메뉴 건너뛰기




Volumn 510, Issue 7503, 2014, Pages 84-91

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; GLUCOSE; INSULIN; LIPID; PROTEIN KINASE C; TRIACYLGLYCEROL;

EID: 84901944641     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13478     Document Type: Review
Times cited : (907)

References (121)
  • 1
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning, J. D. et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40, 1387-1395 (2004).
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1
  • 2
    • 84875625146 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups
    • Smits, M. M., Ioannou, G. N., Boyko, E. J. & Utzschneider, K. M. Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: results of a US national survey in three ethnic groups. J. Gastroenterol. Hepatol. 28, 664-670 (2013).
    • (2013) J. Gastroenterol. Hepatol. , vol.28 , pp. 664-670
    • Smits, M.M.1    Ioannou, G.N.2    Boyko, E.J.3    Utzschneider, K.M.4
  • 3
    • 23444451889 scopus 로고    scopus 로고
    • Prevalence of and risk factors for fatty liver in a general population of Shanghai China
    • Fan, J.-G. et al. Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J. Hepatol. 43, 508-514 (2005).
    • (2005) J. Hepatol. , vol.43 , pp. 508-514
    • Fan, J.-G.1
  • 4
    • 84984562986 scopus 로고    scopus 로고
    • How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences J
    • Amarapurkar, D. N. et al. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences J. Gastroenterol. Hepatol. 22, 788-793 (2007).
    • (2007) Gastroenterol. Hepatol. , vol.22 , pp. 788-793
    • Amarapurkar, D.N.1
  • 5
    • 33845315534 scopus 로고    scopus 로고
    • Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
    • Petersen, K. F. et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc. Natl Acad. Sci. USA 103, 18273-18277 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18273-18277
    • Petersen, K.F.1
  • 6
    • 77951493150 scopus 로고    scopus 로고
    • Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease
    • Das, K. et al. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology 51, 1593-1602 (2010).
    • (2010) Hepatology , vol.51 , pp. 1593-1602
    • Das, K.1
  • 7
    • 33847629709 scopus 로고    scopus 로고
    • Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease
    • Tolman, K. G., Fonseca, V., Dalpiaz, A. & Tan, M. H. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease. Diabetes Care 30, 734-743 (2007).
    • (2007) Diabetes Care , vol.30 , pp. 734-743
    • Tolman, K.G.1    Fonseca, V.2    Dalpiaz, A.3    Tan, M.H.4
  • 8
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless, I. R. & Lentz, J. S. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 12, 1106-1110 (1990).
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 9
    • 0025002079 scopus 로고
    • Liver pathology in morbidly obese patients with and without diabetes
    • Silverman, J. F. et al. Liver pathology in morbidly obese patients with and without diabetes. Am. J. Gastroenterol. 85, 1349-1355 (1990).
    • (1990) Am. J. Gastroenterol. , vol.85 , pp. 1349-1355
    • Silverman, J.F.1
  • 10
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
    • Fabbrini, E., Sullivan, S. & Klein, S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51, 679-689 (2010).
    • (2010) Hepatology , vol.51 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 11
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman, G. I. Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171-176 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 12
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner, D. E. et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313-1321 (2005).
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1
  • 13
    • 0043268063 scopus 로고    scopus 로고
    • Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    • Hui, J. M. et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology 38, 420-427 (2003).
    • (2003) Hepatology , vol.38 , pp. 420-427
    • Hui, J.M.1
  • 14
    • 77952529040 scopus 로고    scopus 로고
    • A position statement on NAFLD/NASH based on the EASL 2009 special conference
    • Ratziu, V., Bellentani, S., Cortez-Pinto, H., Day, C. & Marchesini, G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J. Hepatol. 53, 372-384 (2010).
    • (2010) J. Hepatol , vol.53 , pp. 372-384
    • Ratziu, V.1    Bellentani, S.2    Cortez-Pinto, H.3    Day, C.4    Marchesini, G.5
  • 15
    • 80053581540 scopus 로고    scopus 로고
    • Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States
    • Charlton, M. R. et al. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology 141, 1249-1253 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1249-1253
    • Charlton, M.R.1
  • 16
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • Samuel, V. T. & Shulman, G. I. Mechanisms for insulin resistance: common threads and missing links. Cell 148, 852-871 (2012).
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 17
    • 77957229010 scopus 로고    scopus 로고
    • Insulin signaling meets mitochondria in metabolism
    • Cheng, Z., Tseng, Y. & White, M. F. Insulin signaling meets mitochondria in metabolism. Trends Endocrinol. Metab. 21, 589-598 (2010).
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 589-598
    • Cheng, Z.1    Tseng, Y.2    White, M.F.3
  • 18
    • 63049091804 scopus 로고    scopus 로고
    • The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2
    • Hanke, S. & Mann, M. The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2. Mol. Cell. Proteomics 8, 519-534 (2009).
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 519-534
    • Hanke, S.1    Mann, M.2
  • 19
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • Franke, T. F., Kaplan, D. R., Cantley, L. C. & Toker, A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4- bisphosphate. Science 275, 665-668 (1997).
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 20
    • 84861523064 scopus 로고    scopus 로고
    • Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA
    • Adina-Zada, A. et al. Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA. Biochem. Soc. Trans. 40, 567-572 (2012).
    • (2012) Biochem. Soc. Trans. , vol.40 , pp. 567-572
    • Adina-Zada, A.1
  • 21
    • 84857833417 scopus 로고    scopus 로고
    • Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA
    • Adina-Zada, A., Zeczycki, T. N. & Attwood, P. V. Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA. Arch. Biochem. Biophys. 519, 118-130 (2012).
    • (2012) Arch. Biochem. Biophys. , vol.519 , pp. 118-130
    • Adina-Zada, A.1    Zeczycki, T.N.2    Attwood, P.V.3
  • 22
    • 0025370482 scopus 로고
    • Fructose-2,6-bisphosphate in control of hepatic gluconeogenesis. from metabolites to molecular genetics
    • Pilkis, S. J., el-Maghrabi, M. R. & Claus, T. H. Fructose-2,6- bisphosphate in control of hepatic gluconeogenesis. From metabolites to molecular genetics. Diabetes Care 13, 582-599 (1990).
    • (1990) Diabetes Care , vol.13 , pp. 582-599
    • Pilkis, S.J.1    El-Maghrabi, M.R.2    Claus, T.H.3
  • 23
    • 0032520870 scopus 로고    scopus 로고
    • Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
    • Petersen, K. F., Laurent, D., Rothman, D. L., Cline, G. W. & Shulman, G. I. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J. Clin. Invest. 101, 1203-1209 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 1203-1209
    • Petersen, K.F.1    Laurent, D.2    Rothman, D.L.3    Cline, G.W.4    Shulman, G.I.5
  • 24
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • Roden, M. et al. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 97, 2859-2865 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 2859-2865
    • Roden, M.1
  • 25
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel, V. T. et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem. 279, 32345-32353 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 32345-32353
    • Samuel, V.T.1
  • 26
    • 33847404482 scopus 로고    scopus 로고
    • Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease
    • Samuel, V. T. et al. Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J. Clin. Invest. 117, 739-745 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 739-745
    • Samuel, V.T.1
  • 27
    • 33847746323 scopus 로고    scopus 로고
    • A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production
    • Dries, D. R., Gallegos, L. L. & Newton, A. C. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J. Biol. Chem. 282, 826-830 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 826-830
    • Dries, D.R.1    Gallegos, L.L.2    Newton, A.C.3
  • 28
    • 80052538157 scopus 로고    scopus 로고
    • Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
    • Raddatz, K. et al. Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice. Diabetologia 54, 1447-1456 (2011).
    • (2011) Diabetologia , vol.54 , pp. 1447-1456
    • Raddatz, K.1
  • 29
    • 80053627289 scopus 로고    scopus 로고
    • Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    • Kumashiro, N. et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc. Natl Acad. Sci. USA 108, 16381-16385 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 16381-16385
    • Kumashiro, N.1
  • 30
    • 84861647226 scopus 로고    scopus 로고
    • Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects
    • Magkos, F. et al. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology 142, 1444-1446.e2 (2012).
    • (2012) Gastroenterology , vol.142
    • Magkos, F.1
  • 31
    • 84892872444 scopus 로고    scopus 로고
    • Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice
    • Funke, A. et al. Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice. Atherosclerosis 232, 390-396 (2014).
    • (2014) Atherosclerosis , vol.232 , pp. 390-396
    • Funke, A.1
  • 32
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: A pathogenic paradox
    • Brown, M. S. & Goldstein, J. L. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 7, 95-96 (2008).
    • (2008) Cell Metab. , vol.7 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 33
    • 76049095119 scopus 로고    scopus 로고
    • Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms
    • Chavez, J. A. & Summers, S. A. Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochim. Biophys. Acta 1801, 252-265 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 252-265
    • Chavez, J.A.1    Summers, S.A.2
  • 34
    • 0035912744 scopus 로고    scopus 로고
    • Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
    • Kim, J. K. et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc. Natl Acad. Sci. USA 98, 7522-7527 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 7522-7527
    • Kim, J.K.1
  • 35
    • 52049117445 scopus 로고    scopus 로고
    • Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia
    • Doege, H. et al. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. J. Biol. Chem. 283, 22186-22192 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 22186-22192
    • Doege, H.1
  • 37
    • 67349268828 scopus 로고    scopus 로고
    • Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content
    • Pardina, E. et al. Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content. Obes. Surg. 19, 894-904 (2009).
    • (2009) Obes. Surg. , vol.19 , pp. 894-904
    • Pardina, E.1
  • 38
    • 21244444320 scopus 로고    scopus 로고
    • The 'obese insulin-sensitive' adolescent: Importance of adiponectin and lipid partitioning
    • Weiss, R. et al. The 'obese insulin-sensitive' adolescent: importance of adiponectin and lipid partitioning. J. Clin. Endocrinol. Metab. 90, 3731-3737 (2005).
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 3731-3737
    • Weiss, R.1
  • 39
    • 33747032339 scopus 로고    scopus 로고
    • Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice
    • Cao, H. et al. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes 55, 1915-1922 (2006).
    • (2006) Diabetes , vol.55 , pp. 1915-1922
    • Cao, H.1
  • 40
    • 59649089306 scopus 로고    scopus 로고
    • AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency
    • Jaworski, K. et al. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nature Med. 15, 159-168 (2009).
    • (2009) Nature Med. , vol.15 , pp. 159-168
    • Jaworski, K.1
  • 41
    • 0345711540 scopus 로고    scopus 로고
    • Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency
    • Mingrone, G. et al. Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency. Diabetes 48, 1258-1263 (1999).
    • (1999) Diabetes , vol.48 , pp. 1258-1263
    • Mingrone, G.1
  • 42
    • 78649331070 scopus 로고    scopus 로고
    • A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis
    • Auinger, A. et al. A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis. Horm. Metab. Res. 42, 854-859 (2010).
    • (2010) Horm. Metab. Res. , vol.42 , pp. 854-859
    • Auinger, A.1
  • 43
    • 77950202777 scopus 로고    scopus 로고
    • Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    • Petersen, K. F. et al. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N. Engl. J. Med. 362, 1082-1089 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1082-1089
    • Petersen, K.F.1
  • 44
    • 84862193848 scopus 로고    scopus 로고
    • Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content
    • Peter, A., Kantartzis, K., Machicao, F. & Machann, J. Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content. J. Obes. 36, 774-782 (2012).
    • (2012) J. Obes. , vol.36 , pp. 774-782
    • Peter, A.1    Kantartzis, K.2    MacHicao, F.3    MacHann, J.4
  • 45
    • 84874607649 scopus 로고    scopus 로고
    • Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance
    • Camporez, J. P. G. et al. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology 154, 1021-1028 (2013).
    • (2013) Endocrinology , vol.154 , pp. 1021-1028
    • Camporez, J.P.G.1
  • 46
    • 84885381567 scopus 로고    scopus 로고
    • A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population
    • Verrijken, A., Beckers, S., Francque, S. & Hilden, H. A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population. Obesity (Silver Spring) 21, 2138-2145 (2013).
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 2138-2145
    • Verrijken, A.1    Beckers, S.2    Francque, S.3    Hilden, H.4
  • 47
    • 79251523832 scopus 로고    scopus 로고
    • Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance
    • Kozlitina, J., Boerwinkle, E., Cohen, J. C. & Hobbs, H. H. Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance. Hepatology 53, 467-474 (2011).
    • (2011) Hepatology , vol.53 , pp. 467-474
    • Kozlitina, J.1    Boerwinkle, E.2    Cohen, J.C.3    Hobbs, H.H.4
  • 48
    • 80055057797 scopus 로고    scopus 로고
    • Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
    • Lee, H.-Y. et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology 54, 1650-1660 (2011).
    • (2011) Hepatology , vol.54 , pp. 1650-1660
    • Lee, H.-Y.1
  • 50
    • 84887474124 scopus 로고    scopus 로고
    • Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ
    • Wang, F., Mullican, S. E., DiSpirito, J. R., Peed, L. C. & Lazar, M. A. Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ. Proc. Natl Acad. Sci. USA 110, 18656-18661 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 18656-18661
    • Wang, F.1    Mullican, S.E.2    Dispirito, J.R.3    Peed, L.C.4    Lazar, M.A.5
  • 51
    • 84893422672 scopus 로고    scopus 로고
    • Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2/lipodystrophic mice independent of hepatocyte leptin receptors
    • Cortés, V. A. et al. Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2/lipodystrophic mice independent of hepatocyte leptin receptors. J. Lipid Res. 55, 276-288 (2014).
    • (2014) J. Lipid Res. , vol.55 , pp. 276-288
    • Cortés, V.A.1
  • 52
    • 15944364442 scopus 로고    scopus 로고
    • Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy
    • Savage, D. B., Murgatroyd, P. R., Chatterjee, V. K. & O'Rahilly, S. Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy. J. Clin. Endocrinol. Metab. 90, 1446-1452 (2005).
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 1446-1452
    • Savage, D.B.1    Murgatroyd, P.R.2    Chatterjee, V.K.3    O'Rahilly, S.4
  • 53
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • Petersen, K. F. et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest. 109, 1345-1350 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 1345-1350
    • Petersen, K.F.1
  • 54
    • 0043172530 scopus 로고    scopus 로고
    • Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy
    • Simha, V., Szczepaniak, L. S., Wagner, A. J., DePaoli, A. M. & Garg, A. Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. Diabetes Care 26, 30-35 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 30-35
    • Simha, V.1    Szczepaniak, L.S.2    Wagner, A.J.3    Depaoli, A.M.4    Garg, A.5
  • 55
    • 79952000272 scopus 로고    scopus 로고
    • Perilipin deficiency and autosomal dominant partial lipodystrophy
    • Gandotra, S. et al. Perilipin deficiency and autosomal dominant partial lipodystrophy. N. Engl. J. Med. 364, 740-748 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 740-748
    • Gandotra, S.1
  • 56
    • 0344874201 scopus 로고    scopus 로고
    • Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
    • Diraison, F., Moulin, P. & Beylot, M. Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab. 29, 478-485 (2003).
    • (2003) Diabetes Metab. , vol.29 , pp. 478-485
    • Diraison, F.1    Moulin, P.2    Beylot, M.3
  • 57
    • 34547911800 scopus 로고    scopus 로고
    • The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
    • Petersen, K. F. et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc. Natl Acad. Sci. USA 104, 12587-12594 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 12587-12594
    • Petersen, K.F.1
  • 58
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly, K. L. et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1
  • 59
    • 84861443900 scopus 로고    scopus 로고
    • Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes
    • Petersen, K. F. et al. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes. Proc. Natl Acad. Sci. USA 109, 8236-8240 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 8236-8240
    • Petersen, K.F.1
  • 60
    • 84868014062 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis hyperlipidemia and hepatic steatosis in the elderly
    • Flannery, C., Dufour, S., Rabøl, R., Shulman, G. I. & Petersen, K. F. Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes 61, 2711-2717 (2012).
    • (2012) Diabetes , vol.61 , pp. 2711-2717
    • Flannery, C.1    Dufour, S.2    Rabøl, R.3    Shulman, G.I.4    Petersen, K.F.5
  • 61
    • 33646088382 scopus 로고    scopus 로고
    • Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters
    • Bilz, S. et al. Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters. Am. J. Physiol. Endocrinol. Metab. 290, E716-E722 (2006).
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Bilz, S.1
  • 62
    • 0030070536 scopus 로고    scopus 로고
    • Effects of free fatty acids on the metabolic response to oral fructose in lean healthy humans
    • Delarue, J., Normand, S., Couet, C. & Pachiaudi, C. Effects of free fatty acids on the metabolic response to oral fructose in lean healthy humans. Int. J. Obes. Relat. Metab. Disord. 20, 130-136 (1996).
    • (1996) Int. J. Obes. Relat. Metab. Disord. , vol.20 , pp. 130-136
    • Delarue, J.1    Normand, S.2    Couet, C.3    Pachiaudi, C.4
  • 63
    • 84862984616 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice
    • Zhang, C. et al. Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice. Toxicol. Lett. 212, 229-240 (2012).
    • (2012) Toxicol. Lett. , vol.212 , pp. 229-240
    • Zhang, C.1
  • 64
    • 19944430411 scopus 로고    scopus 로고
    • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP
    • Lin, J. et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell 120, 261-273 (2005).
    • (2005) Cell , vol.120 , pp. 261-273
    • Lin, J.1
  • 65
    • 60649109153 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor γ coactivator-1 β in the pathogenesis of fructose-induced insulin resistance
    • Nagai, Y. et al. The role of peroxisome proliferator-activated receptor γ coactivator-1 β in the pathogenesis of fructose-induced insulin resistance. Cell Metab. 9, 252-264 (2009).
    • (2009) Cell Metab. , vol.9 , pp. 252-264
    • Nagai, Y.1
  • 66
    • 33644654777 scopus 로고    scopus 로고
    • Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
    • Savage, D. B. et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J. Clin. Invest. 116, 817-824 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 817-824
    • Savage, D.B.1
  • 67
    • 0034946949 scopus 로고    scopus 로고
    • Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4
    • Kim, J. K. et al. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J. Clin. Invest. 108, 153-160 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 153-160
    • Kim, J.K.1
  • 68
    • 84871447109 scopus 로고    scopus 로고
    • AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues
    • Wang, H. Y. et al. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem. J. 449, 479-489 (2013).
    • (2013) Biochem. J. , vol.449 , pp. 479-489
    • Wang, H.Y.1
  • 69
    • 84900345833 scopus 로고    scopus 로고
    • Dissociation of hepatic insulin resistance from susceptibility of non-alcoholic fatty liver disease induced by a high fat and high carbohydrate diet in mice
    • Asai, A. et al. Dissociation of hepatic insulin resistance from susceptibility of non-alcoholic fatty liver disease induced by a high fat and high carbohydrate diet in mice. Am. J. Physiol. Gastrointest. Liver Physiol. http:dx.doi.org/10.1152/ajpgi.00291.2013 (2014).
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol
    • Asai, A.1
  • 70
    • 80051971972 scopus 로고    scopus 로고
    • Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals
    • Rabøl, R., Petersen, K. F., Dufour, S., Flannery, C. & Shulman, G. I. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc. Natl Acad. Sci. USA 108, 13705-13709 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 13705-13709
    • Rabøl, R.1    Petersen, K.F.2    Dufour, S.3    Flannery, C.4    Shulman, G.I.5
  • 71
    • 34347238724 scopus 로고    scopus 로고
    • Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
    • Nagle, C. A. et al. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J. Biol. Chem. 282, 14807-14815 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 14807-14815
    • Nagle, C.A.1
  • 72
    • 27244440736 scopus 로고    scopus 로고
    • Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA: Glycerol-sn-3-phosphate acyltransferase 1 knockout mice
    • Neschen, S., Morino, K., Hammond, L. E., Zhang, D. & Liu, Z. X. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA: glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab. 2, 55-65 (2005).
    • (2005) Cell Metab. , vol.2 , pp. 55-65
    • Neschen, S.1    Morino, K.2    Hammond, L.E.3    Zhang, D.4    Liu, Z.X.5
  • 73
    • 23044450772 scopus 로고    scopus 로고
    • Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice
    • Yu, X. X. et al. Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology 42, 362-371 (2005).
    • (2005) Hepatology , vol.42 , pp. 362-371
    • Yu, X.X.1
  • 74
    • 34547946930 scopus 로고    scopus 로고
    • Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
    • Choi, C. S. et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282, 22678-22688 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 22678-22688
    • Choi, C.S.1
  • 75
    • 34347235098 scopus 로고    scopus 로고
    • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    • Monetti, M. et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6, 69-78 (2007).
    • (2007) Cell Metab. , vol.6 , pp. 69-78
    • Monetti, M.1
  • 76
    • 79954996869 scopus 로고    scopus 로고
    • Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2
    • Jornayvaz, F. R. et al. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc. Natl Acad. Sci. USA 108, 5748-5752 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 5748-5752
    • Jornayvaz, F.R.1
  • 77
    • 65549151428 scopus 로고    scopus 로고
    • The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans
    • Kantartzis, K. et al. The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans. Clin. Sci. 116, 531-537 (2009).
    • (2009) Clin. Sci. , vol.116 , pp. 531-537
    • Kantartzis, K.1
  • 78
    • 77952425688 scopus 로고    scopus 로고
    • Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model
    • Shindo, N. et al. Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model. J. Hepatol. 52, 903-912 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 903-912
    • Shindo, N.1
  • 79
    • 84869128653 scopus 로고    scopus 로고
    • Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats
    • Morán-Ramos, S. et al. Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats. J. Nutr. 142, 1956-1963 (2012).
    • (2012) J. Nutr. , vol.142 , pp. 1956-1963
    • Morán-Ramos, S.1
  • 80
    • 52649142089 scopus 로고    scopus 로고
    • Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice
    • Singhal, N. S., Patel, R. T., Qi, Y., Lee, Y. S. & Ahima, R. S. Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am. J. Physiol. Endocrinol. Metab. 295, E331-E338 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295
    • Singhal, N.S.1    Patel, R.T.2    Qi, Y.3    Lee, Y.S.4    Ahima, R.S.5
  • 81
    • 34047166373 scopus 로고    scopus 로고
    • N-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner
    • Neschen, S. et al. n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Diabetes 56, 1034-1041 (2007).
    • (2007) Diabetes , vol.56 , pp. 1034-1041
    • Neschen, S.1
  • 82
    • 36749082168 scopus 로고    scopus 로고
    • Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance
    • Zhang, D. et al. Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. Proc. Natl Acad. Sci. USA 104, 17075-17080 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 17075-17080
    • Zhang, D.1
  • 83
    • 84887896439 scopus 로고    scopus 로고
    • Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects
    • Houten, S. M. et al. Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects. Hum. Mol. Genet. 22, 5249-5261 (2013).
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 5249-5261
    • Houten, S.M.1
  • 84
    • 78349242167 scopus 로고    scopus 로고
    • A high fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
    • Jornayvaz, F. R. et al. A high fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. Am. J. Physiol. Endocrinol. Metab. 299, E808-E815 (2010).
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299
    • Jornayvaz, F.R.1
  • 85
    • 84862907611 scopus 로고    scopus 로고
    • Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance
    • Jornayvaz, F. R. et al. Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology 153, 583-591 (2012).
    • (2012) Endocrinology , vol.153 , pp. 583-591
    • Jornayvaz, F.R.1
  • 86
    • 84883167011 scopus 로고    scopus 로고
    • Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice
    • Camporez, J. P. G. et al. Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology 154, 3099-3109 (2013).
    • (2013) Endocrinology , vol.154 , pp. 3099-3109
    • Camporez, J.P.G.1
  • 87
    • 84866296565 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
    • Brown, W. H. et al. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proc. Natl Acad. Sci. USA 109, 14966-14971 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 14966-14971
    • Brown, W.H.1
  • 88
    • 84889887123 scopus 로고    scopus 로고
    • Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
    • Fullerton, M. D. et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nature Med. 19, 1649-1654 (2013).
    • (2013) Nature Med. , vol.19 , pp. 1649-1654
    • Fullerton, M.D.1
  • 89
    • 79960969204 scopus 로고    scopus 로고
    • Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice
    • Birkenfeld, A. L. et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab. 14, 184-195 (2011).
    • (2011) Cell Metab. , vol.14 , pp. 184-195
    • Birkenfeld, A.L.1
  • 90
    • 82955239838 scopus 로고    scopus 로고
    • Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    • Sunny, N. E., Parks, E. J., Browning, J. D. & Burgess, S. C. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 14, 804-810 (2011).
    • (2011) Cell Metab. , vol.14 , pp. 804-810
    • Sunny, N.E.1    Parks, E.J.2    Browning, J.D.3    Burgess, S.C.4
  • 91
    • 84861451144 scopus 로고    scopus 로고
    • Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
    • Satapati, S. et al. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J. Lipid Res. 53, 1080-1092 (2012).
    • (2012) J. Lipid Res. , vol.53 , pp. 1080-1092
    • Satapati, S.1
  • 92
    • 70350043496 scopus 로고    scopus 로고
    • Abnormal hepatic energy homeostasis in type 2 diabetes
    • Szendroedi, J. et al. Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology 50, 1079-1086 (2009).
    • (2009) Hepatology , vol.50 , pp. 1079-1086
    • Szendroedi, J.1
  • 93
    • 79951697487 scopus 로고    scopus 로고
    • Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes
    • Schmid, A. I. et al. Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes. Diabetes Care 34, 448-453 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 448-453
    • Schmid, A.I.1
  • 94
    • 84891859110 scopus 로고    scopus 로고
    • Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy
    • Befroy, D. E. et al. Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nature Med. 20, 98-102 (2014).
    • (2014) Nature Med. , vol.20 , pp. 98-102
    • Befroy, D.E.1
  • 95
    • 84860455885 scopus 로고    scopus 로고
    • The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    • Farese, R. V., Jr, Zechner, R., Newgard, C. B. & Walther, T. C. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 15, 570-573 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 570-573
    • Farese, R.V.1    Zechner Jr., R.2    Newgard, C.B.3    Walther, T.C.4
  • 96
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen, J. C., Horton, J. D. & Hobbs, H. H. Human fatty liver disease: old questions and new insights. Science 332, 1519-1523 (2011).
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 97
    • 84871655682 scopus 로고    scopus 로고
    • Dissociating fatty liver and diabetes
    • Sun, Z. & Lazar, M. A. Dissociating fatty liver and diabetes. Trends Endocrinol. Metab. 24, 4-12 (2013).
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 4-12
    • Sun, Z.1    Lazar, M.A.2
  • 98
    • 81755174117 scopus 로고    scopus 로고
    • Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis
    • Niebergall, L. J., Jacobs, R. L., Chaba, T. & Vance, D. E. Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. Biochim. Biophys. Acta 1811, 1177-1185 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1811 , pp. 1177-1185
    • Niebergall, L.J.1    Jacobs, R.L.2    Chaba, T.3    Vance, D.E.4
  • 99
    • 77954575279 scopus 로고    scopus 로고
    • Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
    • Jacobs, R. L. et al. Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J. Biol. Chem. 285, 22403-22413 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 22403-22413
    • Jacobs, R.L.1
  • 100
    • 84899477570 scopus 로고    scopus 로고
    • Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPARγ
    • Xu, E. et al. Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ. Hepatology 59, 1803-1815(2013).
    • (2013) Hepatology , vol.59 , pp. 1803-1815
    • Xu, E.1
  • 101
    • 84896848270 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver
    • Ruiz, R. et al. Sterol regulatory element binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J. Biol. Chem. 289, 5510-5517 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 5510-5517
    • Ruiz, R.1
  • 102
    • 84861809881 scopus 로고    scopus 로고
    • The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
    • Benhamed, F. et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J. Clin. Invest. 122, 2176-2194 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 2176-2194
    • Benhamed, F.1
  • 103
    • 78149346457 scopus 로고    scopus 로고
    • CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
    • Brown, J. M. et al. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J. Lipid Res. 51, 3306-3315 (2010).
    • (2010) J. Lipid Res. , vol.51 , pp. 3306-3315
    • Brown, J.M.1
  • 104
    • 84873178604 scopus 로고    scopus 로고
    • CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER- preventing diacylglycerol-mediated hepatic insulin resistance
    • Cantley, J. L. et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proc. Natl Acad. Sci. USA 110, 1869-1874 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 1869-1874
    • Cantley, J.L.1
  • 105
    • 84862330756 scopus 로고    scopus 로고
    • Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans
    • Bergman, B. C., Hunerdosse, D. M., Kerege, A., Playdon, M. C. & Perreault, L. Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans. Diabetologia 55, 1140-1150 (2012).
    • (2012) Diabetologia , vol.55 , pp. 1140-1150
    • Bergman, B.C.1    Hunerdosse, D.M.2    Kerege, A.3    Playdon, M.C.4    Perreault, L.5
  • 106
    • 84862025421 scopus 로고    scopus 로고
    • Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
    • Sun, Z. et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Med. 18, 934-942 (2012).
    • (2012) Nature Med. , vol.18 , pp. 934-942
    • Sun, Z.1
  • 107
    • 84876718085 scopus 로고    scopus 로고
    • Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats
    • Kumashiro, N. et al. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology 57, 1763-1772 (2013).
    • (2013) Hepatology , vol.57 , pp. 1763-1772
    • Kumashiro, N.1
  • 108
    • 84860465005 scopus 로고    scopus 로고
    • Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase
    • Kumari, M. et al. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab. 15, 691-702 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 691-702
    • Kumari, M.1
  • 109
    • 79953745343 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    • Speliotes, E. K. et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 7, e1001324 (2011).
    • (2011) PLoS Genet. , vol.7
    • Speliotes, E.K.1
  • 110
    • 84896939136 scopus 로고    scopus 로고
    • Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals
    • Lin, Y.-C., Chang, P.-F., Chang, M.-H. & Ni, Y.-H. Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Am. J. Clin. Nutr. 99, 869-874 (2014).
    • (2014) Am. J. Clin. Nutr. , vol.99 , pp. 869-874
    • Lin, Y.-C.1    Chang, P.-F.2    Chang, M.-H.3    Ni, Y.-H.4
  • 111
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • Petersen, K. F. et al. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 54, 603-608 (2005).
    • (2005) Diabetes , vol.54 , pp. 603-608
    • Petersen, K.F.1
  • 112
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • Lim, E. L. et al. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 54, 2506-2514 (2011).
    • (2011) Diabetologia , vol.54 , pp. 2506-2514
    • Lim, E.L.1
  • 114
  • 115
    • 84891874234 scopus 로고    scopus 로고
    • Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss
    • Haufe, S. et al. Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss. Diabetes Care 36, 3786-3792 (2013).
    • (2013) Diabetes Care , vol.36 , pp. 3786-3792
    • Haufe, S.1
  • 116
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • Mayerson, A. B., Hundal, R. S., Dufour, S. & Lebon, V. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51, 797-802 (2002).
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3    Lebon, V.4
  • 117
    • 0038549106 scopus 로고    scopus 로고
    • Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice
    • Kim, J. K. et al. Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice. Diabetes 52, 1311-1318 (2003).
    • (2003) Diabetes , vol.52 , pp. 1311-1318
    • Kim, J.K.1
  • 118
    • 84879955522 scopus 로고    scopus 로고
    • Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice
    • Prieur, X. et al. Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice. Diabetologia 56, 1813-1825 (2013).
    • (2013) Diabetologia , vol.56 , pp. 1813-1825
    • Prieur, X.1
  • 119
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • Dutchak, P. A. et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 148, 556-567 (2012).
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1
  • 120
    • 0037883037 scopus 로고    scopus 로고
    • Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    • Miyazaki, Y. et al. Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients. Diabetes 52, 1943-1950 (2003).
    • (2003) Diabetes , vol.52 , pp. 1943-1950
    • Miyazaki, Y.1
  • 121
    • 84887432240 scopus 로고    scopus 로고
    • Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler
    • Perry, R. J. et al. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metab. 18, 740-748 (2013).
    • (2013) Cell Metab. , vol.18 , pp. 740-748
    • Perry, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.