Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation

Journal of Clinical Investigation

Volumn 124, Issue 11, 2014, Pages 4926-4940

  Wegiel, Barbara ^a   Larsen, Rasmus ^b   Gallo, David ^a   Chin, Beek Yoke ^a   Harris, Clair ^a   Mannam, Praveen ^c   Kaczmarek, Elzbieta ^a   Lee, Patty J ^c   Zuckerbraun, Brian S ^d   Flavell, Richard ^c,e   Soares, Miguel P ^b   Otterbein, Leo E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BILIVERDIN; CARBON MONOXIDE; CATHEPSIN B; CRYOPYRIN; HEME OXYGENASE 1; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; NUCLEOTIDE; POTASSIUM CHANNEL; PROTOPORPHYRIN TIN; PURINERGIC P2 RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; POTASSIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENTEROCOCCAL INFECTION; ENTEROCOCCUS FAECALIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; ESCHERICHIA COLI; HOST RESISTANCE; HUMAN; IMMUNOBLOTTING; MACROPHAGE ACTIVATION; MALE; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PROTEIN CLEAVAGE; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SEPTIC SHOCK; SIGNAL TRANSDUCTION; THIN LAYER CHROMATOGRAPHY; UREA NITROGEN BLOOD LEVEL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; ENZYMOLOGY; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; SEPSIS; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; ADMINISTRATION, INHALATION; ANIMALS; CARBON MONOXIDE; CARRIER PROTEINS; CELLS, CULTURED; ESCHERICHIA COLI; HEME OXYGENASE-1; HOST-PATHOGEN INTERACTIONS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PHAGOCYTOSIS; POTASSIUM; SEPSIS;

EID: 84908610651     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI72853     Document Type: Article

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