Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye

Experimental Eye Research

Volumn 125, Issue , 2014, Pages 1-8

  Zheng, Qinxiang ^a   Ren, Yueping ^a   Reinach, Peter S ^b   She, Yujing ^a   Xiao, Bing ^a   Hua, Shanshan ^a   Qu, Jia ^a   Chen, Wei ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Caspase 1; Dry eye; ICES; IL 1 ; Inflammasomes; Inflammation; NLRP3; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CRYOPYRIN; EYE DROPS; FLUORESCEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CORNEAL FLUORESCEIN STAINING; CYTOKINE RELEASE; DISEASE COURSE; DOWN REGULATION; DRY EYE; ENVIRONMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPEROSMOTIC STRESS; IMMUNOHISTOCHEMISTRY; INTELLIGENTLY CONTROLLED ENVIRONMENTAL SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STAINING; UPREGULATION;

CASPASE-1; DRY EYE; ICES; IL-1Β; INFLAMMASOMES; INFLAMMATION; NLRP3; REACTIVE OXYGEN SPECIES;

ACETYLCYSTEINE; ANALYSIS OF VARIANCE; ANIMALS; CARRIER PROTEINS; CASPASE 1; CONJUNCTIVA; CORNEA; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRY EYE SYNDROMES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FREE RADICAL SCAVENGERS; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84901985008     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2014.05.001     Document Type: Article

References (48)

1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007a). Ocul. Surf. 5, 75-92.
2. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007b). Ocul. Surf. 5, 93-107.
3. Abelson M.B., Ousler G.W., Nally L.A., Welch D., Krenzer K. Alternative reference values for tear film break up time in normal and dry eye populations. Adv. Exp. Med. Biol. 2002, 506:1121-1125.
4. Abetz L., Rajagopalan K., Mertzanis P., Begley C., Barnes R., Chalmers R. Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients. Health Qual. Life Outcomes 2011, 9:111. Impact of Dry Eye on Everyday Life Study, G.
5. Annunziato F., Cosmi L., Liotta F., Maggi E., Romagnani S. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int. Immunol. 2008, 20:1361-1368.
6. Augustin A.J., Spitznas M., Kaviani N., Meller D., Koch F.H., Grus F., Gobbels M.J. Oxidative reactions in the tear fluid of patients suffering from dry eyes. Graefes Arch. Clin. Exp. Ophthalmol. 1995, 233:694-698.
7. Backman H., Haghighat F. Indoor-air quality and ocular discomfort. J.Am. Optom. Assoc. 1999, 70:309-316.
8. Barbieri E., Sestili P. Reactive oxygen species in skeletal muscle signaling. J.Signal Transduct. 2012, 2012:982794.
9. Bauernfeind F., Bartok E., Rieger A., Franchi L., Nunez G., Hornung V. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J.Immunol. 2011, 187:613-617.
10. Cerretti D.P., Kozlosky C.J., Mosley B., Nelson N., Van Ness K., Greenstreet T.A., March C.J., Kronheim S.R., Druck T., Cannizzaro L.A., et al. Molecular cloning of the interleukin-1 beta converting enzyme. Science 1992, 256:97-100.
11. Chen W., Zhang X., Liu M., Zhang J., Ye Y., Lin Y., Luyckx J., Qu J. Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis. Exp. Eye Res. 2009, 89:311-318.
12. Clouzeau C., Godefroy D., Riancho L., Rostene W., Baudouin C., Brignole-Baudouin F. Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells invitro. Mol. Vis. 2012, 18:851-863.
13. Conforti-Andreoni C., Ricciardi-Castagnoli P., Mortellaro A. The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond. Cell. Mol. Immunol. 2011, 8:135-145.
14. Devi T.S., Lee I., Huttemann M., Kumar A., Nantwi K.D., Singh L.P. TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy. Exp. Diabetes Res. 2012, 2012:438238.
15. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev. Immunol. 2009, 27:519-550.
16. Doyle S.L., Campbell M., Ozaki E., Salomon R.G., Mori A., Kenna P.F., Farrar G.J., Kiang A.S., Humphries M.M., Lavelle E.C., O'Neill L.A., Hollyfield J.G., Humphries P. NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat. Med. 2012, 18:791-798.
17. Gross O., Thomas C.J., Guarda G., Tschopp J. The inflammasome: an integrated view. Immunol. Rev. 2011, 243:136-151.
18. Hu Y., Mao K., Zeng Y., Chen S., Tao Z., Yang C., Sun S., Wu X., Meng G., Sun B. Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production. J.Immunol. 2010, 185:7699-7705.
19. Inoue M., Shinohara M.L. NLRP3 Inflammasome and MS/EAE. Autoimmune Dis. 2013, 2013:859145.
20. Kummer J.A., Broekhuizen R., Everett H., Agostini L., Kuijk L., Martinon F., van Bruggen R., Tschopp J. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J.Histochem. Cytochem. 2007, 55:443-452.
21. Lam H., Bleiden L., de Paiva C.S., Farley W., Stern M.E., Pflugfelder S.C. Tear cytokine profiles in dysfunctional tear syndrome. Am. J. Ophthalmol. 2009, 147:198-205. e191.
22. Lamkanfi M., Dixit V.M. Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev. 2009, 227:95-105.
23. Lemp M.A. Report of the National Eye Institute/Industry workshop on Clinical trials in dry eyes. Clao J. 1995, 21:221-232.
24. Li D.Q., Chen Z., Song X.J., Luo L., Pflugfelder S.C. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Investig. Ophthalmol. Vis. Sci. 2004, 45:4302-4311.
25. Liang L., Tan X., Zhou Q., Zhu Y., Tian Y., Yu H., Kijlstra A., Yang P. IL-1beta triggered by peptidoglycan and lipopolysaccharide through TLR2/4 and ROS-NLRP3 inflammasome-dependent pathways is involved in ocular Behcet's disease. Investig. Ophthalmol. Vis. Sci. 2013, 54:402-414.
26. Liu H., Begley C., Chen M., Bradley A., Bonanno J., McNamara N.A., Nelson J.D., Simpson T. Alink between tear instability and hyperosmolarity in dry eye. Investig. Ophthalmol. Vis. Sci. 2009, 50:3671-3679.
27. Liu R.T., Gao J., Cao S., Sandhu N., Cui J.Z., Chou C.L., Fang E., Matsubara J.A. Inflammatory mediators induced by amyloid-beta in the retina and RPE invivo: implications for inflammasome activation in age-related macular degeneration. Investig. Ophthalmol. Vis. Sci. 2013, 54:2225-2237.
28. Luo L., Li D.Q., Doshi A., Farley W., Corrales R.M., Pflugfelder S.C. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Investig. Ophthalmol. Vis. Sci. 2004, 45:4293-4301.
29. Martinon F., Mayor A., Tschopp J. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 2009, 27:229-265.
30. McGilligan V.E., Gregory-Ksander M.S., Li D., Moore J.E., Hodges R.R., Gilmore M.S., Moore T.C., Dartt D.A. Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS One 2013, 8:e74010.
31. Na K.S., Mok J.W., Kim J.Y., Rho C.R., Joo C.K. Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease. Investig. Ophthalmol. Vis. Sci. 2012, 53:5443-5450.
32. Nakamura S., Shibuya M., Nakashima H., Hisamura R., Masuda N., Imagawa T., Uehara M., Tsubota K. Involvement of oxidative stress on corneal epithelial alterations in a blink-suppressed dry eye. Investig. Ophthalmol. Vis. Sci. 2007, 48:1552-1558.
33. Ousler G.W., Abelson M.B., Nally L.A., Welch D., Casavant J.S. Evaluation of the time to "natural compensation" in normal and dry eye subject populations during exposure to a controlled adverse environment. Adv. Exp. Med. Biol. 2002, 506:1057-1063.
34. Pandey V., Ranjan S., Deeba F., Pandey A.K., Singh R., Shirke P.A., Pathre U.V. Desiccation-induced physiological and biochemical changes in resurrection plant, Selaginella bryopteris. J.Plant Physiol. 2010, 167:1351-1359.
35. Pouyeh B., Viteri E., Feuer W., Lee D.J., Florez H., Fabian J.A., Perez V.L., Galor A. Impact of ocular surface symptoms on quality of life in a United States veterans affairs population. Am. J. Ophthalmol. 2012, 153:1061-1066. e1063.
36. Rubartelli A., Gattorno M., Netea M.G., Dinarello C.A. Interplay between redox status and inflammasome activation. Trends Immunol. 2011, 32:559-566.
37. Sacca S.C., Roszkowska A.M., Izzotti A. Environmental light and endogenous antioxidants as the main determinants of non-cancer ocular diseases. Mutat. Res. 2013, 752:153-171.
38. Salminen A., Ojala J., Kaarniranta K., Kauppinen A. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell. Mol. Life Sci. 2012, 69:2999-3013.
39. Schaumberg D.A., Sullivan D.A., Dana M.R. Epidemiology of dry eye syndrome. Adv. Exp. Med. Biol. 2002, 506:989-998.
40. Schaumburg C.S., Siemasko K.F., De Paiva C.S., Wheeler L.A., Niederkorn J.Y., Pflugfelder S.C., Stern M.E. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J.Immunol. 2011, 187:3653-3662.
41. Schlote T., Kadner G., Freudenthaler N. Marked reduction and distinct patterns of eye blinking in patients with moderately dry eyes during video display terminal use. Graefes Arch. Clin. Exp. Ophthalmol. 2004, 242:306-312.
42. Stern M.E., Schaumburg C.S., Pflugfelder S.C. Dry eye as a mucosal autoimmune disease. Int. Rev. Immunol. 2013, 32:19-41.
43. Stritesky G.L., Yeh N., Kaplan M.H. IL-23 promotes maintenance but not commitment to the Th17 lineage. J.Immunol. 2008, 181:5948-5955.
44. Tarallo V., Hirano Y., Gelfand B.D., Dridi S., Kerur N., Kim Y., Cho W.G., Kaneko H., Fowler B.J., Bogdanovich S., Albuquerque R.J., Hauswirth W.W., Chiodo V.A., Kugel J.F., Goodrich J.A., Ponicsan S.L., Chaudhuri G., Murphy M.P., Dunaief J.L., Ambati B.K., Ogura Y., Yoo J.W., Lee D.K., Provost P., Hinton D.R., Nunez G., Baffi J.Z., Kleinman M.E., Ambati J. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 2012, 149:847-859.
45. Uchino Y., Kawakita T., Miyazawa M., Ishii T., Onouchi H., Yasuda K., Ogawa Y., Shimmura S., Ishii N., Tsubota K. Oxidative stress induced inflammation initiates functional decline of tear production. PLoS One 2012, 7:e45805.
46. Wakamatsu T.H., Dogru M., Matsumoto Y., Kojima T., Kaido M., Ibrahim O.M., Sato E.A., Igarashi A., Ichihashi Y., Satake Y., Shimazaki J., Tsubota K. Evaluation of lipid oxidative stress status in Sjogren syndrome patients. Investig. Ophthalmol. Vis. Sci. 2013, 54:201-210.
47. Wewers M.D., Pope H.A., Miller D.K. Processing proIL-1 beta decreases detection by a proIL-1 beta specific ELISA but increases detection by a conventional ELISA. J.Immunol. Methods 1993, 165:269-278.
48. Zheng X., Bian F., Ma P., De Paiva C.S., Stern M., Pflugfelder S.C., Li D.Q. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J.Cell. Physiol. 2010, 222:95-102.