로고    scopus 로고
    • Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis
    • Minato, T. et al. 2014. Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis. Mol. Med. 20: 490-502.
    • (2014) Mol. Med. , vol.20 , pp. 490-502
    • Minato, T.1
  • 160
    • 77749295136 scopus 로고    scopus 로고
    • Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats
    • Wang, Y., H.K. Seitz, & X.D. Wang . 2010. Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats. Alcohol. Clin. Exp. Res. 34: 567-573.
    • (2010) Alcohol. Clin. Exp. Res. , vol.34 , pp. 567-573
    • Wang, Y.1    Seitz, H.K.2    Wang, X.D.3
  • 161
    • 84905989068 scopus 로고    scopus 로고
    • Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats
    • Nascimento, A.F. et al. 2013. Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. Hepatobiliary Surg. Nutr. 2: 252-259.
    • (2013) Hepatobiliary Surg. Nutr. , vol.2 , pp. 252-259
    • Nascimento, A.F.1
  • 162
    • 0022830407 scopus 로고
    • Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat
    • French, S.W., K. Miyamoto, & H. Tsukamoto . 1986. Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin. Exp. Res. 10: 13S-19S.
    • (1986) Alcohol Clin. Exp. Res. , vol.10 , pp. 13S-19S
    • French, S.W.1    Miyamoto, K.2    Tsukamoto, H.3
  • 163
    • 0022510347 scopus 로고
    • Ethanol-induced liver fibrosis in rats fed high fat diet
    • Tsukamoto, H. et al. 1986. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 6: 814-822.
    • (1986) Hepatology , vol.6 , pp. 814-822
    • Tsukamoto, H.1
  • 164
    • 84857350273 scopus 로고    scopus 로고
    • Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance
    • Zong, H. et al. 2012. Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 302: E532-E539.
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302 , pp. E532-E539
    • Zong, H.1
  • 165
    • 0033520484 scopus 로고    scopus 로고
    • Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs
    • Kim, H.J., M. Takahashi, & O. Ezaki . 1999. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs. J. Biol. Chem. 274: 25892-25898.
    • (1999) J. Biol. Chem , vol.274 , pp. 25892-25898
    • Kim, H.J.1    Takahashi, M.2    Ezaki, O.3
  • 166
    • 0033551846 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
    • Xu, J. et al. 1999. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J. Biol. Chem. 274: 23577-23583.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23577-23583
    • Xu, J.1
  • 167
    • 7244223648 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid deficiency reverses effects of alcohol on mitochondrial energy metabolism
    • Piquet, M.A. et al. 2004. Polyunsaturated fatty acid deficiency reverses effects of alcohol on mitochondrial energy metabolism. J. Hepatol. 41: 721-729.
    • (2004) J. Hepatol. , vol.41 , pp. 721-729
    • Piquet, M.A.1
  • 168
    • 40449093056 scopus 로고    scopus 로고
    • Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    • You, M. et al. 2008. Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. J. Nutr. 138: 497-501.
    • (2008) J. Nutr. , vol.138 , pp. 497-501
    • You, M.1
  • 169
    • 84870541988 scopus 로고    scopus 로고
    • Elovl6 promotes nonalcoholic steatohepatitis
    • Matsuzaka, T. et al. 2012. Elovl6 promotes nonalcoholic steatohepatitis. Hepatology 56: 2199-2208.
    • (2012) Hepatology , vol.56 , pp. 2199-2208
    • Matsuzaka, T.1
  • 170
    • 34547882082 scopus 로고    scopus 로고
    • Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease
    • Zivkovic, A.M., J.B. German, & A.J. Sanyal . 2007. Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am. J. Clin. Nutr. 86: 285-300.
    • (2007) Am. J. Clin. Nutr. , vol.86 , pp. 285-300
    • Zivkovic, A.M.1    German, J.B.2    Sanyal, A.J.3
  • 171
    • 84922630906 scopus 로고    scopus 로고
    • Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice
    • Chen, P. et al. 2015. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology 148: 203-214.e16.
    • (2015) Gastroenterology , vol.148 , pp. 203-214e16
    • Chen, P.1
  • 172
    • 84860433691 scopus 로고    scopus 로고
    • The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease
    • Kirpich, I.A. et al. 2012. The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. Alcohol. Clin. Exp. Res. 36: 835-846.
    • (2012) Alcohol. Clin. Exp. Res. , vol.36 , pp. 835-846
    • Kirpich, I.A.1
  • 173
    • 84884414277 scopus 로고    scopus 로고
    • Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
    • Le Roy, T. et al. 2013. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut 62: 1787-1794.
    • (2013) Gut , vol.62 , pp. 1787-1794
    • Le Roy, T.1
  • 174
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia, J. et al. 2012. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482: 179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1
  • 175
    • 0019129904 scopus 로고
    • Alcoholic liver disease: roles of alcohol and malnutrition
    • Mezey, E. 1980. Alcoholic liver disease: roles of alcohol and malnutrition. Am. J. Clin. Nutr. 33: 2709-2718.
    • (1980) Am. J. Clin. Nutr. , vol.33 , pp. 2709-2718
    • Mezey, E.1
  • 176
    • 84881245807 scopus 로고    scopus 로고
    • Impact of PPAR-α induction on glucose homeostasis in alcohol-fed mice
    • Lebrun, V. et al. 2013. Impact of PPAR-α induction on glucose homeostasis in alcohol-fed mice. Clin. Sci. (Lond.) 125: 501-511.
    • (2013) Clin. Sci. (Lond.) , vol.125 , pp. 501-511
    • Lebrun, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.