Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis

American Journal of Respiratory and Critical Care Medicine

Volumn 185, Issue 8, 2012, Pages 851-861

  MacGarvey, Nancy Chou ^a,c   Suliman, Hagir B ^a   Bartz, Raquel R ^a,b   Fu, Ping ^a   Withers, Crystal M ^a   Welty Wolf, Karen E ^a,b   Piantadosi, Claude A ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Akt PKB; Carbon monoxide; Cytokines; Mitochondrial DNA; Oxidative stress

Indexed keywords

CARBON MONOXIDE; CITRATE SYNTHASE; HEME OXYGENASE 1; INTERLEUKIN 10; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCAL BACTEREMIA; STAPHYLOCOCCUS AUREUS; UPREGULATION;

ADMINISTRATION, INHALATION; ANIMALS; BIOGENESIS; BLOTTING, WESTERN; CARBON MONOXIDE; DISEASE MODELS, ANIMAL; FEMALE; HEME OXYGENASE-1; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; PERITONITIS; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SEPSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SURVIVAL RATE; UP-REGULATION;

EID: 84860189098     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201106-1152OC     Document Type: Article

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