Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Kong, Lingbo ^a   Ren, Weiguang ^a   Li, Wencong ^a   Zhao, Suxian ^a   Mi, Hongmei ^a   Wang, Rongqi ^a   Zhang, Yuguo ^a   Wu, Wenjuan ^a   Nan, Yuemin ^a   Yu, Jun ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

animal experiment; ethanol; Peroxisome proliferator activated receptor alpha; steatohepatitis

Indexed keywords

ADIPOCYTOKINE; ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CYCLOOXYGENASE 2; CYTOCHROME P450; CYTOKINE; GW 6471; HEME OXYGENASE 1; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PHOSPHATIDYLINOSITOL 3 KINASE; PIRINIXIC ACID; SIRTUIN 1; UNCLASSIFIED DRUG; ADIPONECTIN; AUTACOID; PYRIMIDINE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; C57BL 6 MOUSE; CONTROLLED STUDY; FATTY ACID SYNTHESIS; FATTY LIVER; GENE EXPRESSION; INFLAMMATION; LIPID METABOLISM; LIPID OXIDATION; LIVER NECROSIS; MALE; MOLECULAR BIOLOGY; MOUSE; NECROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; ALCOHOLIC FATTY LIVER; ANIMAL; BLOOD; C57BL MOUSE; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; LIVER; LIVER CELL; METABOLISM; PATHOLOGY;

ANIMALIA; MUS;

ADIPONECTIN; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; ETHANOL; FATTY LIVER, ALCOHOLIC; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HEPATOCYTES; INFLAMMATION MEDIATORS; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; PPAR ALPHA; PYRIMIDINES;

EID: 84855177721     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-246     Document Type: Article

References (37)

1. Cytokines in alcoholic and nonalcoholic steatohepatitis. Tilg H, Diehl AM, N Engl J Med 2000 343 1467 1476 10.1056/NEJM200011163432007 11078773
2. Suppression of PGC-1alpha by Ethanol: Implications of Its Role in Alcohol Induced Liver Injury. Chaung WW, Jacob A, Ji Y, Wang P, Int J Clin Exp Med 2008 1 161 170 19079670
3. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. Ji C, Chan C, Kaplowitz N, J Hepatol 2006 45 717 724 10.1016/j.jhep.2006.05.009 16879892 (Pubitemid 44479875)
4. The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: a potential biomarker. Banerjee A, Burghardt RC, Johnson GA, White FJ, Ramaiah SK, Toxicol Pathol 2006 34 373 384 10.1080/01926230600806543 16844665
5. Higher neutrophil infiltration mediated by osteopontin is a likely contributing factor to the increased susceptibility of females to alcoholic liver disease. Banerjee A, Apte UM, Smith R, Ramaiah SK, J Pathol 2006 208 473 485 10.1002/path.1917 16440289 (Pubitemid 43329334)
6. Ethanol and LPS modulate NF-kappaB activation, inducible NO synthase and COX-2 gene expression in rat liver cells in vivo. Spitzer JA, Zheng M, Kolls JK, Vande Stouwe C, Spitzer JJ, Front Biosci 2002 7 99 108 10.2741/spitzer 11994208
7. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. Crabb DW, Galli A, Fischer M, You M, Alcohol 2004 34 35 38 10.1016/j.alcohol.2004.07.005 15670663
8. Alcohol-induced steatosis in liver cells. Donohue TM Jr, World J Gastroenterol 2007 13 4974 4978 17854140 (Pubitemid 47496830)
9. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). Aoyama T, Peters JM, Iritani N, Nakajima T, Furihata K, Hashimoto T, Gonzalez FJ, J Biol Chem 1998 273 5678 5684 10.1074/jbc.273.10.5678 9488698 (Pubitemid 28124039)
10. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. Watanabe K, Fujii H, Takahashi T, Kodama M, Aizawa Y, Ohta Y, Ono T, Hasegawa G, Naito M, Nakajima T, Kamijo Y, Gonzalez FJ, Aoyama T, J Biol Chem 2000 275 22293 22299 10.1074/jbc.M000248200 10801788 (Pubitemid 30621813)
11. "Hypothesis of Seven Balances": Molecular Mechanisms behind Alcoholic Liver Diseases and Association with PPAR. Moriya T, Naito H, Ito Y, Nakajima T, J Occup Health 2009 51 391 403 10.1539/joh.K9001 19706994
12. Retinoid X Receptor heterodimers in the metabolic syndrome. Shulman AI, Mangelsdorf DJ, N Engl J Med 2005 353 604 615 10.1056/NEJMra043590 16093469 (Pubitemid 41138942)
13. Fatty acid activation of peroxisome proliferator-activated receptor (PPAR). Bocos C, Göttlicher M, Gearing K, Banner C, Enmark E, Teboul M, Crickmore A, Gustafsson JA, J Steroid Biochem Mol Biol 1995 53 467 473 10.1016/0960-0760(95)00093-F 7626496
14. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Issemann I, Green S, Nature 1990 347 645 650 10.1038/347645a0 2129546 (Pubitemid 20356241)
15. Peroxisome Proliferator- Activated Receptor Mediates the Effects of High-Fat Diet on Hepatic Gene Expression. Patsouris D, Reddy JK, Müller M, Kersten S, Endocrinology 2006 147 1508 1516 16357043 (Pubitemid 43244386)
16. Hepatic fibroblast growth factor 21 is regulated by PPAR and is a key mediator of hepatic lipid metabolism in ketotic states. Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E, Cell Metab 2007 5 426 437 10.1016/j.cmet.2007.05.002 17550778 (Pubitemid 46825495)
17. Endocrine regulation of the fasting response by PPAR-mediated induction of fibroblast growth factor 21. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA, Cell Metab 2007 5 415 425 10.1016/j.cmet.2007.05.003 17550777 (Pubitemid 46825496)
18. FGF-21 as a novel metabolic regulator. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB, J Clin Invest 2005 115 1627 1635 10.1172/JCI23606 15902306 (Pubitemid 40814671)
19. Effect of chronic alcohol consumption on hepatic SIRT1 and PGC-1alpha in rats. Lieber CS, Leo MA, Wang X, Decarli LM, Biochem Biophys Res Commun 2008 370 44 48 10.1016/j.bbrc.2008.03.005 18342626
20. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. You M, Liang X, Ajmo JM, Ness GC, Am J Physiol Gastrointest Liver Physiol 2008 294 892 898 10.1152/ajpgi.00575.2007 18239056 (Pubitemid 351520077)
21. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1 pathway. Chau MD, Gao J, Yang Q, Wu Z, Gromada J, Proc Natl Acad Sci USA 2010 107 12553 12558 10.1073/pnas.1006962107 20616029
22. Peroxisome proliferator-activated receptor coactivator 1 coactivators, energy homeostasis, and metabolism. Handschin C, Spiegelman BM, Endocr Rev 2006 27 728 735 17018837 (Pubitemid 44936056)
23. Peroxisome proliferator-activated receptorgamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Puigserver P, Spiegelman BM, Endocr Rev 2003 24 78 90 10.1210/er.2002-0012 12588810 (Pubitemid 36223280)
24. Metabolic control through the PGC-1 family of transcription coactivators. Lin J, Handschin C, Spiegelman BM, Cell Metab 2005 1 361 370 10.1016/j.cmet.2005.05.004 16054085 (Pubitemid 43960626)
25. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Cantá C, Auwerx J, Curr Opin Lipidol 2009 20 98 105 10.1097/MOL.0b013e328328d0a4 19276888
26. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Cantá C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J, Nature 2009 458 1056 1060 10.1038/nature07813 19262508
27. Hepatocyte- specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X, Cell Metab 2009 9 327 338 10.1016/j.cmet.2009.02.006 19356714
28. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB, Biochem Biophys Res Commun 2009 378 836 841 10.1016/j.bbrc.2008.11.130 19071085
29. Adiponectin and alcoholic fatty liver disease. Rogers CQ, Ajmo JM, You M, IUBMB Life 2008 60 790 797 10.1002/iub.124 18709650
30. Adiponectin: a key adipokine in alcoholic fatty liver. You M, Rogers CQ, Exp Biol Med (Maywood) 2009 234 2850 2959
31. Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Yu W, Chen Z, Zhang J, Zhang L, Ke H, Huang L, Peng Y, Zhang X, Li S, Lahn BT, Xiang AP, Mol Cell Biochem 2008 310 11 18 10.1007/s11010-007-9661-9 18060476
32. Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline- deficient medium. Sahai A, Pan X, Paul R, Malladi P, Kohli R, Whitington PF, Am J Physiol Gastrointest Liver Physiol 2006 291 55 62 10.1152/ajpgi.00360.2005 16439472 (Pubitemid 44024661)
33. Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. Masaki T, Chiba S, Tatsukawa H, Yasuda T, Noguchi H, Seike M, Yoshimatsu H, Hepatology 2004 40 177 184 15239101 (Pubitemid 38868936)
34. The Anti-Inflammatory Effects of Adiponectin Are Mediated via a Heme Oxygenase-1 Dependent Pathway in Rat Kupffer Cells. Mandal P, Park PH, McMullen MR, Pratt BT, Nagy LE, Hepatology 2010 51 1420 1429 10.1002/hep.23427 20052772
35. Heme oxygenase-1: unleashing the protective properties of heme. Otterbein LE, Soares MP, Yamashita K, Bach FH, Trends Immunol 2003 24 449 455 10.1016/S1471-4906(03)00181-9 12909459 (Pubitemid 36928103)
36. Adiponectin- mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPAR dependent mechanism. Lin H, Yu CH, Jen CY, Cheng CF, Chou Y, Chang CC, Juan SH, Am J Pathol 2010 177 1697 1709 10.2353/ajpath.2010.090789 20709802
37. A new scoring system for prognostic stratification of patients with alcoholic hepatitis. Dominguez M, Rincán D, Abraldes JG, Miquel R, Colmenero J, Bellot P, García-Pagán JC, Fernández R, Moreno M, Bãares R, Arroyo V, Caballería J, Ginès P, Bataller R, Am J Gastroenterol 2008 103 2747 2756 10.1111/j.1572-0241.2008.02104.x 18721242