Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1β and IL-18 in mice

American Journal of Pathology

Volumn 184, Issue 7, 2014, Pages 2023-2034

  Arifa, Raquel D N ^a   Madeira, Mila F M ^a   De Paula, Talles P ^a   Lima, Renata L ^a   Tavares, Livia D ^a   Menezes Garcia, Zélia ^a   Fagundes, Caio T ^a   Rachid, Milene A ^a   Ryffel, Bernhard ^b   Zamboni, Dario S ^c   Teixeira, Mauro M ^a   Souza, Danielle G ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b National Center for Research and Science   (France)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

APOCYNIN; GLUTATHIONE; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; IRINOTECAN; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; THIOBARBITURIC ACID REACTIVE SUBSTANCE; CAMPTOTHECIN; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENTERITIS; ENZYME ACTIVATION; INTESTINE INJURY; MALE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SMALL INTESTINE; SMALL INTESTINE MUCOSA; WEIGHT REDUCTION; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; ILEUM; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; CAMPTOTHECIN; CASPASE 1; ILEUM; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; MALE; MEMBRANE GLYCOPROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOSITIS; NADPH OXIDASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84903193283     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.03.012     Document Type: Article

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