Ethanol-Induced Alterations in Fatty Acid-Related Lipids in Serum and Tissues in Mice

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 2, 2011, Pages 229-234

  Zhao, Zhenwen ^a   Yu, Menggang ^a   Crabb, David ^a   Xu, Yan ^a   Liangpunsakul, Suthat ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ethanol; Fatty Acid Related Lipids; HPLC ESI MS MS; Phospholipids

Indexed keywords

ALCOHOL; CERAMIDE; FATTY ACID; LIPID; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHATIDYLETHANOLAMINE; LYSOPHOSPHATIDYLINOSITOL; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; KIDNEY; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM; SKELETAL MUSCLE;

ALCOHOLISM; ANIMALS; ETHANOL; FATTY ACIDS; HUMANS; KIDNEY; LIPID METABOLISM; LIPIDS; LIPOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL;

MUS;

EID: 78851468901     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01338.x     Document Type: Article

References (21)

1. Billich A, Baumruker T (2008) Sphingolipid metabolizing enzymes as novel therapeutic targets. Subcell Biochem 49:487-522.
2. Chatterjee S, Kolmakova A, Miller M (2006) The role of the phospholipid sphingomyelin in heart disease. Curr Opin Investig Drugs 7:219-228.
3. Claus RA, Dorer MJ, Bunck AC, Deigner HP (2009) Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate. Curr Med Chem 16:1978-2000.
4. Crabb DW, Liangpunsakul S (2006) Alcohol and lipid metabolism. J Gastroenterol Hepatol 21:S56-S60.
5. de Deckere EAM, Korver O, Verschuren PM, Katan MB (1998) Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 52:749-753.
6. Harris W (2007) Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor. Pharmacol Res 55:217-223.
7. Harris W (2010) Omega-6 and omega-3 fatty acids: partners in prevention. Curr Opin Clin Nutr Metab Care 13:125-129.
8. Liangpunsakul S, Sozio MS, Shin E, Zhao Z, Xu Y, Ross RA, Crabb DW (2010) Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. Am J Physiol Gastrointest Liver Physiol 298:G1004-G1012.
9. Merrill AH (1983) Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells. Biochim Biophys Acta 754:284-291.
10. Merrill AH, Williams RD (1984) Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain. J Lipid Res 25:185-188.
11. Moolenaar WH (1999) Bioactive lysophospholipids and their G protein-coupled receptors. Exp Cell Res 253:230-238.
12. Room R, Babor T, Rehm J (2005) Alcohol and public health. Lancet 365:519-530.
13. Salaspuro MP, Lieber CS (1979) Metabolic consequences of chronic alcohol consumption: attenuation of hepatic redox changes despite enhanced capacity to eliminate ethanol. Curr Alcohol 5:109-118.
14. Sutphen R, Xu Y, Wilbanks GD, Fiorica J, Grendys EC, Lapolla JP, Arango H, Hoffman MS, Martino M, Wakeley K, Griffin D, Blanco RW, Cantor AB, Xiao YJ, Krischer JP (2004) Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol Biomarkers Prev 13:1185-1191.
15. Xiao Y, Chen Y, Kennedy AW, Belinson J, Xu Y (2000) Evaluation of plasma lysophospholipids for diagnostic significance using electrospray ionization mass spectrometry (ESI-MS) analyses. Ann N Y Acad Sci 905:242-259.
16. Xiao YJ, Schwartz B, Washington M, Kennedy A, Webster K, Belinson J, Xu Y (2001) Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids. Anal Biochem 290:302-313.
17. Xu Y, Shen Z, Wiper DW, Wu M, Morton RE, Elson P, Kennedy AW, Belinson J, Markman M, Casey G (1998) Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA 280:719-723.
18. You M, Fischer M, Deeg MA, Crabb DW (2002) Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277:29342-29347.
19. You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW (2004) The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127:1798-1808.
20. Zhao Z, Xiao Y, Elson P, Tan H, Plummer SJ, Berk M, Aung PP, Lavery IC, Achkar JP, Li L, Casey G, Xu Y (2007) Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer. J Clin Oncol 25:2696-2701.
21. Zhao Z, Xu Y (2010) An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples. J Lipid Res 51:652-659.