-
1
-
-
0033772936
-
Apoptosis and dysregulated ceramide metabolism in a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity
-
Deaciuc IV, Nikolova-Karakashian M, Fortunato F, Lee EY, Hill DB, McClain CJ. Apoptosis and dysregulated ceramide metabolism in a murine model of alcohol-enhanced lipopolysaccharide hepatotoxicity. Alcohol Clin Exp Res 24: 1557-1565, 2000.
-
(2000)
Alcohol Clin Exp Res
, vol.24
, pp. 1557-1565
-
-
Deaciuc, I.V.1
Nikolova-Karakashian, M.2
Fortunato, F.3
Lee, E.Y.4
Hill, D.B.5
McClain, C.J.6
-
2
-
-
0027202552
-
Ceramide activates heterotrimeric protein phosphatase 2A
-
Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem 268: 15523-15530, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 15523-15530
-
-
Dobrowsky, R.T.1
Kamibayashi, C.2
Mumby, M.C.3
Hannun, Y.A.4
-
3
-
-
0027202552
-
Ceramide activates heterotrimeric protein phosphatase 2A
-
Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem 268: 15523-15530, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 15523-15530
-
-
Dobrowsky, R.T.1
Kamibayashi, C.2
Mumby, M.C.3
Hannun, Y.A.4
-
4
-
-
13844250258
-
Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
-
Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 288: E599-E607, 2005.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.288
-
-
Dobrzyn, A.1
Dobrzyn, P.2
Lee, S.H.3
Miyazaki, M.4
Cohen, P.5
Asilmaz, E.6
Hardie, D.G.7
Friedman, J.M.8
Ntambi, J.M.9
-
5
-
-
40749083610
-
Cholesterol and sphingolipids in alcohol-induced liver injury
-
Fernandez A, Colell A, Garcia-Ruiz C, Fernandez-Checa JC. Cholesterol and sphingolipids in alcohol-induced liver injury. J Gastroenterol Hepatol 23, Suppl 1: S9-S15, 2008.
-
(2008)
J Gastroenterol Hepatol
, vol.23
, Issue.1
-
-
Fernandez, A.1
Colell, A.2
Garcia-Ruiz, C.3
Fernandez-Checa, J.C.4
-
6
-
-
32044435586
-
Ceramide, tumor necrosis factor and alcohol-induced liver disease
-
DOI 10.1097/01.alc.0000189285.04059.b3
-
Fernandez-Checa JC, Colell A, Mari M, Garcia-Ruiz C. Ceramide, tumor necrosis factor and alcohol-induced liver disease. Alcohol Clin Exp Res 29: 151S-1-57S, 2005. (Pubitemid 43194343)
-
(2005)
Alcoholism: Clinical and Experimental Research
, vol.29
, Issue.11 SUPPL.
-
-
Fernandez-Checa, J.C.1
Colell, A.2
Mari, M.3
Garcia-Ruiz, C.4
-
7
-
-
0037237733
-
Defective TNF-α-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice
-
DOI 10.1172/JCI200316010
-
Garcia-Ruiz C, Colell A, Mari M, Morales A, Calvo M, Enrich C, Fernandez-Checa JC. Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest 111: 197-208, 2003. (Pubitemid 36105918)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.2
, pp. 197-208
-
-
Garcia-Ruiz, C.1
Colell, A.2
Mari, M.3
Morales, A.4
Calvo, M.5
Enrich, C.6
Fernandez-Checa, J.C.7
-
8
-
-
0141679096
-
A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi
-
DOI 10.1042/BJ20030215
-
Gonzalez J, Cornejo A, Santos MR, Cordero EM, Gutierrez B, Porcile P, Mortara RA, Sagua H, Da Silveira JF, Araya JE. A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi. Biochem J 374: 647-656, 2003. (Pubitemid 37163910)
-
(2003)
Biochemical Journal
, vol.374
, Issue.3
, pp. 647-656
-
-
Gonzalez, J.1
Cornejo, A.2
Santos, M.R.M.3
Cordero, E.M.4
Gutierrez, B.5
Porcile, P.6
Mortara, R.A.7
Sagua, H.8
Da Silveira, J.F.9
Araya, J.E.10
-
9
-
-
62649146372
-
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
-
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J 28: 677-685, 2009.
-
(2009)
EMBO J
, vol.28
, pp. 677-685
-
-
Herrero-Martin, G.1
Hoyer-Hansen, M.2
Garcia-Garcia, C.3
Fumarola, C.4
Farkas, T.5
Lopez-Rivas, A.6
Jaattela, M.7
-
10
-
-
23844471263
-
2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
-
DOI 10.1074/jbc.M503824200
-
Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem 280: 29060-29066, 2005. (Pubitemid 41161355)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.32
, pp. 29060-29066
-
-
Hurley, R.L.1
Anderson, K.A.2
Franzone, J.M.3
Kemp, B.E.4
Means, A.R.5
Witters, L.A.6
-
11
-
-
0035252894
-
Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
-
DOI 10.1042/0264-6021:3530417
-
Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353: 417-439, 2001. (Pubitemid 32158309)
-
(2001)
Biochemical Journal
, vol.353
, Issue.3
, pp. 417-439
-
-
Janssens, V.1
Goris, J.2
-
12
-
-
70849112199
-
AMPK inhibitor compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells
-
Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT. AMPK inhibitor compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res 50: 2389-2397, 2009.
-
(2009)
J Lipid Res
, vol.50
, pp. 2389-2397
-
-
Jin, J.1
Mullen, T.D.2
Hou, Q.3
Bielawski, J.4
Bielawska, A.5
Zhang, X.6
Obeid, L.M.7
Hannun, Y.A.8
Hsu, Y.T.9
-
13
-
-
0042531617
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
-
DOI 10.1074/jbc.M302548200
-
Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 278: 30015-30021, 2003. (Pubitemid 36962391)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.32
, pp. 30015-30021
-
-
Kelpe, C.L.1
Moore, P.C.2
Parazzoli, S.D.3
Wicksteed, B.4
Rhodes, C.J.5
Poitout, V.6
-
14
-
-
0032570828
-
Tumor necrosis factor-α stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase
-
DOI 10.1074/jbc.273.9.5053
-
Lawler JF Jr, Yin M, Diehl AM, Roberts E, Chatterjee S. Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J Biol Chem 273: 5053-5059, 1998. (Pubitemid 28108663)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.9
, pp. 5053-5059
-
-
Lawler Jr., J.F.1
Yin, M.2
Diehl, A.M.3
Roberts, E.4
Chatterjee, S.5
-
15
-
-
34548522699
-
2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase
-
DOI 10.1021/bi700017z
-
Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S. The group VIA calcium-independent phospholipase A2 participates in ER stressinduced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Biochemistry 46: 10170-10185, 2007. (Pubitemid 47381276)
-
(2007)
Biochemistry
, vol.46
, Issue.35
, pp. 10170-10185
-
-
Lei, X.1
Zhang, S.2
Bohrer, A.3
Bao, S.4
Song, H.5
Ramanadham, S.6
-
16
-
-
57349088281
-
Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation
-
Liangpunsakul S, Wou SE, Zeng Y, Ross RA, Jayaram HN, Crabb DW. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation. Am J Physiol Gastrointest Liver Physiol 295: G1173-G1181, 2008.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.295
-
-
Liangpunsakul, S.1
Wou, S.E.2
Zeng, Y.3
Ross, R.A.4
Jayaram, H.N.5
Crabb, D.W.6
-
18
-
-
40949146900
-
Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase α1 following overload in LKB1 knockout mice
-
DOI 10.1113/jphysiol.2007.143685
-
McGee SL, Mustard KJ, Hardie DG, Baar K. Normal hypertrophy accompanied by phosphorylation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 586: 1731-1741, 2008. (Pubitemid 351404971)
-
(2008)
Journal of Physiology
, vol.586
, Issue.6
, pp. 1731-1741
-
-
Mcgee, S.L.1
Mustard, K.J.2
Hardie, D.G.3
Baar, K.4
-
19
-
-
61549109860
-
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling
-
Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J 23: 751-763, 2009.
-
(2009)
FASEB J
, vol.23
, pp. 751-763
-
-
Mukhopadhyay, A.1
Saddoughi, S.A.2
Song, P.3
Sultan, I.4
Ponnusamy, S.5
Senkal, C.E.6
Snook, C.F.7
Arnold, H.K.8
Sears, R.C.9
Hannun, Y.A.10
Ogretmen, B.11
-
20
-
-
57649199203
-
Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells
-
Nofziger C, Kalsi K, West TA, Baines D, Blazer-Yost BL. Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells. Cell Physiol Biochem 22: 487-496, 2008.
-
(2008)
Cell Physiol Biochem
, vol.22
, pp. 487-496
-
-
Nofziger, C.1
Kalsi, K.2
West, T.A.3
Baines, D.4
Blazer-Yost, B.L.5
-
21
-
-
33646142778
-
Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation
-
Ravnskjaer K, Boergesen M, Dalgaard LT, Mandrup S. Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation. J Mol Endocrinol 36: 289-299, 2006.
-
(2006)
J Mol Endocrinol
, vol.36
, pp. 289-299
-
-
Ravnskjaer, K.1
Boergesen, M.2
Dalgaard, L.T.3
Mandrup, S.4
-
22
-
-
35848937327
-
Regulation of neutral sphingomyelinase-2 by GSH: A new insight to the role of oxidative stress in aging-associated inflammation
-
DOI 10.1194/jlr.M700227-JLR200
-
Rutkute K, Asmis RH, Nikolova-Karakashian MN. Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation. J Lipid Res 48: 2443-2452, 2007. (Pubitemid 350058755)
-
(2007)
Journal of Lipid Research
, vol.48
, Issue.11
, pp. 2443-2452
-
-
Rutkute, K.1
Asmis, R.H.2
Nikolova-Karakashian, M.N.3
-
23
-
-
14844366592
-
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins
-
DOI 10.1042/BJ20040609
-
Samari HR, Moller MT, Holden L, Asmyhr T, Seglen PO. Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. Biochem J 386: 237-244, 2005. (Pubitemid 40352557)
-
(2005)
Biochemical Journal
, vol.386
, Issue.2
, pp. 237-244
-
-
Samari, H.R.1
Moller, M.T.N.2
Holden, L.3
Asmyhr, T.4
Seglen, P.O.5
-
24
-
-
35548999608
-
AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner
-
DOI 10.1007/s11010-007-9575-6
-
Sun Y, Connors KE, Yang DQ. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Mol Cell Biochem 306: 239-245, 2007. (Pubitemid 350001836)
-
(2007)
Molecular and Cellular Biochemistry
, vol.306
, Issue.1-2
, pp. 239-245
-
-
Sun, Y.1
Connors, K.E.2
Yang, D.-Q.3
-
25
-
-
67349084190
-
Effects of ethanol and lipopolysaccharide on the sphingomyelin cycle in rat hepatocytes
-
Viktorov AV, Yurkiv VA. Effects of ethanol and lipopolysaccharide on the sphingomyelin cycle in rat hepatocytes. Bull Exp Biol Med 146: 753-755, 2008.
-
(2008)
Bull Exp Biol Med
, vol.146
, pp. 753-755
-
-
Viktorov, A.V.1
Yurkiv, V.A.2
-
26
-
-
11144283125
-
Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone
-
Wang MY, Unger RH. Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone. Am J Physiol Endocrinol Metab 288: E216-E221, 2005.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.288
-
-
Wang, M.Y.1
Unger, R.H.2
-
27
-
-
34248199965
-
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
-
DOI 10.1074/jbc.M608310200
-
Wu Y, Song P, Xu J, Zhang M, Zou MH. Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase. J Biol Chem 282: 9777-9788, 2007. (Pubitemid 47104626)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.13
, pp. 9777-9788
-
-
Wu, Y.1
Song, P.2
Xu, J.3
Zhang, M.4
Zou, M.-H.5
-
28
-
-
39449096289
-
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells
-
DOI 10.1161/CIRCULATIONAHA.107.744490, PII 0000301720080219000014
-
Xie Z, Dong Y, Scholz R, Neumann D, Zou MH. Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation 117: 952-962, 2008. (Pubitemid 351272593)
-
(2008)
Circulation
, vol.117
, Issue.7
, pp. 952-962
-
-
Xie, Z.1
Dong, Y.2
Scholz, R.3
Neumann, D.4
Zou, M.-H.5
-
29
-
-
0037047284
-
Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
-
You M, Fischer M, Deeg MA, Crabb DW. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277: 29342-29347, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 29342-29347
-
-
You, M.1
Fischer, M.2
Deeg, M.A.3
Crabb, D.W.4
-
30
-
-
9644290860
-
The role of AMP-activated protein kinase in the action of ethanol in the liver
-
You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127: 1798 - 1808, 2004.
-
(2004)
Gastroenterology
, vol.127
, pp. 1798-1808
-
-
You, M.1
Matsumoto, M.2
Pacold, C.M.3
Cho, W.K.4
Crabb, D.W.5
-
31
-
-
77954709548
-
The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation
-
In press
-
Zeidan YH, Hannun YA. The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med. In press.
-
Curr Mol Med
-
-
Zeidan, Y.H.1
Hannun, Y.A.2
-
32
-
-
34548402471
-
Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms
-
DOI 10.1016/j.cellsig.2007.07.013, PII S0898656807002239
-
Zhang Y, Venugopal SK, He S, Liu P, Wu J, Zern MA. Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Cell Signal 19: 2339-2350, 2007. (Pubitemid 47361689)
-
(2007)
Cellular Signalling
, vol.19
, Issue.11
, pp. 2339-2350
-
-
Zhang, Y.1
Venugopal, S.K.2
He, S.3
Liu, P.4
Wu, J.5
Zern, M.A.6
-
33
-
-
69249147344
-
Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1- Dependent and phospholipase C/Ca2/Ca2/calmodulin-dependent protein kinase kinase-dependent pathways
-
Zhou L, Deepa SS, Etzler JC, Ryu J, Mao X, Fang Q, Liu DD, Torres JM, Jia W, Lechleiter JD, Liu F, Dong LQ. Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1- dependent and phospholipase C/Ca2/Ca2/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem 284: 22426-22435, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 22426-22435
-
-
Zhou, L.1
Deepa, S.S.2
Etzler, J.C.3
Ryu, J.4
Mao, X.5
Fang, Q.6
Liu, D.D.7
Torres, J.M.8
Jia, W.9
Lechleiter, J.D.10
Liu, F.11
Dong, L.Q.12
|