Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells

Alcoholism: Clinical and Experimental Research

Volumn 22, Issue 9, 1998, Pages 2093-2101

  Banerjee, Kakoli ^a   Mohr, Leonhard ^a   Wands, Jack R ^a   De La Monte, Suzanne M ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

Ethanol; Hepatocellular Carcinoma; Insulin Receptor Substrate 1; Mitogen Activated Protein Kinase; Signal Transduction

Indexed keywords

ALCOHOL; DNA; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE;

ALCOHOL INTOXICATION; ARTICLE; BETA CHAIN; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER REGENERATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

CARCINOMA, HEPATOCELLULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; INSULIN; LIVER NEOPLASMS; LIVER REGENERATION; PHOSPHOPROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0032407769     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-199812000-00028     Document Type: Article

References (55)

1. Bucher ML, Swaffield MN: Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon. Proc Natl Acad Sci USA 72:1157-1160, 1975
2. Starzl TE, Francavilla A, Halgrimson CG, Francavilla FR, Porter KA, Brown TH, Putnam CW: The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet 137:179-199, 1973
3. Myers MJ, White MF: The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes 42:643-650, 1993
4. Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, et al: The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling. Cell 40:747-758, 1985
5. Hanks SK, Quinn AM, Hunter T: The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52, 1988
6. Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzelli LM, Dull TJ, Gray A, et al: Human insulin receptor and its relationship to the tyrosine kinase family of oncogencs. Nature 313:756-761, 1985
7. Sun XJ, Crimmins DL, Myers MJ, Miralpeix M, White MF: Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 13:7418-7428, 1993
8. White MF, Maron R, Kahn CR: Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature 318:183-186, 1985
9. Tashiro HY, Tobe K, Koshio O, Izumi T, Takaku F, Akanuma Y, Kasuga M: Tyrosine phosphorylation of pp185 by insulin receptor kinase in a cell-free system. J Biol Chem 264:6879-6885, 1989
10. Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, et al: Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77, 1991
11. Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, et al: The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260:1953-1955, 1993
12. Baltensperger K, Kozma LM, Cherniack AD, Klarlund JK, Chawla A, Banerjee U, Czech MP: Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science 260:1950-1952, 1993
13. Medema RH, de V, Smits AM, van der Zon GC, et al: Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Mol Cell Biol 13:155-162, 1993
14. Draznin B, Chang L, Leitner JW, Takata Y, Olefsky JM: Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors. J Biol Chem 268:19998-20001, 1993
15. Kanai F, Ito K, Todaka M, Hayashi H, Kamohara S, Ishii K, Okada T, et al: Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase. Biochem Biophys Res Comm 195:762-768, 1993
16. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem 269:3568-3573, 1994
17. Kelly KL, Ruderman NB, Chen KS: Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution. J Biol Chem 267:3423-3428, 1992
18. Rahn T, Ridderstrale M, Tornqvist H, Manganiello V, Fredrikson G, Belfrage P, Degerman E: Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin. FEBS Lett 350:314-318, 1994
19. Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL: The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem 269:20648-20652, 1994
20. Wands JR, Carter EA, Bucher NL, Isselbacher KJ: Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication. Gastroenterology 77:528-531, 1979
21. Duguay L, Coutu D, Hetu C, Joly JG: Inhibition of liver regeneration by chronic alcohol administration. Gut 23:8-13, 1982
22. Carter EA, Wands JR: Ethanol inhibits hormone stimulated hepatocyte DNA synthesis. Biochem Biophys Res Comm 128:767-774, 1985
23. Diehl AM, Yang SQ, Cote P, Wand GS: Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver. Hepatology 16:1212-1219, 1992
24. Hoek JB, Thomas AP, Rubin R, Rubin E: Ethanol-induced mobilization of calcium by activation of phosphoinositide-spccific phospholipase C in intact hepatocytes. J Biol Chem 262:682-691, 1987
25. Higashi K, Hoek JB: Ethanol causes desensitization of receptor-mediated phospholipase C activation in isolated hepatocytes [published erratum appears in J Biol Chem 1991 Apr 5:266:6657]. J Biol Chem 266:2178-2190, 1991
26. Sasaki Y, Hayashi N, Ito T, Fusamoto H, Kamada T, Wands JR: Influence of ethanol on insulin receptor substrate-1-mediated signal transduction during rat liver regeneration. Alcohol Alcohol 1:99-106, 1994
27. He L, Isselbacher KJ, Wands JR, Goodman HM, Shih C, Quaroni A: Establishment and characterization of a new human hepatoccllular carcinoma cell line. In Vitro 20:493-504, 1984
28. Karl PI, Fisher SE: Ethanol alters hormone production in cultured human placental trophoblasts. Alcohol Clin Exp Res 17:816-821, 1993
29. Urso T, Gavaler JS, Van TD: Blood ethanol levels in sober alcohol users seen in an emergency room. Life Sci 28:1053-1056, 1981
30. Lowry OH RN, Farr AL, Randall AJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951
31. Wands JR, Bhavani K, Sasaki Y: Alcohol & hormones. Drug Alcohol Abuse Rev 6:245-259, 1995
32. Nishiyama M, Wands JR: Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem Biophys Res Comm 183:280-285, 1992
33. Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, et al: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and She: Implications for insulin control of ras signalling. EMBO J 12:1929-1936, 1993
34. Tanaka S, Wands JR: A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype. J Clin Invest 98:2100-2108, 1996
35. Ridderstrale M, Degerman E, Tornqvist H: Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes. J Biol Chem 270:3471-3474, 1995
36. Yamamoto HR, Honda Z, Ueki K, Tobe K, Kaburagi Y, Takahashi Y, Tamemoto H, et al: Mutant of insulin receptor substrate-1 incapable of activating phosphatidylinositol 3-kinase did not mediate insulin-stimulated maturation of Xenopus laevis oocytes. J Biol Chem 271:28677-28681, 1996
37. Tobe K, Kadowaki T, Tamemoto H, Ueki K, Hara K, Koshio O, Momomura K, et al: Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/ microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. J Biol Chem 266:24793-24803, 1991
38. Ito T, Sasaki Y, Wands JR: Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases. Mol Cell Biol 16:943-951, 1996
39. Greenberg ME, Greene LA, Ziff EB: Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem 260:14101-14110, 1985
40. Stumpo DJ, Stewart TN, Gilman MZ, Blackshear PJ: Identification of c-fos sequences involved in induction by insulin and phorbol esters. J Biol Chem 263:1611-1614, 1988
41. Stumpo DJ, Blackshear PJ: Cellular expression of mutant insulin receptors interferes with the rapid transcriptional response to both insulin and insulin-like growth factor I. J Biol Chem 266:455-460, 1991
42. Resnicoff M, Rubini M, Baserga R, Rubin R: Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells. Lab Invest 71:657-662, 1994
43. Macaulay VM: Insulin-like growth factors and cancer. Br J Cancer 65:311-320, 1992
44. Kaleko M, Rutter WJ, Miller AD: Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol 10:464-473, 1990
45. Myers MJ, Sun XJ, White MF: The IRS-1 signaling system. Trends Biochem Sci 19:289-293, 1994
46. White MF, Kahn CR: The insulin signaling system. J Biol Chem 269:1-4, 1994
47. Younger LR, King J, Steiner DF: Hepatic proliferative response to insulin in severe alloxan diabetes. Cancer Res 26:1408-1414, 1966
48. Saso K, Moehren G, Higashi K, Hoek JB: Differential inhibition of epidermal growth factor signaling pathways in rat hepatocytes by long-term ethanol treatment. Gastroenterology 112:2073-2088, 1997
49. Pronk GJ, McGlade J, Pelicci G, Pawson T, Bos JL: Insulin-induced phosphorylation of the 46- and 52-kDa She proteins. J Biol Chem 268:5748-5753, 1993
50. Sasaki Y, Wands JR: Ethanol impairs insulin receptor substrate-1 mediated signal transduction during rat liver regeneration. Biochem Biophys Res Comm 199:403-409, 1994
51. Xu YY, Bhavani K, Wands JR, de la Monte SM: Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression. Biochem J 301:125-132, 1995
52. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, et al: Regulation of neuronal survival by the serine-threonine protein kinase Akt [see comments]. Science 275:661-665, 1997
53. Yao R, Cooper GM: Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006, 1995
54. Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT: Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268:100-102, 1995
55. Tanaka S, Mohr L, Schmidt EV, Sugimachi K, Wands JR: Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes. Hepatology 26:598-604, 1997