ATP release and purinergic signaling: A common pathway for particle-mediated inflammasome activation

Cell Death and Disease

Volumn 3, Issue 10, 2012, Pages

  Riteau, N ^a   Baron, L ^a   Villeret, B ^a   Guillou, N ^a   Savigny, F ^a   Ryffel, B ^a   Rassendren, F ^b   Le Bert, M ^a   Gombault, A ^a   Couillin, I ^a,c  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^c Laboratoire d'Immunologie et Embryologie Moleculaires Orleans   (France)

Author keywords

ATP; Danger signal; Inflammasome; NLR; P2R

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALUMINUM POTASSIUM SULFATE; CRYOPYRIN; GAP JUNCTION PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; PURINERGIC RECEPTOR; SILICON DIOXIDE; URIC ACID; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALUMINUM; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; CONNEXINS; CYSTEINE PROTEASES; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE; RECEPTORS, PURINERGIC; SIGNAL TRANSDUCTION; SILICON DIOXIDE; URIC ACID; URIDINE TRIPHOSPHATE;

EID: 84870514546     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.144     Document Type: Article

References (38)

1. Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008; 320: 674-677.
2. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008; 14: 1256-1263.
3. Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008; 453: 1122-1126.
4. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2010; 11: 136-140.
5. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010; 464: 1357-1361.
6. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 2008; 9: 857-865.
7. Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF et al. Biglycan: a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 2009; 284: 24035-24048.
8. Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440: 228-232.
9. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440: 237-241.
10. Cassel SL, Joly S, Sutterwala FS. The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol 2009; 21: 194-198.
11. Pelegrin P, Surprenant A. Pannexin-1 couples to maitotoxin-and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem 2007; 282: 2386-2394.
12. Praetorius HA, Leipziger J. ATP release from non-excitable cells. Purinergic Signal 2009; 5: 433-446.
13. Lazarowski ER, Boucher RC, Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X-and P2Y-receptor activating molecules. Mol Pharmacol 2003; 64: 785-795.
14. Yegutkin GG. Nucleotide-and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim Biophys Acta 2008; 1783: 673-694.
15. Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA 2009; 106: 20388-20393.
16. Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L et al. Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 2010; 182: 774-783.
17. Okada SF, Nicholas RA, Kreda SM, Lazarowski ER, Boucher RC. Physiological regulation of ATP release at the apical surface of human airway epithelia. J Biol Chem 2006; 281: 22992-23002.
18. Joseph SM, Buchakjian MR, Dubyak GR. Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem 2003; 278: 23331-23342.
19. Bao L, Locovei S, Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett 2004; 572: 65-68.
20. Harris AL. Connexin channel permeability to cytoplasmic molecules. Prog Biophys Mol Biol 2007; 94: 120-143.
21. Orellana JA, Froger N, Ezan P, Jiang JX, Bennett MV, Naus CC et al. ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem 2011; 118: 826-840.
22. Scemes E, Spray DC, Meda P. Connexins, pannexins, innexins: novel roles of 'hemi-channels'. Pflugers Arch 2009; 457: 1207-1226.
23. King BF. Novel P2X7 receptor antagonists ease the pain. Br J Pharmacol 2007; 151: 565-567.
24. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A et al. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 2006; 314: 1792-1795.
25. Perregaux D, Gabel CA. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 1994; 269: 15195-15203.
26. Di Virgilio F. Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci 2007; 28: 465-472.
27. Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, Idzko M et al. The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 2006; 176: 3877-3883.
28. Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 2009; 113: 2324-2335.
29. Piccini A, Carta S, Tassi S, Lasiglie D, Fossati G, Rubartelli A. ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way. Proc Natl Acad Sci USA 2008; 105: 8067-8072.
30. Sanz JM, Chiozzi P, Ferrari D, Colaianna M, Idzko M, Falzoni S et al. Activation of microglia by amyloid {beta} requires P2X7 receptor expression. J Immunol 2009; 182: 4378-4385.
31. Di Virgilio F, Borea PA, Illes P. P2 receptors meet the immune system. Trends Pharmacol Sci 2001; 22: 5-7.
32. Bours MJ, Swennen EL, Di Virgilio F, Cronstein BN, Dagnelie PC. Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther 2006; 112: 358-404.
33. Brough D, Pelegrin P, Rothwell NJ. Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc. Eur J Immunol 2009; 39: 352-358.
34. Franchi L, Kanneganti TD, Dubyak GR, Nunez G. Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem 2007; 282: 18810-18818.
35. Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. Embo J 2006; 25: 5071-5082.
36. Qu Y, Misaghi S, Newton K, Gilmour LL, Louie S, Cupp JE et al. Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J Immunol 2011; 186: 6553-6561.
37. Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER et al. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature 2010; 467: 863-867.
38. Gasse P, Riteau N, Charron S, Girre S, Fick L, Petrilli V et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 2009; 179: 903-913.