AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 12 SUPPL., 2005, Pages

  Tomita, Kengo ^a   Tamiya, Gen ^b   Ando, Satoshi ^b   Kitamura, Naoto ^a   Koizumi, Haruna ^a   Kato, Shinzo ^a   Horie, Yoshinori ^a   Kaneko, Takehiko ^a   Azuma, Toshifumi ^c   Nagata, Hiroshi ^a   Ishii, Hiromasa ^a   Hibi, Toshifumi ^a  

^a KEIO UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

AICAR; Alcohol; AMPK; Fatty Liver

Indexed keywords

4 HYDROXYNONENAL; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ALCOHOL; ENZYME ACTIVATOR; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER PROTECTIVE AGENT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD ANALYSIS; BODY WEIGHT; CALORIC INTAKE; CHEMICAL ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; DIET; DRUG EFFECT; FEEDING; HISTOPATHOLOGY; LIPID PEROXIDATION; LIPOGENESIS; LIVER; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ALDEHYDES; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATORS; ETHANOL; FATTY ACID SYNTHETASE COMPLEX; FATTY LIVER; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER; MALE; MULTIENZYME COMPLEXES; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEOTIDES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIGLYCERIDES;

ANIMALIA;

EID: 30144445780     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000191126.11479.69     Document Type: Conference Paper

References (15)

1. Corton JM Gillespie JG, Hawley SA, Hardie DG (1995) 5-aminoimidazole-4- carboxamide ribonucleoside; a specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229:558-565.
2. Enomoto N, Takei Y, Hirose M, Konno A, Shibuya T, Matsuyama S, Suzuki S, Ikejima K, Kitamura T, Sato N (2003) Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptor-γ, pioglitazone. J Pharmacol Exp Ther 306:846-854.
3. Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW (2002) AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes 51:2886-2894.
4. Lieber CS, Decarli LM, Sorrell MF (1989) Experimental methods of ethanol administration. Hepatology 10:501-510.
5. Lin HA, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM (2000) Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med 6:998-1003.
6. McCarty MF (2004) Chronic activation of AMP-activated kinase as a strategy for slowing aging. Med Hypotheses 63:334-339.
7. Sorensen TI, Orholm M, Bentsen KD, Hoybye G, Eghoje K, Christoffersen P (1984) Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis. Lancet 2:241-244.
8. Teli MR, Day CP, Burt AD, Bennett MK, James OFW (1995) Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 346:987-990.
9. Tomita K, Azuma T, Kitamura N, Nishimura T, Inokuchi S, Kato S, Ishii H (2001) Pioglitazone, a PPAR-gamma agonist, prevents alcohol-induced fatty liver in rats. Hepatology 34:A464.
10. Tomita K, Azuma T, Inokuchi S, Kitamura N, Nishimura T, Kato S, Ishii H (2003) Regulation of mouse retinol dehydrogenases and retinal dehydrogenases in hepatocyte differentiation. Jpn. J. Alcohol & Drug Dependence 38:46-57.
11. Tomita K, Azuma T, Kitamura N, Nishida J, Tamiya G, Oka A, Inokuchi S, Nishimura T, Suematsu M, Ishii H (2004) Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Gastroenterology 126:873-885.
12. Tomita K, Sato M, Kajiwara K, Tanaka M, Tamiya G, Makino S, Tomizawa M, Mizutani A, Kuwano Y, Shiina T, Ishii H, Kimura M (2000) Gene structure and promoter for Crad2 encoding mouse cis-retinol/3α-hydroxysterol short-chain dehydrogenase isozyme. Gene 251:175-186.
13. Xu A, Wang Y, Keshaw H, Xu LY, Lam KSL, Cooper GJS (2003) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112:91-100.
14. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288-1295.
15. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174.