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Volumn 190, Issue 4, 2013, Pages 1714-1724

NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 CYANO 3,12 DIOXOOLEANA 1,9 (11)DIEN 28 OYL]IMIDAZOLE; ALBUMIN; INTERLEUKIN 1BETA; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR NRF2; TRITERPENOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84873550167     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202410     Document Type: Article
Times cited : (49)

References (69)
  • 2
    • 66449134287 scopus 로고    scopus 로고
    • A simple clinical predictive index for objective estimates of mortality in acute lung injury
    • National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
    • Cooke, C. R., C. V. Shah, R. Gallop, S. Bellamy, M. Ancukiewicz, M. D. Eisner, P. N. Lanken, A. R. Localio, and J. D. Christie; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. 2009. A simple clinical predictive index for objective estimates of mortality in acute lung injury. Crit. Care Med. 37: 1913-1920.
    • (2009) Crit. Care Med. , vol.37 , pp. 1913-1920
    • Cooke, C.R.1    Shah, C.V.2    Gallop, R.3    Bellamy, S.4    Ancukiewicz, M.5    Eisner, M.D.6    Lanken, P.N.7    Localio, A.R.8    Christie, J.D.9
  • 3
    • 76749100153 scopus 로고    scopus 로고
    • Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury
    • NHLBI ARDS Clinical Trials Network
    • Ware, L. B., T. Koyama, D. D. Billheimer, W. Wu, G. R. Bernard, B. T. Thompson, R. G. Brower, T. J. Standiford, T. R. Martin, and M. A. Matthay; NHLBI ARDS Clinical Trials Network. 2010. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest 137: 288-296.
    • (2010) Chest , vol.137 , pp. 288-296
    • Ware, L.B.1    Koyama, T.2    Billheimer, D.D.3    Wu, W.4    Bernard, G.R.5    Thompson, B.T.6    Brower, R.G.7    Standiford, T.J.8    Martin, T.R.9    Matthay, M.A.10
  • 4
    • 0031059884 scopus 로고    scopus 로고
    • Plasma hypoxanthine levels in ARDS: Implications for oxidative stress, morbidity, and mortality
    • Quinlan, G. J., N. J. Lamb, R. Tilley, T. W. Evans, and J. M. Gutteridge. 1997. Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity, and mortality. Am. J. Respir. Crit. Care Med. 155: 479-484.
    • (1997) Am. J. Respir. Crit. Care Med. , vol.155 , pp. 479-484
    • Quinlan, G.J.1    Lamb, N.J.2    Tilley, R.3    Evans, T.W.4    Gutteridge, J.M.5
  • 6
    • 34250378820 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates lung ischemia-reperfusion injury after lung transplantation
    • discussion 246
    • Inci, I., W. Zhai, S. Arni, S. Hillinger, P. Vogt, and W. Weder. 2007. N-acetylcysteine attenuates lung ischemia-reperfusion injury after lung transplantation. Ann. Thorac. Surg. 84: 240-246, discussion 246.
    • (2007) Ann. Thorac. Surg. , vol.84 , pp. 240-246
    • Inci, I.1    Zhai, W.2    Arni, S.3    Hillinger, S.4    Vogt, P.5    Weder, W.6
  • 7
    • 33845724468 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
    • Fialkow, L., Y. Wang, and G. P. Downey. 2007. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic. Biol. Med. 42: 153-164.
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 153-164
    • Fialkow, L.1    Wang, Y.2    Downey, G.P.3
  • 9
    • 11044233228 scopus 로고    scopus 로고
    • Pharmacologic therapies for adults with acute lung injury and acute respiratory distress syndrome
    • Adhikari, N., K. E. Burns, and M. O. Meade. 2004. Pharmacologic therapies for adults with acute lung injury and acute respiratory distress syndrome. Cochrane Database Syst. Rev. 4: CD004477.
    • (2004) Cochrane Database Syst. Rev. , vol.4
    • Adhikari, N.1    Burns, K.E.2    Meade, M.O.3
  • 11
    • 34447525439 scopus 로고    scopus 로고
    • Beneficial suicide: Why neutrophils die to make NETs
    • Brinkmann, V., and A. Zychlinsky. 2007. Beneficial suicide: why neutrophils die to make NETs. Nat. Rev. Microbiol. 5: 577-582.
    • (2007) Nat. Rev. Microbiol. , vol.5 , pp. 577-582
    • Brinkmann, V.1    Zychlinsky, A.2
  • 16
    • 0034128751 scopus 로고    scopus 로고
    • Genetic, biochemical, and clinical features of chronic granulomatous disease
    • Segal, B. H., T. L. Leto, J. I. Gallin, H. L. Malech, and S. M. Holland. 2000. Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore) 79: 170-200.
    • (2000) Medicine (Baltimore) , vol.79 , pp. 170-200
    • Segal, B.H.1    Leto, T.L.2    Gallin, J.I.3    Malech, H.L.4    Holland, S.M.5
  • 18
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono, H., and K. L. Rock. 2008. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8: 279-289.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 20
    • 0343893748 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome network
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
    • -2000. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N. Engl. J. Med. 342: 1301-1308.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1301-1308
  • 21
    • 3242703034 scopus 로고    scopus 로고
    • Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome
    • National Heart, Lung, and Blood Institute ARDS Clinical Trials Network
    • Brower, R. G., P. N. Lanken, N. MacIntyre, M. A. Matthay, A. Morris, M. Ancukiewicz, D. Schoenfeld, and B. T. Thompson; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. 2004. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N. Engl. J. Med. 351: 327-336.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 327-336
    • Brower, R.G.1    Lanken, P.N.2    MacIntyre, N.3    Matthay, M.A.4    Morris, A.5    Ancukiewicz, M.6    Schoenfeld, D.7    Thompson, B.T.8
  • 24
    • 0035880166 scopus 로고    scopus 로고
    • Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome
    • Acute Respiratory Distress Syndrome Network
    • Eisner, M. D., T. Thompson, L. D. Hudson, J. M. Luce, D. Hayden, D. Schoenfeld, and M. A. Matthay; Acute Respiratory Distress Syndrome Network. 2001. Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 164: 231-236.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.164 , pp. 231-236
    • Eisner, M.D.1    Thompson, T.2    Hudson, L.D.3    Luce, J.M.4    Hayden, D.5    Schoenfeld, D.6    Matthay, M.A.7
  • 26
  • 28
    • 0027521990 scopus 로고
    • Pathogenesis of gastric particulate lung injury: A comparison and interaction with acidic pneumonitis
    • Knight, P. R., T. Rutter, A. R. Tait, E. Coleman, and K. Johnson. 1993. Pathogenesis of gastric particulate lung injury: a comparison and interaction with acidic pneumonitis. Anesth. Analg. 77: 754-760.
    • (1993) Anesth. Analg. , vol.77 , pp. 754-760
    • Knight, P.R.1    Rutter, T.2    Tait, A.R.3    Coleman, E.4    Johnson, K.5
  • 32
    • 0026661661 scopus 로고
    • The role of neutrophils, oxidants, and proteases in the pathogenesis of acid pulmonary injury
    • Knight, P. R., G. Druskovich, A. R. Tait, and K. J. Johnson. 1992. The role of neutrophils, oxidants, and proteases in the pathogenesis of acid pulmonary injury. Anesthesiology 77: 772-778.
    • (1992) Anesthesiology , vol.77 , pp. 772-778
    • Knight, P.R.1    Druskovich, G.2    Tait, A.R.3    Johnson, K.J.4
  • 34
    • 0028984840 scopus 로고
    • The p47phox mouse knockout model of chronic granulomatous disease
    • Jackson, S. H., J. I. Gallin, and S. M. Holland. 1995. The p47phox mouse knockout model of chronic granulomatous disease. J. Exp. Med. 182: 751-758.
    • (1995) J. Exp. Med. , vol.182 , pp. 751-758
    • Jackson, S.H.1    Gallin, J.I.2    Holland, S.M.3
  • 35
    • 0034672595 scopus 로고    scopus 로고
    • Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
    • Chan, J. Y., and M. Kwong. 2000. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim. Biophys. Acta 1517: 19-26.
    • (2000) Biochim. Biophys. Acta , vol.1517 , pp. 19-26
    • Chan, J.Y.1    Kwong, M.2
  • 36
    • 21144431523 scopus 로고    scopus 로고
    • The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling
    • Liby, K., T. Hock, M. M. Yore, N. Suh, A. E. Place, R. Risingsong, C. R. Williams, D. B. Royce, T. Honda, Y. Honda, et al. 2005. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 65: 4789-4798.
    • (2005) Cancer Res. , vol.65 , pp. 4789-4798
    • Liby, K.1    Hock, T.2    Yore, M.M.3    Suh, N.4    Place, A.E.5    Risingsong, R.6    Williams, C.R.7    Royce, D.B.8    Honda, T.9    Honda, Y.10
  • 37
    • 0001637870 scopus 로고
    • Permanent cell line expressing human factor VIII-related antigen established by hybridization
    • Edgell, C. J., C. C. McDonald, and J. B. Graham. 1983. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. USA 80: 3734-3737.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3734-3737
    • Edgell, C.J.1    McDonald, C.C.2    Graham, J.B.3
  • 38
    • 0025916059 scopus 로고
    • Micromotion of mammalian cells measured electrically
    • Giaever, I., and C. R. Keese. 1991. Micromotion of mammalian cells measured electrically. Proc. Natl. Acad. Sci. USA 88: 7896-7900.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7896-7900
    • Giaever, I.1    Keese, C.R.2
  • 39
    • 0034714440 scopus 로고    scopus 로고
    • Electric cell-substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces
    • Wegener, J., C. R. Keese, and I. Giaever. 2000. Electric cell-substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces. Exp. Cell Res. 259: 158-166.
    • (2000) Exp. Cell Res. , vol.259 , pp. 158-166
    • Wegener, J.1    Keese, C.R.2    Giaever, I.3
  • 40
    • 77954740194 scopus 로고    scopus 로고
    • Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils
    • Itagaki, K., Q. Zhang, and C. J. Hauser. 2010. Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. Shock 33: 381-386.
    • (2010) Shock , vol.33 , pp. 381-386
    • Itagaki, K.1    Zhang, Q.2    Hauser, C.J.3
  • 41
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa, R. K., K. H. Mai, S. Srisuma, T. W. Kensler, M. Yamamoto, and S. Biswal. 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62: 5196-5203.
    • (2002) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 43
    • 81755166339 scopus 로고    scopus 로고
    • Bacterial DNA induces pulmonary damage via TLR-9 through cross-talk with neutrophils
    • Itagaki, K., Y. Adibnia, S. Sun, C. Zhao, T. Sursal, Y. Chen, W. Junger, and C. J. Hauser. 2011. Bacterial DNA induces pulmonary damage via TLR-9 through cross-talk with neutrophils. Shock 36: 548-552.
    • (2011) Shock , vol.36 , pp. 548-552
    • Itagaki, K.1    Adibnia, Y.2    Sun, S.3    Zhao, C.4    Sursal, T.5    Chen, Y.6    Junger, W.7    Hauser, C.J.8
  • 48
    • 20744460187 scopus 로고    scopus 로고
    • Serine antiproteinase administration preserves innate superoxide dismutase levels after acid aspiration and hyperoxia but does not decrease lung injury
    • Nader, N. D., B. A. Davidson, A. R. Tait, B. A. Holm, and P. R. Knight. 2005. Serine antiproteinase administration preserves innate superoxide dismutase levels after acid aspiration and hyperoxia but does not decrease lung injury. Anesth. Analg. 101: 213-219.
    • (2005) Anesth. Analg. , vol.101 , pp. 213-219
    • Nader, N.D.1    Davidson, B.A.2    Tait, A.R.3    Holm, B.A.4    Knight, P.R.5
  • 49
    • 0030483324 scopus 로고    scopus 로고
    • A novel role for the beta 2 integrin CD11β/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation
    • Coxon, A., P. Rieu, F. J. Barkalow, S. Askari, A. H. Sharpe, U. H. von Andrian, M. A. Arnaout, and T. N. Mayadas. 1996. A novel role for the beta 2 integrin CD11β/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5: 653-666.
    • (1996) Immunity , vol.5 , pp. 653-666
    • Coxon, A.1    Rieu, P.2    Barkalow, F.J.3    Askari, S.4    Sharpe, A.H.5    Von Andrian, U.H.6    Arnaout, M.A.7    Mayadas, T.N.8
  • 50
    • 78649469767 scopus 로고    scopus 로고
    • PPARg activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease
    • Fernandez-Boyanapalli, R., S. C. Frasch, D. W. Riches, R. W. Vandivier, P. M. Henson, and D. L. Bratton. 2010. PPARg activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. Blood 116: 4512-4522.
    • (2010) Blood , vol.116 , pp. 4512-4522
    • Fernandez-Boyanapalli, R.1    Frasch, S.C.2    Riches, D.W.3    Vandivier, R.W.4    Henson, P.M.5    Bratton, D.L.6
  • 51
    • 61849091325 scopus 로고    scopus 로고
    • Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
    • Fernandez-Boyanapalli, R. F., S. C. Frasch, K. McPhillips, R. W. Vandivier, B. L. Harry, D. W. Riches, P. M. Henson, and D. L. Bratton. 2009. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood 113: 2047-2055.
    • (2009) Blood , vol.113 , pp. 2047-2055
    • Fernandez-Boyanapalli, R.F.1    Frasch, S.C.2    McPhillips, K.3    Vandivier, R.W.4    Harry, B.L.5    Riches, D.W.6    Henson, P.M.7    Bratton, D.L.8
  • 54
    • 41549148595 scopus 로고    scopus 로고
    • Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling
    • Zhu, L., J. Pi, S. Wachi, M. E. Andersen, R. Wu, and Y. Chen. 2008. Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L469-L477.
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.294
    • Zhu, L.1    Pi, J.2    Wachi, S.3    Andersen, M.E.4    Wu, R.5    Chen, Y.6
  • 55
    • 67349214659 scopus 로고    scopus 로고
    • Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages
    • Woods, C. G., J. Fu, P. Xue, Y. Hou, L. J. Pluta, L. Yang, Q. Zhang, R. S. Thomas, M. E. Andersen, and J. Pi. 2009. Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. Toxicol. Appl. Pharmacol. 238: 27-36.
    • (2009) Toxicol. Appl. Pharmacol. , vol.238 , pp. 27-36
    • Woods, C.G.1    Fu, J.2    Xue, P.3    Hou, Y.4    Pluta, L.J.5    Yang, L.6    Zhang, Q.7    Thomas, R.S.8    Andersen, M.E.9    Pi, J.10
  • 56
    • 67849123906 scopus 로고    scopus 로고
    • Taurine chloramine activates Nrf2, increases HO-1 expression and protects cells from death caused by hydrogen peroxide
    • Sun Jang, J., S. Piao, Y. N. Cha, and C. Kim. 2009. Taurine chloramine activates Nrf2, increases HO-1 expression and protects cells from death caused by hydrogen peroxide. J. Clin. Biochem. Nutr. 45: 37-43.
    • (2009) J. Clin. Biochem. Nutr. , vol.45 , pp. 37-43
    • Sun Jang, J.1    Piao, S.2    Cha, Y.N.3    Kim, C.4
  • 57
    • 51049090388 scopus 로고    scopus 로고
    • MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8
    • Agata, N., R. Ahmad, T. Kawano, D. Raina, S. Kharbanda, and D. Kufe. 2008. MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8. Cancer Res. 68: 6136-6144.
    • (2008) Cancer Res. , vol.68 , pp. 6136-6144
    • Agata, N.1    Ahmad, R.2    Kawano, T.3    Raina, D.4    Kharbanda, S.5    Kufe, D.6
  • 61
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • Dostert, C., V. Pétrilli, R. Van Bruggen, C. Steele, B. T. Mossman, and J. Tschopp. 2008. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320: 674-677.
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Pétrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 63
    • 22844440703 scopus 로고    scopus 로고
    • Cytokines in host defense against Aspergillus: Recent advances
    • Phadke, A. P., and B. Mehrad. 2005. Cytokines in host defense against Aspergillus: recent advances. Med. Mycol. 43(Suppl 1): S173-S176.
    • (2005) Med. Mycol. , vol.43 , Issue.SUPPL. 1
    • Phadke, A.P.1    Mehrad, B.2
  • 64
    • 0034117341 scopus 로고    scopus 로고
    • Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease
    • Segal, B. H., N. Sakamoto, M. Patel, K. Maemura, A. S. Klein, S. M. Holland, and G. B. Bulkley. 2000. Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease. Infect. Immun. 68: 2374-2378.
    • (2000) Infect. Immun. , vol.68 , pp. 2374-2378
    • Segal, B.H.1    Sakamoto, N.2    Patel, M.3    Maemura, K.4    Klein, A.S.5    Holland, S.M.6    Bulkley, G.B.7
  • 66
    • 0037090069 scopus 로고    scopus 로고
    • Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: Studies in p47phox-/- and gp91phox-/- mice
    • Gao, X. P., T. J. Standiford, A. Rahman, M. Newstead, S. M. Holland, M. C. Dinauer, Q. H. Liu, and A. B. Malik. 2002. Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice. J. Immunol. 168: 3974-3982.
    • (2002) J. Immunol. , vol.168 , pp. 3974-3982
    • Gao, X.P.1    Standiford, T.J.2    Rahman, A.3    Newstead, M.4    Holland, S.M.5    Dinauer, M.C.6    Liu, Q.H.7    Malik, A.B.8
  • 67
    • 38949206624 scopus 로고    scopus 로고
    • Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome
    • Tasaka, S., F. Amaya, S. Hashimoto, and A. Ishizaka. 2008. Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome. Antioxid. Redox Signal. 10: 739-753.
    • (2008) Antioxid. Redox Signal. , vol.10 , pp. 739-753
    • Tasaka, S.1    Amaya, F.2    Hashimoto, S.3    Ishizaka, A.4
  • 68
    • 33744780420 scopus 로고    scopus 로고
    • Antioxidant therapeutic targets in COPD
    • Rahman, I., and I. Kilty. 2006. Antioxidant therapeutic targets in COPD. Curr. Drug Targets 7: 707-720.
    • (2006) Curr. Drug Targets , vol.7 , pp. 707-720
    • Rahman, I.1    Kilty, I.2
  • 69
    • 0037369376 scopus 로고    scopus 로고
    • Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium
    • Zhang, X., P. Shan, M. Sasidhar, G. L. Chupp, R. A. Flavell, A. M. Choi, and P. J. Lee. 2003. Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am. J. Respir. Cell Mol. Biol. 28: 305-315.
    • (2003) Am. J. Respir. Cell Mol. Biol. , vol.28 , pp. 305-315
    • Zhang, X.1    Shan, P.2    Sasidhar, M.3    Chupp, G.L.4    Flavell, R.A.5    Choi, A.M.6    Lee, P.J.7


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