Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice

American Journal of Pathology

Volumn 181, Issue 4, 2012, Pages 1279-1286

  Tan, Xiaobing ^a   Sun, Xiuhua ^a   Li, Qiong ^a   Zhao, Yantao ^b   Zhong, Wei ^a   Sun, Xinguo ^a   Jia, Wei ^a   McClain, Craig J ^c,d   Zhou, Zhanxiang ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b AGRICULTURAL UNIVERSITY OF HEBEI   (China)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; LIPID; STAT3 PROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ALCOHOL CONSUMPTION; ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE EXPRESSION; HISTOPATHOLOGY; HOMEOSTASIS; LEPTIN DEFICIENCY; LIPID METABOLISM; LIPID STORAGE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WHITE ADIPOSE TISSUE;

ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; ETHANOL; FATTY LIVER, ALCOHOLIC; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; LEPTIN; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; ORGAN SIZE; PPAR ALPHA;

EID: 84866488176     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.06.013     Document Type: Article

References (50)

1. P. Hall Pathological spectrum of alcoholic liver disease Alcoholic Liver Disease ed 2 1995 Edward Arnold London 41 88
2. M.R. Lakshman Some novel insights into the pathogenesis of alcoholic steatosis Alcohol 34 2004 45 48
3. B. Gao, R. Bataller Alcoholic liver disease: pathogenesis and new therapeutic targets Gastroenterology 141 2011 1572 1585
4. C.Q. Rogers, J.M. Ajmo, M. You Adiponectin and alcoholic fatty liver disease IUBMB Life 60 2008 790 797
5. M. You, C.Q. Rogers Adiponectin: a key adipokine in alcoholic fatty liver Exp Biol Med (Maywood) 234 2009 850 859
6. S. Galic, J.S. Oakhill, G.R. Steinberg Adipose tissue as an endocrine organ Mol Cell Endocrinol 316 2010 129 139
7. F. Marra, C. Bertolani Adipokines in liver disease Hepatology 50 2009 957 969
8. G. Addolorato, E. Capristo, A.V. Greco, G.F. Stefanini, G. Gasbarrini Energy expenditure, substrate oxidation, and body composition in subjects with chronic alcoholism: new findings from metabolic assessment Alcohol Clin Exp Res 21 1997 962 967 (Pubitemid 27407155)
9. G. Addolorato, E. Capristo, A.V. Greco, G.F. Stefanini, G. Gasbarrini Influence of chronic alcohol abuse on body weight and energy metabolism: is excess ethanol consumption a risk factor for obesity or malnutrition? J Intern Med 244 1998 387 395 (Pubitemid 28513126)
10. G. Addolorato, E. Capristo, M. Marini, P. Santini, U. Scognamiglio, M.L. Attilia, D. Messineo, G.F. Sasso, G. Gasbarrini, M. Ceccanti Body composition changes induced by chronic ethanol abuse: evaluation by dual energy X-ray absorptiometry Am J Gastroenterol 95 2000 2323 2327
11. A.V. Greco, G. Mingrone, A. Favuzzi, E. Capristo, D. Gniuli, G. Addolorato, A. Brunani, F. Cavagnin, G. Gasbarrini Serum leptin levels in post-hepatitis liver cirrhosis J Hepatol 33 2000 38 42 (Pubitemid 30418932)
12. F. Santolaria, A. Pérez-Cejas, M.R. Alemán, E. González-Reimers, A. Milena, M.J. de la Vega, A. Martínez-Riera, M.A. Gómez-Rodríguez Low serum leptin levels and malnutrition in chronic alcohol misusers hospitalized by somatic complications Alcohol Alcohol 38 2003 60 66 (Pubitemid 36204367)
13. J. Calissendorff, K. Brismar, S. Röjdmark Is decreased leptin secretion after alcohol ingestion catecholamine-mediated? Alcohol Alcohol 39 2004 281 286 (Pubitemid 38968081)
14. M. Kalousová, T. Zima, P. Popov, P. Spacek, M. Braun, J. Soukupová, K. Pelinkova, R. Kientsch-Engel Advanced glycation end-products in patients with chronic alcohol misuse Alcohol Alcohol 39 2004 316 320
15. L. Kang, X. Chen, B.M. Sebastian, B.T. Pratt, I.R. Bederman, J.C. Alexander, S.F. Previs, L.E. Nagy Chronic ethanol and triglyceride turnover in white adipose tissue in rats: inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation J Biol Chem 282 2007 28465 28473 (Pubitemid 47606032)
16. X. Kang, W. Zhong, J. Liu, Z. Song, C.J. McClain, Y.J. Kang, Z. Zhou Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha Hepatology 50 2009 1241 1250
17. W. Zhong, Y. Zhao, Y. Tang, X. Wei, X. Shi, W. Sun, X. Sun, X. Yin, X. Sun, S. Kim, C.J. McClain, X. Zhang, Z. Zhou Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis Am J Pathol 180 2012 998 1007
18. A. Xu, Y. Wang, H. Keshaw, L.Y. Xu, K.S. Lam, G.J. Cooper The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice J Clin Invest 112 2003 91 100 (Pubitemid 38056380)
19. M. You, R.V. Considine, T.C. Leone, D.P. Kelly, D.W. Crabb Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice Hepatology 42 2005 568 577 (Pubitemid 41233649)
20. X. Chen, B.M. Sebastian, L.E. Nagy Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes Am J Physiol Endocrinol Metab 292 2007 E621 E628
21. F. Esfandiari, M. You, J.A. Villanueva, D.H. Wong, S.W. French, C.H. Halsted S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet Alcohol Clin Exp Res 31 2007 1231 1239 (Pubitemid 46934391)
22. Z. Song, Z. Zhou, I. Deaciuc, T. Chen, C.J. McClain Inhibition of adiponectin production by homocysteine: potential mechanism for alcoholic liver disease Hepatology 47 2008 867 879 (Pubitemid 351449678)
23. Z. Shen, X. Liang, C.Q. Rogers, D. Rideout, M. You Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice Am J Physiol Gastrointest Liver Physiol 298 2010 G364 G374
24. M. Otaka, N. Konishi, M. Odashima, M. Jin, I. Wada, T. Matsuhashi, R. Ohba, S. Watanabe Effect of alcohol consumption on leptin level in serum, adipose tissue, and gastric mucosa Dig Dis Sci 52 2007 3066 3069 (Pubitemid 47512520)
25. G.F. Maddalozzo, R.T. Turner, C.H. Edwards, K.S. Howe, J.J. Widrick, C.J. Rosen, U.T. Iwaniec Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats Osteoporos Int 20 2009 1529 1538
26. J.M. Ajmo, X. Liang, C.Q. Rogers, B. Pennock, M. You Resveratrol alleviates alcoholic fatty liver in mice Am J Physiol Gastrointest Liver Physiol 295 2008 G833 G842
27. J. Xu, K.K. Lai, A. Verlinsky, A. Lugea, S.W. French, M.P. Cooper, C. Ji, H. Tsukamoto Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK J Hepatol 55 2011 673 682
28. C. Buechler, A. Schäffler, M. Johann, M. Neumeier, P. Köhl, T. Weiss, N. Wodarz, P. Kiefer, C. Hellerbrand Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal J Gastroenterol Hepatol 24 2009 558 563
29. J. Gómez-Ambrosi, S. Becerril, P. Oroz, S. Zabalza, A. Rodríguez, F.J. Muruzábal, M. Archanco, M.J. Gil, M.A. Burrell, G. Frühbeck Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice: effect of LPS on plasma leptin and adiponectin concentrations FEBS Lett 577 2004 351 356 (Pubitemid 39535312)
30. B. Campillo, E. Sherman, J.P. Richardet, P.N. Bories Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism Eur J Clin Nutr 55 2001 980 988 (Pubitemid 33040095)
31. Q.M. Anstee, R.D. Goldin Mouse models in non-alcoholic fatty liver disease and steatohepatitis research Int J Exp Pathol 87 2006 1 16
32. K. Tomita, T. Azuma, N. Kitamura, G. Tamiya, S. Ando, H. Nagata, S. Kato, S. Inokuchi, T. Nishimura, H. Ishii, T. Hibi Leptin deficiency enhances sensitivity of rats to alcoholic steatohepatitis through suppression of metallothionein Am J Physiol Gastrointest Liver Physiol 287 2004 G1078 G1085
33. E.A. Oral, V. Simha, E. Ruiz, A. Andewelt, A. Premkumar, P. Snell, A.J. Wagner, A.M. DePaoli, M.L. Reitman, S.I. Taylor, P. Gorden, A. Garg Leptin-administration therapy for lipodystrophy N Engl J Med 346 2002 570 578
34. K.F. Petersen, E.A. Oral, S. Dufour, D. Befroy, C. Ariyan, C. Yu, G.W. Cline, A.M. DePaoli, S.I. Taylor, P. Gorden, G.I. Shulman Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy J Clin Invest 109 2002 1345 1350 (Pubitemid 34546899)
35. E.D. Javor, M.G. Ghany, E.K. Cochran, E.A. Oral, A.M. DePaoli, A. Premkumar, D.E. Kleiner, P. Gorden Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy Hepatology 41 2005 753 760 (Pubitemid 40462937)
36. T. Fujikawa, J.C. Chuang, I. Sakata, G. Ramadori, R. Coppari Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice Proc Natl Acad Sci USA 107 2010 17391 17396
37. M.Y. Wang, L. Chen, G.O. Clark, Y. Lee, R.D. Stevens, O.R. Ilkayeva, B.R. Wenner, J.R. Bain, M.J. Charron, C.B. Newgard, R.H. Unger Leptin therapy in insulin-deficient type I diabetes Proc Natl Acad Sci USA 107 2010 4813 4819
38. B.P. Cummings, A. Bettaieb, J.L. Graham, K.L. Stanhope, R. Dill, G.J. Morton, F.G. Haj, P.J. Havel Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats Proc Natl Acad Sci USA 108 2011 14670 14675
39. M.C. Sugden, K. Bulmer, G.F. Gibbons, B.L. Knight, M.J. Holness Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin Biochem J 364 2002 361 368 (Pubitemid 34620795)
40. T.E. Akiyama, J.M. Ward, F.J. Gonzalez Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha): alterations in fatty acid homeostasis in HNF1alpha-deficient mice J Biol Chem 275 2000 27117 27122
41. M. Fischer, M. You, M. Matsumoto, D.W. Crabb Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice J Biol Chem 278 2003 27997 28004 (Pubitemid 36899995)
42. S.H. Ki, O. Park, M. Zheng, O. Morales-Ibanez, J.K. Kolls, R. Bataller, B. Gao Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3 Hepatology 52 2010 1291 1300
43. A.M. Miller, H. Wang, A. Bertola, O. Park, N. Horiguchi, S.H. Ki, S. Yin, F. Lafdil, B. Gao Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10-deficient mice Hepatology 54 2011 846 856
44. V. Balasubramaniyan, G. Murugaiyan, R. Shukla, R.R. Bhonde, N. Nalini Leptin downregulates ethanol-induced secretion of proinflammatory cytokines and growth factor Cytokine 37 2007 96 100 (Pubitemid 46575282)
45. V. Balasubramaniyan, R. Shukla, G. Murugaiyan, R.R. Bhonde, N. Nalini Mouse recombinant leptin protects human hepatoma HepG2 against apoptosis: TNF-alpha response and oxidative stress induced by the hepatotoxin-ethanol Biochim Biophys Acta 1770 2007 1136 1144 (Pubitemid 47002151)
46. K. Serbetçi, O. Uysal, N. Erkasap, T. Köken, C. Baydemir, S. Erkasap Anti-apoptotic and antioxidant effect of leptin on CCl(4)-induced acute liver injury in rats Mol Biol Rep 39 2012 1173 1180
47. J.B. Sailaja, V. Balasubramaniyan, N. Nalini Effect of exogenous leptin administration on high fat diet induced oxidative stress Pharmazie 59 2004 475 479 (Pubitemid 38828638)
48. Z. Zhou, L. Wang, Z. Song, J.T. Saari, C.J. McClain, Y.J. Kang Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress Am J Pathol 166 2005 1681 1690 (Pubitemid 40734391)
49. Z. Zhou, X. Sun, Y. James Kang Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress Exp Biol Med (Maywood) 227 2002 214 222
50. I.A. Leclercq, G.C. Farrell, R. Schriemer, G.R. Robertson Leptin is essential for the hepatic fibrogenic response to chronic liver injury J Hepatol 37 2002 206 213 (Pubitemid 34833082)