Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal

Journal of Gastroenterology and Hepatology (Australia)

Volumn 24, Issue 4, 2009, Pages 558-563

  Buechler, Christa ^a   Schäffler, Andreas ^a   Johann, Monika ^a   Neumeier, Markus ^a   Köhl, Philip ^a   Weiss, Thomas ^a   Wodarz, Norbert ^a   Kiefer, Paul ^a   Hellerbrand, Claus ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adipocytes; Adiponectin; Alcohol; Hepatocytes

Indexed keywords

ADIPONECTIN; AMINOTRANSFERASE; BIOLOGICAL MARKER;

ABDOMINAL RADIOGRAPHY; ADIPOCYTE; ADULT; ALCOHOL LIVER CIRRHOSIS; ALCOHOL WITHDRAWAL; ALCOHOLISM; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CLINICAL EXAMINATION; CONTROLLED STUDY; DETERIORATION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENE EXPRESSION; HEPATITIS; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; INTERNATIONAL CLASSIFICATION OF DISEASES; LIVER BIOPSY; LIVER CELL CULTURE; LIVER FIBROSIS; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 63849211696     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05693.x     Document Type: Article

References (29)

1. Gavrila A, Chan JL, Yiannakouris N et al. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J. Clin. Endocrinol. Metab. 2003 88 : 4823 31.
2. Gil-Campos M, Canete RR, Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin. Nutr. 2004 23 : 963 74.
3. Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J. Clin. Endocrinol. Metab. 2004 89 : 2563 8.
4. Fueki Y, Miida T, Wardaningsih E et al. Regular alcohol consumption improves insulin resistance in healthy Japanese men independent of obesity. Clin. Chim. Acta 2007 382 : 71 6.
5. Koppes LL, Dekker JM, Hendriks HF, Bouter LM, Heine RJ. Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care 2005 28 : 719 25.
6. Beulens JW, van Beers RM, Stolk RP, Schaafsma G, Hendriks HF. The effect of moderate alcohol consumption on fat distribution and adipocytokines. Obesity (Silver Spring) 2006 14 : 60 6.
7. Sierksma A, Vermunt SH, Lankhuizen IM et al. Effect of moderate alcohol consumption on parameters of reverse cholesterol transport in postmenopausal women. Alcohol. Clin. Exp. Res. 2004 28 : 662 6.
8. Beulens JW, Sierksma A, van Tol A et al. Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1. J. Lipid Res. 2004 45 : 1716 23.
9. Sierksma A, Patel H, Ouchi N et al. Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care 2004 27 : 184 9.
10. Zietz B, Herfarth H, Paul G et al. Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes. FEBS Lett. 2003 545 : 103 4.
11. Neumeier M, Sigruener A, Eggenhofer E et al. High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes. Biochem. Biophys. Res. Commun. 2007 352 : 543 8.
12. Marmillot P, Munoz J, Patel S, Garige M, Rosse RB, Lakshman MR. Long-term ethanol consumption impairs reverse cholesterol transport function of high-density lipoproteins by depleting high-density lipoprotein sphingomyelin both in rats and in humans. Metabolism 2007 56 : 947 53.
13. Masaki T, Chiba S, Tatsukawa H et al. Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. Hepatology 2004 40 : 177 84.
14. Park PH, Thakur V, Pritchard MT, McMullen MR, Nagy LE. Regulation of Kupffer cell activity during chronic ethanol exposure: role of adiponectin. J. Gastroenterol. Hepatol. 2006 21 (Suppl. 3 S30 3.
15. Thakur V, Pritchard MT, McMullen MR, Nagy LE. Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding. Am. J. Physiol. Gastrointest. Liver Physiol. 2006 290 : G998 1007.
16. Tsochatzis E, Papatheodoridis GV, Archimandritis AJ. The evolving role of leptin and adiponectin in chronic liver diseases. Am. J. Gastroenterol. 2006 101 : 2629 40.
17. Kang L, Sebastian BM, Pritchard MT, Pratt BT, Previs SF, Nagy LE. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol. Clin. Exp. Res. 2007 31 : 1581 8.
18. You M, Considine RV, Leone TC, Kelly DP, Crabb DW. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 2005 42 : 568 77.
19. Chen X, Sebastian BM, Nagy LE. Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes. Am. J. Physiol. Endocrinol. Metab. 2007 292 : E621 8.
20. Miller PM, Plant M. Drinking, smoking, and illicit drug use among 15 and 16 year olds in the United Kingdom. BMJ 1996 313 : 394 7.
21. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994 19 : 1513 20.
22. Muhlbauer M, Fleck M, Schutz C et al. L1 is induced in hepatocytes by viral infection and by interferon-alpha and -gamma and mediates T cell apoptosis. J. Hepatol. 2006 45 : 520 8.
23. Weiss TS, Jahn B, Cetto M, Jauch KW, Thasler WE. Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes. Cell Prolif. 2002 35 : 257 67.
24. Schaffler A, Ehling A, Neumann E et al. Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter. Biochim. Biophys. Acta 2004 1678 : 150 6.
25. Neumeier M, Hellerbrand C, Gabele E et al. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. World J. Gastroenterol. 2006 12 : 5490 4.
26. Sohara N, Takagi H, Kakizaki S, Sato K, Mori M. Elevated plasma adiponectin concentrations in patients with liver cirrhosis correlate with plasma insulin levels. Liver Int. 2005 25 : 28 32.
27. Targher G, Bertolini L, Scala L, Poli F, Zenari L, Falezza G. Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals. Clin. Endocrinol. (Oxf.) 2004 61 : 700 3.
28. Yoneda M, Iwasaki T, Fujita K et al. Hypoadiponectinemia plays a crucial role in the development of nonalcoholic Fatty liver disease in patients with type 2 diabetes mellitus independent of visceral adipose tissue. Alcohol. Clin. Exp. Res. 2007 31 : S15 21.
29. Esfandiari F, You M, Villanueva JA, Wong DH, French SW, Halsted CH. S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet. Alcohol. Clin. Exp. Re.s 2007 31 : 1231 9.