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Volumn 217, Issue , 2014, Pages 19-27

The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice

Author keywords

6ECDCA; Ethanol; FXR; Liver; Oxidative stress; Steatosis

Indexed keywords

ALCOHOL; AMINOTRANSFERASE; CHOLESTEROL; FAS ANTIGEN; OBETICHOLIC ACID; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL;

EID: 84899841383     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.03.014     Document Type: Article
Times cited : (54)

References (44)
  • 2
    • 1642524322 scopus 로고    scopus 로고
    • Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid
    • K. Henzel, C. Thorborg, M. Hofmann, G. Zimmer, and U. Leuschner Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid Biochim. Biophys. Acta 1644 2004 37 45
    • (2004) Biochim. Biophys. Acta , vol.1644 , pp. 37-45
    • Henzel, K.1    Thorborg, C.2    Hofmann, M.3    Zimmer, G.4    Leuschner, U.5
  • 3
    • 79955475669 scopus 로고    scopus 로고
    • Drinks like a fish: Using zebrafish to understand alcoholic liver disease
    • D.L. Howarth, M. Passeri, and K.C. Sadler Drinks like a fish: using zebrafish to understand alcoholic liver disease Alcohol. Clin. Exp. Res. 35 2011 826 829
    • (2011) Alcohol. Clin. Exp. Res. , vol.35 , pp. 826-829
    • Howarth, D.L.1    Passeri, M.2    Sadler, K.C.3
  • 4
    • 0036186124 scopus 로고    scopus 로고
    • Comparative study of the effects of short- and long-term ethanol treatment and alcohol withdrawal on phospholipid biosynthesis in rat hepatocytes
    • M.P. Carrasco, J.M. Jimenez-Lopez, J.L. Segovia, and C. Marco Comparative study of the effects of short- and long-term ethanol treatment and alcohol withdrawal on phospholipid biosynthesis in rat hepatocytes Comp. Biochem. Physiol. B Biochem. Mol. Biol. 131 2002 491 497
    • (2002) Comp. Biochem. Physiol. B Biochem. Mol. Biol. , vol.131 , pp. 491-497
    • Carrasco, M.P.1    Jimenez-Lopez, J.M.2    Segovia, J.L.3    Marco, C.4
  • 5
    • 33645997399 scopus 로고    scopus 로고
    • The apoB/apoA-I ratio: A strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy - A review of the evidence
    • G. Walldius, and I. Jungner The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy - a review of the evidence J. Intern. Med. 259 2006 493 519
    • (2006) J. Intern. Med. , vol.259 , pp. 493-519
    • Walldius, G.1    Jungner, I.2
  • 6
    • 28444433025 scopus 로고    scopus 로고
    • Oxidized phospholipids, isolevuglandins, and atherosclerosis
    • W. Zhang, and R.G. Salomon Oxidized phospholipids, isolevuglandins, and atherosclerosis Mol. Nutr. Food Res. 49 2005 1050 1062
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 1050-1062
    • Zhang, W.1    Salomon, R.G.2
  • 7
    • 39149094259 scopus 로고    scopus 로고
    • Interplay between oxidative stress andimmunity in the progression of alcohol-mediated liver injury
    • M. Vidali, S.F. Stewart, and E. Albano Interplay between oxidative stress andimmunity in the progression of alcohol-mediated liver injury Trends Mol. Med. 14 2008 63 71
    • (2008) Trends Mol. Med. , vol.14 , pp. 63-71
    • Vidali, M.1    Stewart, S.F.2    Albano, E.3
  • 8
    • 77952950795 scopus 로고    scopus 로고
    • Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity
    • G. Zollner, M. Wagner, and M. Trauner Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity Pharmacol. Ther. 126 2010 228 243
    • (2010) Pharmacol. Ther. , vol.126 , pp. 228-243
    • Zollner, G.1    Wagner, M.2    Trauner, M.3
  • 9
    • 0024422077 scopus 로고
    • Hepatic steatosis and serum very low density lipoproteins during two types of protein malnutrition followed by balanced refeeding
    • M. Meghelli-Bouchenak, J. Belleville, and M. Boquillon Hepatic steatosis and serum very low density lipoproteins during two types of protein malnutrition followed by balanced refeeding Nutrition 5 1989 321 329
    • (1989) Nutrition , vol.5 , pp. 321-329
    • Meghelli-Bouchenak, M.1    Belleville, J.2    Boquillon, M.3
  • 10
    • 0017358144 scopus 로고
    • Effect of oral amino acid supplementation on liver disease after jejunoileal bypass for morbid obesity
    • D.H. Lockwood, J.M. Amatruda, R.T. Moxley, T. Pozefsky, and J.K. Boitnott Effect of oral amino acid supplementation on liver disease after jejunoileal bypass for morbid obesity Am. J. Clin. Nutr. 30 1977 58 63
    • (1977) Am. J. Clin. Nutr. , vol.30 , pp. 58-63
    • Lockwood, D.H.1    Amatruda, J.M.2    Moxley, R.T.3    Pozefsky, T.4    Boitnott, J.K.5
  • 12
    • 0029052203 scopus 로고
    • Glucocorticoids are ineffective in alcoholic hepatitis: A meta-analysis adjusting for confounding variables
    • E. Christensen, and C. Gluud Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables Gut 37 1995 113 118
    • (1995) Gut , vol.37 , pp. 113-118
    • Christensen, E.1    Gluud, C.2
  • 13
    • 0025915308 scopus 로고
    • Ursodeoxycholic acid in the treatment of alcoholic liver disease
    • J.N. Plevris Ursodeoxycholic acid in the treatment of alcoholic liver disease Eur. J. Gastroenterol. Hepatol. 3 1991 653 656
    • (1991) Eur. J. Gastroenterol. Hepatol. , vol.3 , pp. 653-656
    • Plevris, J.N.1
  • 14
    • 67649210759 scopus 로고    scopus 로고
    • Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
    • S. Zhang, J. Wang, Q. Liu, and D.C. Harnish Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis J. Hepatol. 51 2009 380 388
    • (2009) J. Hepatol. , vol.51 , pp. 380-388
    • Zhang, S.1    Wang, J.2    Liu, Q.3    Harnish, D.C.4
  • 15
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, and B. Staels Role of bile acids and bile acid receptors in metabolic regulation Physiol. Rev. 89 2009 147 191
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 16
    • 65449142039 scopus 로고    scopus 로고
    • Bile acids and insulin resistance. Implications for treating nonalcoholic fatty liver disease
    • J. Wei, D.K. Qiu, and X. Ma Bile acids and insulin resistance. implications for treating nonalcoholic fatty liver disease J. Dig. Dis. 10 2009 85 90
    • (2009) J. Dig. Dis. , vol.10 , pp. 85-90
    • Wei, J.1    Qiu, D.K.2    Ma, X.3
  • 17
    • 25644443217 scopus 로고    scopus 로고
    • Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis
    • S. Fiorucci, G. Rizzo, E. Antonelli, B. Renga, A. Mencarelli, L. Riccardi, A. Morelli, M. Pruzanski, and R. Pellicciari Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis J. Pharmacol. Exp. Ther. 315 2005 58 68
    • (2005) J. Pharmacol. Exp. Ther. , vol.315 , pp. 58-68
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6    Morelli, A.7    Pruzanski, M.8    Pellicciari, R.9
  • 18
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • J. Folch, M. Lees, and G.A. Stanley A simple method for the isolation and purification of total lipids from animal tissues J. Biol. Chem. 226 1957 497 509
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Stanley, G.A.3
  • 19
    • 0021318441 scopus 로고
    • Catalase in vitro
    • H. Aebi Catalase in vitro Methods Enzymol. 105 1984 121 126
    • (1984) Methods Enzymol. , vol.105 , pp. 121-126
    • Aebi, H.1
  • 20
    • 0032029129 scopus 로고    scopus 로고
    • Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity
    • R. Gao, Z. Yuan, Z. Zhao, and X. Gao Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity Bioelectrochem. Bioenerg. 45 1998 41 45
    • (1998) Bioelectrochem. Bioenerg. , vol.45 , pp. 41-45
    • Gao, R.1    Yuan, Z.2    Zhao, Z.3    Gao, X.4
  • 21
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • W.H. Habig, M.J. Pabst, and W.B. Jakoby Glutathione S-transferases. The first enzymatic step in mercapturic acid formation J. Biol. Chem. 249 1974 7130 7138
    • (1974) J. Biol. Chem. , vol.249 , pp. 7130-7138
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 22
    • 0026009332 scopus 로고
    • 2+ in the presence of xylenol orange. Comparison with the TBA assay and an iodometric method
    • 2+ in the presence of xylenol orange. Comparison with the TBA assay and an iodometric method Lipids 26 1991 853 856
    • (1991) Lipids , vol.26 , pp. 853-856
    • Jiang, Z.Y.1    Woollard, A.C.2    Wolff, S.P.3
  • 23
    • 0014428865 scopus 로고
    • Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
    • J. Sedlak, and R.H. Lindsay Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal. Biochem. 25 1968 192 205
    • (1968) Anal. Biochem. , vol.25 , pp. 192-205
    • Sedlak, J.1    Lindsay, R.H.2
  • 24
    • 0034603580 scopus 로고    scopus 로고
    • Age-related changes in reactive oxygen species production in rat brain homogenates
    • A.S. Driver, P.R.S.K. Kodavanti, and W.R. Mundy Age-related changes in reactive oxygen species production in rat brain homogenates Neurotoxicol. Teratol. 22 2000 175 181
    • (2000) Neurotoxicol. Teratol. , vol.22 , pp. 175-181
    • Driver, A.S.1    Kodavanti, P.R.S.K.2    Mundy, W.R.3
  • 25
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 26
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • D.E. Kleiner, E.M. Brunt, and N.M. Van et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van, N.M.3
  • 27
    • 84862326895 scopus 로고    scopus 로고
    • Dietary protein restriction induces steatohepatitis and alters leptin/signal transducers and activators of transcription 3 signaling in lactating rats
    • D.H. Kwon, W. Kang, and Y.S. Nam et al. Dietary protein restriction induces steatohepatitis and alters leptin/signal transducers and activators of transcription 3 signaling in lactating rats J. Nutr. Biochem. 23 2012 791 799
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 791-799
    • Kwon, D.H.1    Kang, W.2    Nam, Y.S.3
  • 28
    • 60749107552 scopus 로고    scopus 로고
    • Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor
    • M. Nomoto, M. Miyata, and S. Yin et al. Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor Biol. Pharm. Bull. 32 2009 172 178
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 172-178
    • Nomoto, M.1    Miyata, M.2    Yin, S.3
  • 29
    • 0032823769 scopus 로고    scopus 로고
    • Antioxidant defence mechanisms: From the beginning to the end (of the beginning)
    • B. Halliwell Antioxidant defence mechanisms: from the beginning to the end (of the beginning) Free Radic. Res. 31 1999 261 272
    • (1999) Free Radic. Res. , vol.31 , pp. 261-272
    • Halliwell, B.1
  • 30
    • 0028016469 scopus 로고
    • Ethanol treatment up-regulates the expression of mitochondrial manganese superoxide dismutase in rat liver
    • O.R. Koch, M.E. De Leo, S. Borrello, G. Palombini, and T. Galeotti Ethanol treatment up-regulates the expression of mitochondrial manganese superoxide dismutase in rat liver Biochem. Biophys. Res. Commun. 201 1994 1356 1365
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 1356-1365
    • Koch, O.R.1    De Leo, M.E.2    Borrello, S.3    Palombini, G.4    Galeotti, T.5
  • 31
    • 1642463814 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant defenses in ethanol-induced cell injury
    • O.R. Koch, G. Pani, and S. Borello et al. Oxidative stress and antioxidant defenses in ethanol-induced cell injury Mol. Aspects Med. 25 2004 191 198
    • (2004) Mol. Aspects Med. , vol.25 , pp. 191-198
    • Koch, O.R.1    Pani, G.2    Borello, S.3
  • 32
    • 0030735567 scopus 로고    scopus 로고
    • Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress
    • H. Ishii, I. Kurose, and S. Kato Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress J. Gastroenterol. Hepatol. 12 1997 272 282
    • (1997) J. Gastroenterol. Hepatol. , vol.12 , pp. 272-282
    • Ishii, H.1    Kurose, I.2    Kato, S.3
  • 33
    • 67649968443 scopus 로고    scopus 로고
    • Oxidative stress and alcoholic liver disease
    • D. Wu, and A.I. Cederbaum Oxidative stress and alcoholic liver disease Semin. Liver Dis. 29 2009 141 154
    • (2009) Semin. Liver Dis. , vol.29 , pp. 141-154
    • Wu, D.1    Cederbaum, A.I.2
  • 35
    • 0035026194 scopus 로고    scopus 로고
    • Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver
    • S.M. Bailey, V.B. Patel, T.A. Young, K. Asayama, and C.C. Cunningham Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver Alcohol. Clin. Exp. Res. 25 2001 726 733
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 726-733
    • Bailey, S.M.1    Patel, V.B.2    Young, T.A.3    Asayama, K.4    Cunningham, C.C.5
  • 36
    • 8844285231 scopus 로고    scopus 로고
    • The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease
    • A.M. Brind, A. Hurlstone, D. Edrisinghe, I. Gilmore, N. Fisher, M. Pirmohamed, and A.A. Fryer The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease Alcohol Alcohol 39 2004 478 483
    • (2004) Alcohol Alcohol , vol.39 , pp. 478-483
    • Brind, A.M.1    Hurlstone, A.2    Edrisinghe, D.3    Gilmore, I.4    Fisher, N.5    Pirmohamed, M.6    Fryer, A.A.7
  • 37
    • 33749253713 scopus 로고    scopus 로고
    • Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    • C. Ji, C. Chan, and N. Kaplowitz Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model J. Hepatol. 45 2006 717 724
    • (2006) J. Hepatol. , vol.45 , pp. 717-724
    • Ji, C.1    Chan, C.2    Kaplowitz, N.3
  • 38
    • 12744267804 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins
    • M. You, and D.W. Crabb Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins Alcohol 34 2002 39 43
    • (2002) Alcohol , vol.34 , pp. 39-43
    • You, M.1    Crabb, D.W.2
  • 39
    • 0037047284 scopus 로고    scopus 로고
    • Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
    • M. You, M. Fischer, M.A. Deeg, and D.W. Crabb Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP) J. Biol. Chem. 277 2002 29342 29347
    • (2002) J. Biol. Chem. , vol.277 , pp. 29342-29347
    • You, M.1    Fischer, M.2    Deeg, M.A.3    Crabb, D.W.4
  • 40
    • 80054860007 scopus 로고    scopus 로고
    • Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet
    • Z.H. Yang, H. Miyahara, J. Takeo, A. Hatanaka, and M. Katayama Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet Lipids Health Dis. 10 2011 189
    • (2011) Lipids Health Dis. , vol.10 , pp. 189
    • Yang, Z.H.1    Miyahara, H.2    Takeo, J.3    Hatanaka, A.4    Katayama, M.5
  • 42
    • 12844288099 scopus 로고    scopus 로고
    • Alcoholic fatty liver: Its pathogenesis and mechanism of progression to inflammation and fibrosis
    • C.S. Lieber Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis Alcohol 34 2004 9 19
    • (2004) Alcohol , vol.34 , pp. 9-19
    • Lieber, C.S.1
  • 43
    • 77449123194 scopus 로고    scopus 로고
    • Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia
    • Y. Zhang, L. Yin, J. Anderson, H. Ma, F.J. Gonzalez, T.M. Willson, and P.A. Edwards Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia J. Biol. Chem. 285 2010 3035 3043
    • (2010) J. Biol. Chem. , vol.285 , pp. 3035-3043
    • Zhang, Y.1    Yin, L.2    Anderson, J.3    Ma, H.4    Gonzalez, F.J.5    Willson, T.M.6    Edwards, P.A.7
  • 44
    • 84890857617 scopus 로고    scopus 로고
    • Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease
    • W. Wu, B. Zhu, X. Peng, M. Zhou, D. Jia, and J. Gu Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease Biochem. Biophys. Res. Commun. 443 2014 68 73
    • (2014) Biochem. Biophys. Res. Commun. , vol.443 , pp. 68-73
    • Wu, W.1    Zhu, B.2    Peng, X.3    Zhou, M.4    Jia, D.5    Gu, J.6


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