메뉴 건너뛰기




Volumn 89, Issue , 2015, Pages 651-661

Heme as a danger molecule in pathogen recognition

Author keywords

ATP; Carbon monoxide (CO); Danger associated molecular patterns (DAMPs); Heme; Heme oxygenase 1; Inflammasome; Reactive oxygen species (ROS)

Indexed keywords

ACUTE PHASE PROTEIN; ADENOSINE TRIPHOSPHATE; CARBON MONOXIDE; CYTOKINE; HEME; HEME OXYGENASE 1; PATTERN RECOGNITION RECEPTOR; REACTIVE OXYGEN METABOLITE;

EID: 84944411374     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.08.020     Document Type: Review
Times cited : (58)

References (147)
  • 1
    • 66449088641 scopus 로고    scopus 로고
    • Pathogen recognition and inflammatory signaling in innate immune defenses
    • Table of Contents
    • T.H. Mogensen Pathogen recognition and inflammatory signaling in innate immune defenses Clinical microbiology reviews 22 2009 240 273 Table of Contents
    • (2009) Clinical Microbiology Reviews , vol.22 , pp. 240-273
    • Mogensen, T.H.1
  • 3
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • T.D. Kanneganti, M. Lamkanfi, and G. Nunez Intracellular NOD-like receptors in host defense and disease Immunity 27 2007 549 559
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Nunez, G.3
  • 7
    • 84871954753 scopus 로고    scopus 로고
    • Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates
    • T. Sursal, D.J. Stearns-Kurosawa, K. Itagaki, S.Y. Oh, S. Sun, S. Kurosawa, and C.J. Hauser Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates Shock 39 2013 55 62
    • (2013) Shock , vol.39 , pp. 55-62
    • Sursal, T.1    Stearns-Kurosawa, D.J.2    Itagaki, K.3    Oh, S.Y.4    Sun, S.5    Kurosawa, S.6    Hauser, C.J.7
  • 10
    • 0030188587 scopus 로고    scopus 로고
    • Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury
    • A.M. Choi, and J. Alam Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury American journal of respiratory cell and molecular biology 15 1996 9 19
    • (1996) American Journal of Respiratory Cell and Molecular Biology , vol.15 , pp. 9-19
    • Choi, A.M.1    Alam, J.2
  • 12
    • 77952430467 scopus 로고    scopus 로고
    • Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death
    • C.F. Lee, M. Qiao, K. Schroder, Q. Zhao, and R. Asmis Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death Circ Res 106 2010 1489 1497
    • (2010) Circ Res , vol.106 , pp. 1489-1497
    • Lee, C.F.1    Qiao, M.2    Schroder, K.3    Zhao, Q.4    Asmis, R.5
  • 17
    • 84865504141 scopus 로고    scopus 로고
    • Sterile inflammation in the liver
    • P. Kubes, and W.Z. Mehal Sterile inflammation in the liver Gastroenterology 143 2012 1158 1172
    • (2012) Gastroenterology , vol.143 , pp. 1158-1172
    • Kubes, P.1    Mehal, W.Z.2
  • 18
    • 84937869611 scopus 로고    scopus 로고
    • The innate immune system, toll-like receptors and dermal wound healing: A review
    • M.J. Portou, D. Baker, D. Abraham, and J. Tsui The innate immune system, toll-like receptors and dermal wound healing: A review Vascular pharmacology 2015
    • (2015) Vascular Pharmacology
    • Portou, M.J.1    Baker, D.2    Abraham, D.3    Tsui, J.4
  • 19
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • C. Dostert, V. Petrilli, R. Van Bruggen, C. Steele, B.T. Mossman, and J. Tschopp Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica Science 320 2008 674 677
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Petrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 20
    • 77951295418 scopus 로고    scopus 로고
    • Influenza virus activates inflammasomes via its intracellular M2 ion channel
    • T. Ichinohe, I.K. Pang, and A. Iwasaki Influenza virus activates inflammasomes via its intracellular M2 ion channel Nature immunology 11 2010 404 410
    • (2010) Nature Immunology , vol.11 , pp. 404-410
    • Ichinohe, T.1    Pang, I.K.2    Iwasaki, A.3
  • 23
    • 77649179433 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
    • J. Tschopp, and K. Schroder NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10 2010 210 215
    • (2010) Nat Rev Immunol , vol.10 , pp. 210-215
    • Tschopp, J.1    Schroder, K.2
  • 25
    • 77956601381 scopus 로고    scopus 로고
    • Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease
    • F. Meissner, R.A. Seger, D. Moshous, A. Fischer, J. Reichenbach, and A. Zychlinsky Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease Blood 116 2010 1570 1573
    • (2010) Blood , vol.116 , pp. 1570-1573
    • Meissner, F.1    Seger, R.A.2    Moshous, D.3    Fischer, A.4    Reichenbach, J.5    Zychlinsky, A.6
  • 26
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • R. Zhou, A. Tardivel, B. Thorens, I. Choi, and J. Tschopp Thioredoxin-interacting protein links oxidative stress to inflammasome activation Nature immunology 11 2010 136 140
    • (2010) Nature Immunology , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 28
    • 77956323967 scopus 로고    scopus 로고
    • The therapeutic potential of carbon monoxide
    • R. Motterlini, and L.E. Otterbein The therapeutic potential of carbon monoxide Nat Rev Drug Discov 9 2010 728 743
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 728-743
    • Motterlini, R.1    Otterbein, L.E.2
  • 31
    • 84880923978 scopus 로고    scopus 로고
    • Newly described pattern recognition receptors team up against intracellular pathogens
    • P. Broz, and D.M. Monack Newly described pattern recognition receptors team up against intracellular pathogens Nature reviews. Immunology 13 2013 551 565
    • (2013) Nature Reviews. Immunology , vol.13 , pp. 551-565
    • Broz, P.1    Monack, D.M.2
  • 32
    • 84875422919 scopus 로고    scopus 로고
    • Effector-triggered versus pattern-triggered immunity: How animals sense pathogens
    • L.M. Stuart, N. Paquette, and L. Boyer Effector-triggered versus pattern-triggered immunity: how animals sense pathogens Nature reviews. Immunology 13 2013 199 206
    • (2013) Nature Reviews. Immunology , vol.13 , pp. 199-206
    • Stuart, L.M.1    Paquette, N.2    Boyer, L.3
  • 33
    • 0038500959 scopus 로고    scopus 로고
    • Toll-like receptor ligand links innate and adaptive immune responses by the production of heat-shock proteins
    • U. Kumaraguru, C.D. Pack, and B.T. Rouse Toll-like receptor ligand links innate and adaptive immune responses by the production of heat-shock proteins Journal of leukocyte biology 73 2003 574 583
    • (2003) Journal of Leukocyte Biology , vol.73 , pp. 574-583
    • Kumaraguru, U.1    Pack, C.D.2    Rouse, B.T.3
  • 35
    • 78650676293 scopus 로고    scopus 로고
    • Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: Effects on macrophage viability and tissue iron distribution
    • G. Kovtunovych, M.A. Eckhaus, M.C. Ghosh, H. Ollivierre-Wilson, and T.A. Rouault Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution Blood 116 2010 6054 6062
    • (2010) Blood , vol.116 , pp. 6054-6062
    • Kovtunovych, G.1    Eckhaus, M.A.2    Ghosh, M.C.3    Ollivierre-Wilson, H.4    Rouault, T.A.5
  • 37
    • 0030886381 scopus 로고    scopus 로고
    • Heme oxygenase 1 is required for mammalian iron reutilization
    • K.D. Poss, and S. Tonegawa Heme oxygenase 1 is required for mammalian iron reutilization Proc Natl Acad Sci U S A 94 1997 10919 10924
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10919-10924
    • Poss, K.D.1    Tonegawa, S.2
  • 39
    • 84944395650 scopus 로고    scopus 로고
    • TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation
    • P.H. Lin, W.M. Lan, and L.Y. Chau TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation Oncogene 2012
    • (2012) Oncogene
    • Lin, P.H.1    Lan, W.M.2    Chau, L.Y.3
  • 40
    • 84892149853 scopus 로고    scopus 로고
    • An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
    • R.A. Ratsimandresy, A. Dorfleutner, and C. Stehlik An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology Frontiers in immunology 4 2013 440
    • (2013) Frontiers in Immunology , vol.4 , pp. 440
    • Ratsimandresy, R.A.1    Dorfleutner, A.2    Stehlik, C.3
  • 41
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • L. Agostini, F. Martinon, K. Burns, M.F. McDermott, P.N. Hawkins, and J. Tschopp NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder Immunity 20 2004 319 325
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5    Tschopp, J.6
  • 42
    • 77749304032 scopus 로고    scopus 로고
    • Signaling by ROS drives inflammasome activation
    • F. Martinon Signaling by ROS drives inflammasome activation European journal of immunology 40 2010 616 619
    • (2010) European Journal of Immunology , vol.40 , pp. 616-619
    • Martinon, F.1
  • 52
    • 84874439878 scopus 로고    scopus 로고
    • Hemolysis and free hemoglobin revisited: Exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
    • D.J. Schaer, P.W. Buehler, A.I. Alayash, J.D. Belcher, and G.M. Vercellotti Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins Blood 121 2013 1276 1284
    • (2013) Blood , vol.121 , pp. 1276-1284
    • Schaer, D.J.1    Buehler, P.W.2    Alayash, A.I.3    Belcher, J.D.4    Vercellotti, G.M.5
  • 53
    • 84877836304 scopus 로고    scopus 로고
    • CD163 and IgG codefend against cytotoxic hemoglobin via autocrine and paracrine mechanisms
    • K. Subramanian, R. Du, N.S. Tan, B. Ho, and J.L. Ding CD163 and IgG codefend against cytotoxic hemoglobin via autocrine and paracrine mechanisms J Immunol 190 2013 5267 5278
    • (2013) J Immunol , vol.190 , pp. 5267-5278
    • Subramanian, K.1    Du, R.2    Tan, N.S.3    Ho, B.4    Ding, J.L.5
  • 55
    • 0023239961 scopus 로고
    • Acute phase protein response to tissue injury
    • W.M. Stahl Acute phase protein response to tissue injury Critical care medicine 15 1987 545 550
    • (1987) Critical Care Medicine , vol.15 , pp. 545-550
    • Stahl, W.M.1
  • 56
    • 84897513452 scopus 로고    scopus 로고
    • Extracellular Hb enhances cardiac toxicity in endotoxemic Guinea pigs: Protective role of haptoglobin
    • J.H. Baek, X. Zhang, M.C. Williams, D.J. Schaer, P.W. Buehler, and F. D'Agnillo Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin Toxins 6 2014 1244 1259
    • (2014) Toxins , vol.6 , pp. 1244-1259
    • Baek, J.H.1    Zhang, X.2    Williams, M.C.3    Schaer, D.J.4    Buehler, P.W.5    D'Agnillo, F.6
  • 57
    • 38949115537 scopus 로고    scopus 로고
    • Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation
    • C.A. Schaer, F. Vallelian, A. Imhof, G. Schoedon, and D.J. Schaer Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation Journal of leukocyte biology 83 2008 325 333
    • (2008) Journal of Leukocyte Biology , vol.83 , pp. 325-333
    • Schaer, C.A.1    Vallelian, F.2    Imhof, A.3    Schoedon, G.4    Schaer, D.J.5
  • 58
    • 79957723868 scopus 로고    scopus 로고
    • Iron trafficking and metabolism in macrophages: Contribution to the polarized phenotype
    • G. Cairo, S. Recalcati, A. Mantovani, and M. Locati Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype Trends in immunology 32 2011 241 247
    • (2011) Trends in Immunology , vol.32 , pp. 241-247
    • Cairo, G.1    Recalcati, S.2    Mantovani, A.3    Locati, M.4
  • 60
    • 84899942981 scopus 로고    scopus 로고
    • Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation
    • H. Hada, T. Shiraki, M. Watanabe-Matsui, and K. Igarashi Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation Biochimica et biophysica acta 1840 2014 2351 2360
    • (2014) Biochimica et Biophysica Acta , vol.1840 , pp. 2351-2360
    • Hada, H.1    Shiraki, T.2    Watanabe-Matsui, M.3    Igarashi, K.4
  • 61
    • 84908373728 scopus 로고    scopus 로고
    • Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development
    • D.J. Schaer, F. Vinchi, G. Ingoglia, E. Tolosano, and P.W. Buehler Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development Frontiers in physiology 5 2014 415
    • (2014) Frontiers in Physiology , vol.5 , pp. 415
    • Schaer, D.J.1    Vinchi, F.2    Ingoglia, G.3    Tolosano, E.4    Buehler, P.W.5
  • 63
    • 84905089416 scopus 로고    scopus 로고
    • Phagocytic uptake of oxidized heme polymer is highly cytotoxic to macrophages
    • R. Deshmukh, and V. Trivedi Phagocytic uptake of oxidized heme polymer is highly cytotoxic to macrophages PloS one 9 2014 e103706
    • (2014) PloS One , vol.9 , pp. e103706
    • Deshmukh, R.1    Trivedi, V.2
  • 64
    • 77953788926 scopus 로고    scopus 로고
    • Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1
    • discussion 1332-1324
    • M. Raoof, Q. Zhang, K. Itagaki, and C.J. Hauser Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1 J Trauma 68 2010 1328 1332 discussion 1332-1324
    • (2010) J Trauma , vol.68 , pp. 1328-1332
    • Raoof, M.1    Zhang, Q.2    Itagaki, K.3    Hauser, C.J.4
  • 65
    • 84871326101 scopus 로고    scopus 로고
    • Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions
    • B. Zhang, S. Asadi, Z. Weng, N. Sismanopoulos, and T.C. Theoharides Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions PloS one 7 2012 e49767
    • (2012) PloS One , vol.7 , pp. e49767
    • Zhang, B.1    Asadi, S.2    Weng, Z.3    Sismanopoulos, N.4    Theoharides, T.C.5
  • 66
    • 84883785469 scopus 로고    scopus 로고
    • The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity
    • P.M. Gallo, and S. Gallucci The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity Frontiers in immunology 4 2013 138
    • (2013) Frontiers in Immunology , vol.4 , pp. 138
    • Gallo, P.M.1    Gallucci, S.2
  • 67
    • 84905503923 scopus 로고    scopus 로고
    • Mitochondria released by cells undergoing TNF-alpha-induced necroptosis act as danger signals
    • A. Maeda, and B. Fadeel Mitochondria released by cells undergoing TNF-alpha-induced necroptosis act as danger signals Cell death & disease 5 2014 e1312
    • (2014) Cell Death & Disease , vol.5 , pp. e1312
    • Maeda, A.1    Fadeel, B.2
  • 71
    • 0042847262 scopus 로고    scopus 로고
    • Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses
    • P. Aichele, J. Zinke, L. Grode, R.A. Schwendener, S.H. Kaufmann, and P. Seiler Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses J Immunol 171 2003 1148 1155
    • (2003) J Immunol , vol.171 , pp. 1148-1155
    • Aichele, P.1    Zinke, J.2    Grode, L.3    Schwendener, R.A.4    Kaufmann, S.H.5    Seiler, P.6
  • 72
    • 34548857335 scopus 로고    scopus 로고
    • Inside, outside, upside down: Damage-associated molecular-pattern molecules (DAMPs) and redox
    • A. Rubartelli, and M.T. Lotze Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox Trends in immunology 28 2007 429 436
    • (2007) Trends in Immunology , vol.28 , pp. 429-436
    • Rubartelli, A.1    Lotze, M.T.2
  • 74
    • 26644447615 scopus 로고    scopus 로고
    • Phagosome maturation proceeds independently of stimulation of toll-like receptors 2 and 4
    • R.M. Yates, and D.G. Russell Phagosome maturation proceeds independently of stimulation of toll-like receptors 2 and 4 Immunity 23 2005 409 417
    • (2005) Immunity , vol.23 , pp. 409-417
    • Yates, R.M.1    Russell, D.G.2
  • 79
    • 0028934533 scopus 로고
    • Regulation and functions of nitric oxide in the liver in sepsis and inflammation
    • C.M. Pastor, and T.R. Billiar Regulation and functions of nitric oxide in the liver in sepsis and inflammation New Horiz 3 1995 65 72
    • (1995) New Horiz , vol.3 , pp. 65-72
    • Pastor, C.M.1    Billiar, T.R.2
  • 81
    • 38149008232 scopus 로고    scopus 로고
    • Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice
    • S.W. Chung, X. Liu, A.A. Macias, R.M. Baron, and M.A. Perrella Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice The Journal of clinical investigation 118 2008 239 247
    • (2008) The Journal of Clinical Investigation , vol.118 , pp. 239-247
    • Chung, S.W.1    Liu, X.2    Macias, A.A.3    Baron, R.M.4    Perrella, M.A.5
  • 85
    • 84878535419 scopus 로고    scopus 로고
    • Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome
    • M. Wallner, R. Marculescu, D. Doberer, M. Wolzt, O. Wagner, L. Vitek, A.C. Bulmer, and K.H. Wagner Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome Clin Sci (Lond) 125 2013 257 264
    • (2013) Clin Sci (Lond) , vol.125 , pp. 257-264
    • Wallner, M.1    Marculescu, R.2    Doberer, D.3    Wolzt, M.4    Wagner, O.5    Vitek, L.6    Bulmer, A.C.7    Wagner, K.H.8
  • 86
    • 81755186976 scopus 로고    scopus 로고
    • Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase
    • B. Wegiel, D. Gallo, E. Csizmadia, T. Roger, E. Kaczmarek, C. Harris, B.S. Zuckerbraun, and L.E. Otterbein Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase Proc Natl Acad Sci U S A 108 2011 18849 18854
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 18849-18854
    • Wegiel, B.1    Gallo, D.2    Csizmadia, E.3    Roger, T.4    Kaczmarek, E.5    Harris, C.6    Zuckerbraun, B.S.7    Otterbein, L.E.8
  • 91
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • R. Stocker, Y. Yamamoto, A.F. McDonagh, A.N. Glazer, and B.N. Ames Bilirubin is an antioxidant of possible physiological importance Science 235 1987 1043 1046
    • (1987) Science , vol.235 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3    Glazer, A.N.4    Ames, B.N.5
  • 92
    • 84945285459 scopus 로고    scopus 로고
    • Bilirubin scavenges chloramines and inhibits myeloperoxidase induced protein/lipid oxidation in physiologically relevant hyperbilirubinaemic serum
    • A.C. Boon, C.L. Hawkins, J.S. Coombes, K.H. Wagner, and A.C. Bulmer Bilirubin scavenges chloramines and inhibits myeloperoxidase induced protein/lipid oxidation in physiologically relevant hyperbilirubinaemic serum Free Radic Biol Med 2015
    • (2015) Free Radic Biol Med
    • Boon, A.C.1    Hawkins, C.L.2    Coombes, J.S.3    Wagner, K.H.4    Bulmer, A.C.5
  • 93
    • 70350351419 scopus 로고    scopus 로고
    • Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase
    • G.J. Maghzal, M.C. Leck, E. Collinson, C. Li, and R. Stocker Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase The Journal of biological chemistry 284 2009 29251 29259
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 29251-29259
    • Maghzal, G.J.1    Leck, M.C.2    Collinson, E.3    Li, C.4    Stocker, R.5
  • 95
    • 33645048994 scopus 로고    scopus 로고
    • Cellular regulation and molecular interactions of the ferritins
    • K.J. Hintze, and E.C. Theil Cellular regulation and molecular interactions of the ferritins Cell Mol Life Sci 63 2006 591 600
    • (2006) Cell Mol Life Sci , vol.63 , pp. 591-600
    • Hintze, K.J.1    Theil, E.C.2
  • 97
    • 0043268709 scopus 로고    scopus 로고
    • Heme oxygenase-1: Unleashing the protective properties of heme
    • L.E. Otterbein, M.P. Soares, K. Yamashita, and F.H. Bach Heme oxygenase-1: unleashing the protective properties of heme Trends Immunol 24 2003 449 455
    • (2003) Trends Immunol , vol.24 , pp. 449-455
    • Otterbein, L.E.1    Soares, M.P.2    Yamashita, K.3    Bach, F.H.4
  • 98
    • 0031714412 scopus 로고    scopus 로고
    • Induction of ferritin and heme oxygenase-1 by endotoxin in the lung
    • M.S. Carraway, A.J. Ghio, J.L. Taylor, and C.A. Piantadosi Induction of ferritin and heme oxygenase-1 by endotoxin in the lung Am J Physiol 275 1998 L583 L592
    • (1998) Am J Physiol , vol.275 , pp. L583-L592
    • Carraway, M.S.1    Ghio, A.J.2    Taylor, J.L.3    Piantadosi, C.A.4
  • 99
    • 33644641067 scopus 로고    scopus 로고
    • The mammalian cap and collar family of transcription factors
    • J. Alam The mammalian cap and collar family of transcription factors Antioxidants & redox signaling 8 2006 39 42
    • (2006) Antioxidants & Redox Signaling , vol.8 , pp. 39-42
    • Alam, J.1
  • 103
    • 84928027734 scopus 로고    scopus 로고
    • The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation
    • D.A. Dorward, C.D. Lucas, G.B. Chapman, C. Haslett, K. Dhaliwal, and A.G. Rossi The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation Am J Pathol 185 2015 1172 1184
    • (2015) Am J Pathol , vol.185 , pp. 1172-1184
    • Dorward, D.A.1    Lucas, C.D.2    Chapman, G.B.3    Haslett, C.4    Dhaliwal, K.5    Rossi, A.G.6
  • 104
    • 79954622511 scopus 로고    scopus 로고
    • Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts
    • K. Hao, H. Hanawa, L. Ding, Y. Ota, K. Yoshida, K. Toba, M. Ogura, H. Ito, M. Kodama, and Y. Aizawa Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts Mol Immunol 48 2011 1191 1202
    • (2011) Mol Immunol , vol.48 , pp. 1191-1202
    • Hao, K.1    Hanawa, H.2    Ding, L.3    Ota, Y.4    Yoshida, K.5    Toba, K.6    Ogura, M.7    Ito, H.8    Kodama, M.9    Aizawa, Y.10
  • 106
    • 60649095328 scopus 로고    scopus 로고
    • Heme oxygenase-1: From biology to therapeutic potential
    • M.P. Soares, and F.H. Bach Heme oxygenase-1: from biology to therapeutic potential Trends in molecular medicine 15 2009 50 58
    • (2009) Trends in Molecular Medicine , vol.15 , pp. 50-58
    • Soares, M.P.1    Bach, F.H.2
  • 107
    • 84864428068 scopus 로고    scopus 로고
    • M. Heme arginate improves reperfusion patterns after ischemia: A randomized, placebo-controlled trial in healthy male subjects
    • Andreas
    • Andreas M. Schmid, A.I. Doberer, D. Schewzow, K. Weisshaar, S. Heinze, G. Bilban, M. Moser, and E. Wolzt M. Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects J Cardiovasc Magn Reson 14 2012 55
    • (2012) J Cardiovasc Magn Reson , vol.14 , pp. 55
    • Schmid, M.1    Doberer, A.I.2    Schewzow, D.3    Weisshaar, K.4    Heinze, S.5    Bilban, G.6    Moser, M.7    Wolzt, E.8
  • 112
  • 113
    • 25444449505 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C
    • S.A. Rushworth, X.L. Chen, N. Mackman, R.M. Ogborne, and M.A. O'Connell Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C J Immunol 175 2005 4408 4415
    • (2005) J Immunol , vol.175 , pp. 4408-4415
    • Rushworth, S.A.1    Chen, X.L.2    Mackman, N.3    Ogborne, R.M.4    O'Connell, M.A.5
  • 114
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications
    • S.W. Ryter, J. Alam, and A.M. Choi Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications Physiol Rev 86 2006 583 650
    • (2006) Physiol Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 115
    • 37849018402 scopus 로고    scopus 로고
    • Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB
    • R.N. Hasan, and A.I. Schafer Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB Circ Res 102 2008 42 50
    • (2008) Circ Res , vol.102 , pp. 42-50
    • Hasan, R.N.1    Schafer, A.I.2
  • 116
    • 84879952268 scopus 로고    scopus 로고
    • Heminmediated neuroglobin induction exerts neuroprotection following ischemic brain injury through PI3K/Akt signaling
    • B. Zhang, X. Ji, S. Zhang, H. Ren, M. Wang, C. Guo, and Y. Li Heminmediated neuroglobin induction exerts neuroprotection following ischemic brain injury through PI3K/Akt signaling Molecular medicine reports 8 2013 681 685
    • (2013) Molecular Medicine Reports , vol.8 , pp. 681-685
    • Zhang, B.1    Ji, X.2    Zhang, S.3    Ren, H.4    Wang, M.5    Guo, C.6    Li, Y.7
  • 117
    • 70350140219 scopus 로고    scopus 로고
    • Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species
    • N. Ogasawara, T. Oguro, T. Sakabe, M. Matsushima, O. Takikawa, K. Isobe, and F. Nagase Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species Journal of cellular biochemistry 108 2009 716 725
    • (2009) Journal of Cellular Biochemistry , vol.108 , pp. 716-725
    • Ogasawara, N.1    Oguro, T.2    Sakabe, T.3    Matsushima, M.4    Takikawa, O.5    Isobe, K.6    Nagase, F.7
  • 119
    • 34250706879 scopus 로고    scopus 로고
    • Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival
    • X.M. Liu, K.J. Peyton, D. Ensenat, H. Wang, M. Hannink, J. Alam, and W. Durante Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival Cardiovascular research 75 2007 381 389
    • (2007) Cardiovascular Research , vol.75 , pp. 381-389
    • Liu, X.M.1    Peyton, K.J.2    Ensenat, D.3    Wang, H.4    Hannink, M.5    Alam, J.6    Durante, W.7
  • 124
  • 126
    • 84925221854 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota
    • J.C. Onyiah, S.Z. Sheikh, N. Maharshak, L.E. Otterbein, and S.E. Plevy Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota Gut microbes 5 2014 220 224
    • (2014) Gut Microbes , vol.5 , pp. 220-224
    • Onyiah, J.C.1    Sheikh, S.Z.2    Maharshak, N.3    Otterbein, L.E.4    Plevy, S.E.5
  • 130
    • 80055033765 scopus 로고    scopus 로고
    • Carbon monoxide induced PPARgamma SUMOylation and UCP2 block inflammatory gene expression in macrophages
    • A. Haschemi, B.Y. Chin, M. Jeitler, H. Esterbauer, O. Wagner, M. Bilban, and L.E. Otterbein Carbon monoxide induced PPARgamma SUMOylation and UCP2 block inflammatory gene expression in macrophages PloS one 6 2011 e26376
    • (2011) PloS One , vol.6 , pp. e26376
    • Haschemi, A.1    Chin, B.Y.2    Jeitler, M.3    Esterbauer, H.4    Wagner, O.5    Bilban, M.6    Otterbein, L.E.7
  • 132
    • 77149179384 scopus 로고    scopus 로고
    • Heme oxygenase 1 protects against hepatic hypoxia and injury from hemorrhage via regulation of cellular respiration
    • R. Vallabhaneni, D.J. Kaczorowski, M.D. Yaakovian, J. Rao, and B.S. Zuckerbraun Heme oxygenase 1 protects against hepatic hypoxia and injury from hemorrhage via regulation of cellular respiration Shock 33 2010 274 281
    • (2010) Shock , vol.33 , pp. 274-281
    • Vallabhaneni, R.1    Kaczorowski, D.J.2    Yaakovian, M.D.3    Rao, J.4    Zuckerbraun, B.S.5
  • 133
    • 27744536929 scopus 로고    scopus 로고
    • Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR)4 expression
    • L.E. Otterbein, A. May, and B.Y. Chin Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR)4 expression Cell Mol Biol (Noisy-le-grand) 51 2005 433 440
    • (2005) Cell Mol Biol (Noisy-le-grand) , vol.51 , pp. 433-440
    • Otterbein, L.E.1    May, A.2    Chin, B.Y.3
  • 134
    • 79251605391 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: Novel therapeutic strategies in critical care medicine
    • S.W. Ryter, and A.M. Choi Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine Current drug targets 11 2010 1485 1494
    • (2010) Current Drug Targets , vol.11 , pp. 1485-1494
    • Ryter, S.W.1    Choi, A.M.2
  • 136
    • 65649135789 scopus 로고    scopus 로고
    • Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis
    • S. Lancel, S.M. Hassoun, R. Favory, B. Decoster, R. Motterlini, and R. Neviere Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis J Pharmacol Exp Ther 329 2009 641 648
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 641-648
    • Lancel, S.1    Hassoun, S.M.2    Favory, R.3    Decoster, B.4    Motterlini, R.5    Neviere, R.6
  • 141
    • 79952192382 scopus 로고    scopus 로고
    • Immune cell regulation by autocrine purinergic signalling
    • W.G. Junger Immune cell regulation by autocrine purinergic signalling Nature reviews. Immunology 11 2011 201 212
    • (2011) Nature Reviews. Immunology , vol.11 , pp. 201-212
    • Junger, W.G.1
  • 143
    • 84884854704 scopus 로고    scopus 로고
    • Systemic inflammatory responses and lung injury following hip fracture surgery increases susceptibility to infection in aged rats
    • H. Zhang, T. Sun, Z. Liu, J. Zhang, X. Wang, and J. Liu Systemic inflammatory responses and lung injury following hip fracture surgery increases susceptibility to infection in aged rats Mediators of inflammation 2013 2013 536435
    • (2013) Mediators of Inflammation , vol.2013 , pp. 536435
    • Zhang, H.1    Sun, T.2    Liu, Z.3    Zhang, J.4    Wang, X.5    Liu, J.6
  • 145
    • 84878077028 scopus 로고    scopus 로고
    • Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome
    • Y. Xiang, X. Wang, C. Yan, Q. Gao, S.A. Li, J. Liu, K. Zhou, X. Guo, W. Lee, and Y. Zhang Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome PloS one 8 2013 e63759
    • (2013) PloS One , vol.8 , pp. e63759
    • Xiang, Y.1    Wang, X.2    Yan, C.3    Gao, Q.4    Li, S.A.5    Liu, J.6    Zhou, K.7    Guo, X.8    Lee, W.9    Zhang, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.