Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors

Journal of Biological Chemistry

Volumn 282, Issue 33, 2007, Pages 24430-24436

  Porto, Bárbara N ^a   Alves, Letícia S ^a   Fernández, Patricia L ^a,b   Dutra, Tatiana P ^a   Figueiredo, Rodrigo T ^a   Graça Souza, Aurélio V ^a   Bozza, Marcelo T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Institute of Advanced Scientific Investigations and High Technology Services   (Panama)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITY; CELL DEATH; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; OXIDATIVE STRESS;

HEME; NEUTROPHILS; PHOSPHOLIPASE; SIGNALING PATHWAYS;

PROTEINS;

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HEME; MESOPORPHYRIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHO KINASE INHIBITOR;

ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL;

ANIMALS; CHEMOTAXIS; HEME; HUMANS; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; NEUTROPHILS; REACTIVE OXYGEN SPECIES; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 34548226931     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703570200     Document Type: Article

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