Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 46, 2011, Pages 18849-18854

  Wegiel, Barbara ^a   Gallo, David ^a   Csizmadia, Eva ^a   Roger, Thierry ^b   Kaczmarek, Elzbieta ^a   Harris, Clair ^a   Zuckerbraun, Brian S ^c   Otterbein, Leo E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Department of Medicine   (Switzerland)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bile pigments; Heme oxygenase; Innate immunity

Indexed keywords

BILIVERDIN; BILIVERDIN REDUCTASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CYSTEINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTOXIN; OXIDOREDUCTASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ACUTE HEPATITIS; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME BINDING; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; INFLAMMATION; LIVER INJURY; MACROPHAGE; MOLECULAR MECHANICS; MOUSE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BILIVERDINE; CELL NUCLEUS; ENDOTOXINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MACROPHAGES; MICE; MICE, TRANSGENIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP-1;

MUS;

EID: 81755186976     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1108571108     Document Type: Article

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