Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt

Journal of Biological Chemistry

Volumn 284, Issue 32, 2009, Pages 21369-21378

  Wegiel, Barbara ^a   Baty, Catherine J ^b   Gallo, David ^a   Csizmadia, Eva ^a   Scott, Jeffrey R ^a   Akhavan, Ardavan ^b   Chin, Beek Y ^a   Kaczmarek, Elzbieta ^a   Alam, Jawed ^c   Bach, Fritz H ^a   Zuckerbraun, Brian S ^b   Otterbein, Leo E ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY EFFECTS; BACTERIAL ENDOTOXINS; CELL SURFACES; CYTOKINES; CYTOPLASMIC TAIL; CYTOPROTECTIVE EFFECTS; ENZYMATIC ACTIVITIES; ENZYMATIC CONVERSIONS; IN-VIVO; INFLAMMATORY RESPONSE; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MOLECULAR MECHANISM; PHOSPHATIDYLINOSITOL 3-KINASE; PLASMA MEMBRANES; PROTECTIVE EFFECTS; RNA INTERFERENCE; SIGNALING CASCADES; SURFACE EXPRESSION; TYROSINE PHOSPHORYLATION;

AMINO ACIDS; MACROPHAGES; NUCLEIC ACIDS; PHOSPHORYLATION; POLYSACCHARIDES; RNA; SIGNALING;

CELL MEMBRANES;

ALANINE AMINOTRANSFERASE; BILIVERDIN; BILIVERDIN REDUCTASE; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; OXIDOREDUCTASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TYROSINE; UNCLASSIFIED DRUG;

ACUTE HEPATITIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CELL MEMBRANE; CELL PROTECTION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; RNA INTERFERENCE; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SURVIVAL TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BILIVERDINE; CELL MEMBRANE; HUMANS; INFLAMMATION; INTERLEUKIN-10; MACROPHAGES; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTO-ONCOGENE PROTEINS C-AKT; SUBCELLULAR FRACTIONS;

BACTERIA (MICROORGANISMS);

EID: 69249110030     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.027433     Document Type: Article

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