-
1
-
-
0033657074
-
Leptin and the neuroendocrinology of fasting
-
Ahima RS: Leptin and the neuroendocrinology of fasting. Front Horm Res 2000;26:42-56.
-
(2000)
Front Horm Res
, vol.26
, pp. 42-56
-
-
Ahima, R.S.1
-
3
-
-
33748992313
-
Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
-
Tilg H, Moschen AR: Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006;6:772-783.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 772-783
-
-
Tilg, H.1
Moschen, A.R.2
-
4
-
-
0036678477
-
Adipose tissue mass can be regulated through the vasculature
-
Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ: Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci USA 2002;99:10730-10735.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10730-10735
-
-
Rupnick, M.A.1
Panigrahy, D.2
Zhang, C.Y.3
Dallabrida, S.M.4
Lowell, B.B.5
Langer, R.6
Folkman, M.J.7
-
5
-
-
2942703809
-
Reversal of obesity by targeted ablation of adipose tissue
-
Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W: Reversal of obesity by targeted ablation of adipose tissue. Nat Med 2004;10:625-632.
-
(2004)
Nat Med
, vol.10
, pp. 625-632
-
-
Kolonin, M.G.1
Saha, P.K.2
Chan, L.3
Pasqualini, R.4
Arap, W.5
-
6
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-1830.
-
(2003)
J Clin Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
7
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr, A.W.6
-
8
-
-
0028139089
-
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432. Erratum in: Nature 1995;374:479.
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432. Erratum in: Nature 1995;374:479.
-
-
-
-
10
-
-
0032741972
-
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
-
Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SR: Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999;104:1051-1059.
-
(1999)
J Clin Invest
, vol.104
, pp. 1051-1059
-
-
Howard, J.K.1
Lord, G.M.2
Matarese, G.3
Vendetti, S.4
Ghatei, M.A.5
Ritter, M.A.6
Lechler, R.I.7
Bloom, S.R.8
-
11
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S: Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093-1103.
-
(2002)
J Clin Invest
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
Keogh, J.M.4
Lawrence, E.5
Agwu, C.6
Sanna, V.7
Jebb, S.A.8
Perna, F.9
Fontana, S.10
Lechler, R.I.11
DePaoli, A.M.12
O'Rahilly, S.13
-
12
-
-
16944364768
-
Human leptin levels are pulsatile and inversely related to pituitary-adrenal function
-
Licinio J, Mantzoros C, Negrao AB, Cizza G, Wong ML, Bongiorno PB, Chrousos GP, Karp B, Allen C, Flier JS, Gold PW: Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 1997;3:575-579.
-
(1997)
Nat Med
, vol.3
, pp. 575-579
-
-
Licinio, J.1
Mantzoros, C.2
Negrao, A.B.3
Cizza, G.4
Wong, M.L.5
Bongiorno, P.B.6
Chrousos, G.P.7
Karp, B.8
Allen, C.9
Flier, J.S.10
Gold, P.W.11
-
13
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS: Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382:250-252.
-
(1996)
Nature
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
Prabakaran, D.2
Mantzoros, C.3
Qu, D.4
Lowell, B.5
Maratos-Flier, E.6
Flier, J.S.7
-
14
-
-
15144356418
-
Sex differences in circulating human leptin pulse amplitude: Clinical implications
-
Licinio J, Negrao AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Negro PP, Mulla A, Veldhuis JD, Cearnal L, Flier JS, Gold PW: Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab 1998;83:4140-4147.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 4140-4147
-
-
Licinio, J.1
Negrao, A.B.2
Mantzoros, C.3
Kaklamani, V.4
Wong, M.L.5
Bongiorno, P.B.6
Negro, P.P.7
Mulla, A.8
Veldhuis, J.D.9
Cearnal, L.10
Flier, J.S.11
Gold, P.W.12
-
15
-
-
0030942844
-
The leptin receptor
-
Tartaglia LA: The leptin receptor. J Biol Chem 1997;272:6093-6096.
-
(1997)
J Biol Chem
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
16
-
-
2342444310
-
Leptin receptor signaling and the regulation of mammalian physiology
-
Myers MG Jr: Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 2004;59:287-304.
-
(2004)
Recent Prog Horm Res
, vol.59
, pp. 287-304
-
-
Myers Jr, M.G.1
-
17
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, Friedman JM: Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 2001;108:1113-1121.
-
(2001)
J Clin Invest
, vol.108
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
Montez, J.M.4
Rohani, S.C.5
Feinstein, P.6
Mombaerts, P.7
Friedman, J.M.8
-
18
-
-
1842584949
-
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
-
Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY: Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci USA 2004;101:4661-4666.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4661-4666
-
-
Gao, Q.1
Wolfgang, M.J.2
Neschen, S.3
Morino, K.4
Horvath, T.L.5
Shulman, G.I.6
Fu, X.Y.7
-
19
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG Jr: STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003;421:856-859.
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
Schubert, M.4
Tso, A.W.5
Wang, Y.6
Banks, A.S.7
Lavery, H.J.8
Haq, A.K.9
Maratos-Flier, E.10
Neel, B.G.11
Schwartz, M.W.12
Myers Jr, M.G.13
-
20
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB: Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004;42:983-991.
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr, S.C.9
Elmquist, J.K.10
Lowell, B.B.11
-
21
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS: Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004;10:734-738.
-
(2004)
Nat Med
, vol.10
, pp. 734-738
-
-
Howard, J.K.1
Cave, B.J.2
Oksanen, L.J.3
Tzameli, I.4
Bjorbaek, C.5
Flier, J.S.6
-
22
-
-
3142723983
-
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
-
Mori H, Hanada R , Hanada T, Ak i D, Mashima R , Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A: Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 2004;10:739-743.
-
(2004)
Nat Med
, vol.10
, pp. 739-743
-
-
Mori, H.1
Hanada, R.2
Hanada, T.3
Ak i, D.4
Mashima, R.5
Nishinakamura, H.6
Torisu, T.7
Chien, K.R.8
Yasukawa, H.9
Yoshimura, A.10
-
23
-
-
33746537247
-
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
-
Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS: Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab 2006;4:123-132.
-
(2006)
Cell Metab
, vol.4
, pp. 123-132
-
-
Kievit, P.1
Howard, J.K.2
Badman, M.K.3
Balthasar, N.4
Coppari, R.5
Mori, H.6
Lee, C.E.7
Elmquist, J.K.8
Yoshimura, A.9
Flier, J.S.10
-
24
-
-
12144289998
-
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
-
Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, Whitby R, Liang L, Cohen P, Bhasin S, Krauss RM, Veldhuis JD, Wagner AJ, DePaoli AM, McCann SM, Wong ML: Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci USA 2004;101:4531-4536.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4531-4536
-
-
Licinio, J.1
Caglayan, S.2
Ozata, M.3
Yildiz, B.O.4
de Miranda, P.B.5
O'Kirwan, F.6
Whitby, R.7
Liang, L.8
Cohen, P.9
Bhasin, S.10
Krauss, R.M.11
Veldhuis, J.D.12
Wagner, A.J.13
DePaoli, A.M.14
McCann, S.M.15
Wong, M.L.16
-
25
-
-
0033304576
-
-
Ozata M, Ozdemir IC, Licinio J: Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999;84:3686-3695. Erratum in: J Clin Endocrinol Metab 2000;85:416.
-
Ozata M, Ozdemir IC, Licinio J: Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999;84:3686-3695. Erratum in: J Clin Endocrinol Metab 2000;85:416.
-
-
-
-
26
-
-
4544286790
-
Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency
-
McDuffie JR, Riggs PA, Calis KA, Freedman RJ, Oral EA, DePaoli AM, Yanovski JA: Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency. J Clin Endocrinol Metab 2004;89:4258-4263.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4258-4263
-
-
McDuffie, J.R.1
Riggs, P.A.2
Calis, K.A.3
Freedman, R.J.4
Oral, E.A.5
DePaoli, A.M.6
Yanovski, J.A.7
-
27
-
-
21344447493
-
Free full text long-term efficacy of leptin replacement in patients with generalized lipodystrophy
-
Javor ED, Cochran EK, Musso C, Young JR, Depaoli AM, Gorden P: Free full text long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes 2005;54:1994-2002.
-
(2005)
Diabetes
, vol.54
, pp. 1994-2002
-
-
Javor, E.D.1
Cochran, E.K.2
Musso, C.3
Young, J.R.4
Depaoli, A.M.5
Gorden, P.6
-
28
-
-
12944321844
-
The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients
-
Musso C, Cochran E, Javor E, Young J, Depaoli AM, Gorden P: The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients. Metabolism 2005;54:255-263.
-
(2005)
Metabolism
, vol.54
, pp. 255-263
-
-
Musso, C.1
Cochran, E.2
Javor, E.3
Young, J.4
Depaoli, A.M.5
Gorden, P.6
-
29
-
-
0037651108
-
The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
-
Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS: The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 2003;111:1409-1421.
-
(2003)
J Clin Invest
, vol.111
, pp. 1409-1421
-
-
Chan, J.L.1
Heist, K.2
DePaoli, A.M.3
Veldhuis, J.D.4
Mantzoros, C.S.5
-
30
-
-
4344690525
-
Recombinant human leptin in women with hypothalamic amenorrhea
-
Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS: Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004;351: 987-997.
-
(2004)
N Engl J Med
, vol.351
, pp. 987-997
-
-
Welt, C.K.1
Chan, J.L.2
Bullen, J.3
Murphy, R.4
Smith, P.5
DePaoli, A.M.6
Karalis, A.7
Mantzoros, C.S.8
-
31
-
-
8744234075
-
Endocrine and metabolic effects of physiologic r-metHuLeptin administration during acute caloric deprivation in normal-weight women
-
Schurgin S, Canavan B, Koutkia P, Depaoli AM, Grinspoon S: Endocrine and metabolic effects of physiologic r-metHuLeptin administration during acute caloric deprivation in normal-weight women. J Clin Endocrinol Metab 2004;89:5402-5409.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5402-5409
-
-
Schurgin, S.1
Canavan, B.2
Koutkia, P.3
Depaoli, A.M.4
Grinspoon, S.5
-
32
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
Flier JS: Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004;116:337-350.
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
33
-
-
0037663897
-
Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible
-
Banks WA, Farrell CL: Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible. Am J Physiol Endocrinol Metab 2003;285:E10-E15.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Banks, W.A.1
Farrell, C.L.2
-
34
-
-
18344379861
-
PTP1B regulates leptin signal transduction in vivo
-
Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG: PTP1B regulates leptin signal transduction in vivo. Dev Cell 2002;2:489-495.
-
(2002)
Dev Cell
, vol.2
, pp. 489-495
-
-
Zabolotny, J.M.1
Bence-Hanulec, K.K.2
Stricker-Krongrad, A.3
Haj, F.4
Wang, Y.5
Minokoshi, Y.6
Kim, Y.B.7
Elmquist, J.K.8
Tartaglia, L.A.9
Kahn, B.B.10
Neel, B.G.11
-
35
-
-
33746810001
-
Neuronal PTP1B regulates body weight, adiposity and leptin action
-
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB: Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 2006;12:917-924.
-
(2006)
Nat Med
, vol.12
, pp. 917-924
-
-
Bence, K.K.1
Delibegovic, M.2
Xue, B.3
Gorgun, C.Z.4
Hotamisligil, G.S.5
Neel, B.G.6
Kahn, B.B.7
-
36
-
-
31544465941
-
Molecular disruption of hypothalamic nutrient sensing induces obesity
-
He W, Lam TK, Obici S, Rossetti L: Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci 2006;9:227-233.
-
(2006)
Nat Neurosci
, vol.9
, pp. 227-233
-
-
He, W.1
Lam, T.K.2
Obici, S.3
Rossetti, L.4
-
37
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ: Hypothalamic mTOR signaling regulates food intake. Science 2006;312:927-930.
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
38
-
-
9244219587
-
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
-
Munzberg H, Flier JS, Bjorbaek C: Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880-4889.
-
(2004)
Endocrinology
, vol.145
, pp. 4880-4889
-
-
Munzberg, H.1
Flier, J.S.2
Bjorbaek, C.3
-
39
-
-
33748541108
-
Leptin regulation of the mesoaccumbens dopamine pathway
-
Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS: Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006;51:811-822.
-
(2006)
Neuron
, vol.51
, pp. 811-822
-
-
Fulton, S.1
Pissios, P.2
Manchon, R.P.3
Stiles, L.4
Frank, L.5
Pothos, E.N.6
Maratos-Flier, E.7
Flier, J.S.8
-
40
-
-
33748540764
-
Leptin receptor signaling in midbrain dopamine neurons regulates feeding
-
Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ: Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 2006;51:801-810.
-
(2006)
Neuron
, vol.51
, pp. 801-810
-
-
Hommel, J.D.1
Trinko, R.2
Sears, R.M.3
Georgescu, D.4
Liu, Z.W.5
Gao, X.B.6
Thurmon, J.J.7
Marinelli, M.8
DiLeone, R.J.9
-
41
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn BB, Alquier T, Carling D, Hardie DG: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005;1:15-25.
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
42
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ, Kahn BB: AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574.
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
Kim, Y.B.4
Lee, A.5
Xue, B.6
Mu, J.7
Foufelle, F.8
Ferre, P.9
Birnbaum, M.J.10
Stuck, B.J.11
Kahn, B.B.12
-
43
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ: Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001;411:480-484.
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdan, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
44
-
-
14244254196
-
Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons
-
Takahashi KA, Cone RD: Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons. Endocrinology 2005;146:1043-1047.
-
(2005)
Endocrinology
, vol.146
, pp. 1043-1047
-
-
Takahashi, K.A.1
Cone, R.D.2
-
45
-
-
0033944152
-
Insulin activates ATP-sensitive K-+ channels in hypothalamic neurons of lean, but not obese rats
-
Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML: Insulin activates ATP-sensitive K-+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 2000;3:757-758.
-
(2000)
Nat Neurosci
, vol.3
, pp. 757-758
-
-
Spanswick, D.1
Smith, M.A.2
Mirshamsi, S.3
Routh, V.H.4
Ashford, M.L.5
-
46
-
-
1842529267
-
Rapid rewiring of arcuate nucleus feeding circuits by leptin
-
Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL: Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 2004;304:110-115.
-
(2004)
Science
, vol.304
, pp. 110-115
-
-
Pinto, S.1
Roseberry, A.G.2
Liu, H.3
Diano, S.4
Shanabrough, M.5
Cai, X.6
Friedman, J.M.7
Horvath, T.L.8
-
47
-
-
17744375347
-
Regulation of neuronal and glial proteins by leptin: Implications for brain development
-
Ahima RS, Bjorbaek C, Osei S, Flier JS: Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 1999;140:2755-2762.
-
(1999)
Endocrinology
, vol.140
, pp. 2755-2762
-
-
Ahima, R.S.1
Bjorbaek, C.2
Osei, S.3
Flier, J.S.4
-
48
-
-
18844435641
-
Effect of leptin replacement on brain structure in genetically leptin-deficient adults
-
Matochik JA, London ED, Yildiz BO, Ozata M, Caglayan S, DePaoli AM, Wong ML, Licinio J: Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J Clin Endocrinol Metab 2005;90:2851-2854.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 2851-2854
-
-
Matochik, J.A.1
London, E.D.2
Yildiz, B.O.3
Ozata, M.4
Caglayan, S.5
DePaoli, A.M.6
Wong, M.L.7
Licinio, J.8
-
49
-
-
1842536210
-
Trophic action of leptin on hypothalamic neurons that regulate feeding
-
Bouret SG, Draper SJ, Simerly RB: Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004;304:108-110.
-
(2004)
Science
, vol.304
, pp. 108-110
-
-
Bouret, S.G.1
Draper, S.J.2
Simerly, R.B.3
-
50
-
-
0030010388
-
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
-
Chehab FF, Lim ME, Lu R: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996;12:318-320.
-
(1996)
Nat Genet
, vol.12
, pp. 318-320
-
-
Chehab, F.F.1
Lim, M.E.2
Lu, R.3
-
51
-
-
0000659858
-
Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
-
Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM: Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997;138:2569-2576.
-
(1997)
Endocrinology
, vol.138
, pp. 2569-2576
-
-
Legradi, G.1
Emerson, C.H.2
Ahima, R.S.3
Flier, J.S.4
Lechan, R.M.5
-
52
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
Cabrol, S.4
Pelloux, V.5
Cassuto, D.6
Gourmelen, M.7
Dina, C.8
Chambaz, J.9
Lacorte, J.M.10
Basdevant, A.11
Bougneres, P.12
Lebouc, Y.13
Froguel, P.14
Guy-Grand, B.15
-
53
-
-
33748920365
-
The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis
-
Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ: The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 2006;4:291-302.
-
(2006)
Cell Metab
, vol.4
, pp. 291-302
-
-
Covey, S.D.1
Wideman, R.D.2
McDonald, C.3
Unniappan, S.4
Huynh, F.5
Asadi, A.6
Speck, M.7
Webber, T.8
Chua, S.C.9
Kieffer, T.J.10
-
54
-
-
33847312289
-
A key role of leptin in the control of regulatory T cell proliferation
-
De Rosa V, Procaccini C, Cali G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G: A key role of leptin in the control of regulatory T cell proliferation. Immunity 2007;26:241-255.
-
(2007)
Immunity
, vol.26
, pp. 241-255
-
-
De Rosa, V.1
Procaccini, C.2
Cali, G.3
Pirozzi, G.4
Fontana, S.5
Zappacosta, S.6
La Cava, A.7
Matarese, G.8
-
55
-
-
32444449415
-
Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
-
De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G: Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest 2006;116:447-455.
-
(2006)
J Clin Invest
, vol.116
, pp. 447-455
-
-
De Rosa, V.1
Procaccini, C.2
La Cava, A.3
Chieffi, P.4
Nicoletti, G.F.5
Fontana, S.6
Zappacosta, S.7
Matarese, G.8
-
56
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006;116:1784-1792.
-
(2006)
J Clin Invest
, vol.116
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
Tobe, K.6
-
57
-
-
33846819836
-
Adiponectin complexes in human cerebrospinal fluid: Distinct complex distribution from serum
-
Kusminski CM, McTernan PG, Schraw T, Kos K, O'hare JP, Ahima R, Kumar S, Scherer PE: Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia 2007;50:634-642.
-
(2007)
Diabetologia
, vol.50
, pp. 634-642
-
-
Kusminski, C.M.1
McTernan, P.G.2
Schraw, T.3
Kos, K.4
O'hare, J.P.5
Ahima, R.6
Kumar, S.7
Scherer, P.E.8
-
58
-
-
0032510463
-
The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor
-
Shapiro L, Scherer PE: The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 1998;8:335-338.
-
(1998)
Curr Biol
, vol.8
, pp. 335-338
-
-
Shapiro, L.1
Scherer, P.E.2
-
59
-
-
33646346627
-
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
-
Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE: Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 2006;281:2654-2660.
-
(2006)
J Biol Chem
, vol.281
, pp. 2654-2660
-
-
Nawrocki, A.R.1
Rajala, M.W.2
Tomas, E.3
Pajvani, U.B.4
Saha, A.K.5
Trumbauer, M.E.6
Pang, Z.7
Chen, A.S.8
Ruderman, N.B.9
Chen, H.10
Rossetti, L.11
Scherer, P.E.12
-
60
-
-
33646852805
-
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways
-
Kubota N, Terauchi Y, Kubota T, Kumagai H, Itoh S, Satoh H, Yano W, Ogata H, Tokuyama K, Takamoto I, Mineyama T, Ishikawa M, Moroi M, Sugi K, Yamauchi T, Ueki K, Tobe K, Noda T, Nagai R, Kadowaki T: Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 2006;281:8748-8755.
-
(2006)
J Biol Chem
, vol.281
, pp. 8748-8755
-
-
Kubota, N.1
Terauchi, Y.2
Kubota, T.3
Kumagai, H.4
Itoh, S.5
Satoh, H.6
Yano, W.7
Ogata, H.8
Tokuyama, K.9
Takamoto, I.10
Mineyama, T.11
Ishikawa, M.12
Moroi, M.13
Sugi, K.14
Yamauchi, T.15
Ueki, K.16
Tobe, K.17
Noda, T.18
Nagai, R.19
Kadowaki, T.20
more..
-
61
-
-
0036063777
-
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
-
Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y: Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002;8:731-737.
-
(2002)
Nat Med
, vol.8
, pp. 731-737
-
-
Maeda, N.1
Shimomura, I.2
Kishida, K.3
Nishizawa, H.4
Matsuda, M.5
Nagaretani, H.6
Furuyama, N.7
Kondo, H.8
Takahashi, M.9
Arita, Y.10
Komuro, R.11
Ouchi, N.12
Kihara, S.13
Tochino, Y.14
Okutomi, K.15
Horie, M.16
Takeda, S.17
Aoyama, T.18
Funahashi, T.19
Matsuzawa, Y.20
more..
-
62
-
-
0034881391
-
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
-
Berg AH, Combs TP, Du X, Brownlee M, Scherer PE: The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-953.
-
(2001)
Nat Med
, vol.7
, pp. 947-953
-
-
Berg, A.H.1
Combs, T.P.2
Du, X.3
Brownlee, M.4
Scherer, P.E.5
-
63
-
-
0037059013
-
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
-
Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc C, Itani SI, Lodish HF, Ruderman NB: Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 2002;99: 16309-16313.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16309-16313
-
-
Tomas, E.1
Tsao, T.S.2
Saha, A.K.3
Murrey, H.E.4
Zhang, C.C.5
Itani, S.I.6
Lodish, H.F.7
Ruderman, N.B.8
-
64
-
-
10744224100
-
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
-
Shklyaev S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Campbell-Thompson M, Crawford J, Shek EW, Scarpace PJ, Zolotukhin S: Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc Natl Acad Sci USA 2003;100:14217-14222.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 14217-14222
-
-
Shklyaev, S.1
Aslanidi, G.2
Tennant, M.3
Prima, V.4
Kohlbrenner, E.5
Kroutov, V.6
Campbell-Thompson, M.7
Crawford, J.8
Shek, E.W.9
Scarpace, P.J.10
Zolotukhin, S.11
-
65
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-1295.
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
Eto, K.11
Akanuma, Y.12
Froguel, P.13
Foufelle, F.14
Ferre, P.15
Carling, D.16
Kimura, S.17
Nagai, R.18
Kahn, B.B.19
Kadowaki, T.20
more..
-
66
-
-
0035852760
-
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
-
Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF: Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001;98:2005-2010.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 2005-2010
-
-
Fruebis, J.1
Tsao, T.S.2
Javorschi, S.3
Ebbets-Reed, D.4
Erickson, M.R.5
Yen, F.T.6
Bihain, B.E.7
Lodish, H.F.8
-
67
-
-
2442659256
-
-
Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS: Adiponectin acts in the brain to decrease body weight. Nat Med 2004;10:524-529. Erratum in: Nat Med 2004;10:649.
-
Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS: Adiponectin acts in the brain to decrease body weight. Nat Med 2004;10:524-529. Erratum in: Nat Med 2004;10:649.
-
-
-
-
68
-
-
27144457438
-
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
-
Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K: Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 2005;11:1096-1103.
-
(2005)
Nat Med
, vol.11
, pp. 1096-1103
-
-
Shibata, R.1
Sato, K.2
Pimentel, D.R.3
Takemura, Y.4
Kihara, S.5
Ohashi, K.6
Funahashi, T.7
Ouchi, N.8
Walsh, K.9
-
69
-
-
0037494960
-
-
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003;423:762-769. Erratum in: Nature 2004;431: 1123.
-
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003;423:762-769. Erratum in: Nature 2004;431: 1123.
-
-
-
-
70
-
-
33644748270
-
Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells
-
Spranger J, Verma S, Gohring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschop M, Banks WA: Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes 2006;55:141-147.
-
(2006)
Diabetes
, vol.55
, pp. 141-147
-
-
Spranger, J.1
Verma, S.2
Gohring, I.3
Bobbert, T.4
Seifert, J.5
Sindler, A.L.6
Pfeiffer, A.7
Hileman, S.M.8
Tschop, M.9
Banks, W.A.10
-
71
-
-
33645420927
-
Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin
-
Pan W, Tu H, Kastin AJ: Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 2006;27:911-916.
-
(2006)
Peptides
, vol.27
, pp. 911-916
-
-
Pan, W.1
Tu, H.2
Kastin, A.J.3
-
72
-
-
33748897492
-
Area postrema n eurons are modulated by the adipocyte hormone adiponectin
-
Fry M, Smith PM, Hoyda TD, Duncan M, Ahima RS, Shark ey KA, Ferguson AV: Area postrema n eurons are modulated by the adipocyte hormone adiponectin. J Neurosci 2006;26:9695-9702.
-
(2006)
J Neurosci
, vol.26
, pp. 9695-9702
-
-
Fry, M.1
Smith, P.M.2
Hoyda, T.D.3
Duncan, M.4
Ahima, R.S.5
Shark ey, K.A.6
Ferguson, A.V.7
-
73
-
-
33847733103
-
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
-
Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T: Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007;13:332-339.
-
(2007)
Nat Med
, vol.13
, pp. 332-339
-
-
Yamauchi, T.1
Nio, Y.2
Maki, T.3
Kobayashi, M.4
Takazawa, T.5
Iwabu, M.6
Okada-Iwabu, M.7
Kawamoto, S.8
Kubota, N.9
Kubota, T.10
Ito, Y.11
Kamon, J.12
Tsuchida, A.13
Kumagai, K.14
Kozono, H.15
Hada, Y.16
Ogata, H.17
Tokuyama, K.18
Tsunoda, M.19
Ide, T.20
Murakami, K.21
Awazawa, M.22
Takamoto, I.23
Froguel, P.24
Hara, K.25
Tobe, K.26
Nagai, R.27
Ueki, K.28
Kadowaki, T.29
more..
-
74
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA: The hormone resistin links obesity to diabetes. Nature 2001;409:307-312.
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
Brown, E.J.4
Banerjee, R.R.5
Wright, C.M.6
Patel, H.R.7
Ahima, R.S.8
Lazar, M.A.9
-
75
-
-
0035895201
-
A family of tissue-specific resistin-like molecules
-
Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, Enders GH, Silberg DG, Wen X, Wu GD, Lazar MA: A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 2001;98:502-506.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 502-506
-
-
Steppan, C.M.1
Brown, E.J.2
Wright, C.M.3
Bhat, S.4
Banerjee, R.R.5
Dai, C.Y.6
Enders, G.H.7
Silberg, D.G.8
Wen, X.9
Wu, G.D.10
Lazar, M.A.11
-
76
-
-
2442707674
-
Disulfide-dependent multimeric assembly of resistin family hormones
-
Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L: Disulfide-dependent multimeric assembly of resistin family hormones. Science 2004;304:1154-1158.
-
(2004)
Science
, vol.304
, pp. 1154-1158
-
-
Patel, S.D.1
Rajala, M.W.2
Rossetti, L.3
Scherer, P.E.4
Shapiro, L.5
-
77
-
-
10744225368
-
Regulation of fasted blood glucose by resistin
-
Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA: Regulation of fasted blood glucose by resistin. Science 2004;303:1195-1198.
-
(2004)
Science
, vol.303
, pp. 1195-1198
-
-
Banerjee, R.R.1
Rangwala, S.M.2
Shapiro, J.S.3
Rich, A.S.4
Rhoades, B.5
Qi, Y.6
Wang, J.7
Rajala, M.W.8
Pocai, A.9
Scherer, P.E.10
Steppan, C.M.11
Ahima, R.S.12
Obici, S.13
Rossetti, L.14
Lazar, M.A.15
-
78
-
-
4043085036
-
Adenovirus-mediated chronic 'hyperresistinemia' leads to in vivo insulin resistance in normal rats
-
Satoh H, Nguyen MT, Miles PD, Imamura T, Usui I, Olefsky JM: Adenovirus-mediated chronic 'hyperresistinemia' leads to in vivo insulin resistance in normal rats. J Clin Invest 2004;114:224-231.
-
(2004)
J Clin Invest
, vol.114
, pp. 224-231
-
-
Satoh, H.1
Nguyen, M.T.2
Miles, P.D.3
Imamura, T.4
Usui, I.5
Olefsky, J.M.6
-
79
-
-
3242806013
-
Abnormal glucose homeostasis due to chronic hyperresistinemia
-
Rangwala SM, Rich AS, Rhoades B, Shapiro JS, Obici S, Rossetti L, Lazar MA: Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes 2004;53:1937-1941.
-
(2004)
Diabetes
, vol.53
, pp. 1937-1941
-
-
Rangwala, S.M.1
Rich, A.S.2
Rhoades, B.3
Shapiro, J.S.4
Obici, S.5
Rossetti, L.6
Lazar, M.A.7
-
80
-
-
0035487109
-
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans
-
Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV, O'Rahilly S: Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001;50:2199-2202.
-
(2001)
Diabetes
, vol.50
, pp. 2199-2202
-
-
Savage, D.B.1
Sewter, C.P.2
Klenk, E.S.3
Segal, D.G.4
Vidal-Puig, A.5
Considine, R.V.6
O'Rahilly, S.7
-
81
-
-
0038506117
-
Resistin and adiponectin-of mice and men
-
Stumvoll M, Haring H: Resistin and adiponectin-of mice and men. Obes Res 2002;10:1197-1199.
-
(2002)
Obes Res
, vol.10
, pp. 1197-1199
-
-
Stumvoll, M.1
Haring, H.2
-
82
-
-
1242313298
-
Correlation between serum resistin level and adiposity in obese individuals
-
Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, Saruta T: Correlation between serum resistin level and adiposity in obese individuals. Obes Res 2003;11:997-1001.
-
(2003)
Obes Res
, vol.11
, pp. 997-1001
-
-
Azuma, K.1
Katsukawa, F.2
Oguchi, S.3
Murata, M.4
Yamazaki, H.5
Shimada, A.6
Saruta, T.7
-
83
-
-
15744403957
-
Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study
-
Bouchard L, Weisnagel SJ, Engert JC, Hudson TJ, Bouchard C, Vohl MC, Perusse L: Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study. J Endocrinol Invest 2004;27:1003-1009.
-
(2004)
J Endocrinol Invest
, vol.27
, pp. 1003-1009
-
-
Bouchard, L.1
Weisnagel, S.J.2
Engert, J.C.3
Hudson, T.J.4
Bouchard, C.5
Vohl, M.C.6
Perusse, L.7
-
84
-
-
0036090282
-
Increased resistin gene and protein expression in human abdominal adipose tissue
-
McTernan PG, McTernan CL, Chetty R, Jenner K, Fisher FM, Lauer MN, Crocker J, Barnett AH, Kumar S: Increased resistin gene and protein expression in human abdominal adipose tissue. J Clin Endocrinol Metab 2002;87:2407-2410.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 2407-2410
-
-
McTernan, P.G.1
McTernan, C.L.2
Chetty, R.3
Jenner, K.4
Fisher, F.M.5
Lauer, M.N.6
Crocker, J.7
Barnett, A.H.8
Kumar, S.9
-
85
-
-
0242320395
-
Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: Cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects
-
Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, Orlova C, Mantzoros CS: Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab 2003;88:4848-4856.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4848-4856
-
-
Lee, J.H.1
Chan, J.L.2
Yiannakouris, N.3
Kontogianni, M.4
Estrada, E.5
Seip, R.6
Orlova, C.7
Mantzoros, C.S.8
-
86
-
-
33846095524
-
The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes
-
Kusminski CM, da Silva NF, Creely SJ, Fisher FM, Harte AL, Baker AR, Kumar S, McTernan PG: The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes. J Clin Endocrinol Metab 2007;92:270-276.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 270-276
-
-
Kusminski, C.M.1
da Silva, N.F.2
Creely, S.J.3
Fisher, F.M.4
Harte, A.L.5
Baker, A.R.6
Kumar, S.7
McTernan, P.G.8
-
87
-
-
33749543444
-
Relationship between serum resistin concentration and proinflammatory cytokines in obese women with impaired and normal glucose tolerance
-
Janowska J, Zahorska-Markiewicz B, Olszanecka-Glinianowicz M: Relationship between serum resistin concentration and proinflammatory cytokines in obese women with impaired and normal glucose tolerance. Metabolism 2006;55:1495-1499.
-
(2006)
Metabolism
, vol.55
, pp. 1495-1499
-
-
Janowska, J.1
Zahorska-Markiewicz, B.2
Olszanecka-Glinianowicz, M.3
-
88
-
-
33745782087
-
High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes
-
Kunnari A, Ukkola O, Paivansalo M, Kesaniemi YA: High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes. J Clin Endocrinol Metab 2006;91:2755-2760.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 2755-2760
-
-
Kunnari, A.1
Ukkola, O.2
Paivansalo, M.3
Kesaniemi, Y.A.4
-
89
-
-
14044257211
-
Resistin is an inflammatory marker of atherosclerosis in humans
-
Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ: Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 2005;111:932-939.
-
(2005)
Circulation
, vol.111
, pp. 932-939
-
-
Reilly, M.P.1
Lehrke, M.2
Wolfe, M.L.3
Rohatgi, A.4
Lazar, M.A.5
Rader, D.J.6
-
90
-
-
19944433652
-
Visfatin: A protein secreted by visceral fat that mimics the effects of insulin
-
Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I: Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005;307:426-430.
-
(2005)
Science
, vol.307
, pp. 426-430
-
-
Fukuhara, A.1
Matsuda, M.2
Nishizawa, M.3
Segawa, K.4
Tanaka, M.5
Kishimoto, K.6
Matsuki, Y.7
Murakami, M.8
Ichisaka, T.9
Murakami, H.10
Watanabe, E.11
Takagi, T.12
Akiyoshi, M.13
Ohtsubo, T.14
Kihara, S.15
Yamashita, S.16
Makishima, M.17
Funahashi, T.18
Yamanaka, S.19
Hiramatsu, R.20
Matsuzawa, Y.21
Shimomura, I.22
more..
-
91
-
-
33645523472
-
An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity
-
Stephens JM, Vidal-Puig AJ: An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity. Curr Opin Lipidol 2006;17:128-131.
-
(2006)
Curr Opin Lipidol
, vol.17
, pp. 128-131
-
-
Stephens, J.M.1
Vidal-Puig, A.J.2
-
92
-
-
33845476276
-
Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: Parallel increase in plasma visfatin
-
Tan BK, Chen J, Digby JE, Keay SD, Kennedy CR, Randeva HS: Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: parallel increase in plasma visfatin. J Clin Endocrinol Metab 2006;91:5022-5028.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 5022-5028
-
-
Tan, B.K.1
Chen, J.2
Digby, J.E.3
Keay, S.D.4
Kennedy, C.R.5
Randeva, H.S.6
-
93
-
-
33846991610
-
Human visfatin expression: Relationship to insulin sensitivity, intramyocellular lipids, and inflammation
-
Varma V, Yao-Borengasser A, Rasouli N, Bodles AM, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ III, McGehee RE Jr, Fried SK, Kern PA: Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation. J Clin Endocrinol Metab 2007;92:666-672.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 666-672
-
-
Varma, V.1
Yao-Borengasser, A.2
Rasouli, N.3
Bodles, A.M.4
Phanavanh, B.5
Lee, M.J.6
Starks, T.7
Kern, L.M.8
Spencer III, H.J.9
McGehee Jr, R.E.10
Fried, S.K.11
Kern, P.A.12
-
94
-
-
22944434929
-
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
-
Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB: Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356-362.
-
(2005)
Nature
, vol.436
, pp. 356-362
-
-
Yang, Q.1
Graham, T.E.2
Mody, N.3
Preitner, F.4
Peroni, O.D.5
Zabolotny, J.M.6
Kotani, K.7
Quadro, L.8
Kahn, B.B.9
-
95
-
-
33745095399
-
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
-
Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB: Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006;354:2552-2563.
-
(2006)
N Engl J Med
, vol.354
, pp. 2552-2563
-
-
Graham, T.E.1
Yang, Q.2
Bluher, M.3
Hammarstedt, A.4
Ciaraldi, T.P.5
Henry, R.R.6
Wason, C.J.7
Oberbach, A.8
Jansson, P.A.9
Smith, U.10
Kahn, B.B.11
-
96
-
-
33846848897
-
Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents
-
Lee DC, Lee JW, Im JA: Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Metabolism 2007;56:327-331.
-
(2007)
Metabolism
, vol.56
, pp. 327-331
-
-
Lee, D.C.1
Lee, J.W.2
Im, J.A.3
-
97
-
-
33845479911
-
Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes
-
Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH, Lee HK, Park KS: Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care 2006;29:2457-2461.
-
(2006)
Diabetes Care
, vol.29
, pp. 2457-2461
-
-
Cho, Y.M.1
Youn, B.S.2
Lee, H.3
Lee, N.4
Min, S.S.5
Kwak, S.H.6
Lee, H.K.7
Park, K.S.8
-
98
-
-
34247590383
-
-
Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E, Fritsche A, Haring HU: High circulating retinol-binding protein 4 is associated with elevated liver fat, but not with total-, subcutaneous-, visceral-, or intramyocellular fat in humans. Diabetes Care 2007 [Epub ahead of print] PMID: 17259477.
-
Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E, Fritsche A, Haring HU: High circulating retinol-binding protein 4 is associated with elevated liver fat, but not with total-, subcutaneous-, visceral-, or intramyocellular fat in humans. Diabetes Care 2007 [Epub ahead of print] PMID: 17259477.
-
-
-
-
99
-
-
33750851422
-
Retinol-binding protein 4 in human obesity
-
Janke J, Engeli S, Boschmann M, Adams F, Bohnke J, Luft FC, Sharma AM, Jordan J: Retinol-binding protein 4 in human obesity. Diabetes 2006;55:2805-2810.
-
(2006)
Diabetes
, vol.55
, pp. 2805-2810
-
-
Janke, J.1
Engeli, S.2
Boschmann, M.3
Adams, F.4
Bohnke, J.5
Luft, F.C.6
Sharma, A.M.7
Jordan, J.8
-
100
-
-
33847671719
-
Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects
-
Graham TE, Wason CJ, Bluher M, Kahn BB: Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia 2007;50:814-823.
-
(2007)
Diabetologia
, vol.50
, pp. 814-823
-
-
Graham, T.E.1
Wason, C.J.2
Bluher, M.3
Kahn, B.B.4
-
101
-
-
33846946440
-
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A
-
Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H: A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 2007;315:820-825.
-
(2007)
Science
, vol.315
, pp. 820-825
-
-
Kawaguchi, R.1
Yu, J.2
Honda, J.3
Hu, J.4
Whitelegge, J.5
Ping, P.6
Wiita, P.7
Bok, D.8
Sun, H.9
-
102
-
-
33847215172
-
-
Pasutto F, Sticht H, Hammersen G, Gillessen-Kaesbach G, Fitzpatrick DR, Nurnberg G, Brasch F, Schirmer-Zimmermann H, Tolmie JL, Chitayat D, Houge G, Fernandez-Martinez L, Keating S, Mortier G, Hennekam RC, von der Wense A, Slavotinek A, Meinecke P, Bitoun P, Becker C, Nurnberg P, Reis A, Rauch A: Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet 2007;80:550-560.
-
Pasutto F, Sticht H, Hammersen G, Gillessen-Kaesbach G, Fitzpatrick DR, Nurnberg G, Brasch F, Schirmer-Zimmermann H, Tolmie JL, Chitayat D, Houge G, Fernandez-Martinez L, Keating S, Mortier G, Hennekam RC, von der Wense A, Slavotinek A, Meinecke P, Bitoun P, Becker C, Nurnberg P, Reis A, Rauch A: Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet 2007;80:550-560.
-
-
-
-
103
-
-
23044473651
-
Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity
-
Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, Shikata K, Hourai S, Futami J, Watanabe E, Matsuki Y, Hiramatsu R, Akagi S, Makino H, Kanwar YS: Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 2005;102:10610-10605.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10610-10605
-
-
Hida, K.1
Wada, J.2
Eguchi, J.3
Zhang, H.4
Baba, M.5
Seida, A.6
Hashimoto, I.7
Okada, T.8
Yasuhara, A.9
Nakatsuka, A.10
Shikata, K.11
Hourai, S.12
Futami, J.13
Watanabe, E.14
Matsuki, Y.15
Hiramatsu, R.16
Akagi, S.17
Makino, H.18
Kanwar, Y.S.19
|