Phagocytic uptake of oxidized heme polymer is highly cytotoxic to macrophages

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Deshmukh, Rohitas ^a   Trivedi, Vishal ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY GUWAHATI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; BETA HEMATIN; ETHIDIUM BROMIDE; HEMATIN; HEME POLYMER; HEMIN; HYDROGEN PEROXIDE; METHEMOGLOBIN; NITRONE; PEROXIDASE; PHENYL N T BUTYL NITRONE; POLYMER; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; GLUTATHIONE; HEME; HEMOPROTEIN; HEMOZOIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LC 50; MACROPHAGE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; REACTION ANALYSIS; SCANNING ELECTRON MICROSCOPY; TOXICITY TESTING; UPREGULATION; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; IMMUNOLOGY; LD50; LIPID PEROXIDATION; MALARIA, FALCIPARUM; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PLASMODIUM FALCIPARUM; PROTEIN CARBONYLATION;

ANIMALS; ANTIMALARIALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; GLUTATHIONE; HEME; HEMEPROTEINS; HYDROGEN PEROXIDE; LETHAL DOSE 50; LIPID PEROXIDATION; MACROPHAGES; MALARIA, FALCIPARUM; METHEMOGLOBIN; MICE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHAGOCYTOSIS; PLASMODIUM FALCIPARUM; POLYMERS; PROTEIN CARBONYLATION; REACTIVE OXYGEN SPECIES;

EID: 84905089416     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103706     Document Type: Article

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