-
1
-
-
84877821168
-
Bloomsbury report on mouse embryo phenotyping: Recommendations from the IMPC workshop on embryonic lethal screening
-
Adams D et al. 2013. Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening. Dis Model Mech 6(3): 571-579.
-
(2013)
Dis Model Mech
, vol.6
, Issue.3
, pp. 571-579
-
-
Adams, D.1
-
2
-
-
0034708480
-
The genome sequence of Drosophila melanogaster
-
Adams MD et al. 2000. The genome sequence of Drosophila melanogaster. Science 287(5461): 2185-2195.
-
(2000)
Science
, vol.287
, Issue.5461
, pp. 2185-2195
-
-
Adams, M.D.1
-
3
-
-
4043122029
-
Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning
-
Ahn S and Joyner AL. 2004. Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118(4): 505-516.
-
(2004)
Cell
, vol.118
, Issue.4
, pp. 505-516
-
-
Ahn, S.1
Joyner, A.L.2
-
4
-
-
84888261840
-
Robust ZFN-mediated genome editing in adult hemophilic mice
-
Anguela XM et al. 2013. Robust ZFN-mediated genome editing in adult hemophilic mice. Blood 122(19): 3283-3287.
-
(2013)
Blood
, vol.122
, Issue.19
, pp. 3283-3287
-
-
Anguela, X.M.1
-
5
-
-
34047118522
-
CRISPR provides acquired resistance against viruses in prokaryotes
-
Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, Romero DA and Horvath P. 2007. CRISPR provides acquired resistance against viruses in prokaryotes. Science 315(5819): 1709-1712.
-
(2007)
Science
, vol.315
, Issue.5819
, pp. 1709-1712
-
-
Barrangou, R.1
Fremaux, C.2
Deveau, H.3
Richards, M.4
Boyaval, P.5
Moineau, S.6
Romero, D.A.7
Horvath, P.8
-
6
-
-
0001194208
-
Genetic Control of Biochemical Reactions in Neurospora
-
Beadle GW and Tatum EL. 1941. Genetic Control of Biochemical Reactions in Neurospora. Proc Natl Acad Sci USA 27(11): 499-506.
-
(1941)
Proc Natl Acad Sci USA
, vol.27
, Issue.11
, pp. 499-506
-
-
Beadle, G.W.1
Tatum, E.L.2
-
7
-
-
84868342049
-
In vivo genome editing using a high-efficiency TALEN system
-
Bedell VM et al. 2012. In vivo genome editing using a high-efficiency TALEN system. Nature 491(7422): 114-118.
-
(2012)
Nature
, vol.491
, Issue.7422
, pp. 114-118
-
-
Bedell, V.M.1
-
8
-
-
0034652141
-
Positive and negative regulation of endogenous genes by designed transcription factors
-
Beerli RR, Dreier B and Barbas CF. 2000. Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci USA 97(4): 1495-1500.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.4
, pp. 1495-1500
-
-
Beerli, R.R.1
Dreier, B.2
Barbas, C.F.3
-
9
-
-
84874601177
-
Highly active zinc-finger nucleases by extended modular assembly
-
Bhakta MS et al. 2012. Highly active zinc-finger nucleases by extended modular assembly. Genome Res 23(3): 530-538.
-
(2012)
Genome Res
, vol.23
, Issue.3
, pp. 530-538
-
-
Bhakta, M.S.1
-
10
-
-
0034749283
-
Stimulation of homologous recombination through targeted cleavage by chimeric nucleases
-
Bibikova M, Carroll D, Segal DJ, Trautman JK, Smith J, Kim YG and Chandrasegaran S. 2001. Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Mol Cell Biol 21(1): 289-297.
-
(2001)
Mol Cell Biol
, vol.21
, Issue.1
, pp. 289-297
-
-
Bibikova, M.1
Carroll, D.2
Segal, D.J.3
Trautman, J.K.4
Smith, J.5
Kim, Y.G.6
Chandrasegaran, S.7
-
11
-
-
0036021389
-
Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases
-
Bibikova M, Golic M, Golic KG and Carroll D. 2002. Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161(3): 1169-1175.
-
(2002)
Genetics
, vol.161
, Issue.3
, pp. 1169-1175
-
-
Bibikova, M.1
Golic, M.2
Golic, K.G.3
Carroll, D.4
-
13
-
-
72149110399
-
Breaking the code of DNA binding specificity of TAL-type III effectors
-
Boch J, Scholze H, Schornack S, Landgraf A, Hahn S, Kay S, Lahaye T, Nickstadt A and Bonas U. 2009. Breaking the code of DNA binding specificity of TAL-type III effectors. Science 326(5959): 1509-1512.
-
(2009)
Science
, vol.326
, Issue.5959
, pp. 1509-1512
-
-
Boch, J.1
Scholze, H.2
Schornack, S.3
Landgraf, A.4
Hahn, S.5
Kay, S.6
Lahaye, T.7
Nickstadt, A.8
Bonas, U.9
-
14
-
-
23844505202
-
Clustered regularly interspaced short palindrome repeats (Crisprs) have spacers of extrachromosomal origin
-
Bolotin A, Quinquis B, Sorokin A and Ehrlich SD. 2005. Clustered regularly interspaced short palindrome repeats (Crisprs) have spacers of extrachromosomal origin. Microbiology 151(8): 2551-2561.
-
(2005)
Microbiology
, vol.151
, Issue.8
, pp. 2551-2561
-
-
Bolotin, A.1
Quinquis, B.2
Sorokin, A.3
Ehrlich, S.D.4
-
15
-
-
84876897705
-
Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/beta-cateninresponsive neural stem cells
-
Bowman AN, Van Amerongen R, Palmer TD and Nusse R. 2013. Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/beta-cateninresponsive neural stem cells. Proc Natl Acad Sci USA 110(18): 7324-7329.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.18
, pp. 7324-7329
-
-
Bowman, A.N.1
Van Amerongen, R.2
Palmer, T.D.3
Nusse, R.4
-
16
-
-
84867332476
-
The mammalian gene function resource: The International Knockout Mouse Consortium
-
Bradley A et al. 2012. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome 23(9-10): 580-586.
-
(2012)
Mamm Genome
, vol.23
, Issue.9-10
, pp. 580-586
-
-
Bradley, A.1
-
17
-
-
0346503889
-
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
-
Branda CS and Dymecki SM. 2004. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell 6(1): 7-28.
-
(2004)
Dev Cell
, vol.6
, Issue.1
, pp. 7-28
-
-
Branda, C.S.1
Dymecki, S.M.2
-
18
-
-
0021183267
-
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors
-
Brinster RL, Chen HY, Messing A, Van Dyke T, Levine AJ and Palmiter RD. 1984. Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37(2): 367-379.
-
(1984)
Cell
, vol.37
, Issue.2
, pp. 367-379
-
-
Brinster, R.L.1
Chen, H.Y.2
Messing, A.3
Van Dyke, T.4
Levine, A.J.5
Palmiter, R.D.6
-
19
-
-
0019859395
-
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs
-
Brinster RL, Chen HY, Trumbauer M, Senear AW, Warren R and Palmiter RD. 1981. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27(1 Pt 2): 223-231.
-
(1981)
Cell
, vol.27
, Issue.1
, pp. 223-231
-
-
Brinster, R.L.1
Chen, H.Y.2
Trumbauer, M.3
Senear, A.W.4
Warren, R.5
Palmiter, R.D.6
-
20
-
-
0020083107
-
Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs
-
Brinster RL, Chen HY, Warren R, Sarthy A and Palmiter RD. 1982. Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature 296(5852): 39-42.
-
(1982)
Nature
, vol.296
, Issue.5852
, pp. 39-42
-
-
Brinster, R.L.1
Chen, H.Y.2
Warren, R.3
Sarthy, A.4
Palmiter, R.D.5
-
21
-
-
84879686686
-
Whole-rat conditional gene knockout via genome editing
-
Brown AJ et al. 2013. Whole-rat conditional gene knockout via genome editing. Nat Methods 10(7): 638-640.
-
(2013)
Nat Methods
, vol.10
, Issue.7
, pp. 638-640
-
-
Brown, A.J.1
-
22
-
-
0029860719
-
Different thermostabilities of FLP and cre recombinases: Implications for applied site-specific recombination
-
Buchholz F, Ringrose L, Angrand PO, Rossi F and Stewart AF. 1996. Different thermostabilities of FLP and cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res 24(21): 4256-4262.
-
(1996)
Nucleic Acids Res
, vol.24
, Issue.21
, pp. 4256-4262
-
-
Buchholz, F.1
Ringrose, L.2
Angrand, P.O.3
Rossi, F.4
Stewart, A.F.5
-
23
-
-
0024328536
-
Altering the genome by homologous recombination
-
Capecchi MR. 1989. Altering the genome by homologous recombination. Science 244(4910): 1288-1292.
-
(1989)
Science
, vol.244
, Issue.4910
, pp. 1288-1292
-
-
Capecchi, M.R.1
-
24
-
-
19544371373
-
Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century
-
Capecchi MR. 2005. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 6(6): 507-512.
-
(2005)
Nat Rev Genet
, vol.6
, Issue.6
, pp. 507-512
-
-
Capecchi, M.R.1
-
25
-
-
78549267889
-
Targeted genome modification in mice using zinc-finger nucleases
-
Carbery ID, Ji D, Harrington A, Brown V, Weinstein EJ, Liaw L and Cui X. 2010. Targeted genome modification in mice using zinc-finger nucleases. Genetics 186(2): 451-459.
-
(2010)
Genetics
, vol.186
, Issue.2
, pp. 451-459
-
-
Carbery, I.D.1
Ji, D.2
Harrington, A.3
Brown, V.4
Weinstein, E.J.5
Liaw, L.6
Cui, X.7
-
26
-
-
78951479577
-
Targeting DNA double-strand breaks with TAL effector nucleases
-
Christian M, Cermak T, Doyle EL, Schmidt C, Zhang F, Hummel A, Bogdanove AJ and Voytas DF. 2010. Targeting DNA double-strand breaks with TAL effector nucleases. Genetics 186(2): 757-761.
-
(2010)
Genetics
, vol.186
, Issue.2
, pp. 757-761
-
-
Christian, M.1
Cermak, T.2
Doyle, E.L.3
Schmidt, C.4
Zhang, F.5
Hummel, A.6
Bogdanove, A.J.7
Voytas, D.F.8
-
27
-
-
0026760426
-
Requirement for a functional Rb-1 gene in murine development
-
Clarke AR, Maandag ER, Van Roon M, Van der Lugt NM, Van der Valk M, Hooper ML, Berns A and Te Riele H. 1992. Requirement for a functional Rb-1 gene in murine development. Nature 359(6393): 328-330.
-
(1992)
Nature
, vol.359
, Issue.6393
, pp. 328-330
-
-
Clarke, A.R.1
Maandag, E.R.2
Van Roon, M.3
Van der Lugt, N.M.4
Van der Valk, M.5
Hooper, M.L.6
Berns, A.7
Te Riele, H.8
-
28
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA and Zhang F. 2013. Multiplex genome engineering using CRISPR/Cas systems. Science 339(6121): 819-823.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
Habib, N.6
Hsu, P.D.7
Wu, X.8
Jiang, W.9
Marraffini, L.A.10
Zhang, F.11
-
29
-
-
84884950106
-
Crispr/ Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity
-
Cradick TJ, Fine EJ, Antico CJ and Bao G. 2013. Crispr/ Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res 41(20): 9584-9592.
-
(2013)
Nucleic Acids Res
, vol.41
, Issue.20
, pp. 9584-9592
-
-
Cradick, T.J.1
Fine, E.J.2
Antico, C.J.3
Bao, G.4
-
30
-
-
70449209123
-
On protein synthesis
-
Crick FH. 1958. On protein synthesis. Symp Soc Exp Biol 12: 138-163.
-
(1958)
Symp Soc Exp Biol
, vol.12
, pp. 138-163
-
-
Crick, F.H.1
-
31
-
-
84892670583
-
Recent progress in genome engineering techniques in the silkworm, bombyx mori
-
Daimon T, Kiuchi T and Takasu Y. 2013. Recent progress in genome engineering techniques in the silkworm, bombyx mori. Dev Growth Differ 56(1): 14-25.
-
(2013)
Dev Growth Differ
, vol.56
, Issue.1
, pp. 14-25
-
-
Daimon, T.1
Kiuchi, T.2
Takasu, Y.3
-
32
-
-
79953250082
-
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
-
Deltcheva E, Chylinski K, Sharma CM, Gonzales K, Chao Y, Pirzada ZA, Eckert MR, Vogel J and Charpentier E. 2011. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature 471(7340): 602-607.
-
(2011)
Nature
, vol.471
, Issue.7340
, pp. 602-607
-
-
Deltcheva, E.1
Chylinski, K.2
Sharma, C.M.3
Gonzales, K.4
Chao, Y.5
Pirzada, Z.A.6
Eckert, M.R.7
Vogel, J.8
Charpentier, E.9
-
33
-
-
38949123143
-
Phage response to CRISPR-encoded resistance in Streptococcus thermophilus
-
Deveau H, Barrangou R, Garneau JE, Labonte J, Fremaux C, Boyaval P, Romero DA, Horvath P and Moineau S. 2008. Phage response to CRISPR-encoded resistance in Streptococcus thermophilus. J Bacteriol 190(4): 1390-1400.
-
(2008)
J Bacteriol
, vol.190
, Issue.4
, pp. 1390-1400
-
-
Deveau, H.1
Barrangou, R.2
Garneau, J.E.3
Labonte, J.4
Fremaux, C.5
Boyaval, P.6
Romero, D.A.7
Horvath, P.8
Moineau, S.9
-
34
-
-
84884904381
-
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
-
Dickinson DJ, Ward JD, Reiner DJ and Goldstein B. 2013. engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat Methods 10(10): 1028-1034.
-
(2013)
Nat Methods
, vol.10
, Issue.10
, pp. 1028-1034
-
-
Dickinson, D.J.1
Ward, J.D.2
Reiner, D.J.3
Goldstein, B.4
-
35
-
-
0023630807
-
Targetted correction of a mutant Hprt gene in mouse embryonic stem cells
-
Doetschman T, Gregg RG, Maeda N, Hooper ML, Melton DW, Thompson S and Smithies O. 1987. Targetted correction of a mutant Hprt gene in mouse embryonic stem cells. Nature 330(6148): 576-578.
-
(1987)
Nature
, vol.330
, Issue.6148
, pp. 576-578
-
-
Doetschman, T.1
Gregg, R.G.2
Maeda, N.3
Hooper, M.L.4
Melton, D.W.5
Thompson, S.6
Smithies, O.7
-
36
-
-
78650912707
-
Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures
-
Doyon Y, Vo TD, Mendel MC, Greenberg SG, Wang J, Xia DF, Miller JC, Urnov FD, Gregory PD and Holmes MC. 2010. Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nat Methods 8(1): 74-79.
-
(2010)
Nat Methods
, vol.8
, Issue.1
, pp. 74-79
-
-
Doyon, Y.1
Vo, T.D.2
Mendel, M.C.3
Greenberg, S.G.4
Wang, J.5
Xia, D.F.6
Miller, J.C.7
Urnov, F.D.8
Gregory, P.D.9
Holmes, M.C.10
-
37
-
-
56649114274
-
A one pot, one step, precision cloning method with high throughput capability
-
Engler C, Kandzia R and Marillonnet S. 2008. A one pot, one step, precision cloning method with high throughput capability. PLoS One 3(11): e3647.
-
(2008)
PLoS One
, vol.3
, Issue.11
-
-
Engler, C.1
Kandzia, R.2
Marillonnet, S.3
-
38
-
-
70349559758
-
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh
-
Favaro R et al. 2009. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12(10): 1248-1256.
-
(2009)
Nat Neurosci
, vol.12
, Issue.10
, pp. 1248-1256
-
-
Favaro, R.1
-
39
-
-
84914162239
-
CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration
-
Fei JF, Schuez M, Tazaki A, Taniguchi Y, Roensch K and Tanaka EM. 2014. CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration. Stem Cell Reports 3(3): 444-459.
-
(2014)
Stem Cell Reports
, vol.3
, Issue.3
, pp. 444-459
-
-
Fei, J.F.1
Schuez, M.2
Tazaki, A.3
Taniguchi, Y.4
Roensch, K.5
Tanaka, E.M.6
-
40
-
-
84900018747
-
Highly efficient targeted mutagenesis in axolotl using Cas9 RNA-guided nuclease
-
Flowers GP, Timberlake AT, Mclean KC, Monaghan JR and Crews CM. 2014. Highly efficient targeted mutagenesis in axolotl using Cas9 RNA-guided nuclease. Development 141(10): 2165-2171.
-
(2014)
Development
, vol.141
, Issue.10
, pp. 2165-2171
-
-
Flowers, G.P.1
Timberlake, A.T.2
McLean, K.C.3
Monaghan, J.R.4
Crews, C.M.5
-
42
-
-
0020396492
-
Patterns of integration of DNA microinjected into cultured mammalian cells: Evidence for homologous recombination between injected plasmid DNA molecules
-
Folger KR, Wong EA, Wahl G and Capecchi MR. 1982. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol 2(11): 1372-1387.
-
(1982)
Mol Cell Biol
, vol.2
, Issue.11
, pp. 1372-1387
-
-
Folger, K.R.1
Wong, E.A.2
Wahl, G.3
Capecchi, M.R.4
-
43
-
-
33748705967
-
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly
-
Forni PE et al. 2006. High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci 26(37): 9593-9602.
-
(2006)
J Neurosci
, vol.26
, Issue.37
, pp. 9593-9602
-
-
Forni, P.E.1
-
44
-
-
84923275611
-
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
-
Frock RL, HU J, Meyers RM, Ho YJ, Kii E and Alt FW. 2015. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol 33(2): 179-186.
-
(2015)
Nat Biotechnol
, vol.33
, Issue.2
, pp. 179-186
-
-
Frock, R.L.1
Hu, J.2
Meyers, R.M.3
Ho, Y.J.4
Kii, E.5
Alt, F.W.6
-
45
-
-
84896929630
-
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
-
Fu Y, Sander JD, Reyon D, Cascio VM and Joung JK. 2014. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol 32(3): 279-284.
-
(2014)
Nat Biotechnol
, vol.32
, Issue.3
, pp. 279-284
-
-
Fu, Y.1
Sander, J.D.2
Reyon, D.3
Cascio, V.M.4
Joung, J.K.5
-
46
-
-
84925405886
-
CRISPR/Cas9-Based Genome editing in Mice by Single Plasmid Injection
-
Fujihara Y and Ikawa M. 2014. CRISPR/Cas9-Based Genome editing in Mice by Single Plasmid Injection. Methods enzymol 546: 319-336.
-
(2014)
Methods enzymol
, vol.546
, pp. 319-336
-
-
Fujihara, Y.1
Ikawa, M.2
-
47
-
-
0028071115
-
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter
-
Furth PA, St Onge L, Boger H, Gruss P, Gossen M, Kistner A, Bujard H and Hennighausen L. 1994. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci USA 91(20): 9302-9306.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.20
, pp. 9302-9306
-
-
Furth, P.A.1
St Onge, L.2
Boger, H.3
Gruss, P.4
Gossen, M.5
Kistner, A.6
Bujard, H.7
Hennighausen, L.8
-
48
-
-
80052766645
-
An unbiased genome-wide analysis of zinc-finger nuclease specificity
-
Gabriel R et al. 2011. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol 29(9): 816-823.
-
(2011)
Nat Biotechnol
, vol.29
, Issue.9
, pp. 816-823
-
-
Gabriel, R.1
-
49
-
-
84864439768
-
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
-
Gaj T, Guo J, Kato Y, Sirk SJ and Barbas CF. 2012. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods 9(8): 805-807.
-
(2012)
Nat Methods
, vol.9
, Issue.8
, pp. 805-807
-
-
Gaj, T.1
Guo, J.2
Kato, Y.3
Sirk, S.J.4
Barbas, C.F.5
-
50
-
-
78149261827
-
The CRISPR/ Cas bacterial immune system cleaves bacteriophage and plasmid DNA
-
Garneau JE, Dupuis ME, Villion M, Romero DA, Barrangou R, Boyaval P, Fremaux C, Horvath P, Magadan AH and Moineau S. 2010. The CRISPR/ Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 468(7320): 67-71.
-
(2010)
Nature
, vol.468
, Issue.7320
, pp. 67-71
-
-
Garneau, J.E.1
Dupuis, M.E.2
Villion, M.3
Romero, D.A.4
Barrangou, R.5
Boyaval, P.6
Fremaux, C.7
Horvath, P.8
Magadan, A.H.9
Moineau, S.10
-
51
-
-
0024043517
-
FLP recombinase is an enzyme
-
Gates CA and Cox MM. 1988. FLP recombinase is an enzyme. Proc Natl Acad Sci USA 85(13): 4628-4632.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, Issue.13
, pp. 4628-4632
-
-
Gates, C.A.1
Cox, M.M.2
-
52
-
-
0024378286
-
The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome
-
Golic KG and Lindquist S. 1989. The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59(3): 499-509.
-
(1989)
Cell
, vol.59
, Issue.3
, pp. 499-509
-
-
Golic, K.G.1
Lindquist, S.2
-
53
-
-
2642522640
-
Genetic transformation of mouse embryos by microinjection of purified DNA
-
Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA and Ruddle FH. 1980. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77(12): 7380-7384.
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, Issue.12
, pp. 7380-7384
-
-
Gordon, J.W.1
Scangos, G.A.2
Plotkin, D.J.3
Barbosa, J.A.4
Ruddle, F.H.5
-
54
-
-
84880088705
-
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease
-
Gratz SJ, Cummings AM, Nguyen JN, Hamm DC, Donohue LK, Harrison MM, Wildonger J and O'Connor-Giles KM. 2013. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics 194(4): 1029-1035.
-
(2013)
Genetics
, vol.194
, Issue.4
, pp. 1029-1035
-
-
Gratz, S.J.1
Cummings, A.M.2
Nguyen, J.N.3
Hamm, D.C.4
Donohue, L.K.5
Harrison, M.M.6
Wildonger, J.7
O'Connor-Giles, K.M.8
-
55
-
-
0031053362
-
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
-
Greisman HA and Pabo CO. 1997. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science 275(5300): 657-661.
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 657-661
-
-
Greisman, H.A.1
Pabo, C.O.2
-
57
-
-
84892771868
-
Efficient RNA/ Cas9-mediated genome editing in Xenopus tropicalis
-
Guo X, Zhang T, Hu Z, Zhang Y, Shi Z, Wang Q, Cui Y, Wang F, Zhao H and Chen Y. 2014. efficient RNA/ Cas9-mediated genome editing in Xenopus tropicalis. Development 141(3): 707-714.
-
(2014)
Development
, vol.141
, Issue.3
, pp. 707-714
-
-
Guo, X.1
Zhang, T.2
Hu, Z.3
Zhang, Y.4
Shi, Z.5
Wang, Q.6
Cui, Y.7
Wang, F.8
Zhao, H.9
Chen, Y.10
-
58
-
-
0021930664
-
Production of transgenic rabbits, sheep and pigs by microinjection
-
Hammer RE, Pursel VG, Rexroad Jr CE, Wall RJ, Bolt DJ, Ebert KM, Palmiter RD and Brinster RL. 1985. Production of transgenic rabbits, sheep and pigs by microinjection. Nature 315(6021): 680-683.
-
(1985)
Nature
, vol.315
, Issue.6021
, pp. 680-683
-
-
Hammer, R.E.1
Pursel, V.G.2
Rexroad, C.E.3
Wall, R.J.4
Bolt, D.J.5
Ebert, K.M.6
Palmiter, R.D.7
Brinster, R.L.8
-
59
-
-
0033230616
-
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
-
Harada N, Tamai Y, Ishikawa T, Sauer B, Takaku K, Oshima M and Taketo MM. 1999. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18(21): 5931-5942.
-
(1999)
EMBO J
, vol.18
, Issue.21
, pp. 5931-5942
-
-
Harada, N.1
Tamai, Y.2
Ishikawa, T.3
Sauer, B.4
Takaku, K.5
Oshima, M.6
Taketo, M.M.7
-
61
-
-
0242609960
-
Maternal inheritance of Cre activity in a Sox2Cre deleter strain
-
Hayashi S, Tenzen T and McMahon AP. 2003. Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis 37(2): 51-53.
-
(2003)
Genesis
, vol.37
, Issue.2
, pp. 51-53
-
-
Hayashi, S.1
Tenzen, T.2
McMahon, A.P.3
-
62
-
-
0031000207
-
Acute leukemia with promyelocytic features in PML/ RARalpha transgenic mice
-
He LZ, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, Soares V, Cattoretti G and Pandolfi PP. 1997. Acute leukemia with promyelocytic features in PML/ RARalpha transgenic mice. Proc Natl Acad Sci USA 94(10): 5302-5307.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.10
, pp. 5302-5307
-
-
He, L.Z.1
Tribioli, C.2
Rivi, R.3
Peruzzi, D.4
Pelicci, P.G.5
Soares, V.6
Cattoretti, G.7
Pandolfi, P.P.8
-
63
-
-
78650735673
-
Human hematopoietic stem/ progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
-
Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, Crooks GM, Kohn DB, Gregory PD, Holmes MC and Cannon PM. 2010. Human hematopoietic stem/ progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8): 839-847.
-
(2010)
Nat Biotechnol
, vol.28
, Issue.8
, pp. 839-847
-
-
Holt, N.1
Wang, J.2
Kim, K.3
Friedman, G.4
Wang, X.5
Taupin, V.6
Crooks, G.M.7
Kohn, D.B.8
Gregory, P.D.9
Holmes, M.C.10
Cannon, P.M.11
-
64
-
-
84884165315
-
DNA targeting specificity of RNA-guided Cas9 nucleases
-
Hsu PD et al. 2013. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol 31(9): 827-832.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.9
, pp. 827-832
-
-
Hsu, P.D.1
-
65
-
-
84874617789
-
Efficient genome editing in zebrafish using a CRISPR-Cas system
-
Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR and Joung JK. 2013. efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol 31(3): 227-229.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.3
, pp. 227-229
-
-
Hwang, W.Y.1
Fu, Y.2
Reyon, D.3
Maeder, M.L.4
Tsai, S.Q.5
Sander, J.D.6
Peterson, R.T.7
Yeh, J.R.8
Joung, J.K.9
-
66
-
-
0023600057
-
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in escherichia Coli, and identification of the gene product
-
Ishino Y, Shinagawa H, Makino K, Amemura M and Nakata A. 1987. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in escherichia Coli, and identification of the gene product. J Bacteriol 169(12): 5429-5433.
-
(1987)
J Bacteriol
, vol.169
, Issue.12
, pp. 5429-5433
-
-
Ishino, Y.1
Shinagawa, H.2
Makino, K.3
Amemura, M.4
Nakata, A.5
-
67
-
-
84882788354
-
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
-
Jao LE, Wente SR and Chen W. 2013. efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci USA 110(34): 13904-13909.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.34
, pp. 13904-13909
-
-
Jao, L.E.1
Wente, S.R.2
Chen, W.3
-
68
-
-
84899719191
-
Essentials of recombinase-based genetic fate mapping in mice
-
Jensen P and Dymecki SM. 2014. essentials of recombinase-based genetic fate mapping in mice. Methods Mol Biol 1092: 437-454.
-
(2014)
Methods Mol Biol
, vol.1092
, pp. 437-454
-
-
Jensen, P.1
Dymecki, S.M.2
-
69
-
-
84886926151
-
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in arabidopsis, tobacco, sorghum and rice
-
Jiang W, Zhou H, BI H, Fromm M, Yang B and Weeks DP. 2013. Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res 41(20): e188.
-
(2013)
Nucleic Acids Res
, vol.41
, Issue.20
-
-
Jiang, W.1
Zhou, H.2
Bi, H.3
Fromm, M.4
Yang, B.5
Weeks, D.P.6
-
70
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA and Charpentier E. 2012. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096): 816-821.
-
(2012)
Science
, vol.337
, Issue.6096
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
Charpentier, E.6
-
71
-
-
0024588265
-
Production of a mutation in mouse en-2 gene by homologous recombination in embryonic stem cells
-
Joyner AL, Skarnes WC and Rossant J. 1989. Production of a mutation in mouse en-2 gene by homologous recombination in embryonic stem cells. Nature 338(6211): 153-156.
-
(1989)
Nature
, vol.338
, Issue.6211
, pp. 153-156
-
-
Joyner, A.L.1
Skarnes, W.C.2
Rossant, J.3
-
72
-
-
0027936418
-
Strain difference in establishment of mouse embryonic stem (ES) cell lines
-
Kawase E, Suemori H, Takahashi N, Okazaki K, Hashimoto K and Nakatsuji N. 1994. Strain difference in establishment of mouse embryonic stem (ES) cell lines. Int J Dev Biol 38(2): 385-390.
-
(1994)
Int J Dev Biol
, vol.38
, Issue.2
, pp. 385-390
-
-
Kawase, E.1
Suemori, H.2
Takahashi, N.3
Okazaki, K.4
Hashimoto, K.5
Nakatsuji, N.6
-
73
-
-
84898778301
-
A guide to genome engineering with programmable nucleases
-
Kim H and Kim JS. 2014. A guide to genome engineering with programmable nucleases. Nat Rev Genet 15(5): 321-334.
-
(2014)
Nat Rev Genet
, vol.15
, Issue.5
, pp. 321-334
-
-
Kim, H.1
Kim, J.S.2
-
74
-
-
84875157258
-
A library of TAL effector nucleases spanning the human genome
-
Kim Y et al. 2013a. A library of TAL effector nucleases spanning the human genome. Nat Biotechnol 31(3): 251-258.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.3
, pp. 251-258
-
-
Kim, Y.1
-
75
-
-
0030032063
-
Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain
-
Kim YG, Cha J and Chandrasegaran S. 1996. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci USA 93(3): 1156-1160.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.3
, pp. 1156-1160
-
-
Kim, Y.G.1
Cha, J.2
Chandrasegaran, S.3
-
77
-
-
84890212376
-
TALEN-based knockout library for human micro RNAs
-
Kim YK, Wee G, Park J, Kim J, Baek D, Kim JS and Kim VN. 2013b. TALEN-based knockout library for human micro RNAs. Nat Struct Mol Biol 20(12): 1458-1464.
-
(2013)
Nat Struct Mol Biol
, vol.20
, Issue.12
, pp. 1458-1464
-
-
Kim, Y.K.1
Wee, G.2
Park, J.3
Kim, J.4
Baek, D.5
Kim, J.S.6
Kim, V.N.7
-
78
-
-
0016669094
-
Evolution at two levels in humans and chimpanzees
-
King MC and Wilson AC. 1975. evolution at two levels in humans and chimpanzees. Science 188(4184): 107-116.
-
(1975)
Science
, vol.188
, Issue.4184
, pp. 107-116
-
-
King, M.C.1
Wilson, A.C.2
-
79
-
-
84914098789
-
Pathways disrupted in human Als motor neurons identified through genetic correction of mutant Sod1
-
Kiskinis E et al. 2014. Pathways disrupted in human Als motor neurons identified through genetic correction of mutant Sod1. Cell Stem Cell 14(6): 781-795.
-
(2014)
Cell Stem Cell
, vol.14
, Issue.6
, pp. 781-795
-
-
Kiskinis, E.1
-
80
-
-
0024332217
-
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells
-
Koller BH, Hagemann LJ, Doetschman T, Hagaman JR, Huang S, Williams PJ, First NL, Maeda N and Smithies O. 1989. Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci USA 86(22): 8927-8931.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, Issue.22
, pp. 8927-8931
-
-
Koller, B.H.1
Hagemann, L.J.2
Doetschman, T.3
Hagaman, J.R.4
Huang, S.5
Williams, P.J.6
First, N.L.7
Maeda, N.8
Smithies, O.9
-
81
-
-
0025313515
-
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
-
Koller BH, Marrack P, Kappler JW and Smithies O. 1990. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248(4960): 1227-1230.
-
(1990)
Science
, vol.248
, Issue.4960
, pp. 1227-1230
-
-
Koller, B.H.1
Marrack, P.2
Kappler, J.W.3
Smithies, O.4
-
82
-
-
84882976110
-
Optical control of mammalian endogenous transcription and epigenetic states
-
Konermann S, Brigham MD, Trevino AE, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM and Zhang F. 2013. Optical control of mammalian endogenous transcription and epigenetic states. Nature 500(7463): 472-476.
-
(2013)
Nature
, vol.500
, Issue.7463
, pp. 472-476
-
-
Konermann, S.1
Brigham, M.D.2
Trevino, A.E.3
Hsu, P.D.4
Heidenreich, M.5
Cong, L.6
Platt, R.J.7
Scott, D.A.8
Church, G.M.9
Zhang, F.10
-
83
-
-
84891757565
-
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
-
Koscielny G et al. 2014. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res 42(Database issue): D802-809.
-
(2014)
Nucleic Acids Res
, vol.42
, Issue.Database issue
, pp. D802-D809
-
-
Koscielny, G.1
-
84
-
-
84916219205
-
TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human embryonic Stem Cells towards endoderm
-
Krentz NA, Nian C and Lynn FC. 2014. TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human embryonic Stem Cells towards endoderm. PLoS One 9(12): e114275.
-
(2014)
PLoS One
, vol.9
, Issue.12
-
-
Krentz, N.A.1
Nian, C.2
Lynn, F.C.3
-
85
-
-
36248958190
-
Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
-
Lagace DC et al. 2007. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci 27(46): 12623-12629.
-
(2007)
J Neurosci
, vol.27
, Issue.46
, pp. 12623-12629
-
-
Lagace, D.C.1
-
86
-
-
0026638820
-
Targeted oncogene activation by site-specific recombination in transgenic mice
-
Lakso M, Sauer B, Mosinger Jr B, Lee EJ, Manning RW, YU SH, Mulder KL and Westphal H. 1992. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci USA 89(14): 6232-6236.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.14
, pp. 6232-6236
-
-
Lakso, M.1
Sauer, B.2
Mosinger, B.3
Lee, E.J.4
Manning, R.W.5
Yu, S.H.6
Mulder, K.L.7
Westphal, H.8
-
87
-
-
0034026486
-
On the possibilities and limitations of rational protein design to expand the specificity of restriction enzymes: A case study employing ecoRV as the target
-
Lanio T, Jeltsch A and Pingoud A. 2000. On the possibilities and limitations of rational protein design to expand the specificity of restriction enzymes: a case study employing ecoRV as the target. Protein eng 13(4): 275-281.
-
(2000)
Protein eng
, vol.13
, Issue.4
, pp. 275-281
-
-
Lanio, T.1
Jeltsch, A.2
Pingoud, A.3
-
88
-
-
84865797462
-
Mastr: A technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice
-
Lao Z, Raju GP, Bai CB and Joyner AL. 2012. Mastr: a technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice. Cell Rep 2(2): 386-396.
-
(2012)
Cell Rep
, vol.2
, Issue.2
, pp. 386-396
-
-
Lao, Z.1
Raju, G.P.2
Bai, C.B.3
Joyner, A.L.4
-
89
-
-
84904737686
-
Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice
-
Lee AY and Lloyd KC. 2014. Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice. FEBS Open Bio 4: 637-642.
-
(2014)
FEBS Open Bio
, vol.4
, pp. 637-642
-
-
Lee, A.Y.1
Lloyd, K.C.2
-
90
-
-
0037819447
-
Transcription regulation and animal diversity
-
Levine M and Tjian R. 2003. Transcription regulation and animal diversity. Nature 424(6945): 147-151.
-
(2003)
Nature
, vol.424
, Issue.6945
, pp. 147-151
-
-
Levine, M.1
Tjian, R.2
-
91
-
-
0035491607
-
Conditional control of gene expression in the mouse
-
Lewandoski M. 2001. Conditional control of gene expression in the mouse. Nat Rev Genet 2(10): 743-755.
-
(2001)
Nat Rev Genet
, vol.2
, Issue.10
, pp. 743-755
-
-
Lewandoski, M.1
-
92
-
-
0031252296
-
Cre-mediated chromosome loss in mice
-
Lewandoski M and Martin GR. 1997. Cre-mediated chromosome loss in mice. Nat Genet 17(2): 223-225.
-
(1997)
Nat Genet
, vol.17
, Issue.2
, pp. 223-225
-
-
Lewandoski, M.1
Martin, G.R.2
-
93
-
-
84897564599
-
Simultaneous gene editing by injection of m RNAs encoding transcription activator-like effector nucleases into mouse zygotes
-
Li C, Qi R, Singleterry R, Hyle J, Balch A, LI X, Sublett J, Berns H, Valentine M, Valentine V and Sherr CJ. 2014. Simultaneous gene editing by injection of m RNAs encoding transcription activator-like effector nucleases into mouse zygotes. Mol Cell Biol 34(9): 1649-1658.
-
(2014)
Mol Cell Biol
, vol.34
, Issue.9
, pp. 1649-1658
-
-
Li, C.1
Qi, R.2
Singleterry, R.3
Hyle, J.4
Balch, A.5
Li, X.6
Sublett, J.7
Berns, H.8
Valentine, M.9
Valentine, V.10
Sherr, C.J.11
-
94
-
-
79960424171
-
In vivo genome editing restores haemostasis in a mouse model of haemophilia
-
Li H et al. 2011. In vivo genome editing restores haemostasis in a mouse model of haemophilia. Nature 475(7355): 217-221.
-
(2011)
Nature
, vol.475
, Issue.7355
, pp. 217-221
-
-
Li, H.1
-
95
-
-
84929490224
-
Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9
-
Li HL et al. 2014. Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9. Stem Cell Reports.
-
(2014)
Stem Cell Reports.
-
-
Li, H.L.1
-
96
-
-
84903818736
-
Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system
-
Liu P, Long L, Xiong K, YU B, Chang N, Xiong JW, Zhu Z and Liu D. 2014. Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system. Cell Res 24(7): 886-889.
-
(2014)
Cell Res
, vol.24
, Issue.7
, pp. 886-889
-
-
Liu, P.1
Long, L.2
Xiong, K.3
Yu, B.4
Chang, N.5
Xiong, J.W.6
Zhu, Z.7
Liu, D.8
-
97
-
-
0033561410
-
Z/AP, a double reporter for cre-mediated recombination
-
Lobe CG, Koop KE, Kreppner W, Lomeli H, Gertsenstein M and Nagy A. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208(2): 281-292.
-
(1999)
Dev Biol
, vol.208
, Issue.2
, pp. 281-292
-
-
Lobe, C.G.1
Koop, K.E.2
Kreppner, W.3
Lomeli, H.4
Gertsenstein, M.5
Nagy, A.6
-
98
-
-
84907200149
-
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline Dna
-
Long C, McAnally JR, Shelton JM, Mireault AA, Bassel-Duby R and Olson EN. 2014. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline Dna. Science 345(6201): 1184-1188.
-
(2014)
Science
, vol.345
, Issue.6201
, pp. 1184-1188
-
-
Long, C.1
McAnally, J.R.2
Shelton, J.M.3
Mireault, A.A.4
Bassel-Duby, R.5
Olson, E.N.6
-
99
-
-
0035979247
-
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
-
Loonstra A, Vooijs M, Beverloo HB, Allak BA, Van Drunen E, Kanaar R, Berns A and Jonkers J. 2001. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci USA 98(16): 9209-9214.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.16
, pp. 9209-9214
-
-
Loonstra, A.1
Vooijs, M.2
Beverloo, H.B.3
Allak, B.A.4
Van Drunen, E.5
Kanaar, R.6
Berns, A.7
Jonkers, J.8
-
100
-
-
0025346057
-
XY female mice resulting from a heritable mutation in the primary testis-determining gene, TDY
-
Lovell-Badge R and Robertson E. 1990. XY female mice resulting from a heritable mutation in the primary testis-determining gene, TDY. Development 109(3): 635-646.
-
(1990)
Development
, vol.109
, Issue.3
, pp. 635-646
-
-
Lovell-Badge, R.1
Robertson, E.2
-
101
-
-
84892689751
-
Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair
-
Low Be, Krebs MP, Joung JK, Tsai SQ, Nishina PM and Wiles MV. 2013. Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci 55(1): 387-395.
-
(2013)
Invest Ophthalmol Vis Sci
, vol.55
, Issue.1
, pp. 387-395
-
-
Low, B.E.1
Krebs, M.P.2
Joung, J.K.3
Tsai, S.Q.4
Nishina, P.M.5
Wiles, M.V.6
-
102
-
-
84893756373
-
Dynamic expression of N-myc in mouse embryonic development using an enhanced green fluorescent protein reporter gene in the N-myc locus
-
Ma M, Zhao K, WU W, Sun R and Fei J. 2014. Dynamic expression of N-myc in mouse embryonic development using an enhanced green fluorescent protein reporter gene in the N-myc locus. Dev Growth Differ 56(2): 152-160.
-
(2014)
Dev Growth Differ
, vol.56
, Issue.2
, pp. 152-160
-
-
Ma, M.1
Zhao, K.2
Wu, W.3
Sun, R.4
Fei, J.5
-
103
-
-
84897068699
-
CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori
-
Ma S, Chang J, Wang X, Liu Y, Zhang J, Lu W, Gao J, Shi R, Zhao P and Xia Q. 2014. CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori. Sci Rep 4: 4489.
-
(2014)
Sci Rep
, vol.4
, pp. 4489
-
-
Ma, S.1
Chang, J.2
Wang, X.3
Liu, Y.4
Zhang, J.5
Lu, W.6
Gao, J.7
Shi, R.8
Zhao, P.9
Xia, Q.10
-
104
-
-
84897140631
-
Heritable multiplex genetic engineering in rats using CRISPR/Cas9
-
Ma Y, Shen B, Zhang X, Lu Y, Chen W, Ma J, Huang X and Zhang L. 2014. Heritable multiplex genetic engineering in rats using CRISPR/Cas9. PLoS One 9(3): e89413.
-
(2014)
PLoS One
, vol.9
, Issue.3
-
-
Ma, Y.1
Shen, B.2
Zhang, X.3
Lu, Y.4
Chen, W.5
Ma, J.6
Huang, X.7
Zhang, L.8
-
105
-
-
84891745242
-
Generating rats with conditional alleles using CRISPR/Cas9
-
Ma Y, Zhang X, Shen B, Lu Y, Chen W, Ma J, Bai L, Huang X and Zhang L. 2013. Generating rats with conditional alleles using CRISPR/Cas9. Cell Res 24(1): 122-125.
-
(2013)
Cell Res
, vol.24
, Issue.1
, pp. 122-125
-
-
Ma, Y.1
Zhang, X.2
Shen, B.3
Lu, Y.4
Chen, W.5
Ma, J.6
Bai, L.7
Huang, X.8
Zhang, L.9
-
106
-
-
2942512013
-
Cell type-specific effects of Rb deletion in the murine retina
-
Macpherson D, Sage J, Kim T, Ho D, Mclaughlin ME and Jacks T. 2004. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev 18(14): 1681-1694.
-
(2004)
Genes Dev
, vol.18
, Issue.14
, pp. 1681-1694
-
-
McPherson, D.1
Sage, J.2
Kim, T.3
Ho, D.4
McLaughlin, M.E.5
Jacks, T.6
-
107
-
-
84890048526
-
Targeted DNA demethylation and activation of endogenous genes using programmable Tale-Tet1 fusion proteins
-
Maeder ML et al. 2013. Targeted DNA demethylation and activation of endogenous genes using programmable Tale-Tet1 fusion proteins. Nat Biotechnol 31(12): 1137-1142.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.12
, pp. 1137-1142
-
-
Maeder, M.L.1
-
108
-
-
47349097567
-
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification
-
Maeder ML et al. 2008. Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell 31(2): 294-301.
-
(2008)
Mol Cell
, vol.31
, Issue.2
, pp. 294-301
-
-
Maeder, M.L.1
-
109
-
-
0023112583
-
Oncogenesis of the lens in transgenic mice
-
Mahon KA, Chepelinsky AB, Khillan JS, Overbeek PA, Piatigorsky J and Westphal H. 1987. Oncogenesis of the lens in transgenic mice. Science 235(4796): 1622-1628.
-
(1987)
Science
, vol.235
, Issue.4796
, pp. 1622-1628
-
-
Mahon, K.A.1
Chepelinsky, A.B.2
Khillan, J.S.3
Overbeek, P.A.4
Piatigorsky, J.5
Westphal, H.6
-
110
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali P, Yang L, Esvelt KM, Aach J, Guell M, Dicarlo JE, Norville JE and Church GM. 2013. RNA-guided human genome engineering via Cas9. Science 339(6121): 823-826.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 823-826
-
-
Mali, P.1
Yang, L.2
Esvelt, K.M.3
Aach, J.4
Guell, M.5
Dicarlo, J.E.6
Norville, J.E.7
Church, G.M.8
-
111
-
-
0024296027
-
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
-
Mansour SL, Thomas KR and Capecchi MR. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336(6197): 348-352.
-
(1988)
Nature
, vol.336
, Issue.6197
, pp. 348-352
-
-
Mansour, S.L.1
Thomas, K.R.2
Capecchi, M.R.3
-
112
-
-
0001007610
-
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
-
Martin GR. 1981. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78(12): 7634-7638.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, Issue.12
, pp. 7634-7638
-
-
Martin, G.R.1
-
113
-
-
85017411131
-
A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis
-
Mazeyrat S, Saut N, Grigoriev V, Mahadevaiah SK, Ojarikre OA, Rattigan A, Bishop C, Eicher EM, Mitchell MJ and Burgoyne PS. 2001. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet 29(1): 49-53.
-
(2001)
Nat Genet
, vol.29
, Issue.1
, pp. 49-53
-
-
Mazeyrat, S.1
Saut, N.2
Grigoriev, V.3
Mahadevaiah, S.K.4
Ojarikre, O.A.5
Rattigan, A.6
Bishop, C.7
Eicher, E.M.8
Mitchell, M.J.9
Burgoyne, P.S.10
-
114
-
-
0026504525
-
Homeobox genes and axial patterning
-
Mcginnis W and Krumlauf R. 1992. Homeobox genes and axial patterning. Cell 68(2): 283-302.
-
(1992)
Cell
, vol.68
, Issue.2
, pp. 283-302
-
-
McGinnis, W.1
Krumlauf, R.2
-
115
-
-
0022803360
-
Identification of the crossover site during FLP-mediated recombination in the Saccharomyces cerevisiae plasmid 2 microns circle
-
Mcleod M, Craft S and Broach JR. 1986. Identification of the crossover site during FLP-mediated recombination in the Saccharomyces cerevisiae plasmid 2 microns circle. Mol Cell Biol 6(10): 3357-3367.
-
(1986)
Mol Cell Biol
, vol.6
, Issue.10
, pp. 3357-3367
-
-
McLeod, M.1
Craft, S.2
Broach, J.R.3
-
116
-
-
84876557961
-
Quantitative analysis of TALE-DNA interactions suggests polarity effects
-
Meckler JF et al. 2013. Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res 41(7): 4118-4128.
-
(2013)
Nucleic Acids Res
, vol.41
, Issue.7
, pp. 4118-4128
-
-
Meckler, J.F.1
-
117
-
-
84886084801
-
Locus-specific editing of histone modifications at endogenous enhancers
-
Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK and Bernstein BE. 2013. Locus-specific editing of histone modifications at endogenous enhancers. Nat Biotechnol 31(12): 1133-1136.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.12
, pp. 1133-1136
-
-
Mendenhall, E.M.1
Williamson, K.E.2
Reyon, D.3
Zou, J.Y.4
Ram, O.5
Joung, J.K.6
Bernstein, B.E.7
-
118
-
-
77957005768
-
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
-
Meyer M, De Angelis MH, Wurst W and Kuhn R. 2010. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci USA 107(34): 15022-15026.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.34
, pp. 15022-15026
-
-
Meyer, M.1
De Angelis, M.H.2
Wurst, W.3
Kuhn, R.4
-
119
-
-
34447319080
-
An improved zinc-finger nuclease architecture for highly specific genome editing
-
Miller JC et al. 2007. An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol 25(7): 778-785.
-
(2007)
Nat Biotechnol
, vol.25
, Issue.7
, pp. 778-785
-
-
Miller, J.C.1
-
120
-
-
79551685675
-
A TALE nuclease architecture for efficient genome editing
-
Miller JC et al. 2010. A TALE nuclease architecture for efficient genome editing. Nat Biotechnol 29(2): 143-148.
-
(2010)
Nat Biotechnol
, vol.29
, Issue.2
, pp. 143-148
-
-
Miller, J.C.1
-
122
-
-
33847682924
-
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
-
Moehle EA, Rock JM, Lee YL, Jouvenot Y, Dekelver RC, Gregory PD, Urnov FD and Holmes MC. 2007. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc Natl Acad Sci USA 104(9): 3055-3060.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.9
, pp. 3055-3060
-
-
Moehle, E.A.1
Rock, J.M.2
Lee, Y.L.3
Jouvenot, Y.4
Dekelver, R.C.5
Gregory, P.D.6
Urnov, F.D.7
Holmes, M.C.8
-
123
-
-
0034034401
-
Biological significance of a family of regularly spaced repeats in the genomes of archaea, bacteria and mitochondria
-
Mojica FJ, Diez-Villasenor C, Soria E and Juez G. 2000. Biological significance of a family of regularly spaced repeats in the genomes of archaea, bacteria and mitochondria. Mol Microbiol 36(1): 244-246.
-
(2000)
Mol Microbiol
, vol.36
, Issue.1
, pp. 244-246
-
-
Mojica, F.J.1
Diez-Villasenor, C.2
Soria, E.3
Juez, G.4
-
124
-
-
16444385662
-
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
-
Mojica FJ, Diez-Villasenor C, Garcia-Martinez J and Soria E. 2005. Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J Mol evol 60(2): 174-182.
-
(2005)
J Mol evol
, vol.60
, Issue.2
, pp. 174-182
-
-
Mojica, F.J.1
Diez-Villasenor, C.2
Garcia-Martinez, J.3
Soria, E.4
-
125
-
-
72149090954
-
A simple cipher governs DNA recognition by TAL effectors
-
Moscou MJ and Bogdanove AJ. 2009. A simple cipher governs DNA recognition by TAL effectors. Science 326(5959): 1501.
-
(2009)
Science
, vol.326
, Issue.5959
, pp. 1501
-
-
Moscou, M.J.1
Bogdanove, A.J.2
-
126
-
-
84894081986
-
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
-
Niu Y et al. 2014. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156(4): 836-843.
-
(2014)
Cell
, vol.156
, Issue.4
, pp. 836-843
-
-
Niu, Y.1
-
127
-
-
0030904130
-
'Green mice' as a source of ubiquitous green cells
-
Okabe M, Ikawa M, Kominami K, Nakanishi T and Nishimune Y. 1997. 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407(3): 313-319.
-
(1997)
FEBS Lett
, vol.407
, Issue.3
, pp. 313-319
-
-
Okabe, M.1
Ikawa, M.2
Kominami, K.3
Nakanishi, T.4
Nishimune, Y.5
-
128
-
-
0026764280
-
Tissue-and site-specific DNA recombination in transgenic mice
-
Orban PC, Chui D and Marth JD. 1992. Tissue-and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA 89(15): 6861-6865.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.15
, pp. 6861-6865
-
-
Orban, P.C.1
Chui, D.2
Marth, J.D.3
-
129
-
-
84878580410
-
TALEN-based gene correction for epidermolysis bullosa
-
Osborn MJ et al. 2013. TALEN-based gene correction for epidermolysis bullosa. Mol Ther 21(6): 1151-1159.
-
(2013)
Mol Ther
, vol.21
, Issue.6
, pp. 1151-1159
-
-
Osborn, M.J.1
-
130
-
-
0020470466
-
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes
-
Palmiter RD, Brinster RL, Hammer RE, Trumbauer Me, Rosenfeld MG, Birnberg NC and Evans RM. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300(5893): 611-615.
-
(1982)
Nature
, vol.300
, Issue.5893
, pp. 611-615
-
-
Palmiter, R.D.1
Brinster, R.L.2
Hammer, R.E.3
Trumbauer, M.4
Rosenfeld, M.G.5
Birnberg, N.C.6
Evans, R.M.7
-
131
-
-
84884155038
-
High-throughput profiling of off-target Dna cleavage reveals Rna-programmed Cas9 nuclease specificity
-
Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna JA and Liu DR. 2013. High-throughput profiling of off-target Dna cleavage reveals Rna-programmed Cas9 nuclease specificity. Nat Biotechnol 31(9): 839-843.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.9
, pp. 839-843
-
-
Pattanayak, V.1
Lin, S.2
Guilinger, J.P.3
Ma, E.4
Doudna, J.A.5
Liu, D.R.6
-
132
-
-
46949095221
-
Establishment of Hiv-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
-
Perez EE et al. 2008. establishment of Hiv-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol 26(7): 808-816.
-
(2008)
Nat Biotechnol
, vol.26
, Issue.7
, pp. 808-816
-
-
Perez, E.E.1
-
133
-
-
84912101598
-
Crispr-Cas9 knockin mice for genome editing and cancer modeling
-
Platt RJ et al. 2014. Crispr-Cas9 knockin mice for genome editing and cancer modeling. Cell 159(2): 440-455.
-
(2014)
Cell
, vol.159
, Issue.2
, pp. 440-455
-
-
Platt, R.J.1
-
134
-
-
15844390228
-
Crispr elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
-
Pourcel C, Salvignol G and Vergnaud G. 2005. Crispr elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology 151(Pt 3): 653-663.
-
(2005)
Microbiology
, vol.151
, pp. 653-663
-
-
Pourcel, C.1
Salvignol, G.2
Vergnaud, G.3
-
135
-
-
84878826580
-
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases
-
Qiu Z et al. 2013. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res 41(11): e120.
-
(2013)
Nucleic Acids Res
, vol.41
, Issue.11
-
-
Qiu, Z.1
-
136
-
-
42949083192
-
Unexpected failure rates for modular assembly of engineered zinc fingers
-
Ramirez CL et al. 2008. Unexpected failure rates for modular assembly of engineered zinc fingers. Nat Methods 5(5): 374-375.
-
(2008)
Nat Methods
, vol.5
, Issue.5
, pp. 374-375
-
-
Ramirez, C.L.1
-
137
-
-
0036195992
-
A Hoxa2 mutant conditional allele generated by Flp-and Cre-mediated recombination
-
Ren SY, Pasqualetti M, Dierich A, Le Meur M and Rijli FM. 2002. A Hoxa2 mutant conditional allele generated by Flp-and Cre-mediated recombination. Genesis 32(2): 105-108.
-
(2002)
Genesis
, vol.32
, Issue.2
, pp. 105-108
-
-
Ren, S.Y.1
Pasqualetti, M.2
Dierich, A.3
Le Meur, M.4
Rijli, F.M.5
-
138
-
-
84888108873
-
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9
-
Ren X et al. 2013. Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci USA 110(47): 19012-19017.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.47
, pp. 19012-19017
-
-
Ren, X.1
-
139
-
-
35548939950
-
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene
-
Romer P, Hahn S, Jordan T, Strauss T, Bonas U and Lahaye T. 2007. Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science 318(5850): 645-648.
-
(2007)
Science
, vol.318
, Issue.5850
, pp. 645-648
-
-
Romer, P.1
Hahn, S.2
Jordan, T.3
Strauss, T.4
Bonas, U.5
Lahaye, T.6
-
140
-
-
78650863981
-
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)
-
Sander JD et al. 2010. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods 8(1): 67-69.
-
(2010)
Nat Methods
, vol.8
, Issue.1
, pp. 67-69
-
-
Sander, J.D.1
-
141
-
-
84900314611
-
CRISPR-Cas systems for editing, regulating and targeting genomes
-
Sander JD and Joung JK. 2014. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol 32(4): 347-355.
-
(2014)
Nat Biotechnol
, vol.32
, Issue.4
, pp. 347-355
-
-
Sander, J.D.1
Joung, J.K.2
-
142
-
-
0024041732
-
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1
-
Sauer B and Henderson N. 1988. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci USA 85(14): 5166-5170.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, Issue.14
, pp. 5166-5170
-
-
Sauer, B.1
Henderson, N.2
-
143
-
-
0034876289
-
Bidirectional transcriptional activity of Pgk-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice
-
Scacheri PC, Crabtree JS, Novotny EA, Garrett-Beal L, Chen A, Edgemon KA, Marx SJ, Spiegel AM, Chandrasekharappa SC and Collins FS. 2001. Bidirectional transcriptional activity of Pgk-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice. Genesis 30(4): 259-263.
-
(2001)
Genesis
, vol.30
, Issue.4
, pp. 259-263
-
-
Scacheri, P.C.1
Crabtree, J.S.2
Novotny, E.A.3
Garrett-Beal, L.4
Chen, A.5
Edgemon, K.A.6
Marx, S.J.7
Spiegel, A.M.8
Chandrasekharappa, S.C.9
Collins, F.S.10
-
144
-
-
34548392767
-
Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination
-
Schmidt-Supprian M, Wunderlich FT and Rajewsky K. 2007. excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination. Transgenic Res 16(5): 657-660.
-
(2007)
Transgenic Res
, vol.16
, Issue.5
, pp. 657-660
-
-
Schmidt-Supprian, M.1
Wunderlich, F.T.2
Rajewsky, K.3
-
145
-
-
0034610394
-
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
-
Schmidt EE, Taylor DS, Prigge JR, Barnett S and Capecchi MR. 2000. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci USA 97(25): 13702-13707.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.25
, pp. 13702-13707
-
-
Schmidt, E.E.1
Taylor, D.S.2
Prigge, J.R.3
Barnett, S.4
Capecchi, M.R.5
-
146
-
-
84905483274
-
Out with the old, in with the new: Reassessing morpholino knockdowns in light of genome editing technology
-
Schulte-Merker S and Stainier DY. 2014. Out with the old, in with the new: reassessing morpholino knockdowns in light of genome editing technology. Development 141(16): 3103-3104.
-
(2014)
Development
, vol.141
, Issue.16
, pp. 3103-3104
-
-
Schulte-Merker, S.1
Stainier, D.Y.2
-
147
-
-
84890033064
-
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
-
Schwank G et al. 2013. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 13(6): 653-658.
-
(2013)
Cell Stem Cell
, vol.13
, Issue.6
, pp. 653-658
-
-
Schwank, G.1
-
148
-
-
0024473608
-
Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells
-
Schwartzberg PL, Goff SP and Robertson EJ. 1989. Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science 246(4931): 799-803.
-
(1989)
Science
, vol.246
, Issue.4931
, pp. 799-803
-
-
Schwartzberg, P.L.1
Goff, S.P.2
Robertson, E.J.3
-
149
-
-
0030662479
-
Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains
-
Schwenk F, Sauer B, Kukoc N, Hoess R, Muller W, Kocks C, Kuhn R and Rajewsky K. 1997. Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains. J Immunol Methods 207(2): 203-212.
-
(1997)
J Immunol Methods
, vol.207
, Issue.2
, pp. 203-212
-
-
Schwenk, F.1
Sauer, B.2
Kukoc, N.3
Hoess, R.4
Muller, W.5
Kocks, C.6
Kuhn, R.7
Rajewsky, K.8
-
150
-
-
80054918967
-
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases
-
Sebastiano V et al. 2011. In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells 29(11): 1717-1726.
-
(2011)
Stem Cells
, vol.29
, Issue.11
, pp. 1717-1726
-
-
Sebastiano, V.1
-
151
-
-
0022389290
-
Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
-
Smithies O, Gregg RG, Boggs SS, Koralewski MA and Kucherlapati RS. 1985. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 317(6034): 230-234.
-
(1985)
Nature
, vol.317
, Issue.6034
, pp. 230-234
-
-
Smithies, O.1
Gregg, R.G.2
Boggs, S.S.3
Koralewski, M.A.4
Kucherlapati, R.S.5
-
152
-
-
84892582306
-
Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases
-
Sommer D et al. 2014. efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat Commun 5: 3045.
-
(2014)
Nat Commun
, vol.5
, pp. 3045
-
-
Sommer, D.1
-
153
-
-
0019967916
-
Transposition of cloned P elements into Drosophila germ line chromosomes
-
Spradling AC and Rubin GM. 1982. Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218(4570): 341-347.
-
(1982)
Science
, vol.218
, Issue.4570
, pp. 341-347
-
-
Spradling, A.C.1
Rubin, G.M.2
-
154
-
-
0019888362
-
Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites
-
Sternberg N and Hamilton D. 1981. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J Mol Biol 150(4): 467-486.
-
(1981)
J Mol Biol
, vol.150
, Issue.4
, pp. 467-486
-
-
Sternberg, N.1
Hamilton, D.2
-
155
-
-
84908042682
-
Tissue-specific genome editing in Ciona embryos by Crispr/Cas9
-
Stolfi A, Gandhi S, Salek F and Christiaen L. 2014. Tissue-specific genome editing in Ciona embryos by Crispr/Cas9. Development 141(21): 4115-4120.
-
(2014)
Development
, vol.141
, Issue.21
, pp. 4115-4120
-
-
Stolfi, A.1
Gandhi, S.2
Salek, F.3
Christiaen, L.4
-
157
-
-
34247191950
-
Tetracycline-inducible expression systems: New strategies and practices in the transgenic mouse modeling
-
Sun Y, Chen X and Xiao D. 2007. Tetracycline-inducible expression systems: new strategies and practices in the transgenic mouse modeling. Acta Biochim Biophys Sin (Shanghai) 39(4): 235-246.
-
(2007)
Acta Biochim Biophys Sin (Shanghai)
, vol.39
, Issue.4
, pp. 235-246
-
-
Sun, Y.1
Chen, X.2
Xiao, D.3
-
158
-
-
84872194963
-
Knockout mice created by TALEN-mediated gene targeting
-
Sung YH, Baek IJ, Kim DH, Jeon J, Lee J, Lee K, Jeong D, Kim JS and Lee HW. 2013. Knockout mice created by TALEN-mediated gene targeting. Nat Biotechnol 31(1): 23-24.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.1
, pp. 23-24
-
-
Sung, Y.H.1
Baek, I.J.2
Kim, D.H.3
Jeon, J.4
Lee, J.5
Lee, K.6
Jeong, D.7
Kim, J.S.8
Lee, H.W.9
-
159
-
-
34447323568
-
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
-
Szczepek M, Brondani V, Buchel J, Serrano L, Segal DJ and Cathomen T. 2007. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol 25(7): 786-793.
-
(2007)
Nat Biotechnol
, vol.25
, Issue.7
, pp. 786-793
-
-
Szczepek, M.1
Brondani, V.2
Buchel, J.3
Serrano, L.4
Segal, D.J.5
Cathomen, T.6
-
160
-
-
0242300262
-
Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse
-
Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K and Kaneko T. 2003. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 467(1): 60-79.
-
(2003)
J Comp Neurol
, vol.467
, Issue.1
, pp. 60-79
-
-
Tamamaki, N.1
Yanagawa, Y.2
Tomioka, R.3
Miyazaki, J.4
Obata, K.5
Kaneko, T.6
-
161
-
-
84882792150
-
A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation
-
Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B and Cepko CL. 2013. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell 154(4): 928-939.
-
(2013)
Cell
, vol.154
, Issue.4
, pp. 928-939
-
-
Tang, J.C.1
Szikra, T.2
Kozorovitskiy, Y.3
Teixiera, M.4
Sabatini, B.L.5
Roska, B.6
Cepko, C.L.7
-
162
-
-
0023646810
-
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
-
Thomas KR and Capecchi MR. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51(3): 503-512.
-
(1987)
Cell
, vol.51
, Issue.3
, pp. 503-512
-
-
Thomas, K.R.1
Capecchi, M.R.2
-
163
-
-
0025074908
-
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
-
Thomas KR and Capecchi MR. 1990. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346(6287): 847-850.
-
(1990)
Nature
, vol.346
, Issue.6287
, pp. 847-850
-
-
Thomas, K.R.1
Capecchi, M.R.2
-
164
-
-
84891509001
-
Tissue-specific and ubiquitous gene knockouts by TALEN electroporation provide new approaches to investigating gene function in Ciona
-
Treen N, Yoshida K, Sakuma T, Sasaki H, Kawai N, Yamamoto T and Sasakura Y. 2013. Tissue-specific and ubiquitous gene knockouts by TALEN electroporation provide new approaches to investigating gene function in Ciona. Development 141(2): 481-487.
-
(2013)
Development
, vol.141
, Issue.2
, pp. 481-487
-
-
Treen, N.1
Yoshida, K.2
Sakuma, T.3
Sasaki, H.4
Kawai, N.5
Yamamoto, T.6
Sasakura, Y.7
-
165
-
-
0037010178
-
When reverse genetics meets physiology: The use of site-specific recombinases in mice
-
Tronche F, Casanova E, Turiault M, Sahly I and Kellendonk C. 2002. When reverse genetics meets physiology: the use of site-specific recombinases in mice. Febs Lett 529(1): 116-121.
-
(2002)
Febs Lett
, vol.529
, Issue.1
, pp. 116-121
-
-
Tronche, F.1
Casanova, E.2
Turiault, M.3
Sahly, I.4
Kellendonk, C.5
-
166
-
-
82655181514
-
Site-specific recombinases: From tag-and-target-to tag-and-exchange-based genomic modifications
-
Turan S and Bode J. 2011. Site-specific recombinases: from tag-and-target-to tag-and-exchange-based genomic modifications. FASEB J 25(12): 4088-4107.
-
(2011)
FASEB J
, vol.25
, Issue.12
, pp. 4088-4107
-
-
Turan, S.1
Bode, J.2
-
167
-
-
18944373328
-
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
-
Urnov FD, Miller JC, Lee YL, Beausejour CM, Rock JM, Augustus S, Jamieson AC, Porteus MH, Gregory PD and Holmes MC. 2005. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435(7042): 646-651.
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 646-651
-
-
Urnov, F.D.1
Miller, J.C.2
Lee, Y.L.3
Beausejour, C.M.4
Rock, J.M.5
Augustus, S.6
Jamieson, A.C.7
Porteus, M.H.8
Gregory, P.D.9
Holmes, M.C.10
-
168
-
-
77955867185
-
Genome editing with engineered zinc finger nucleases
-
Urnov FD, Rebar EJ, Holmes MC, Zhang HS and Gregory PD. 2010. Genome editing with engineered zinc finger nucleases. Nat Rev Genet 11(9): 636-646.
-
(2010)
Nat Rev Genet
, vol.11
, Issue.9
, pp. 636-646
-
-
Urnov, F.D.1
Rebar, E.J.2
Holmes, M.C.3
Zhang, H.S.4
Gregory, P.D.5
-
169
-
-
84866114887
-
Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland
-
Van Amerongen R, Bowman AN and Nusse R. 2012. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11(3): 387-400.
-
(2012)
Cell Stem Cell
, vol.11
, Issue.3
, pp. 387-400
-
-
Van Amerongen, R.1
Bowman, A.N.2
Nusse, R.3
-
170
-
-
0035895505
-
The sequence of the human genome
-
Venter JC et al. 2001. The sequence of the human genome. Science 291(5507): 1304-1351.
-
(2001)
Science
, vol.291
, Issue.5507
, pp. 1304-1351
-
-
Venter, J.C.1
-
171
-
-
0035029433
-
A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
-
Vooijs M, Jonkers J and Berns A. 2001. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep 2(4): 292-297.
-
(2001)
EMBO Rep
, vol.2
, Issue.4
, pp. 292-297
-
-
Vooijs, M.1
Jonkers, J.2
Berns, A.3
-
172
-
-
84880285567
-
TALEN-mediated editing of the mouse Y chromosome
-
Wang H et al. 2013. TALEN-mediated editing of the mouse Y chromosome. Nat Biotechnol 31(6): 530-532.
-
(2013)
Nat Biotechnol
, vol.31
, Issue.6
, pp. 530-532
-
-
Wang, H.1
-
173
-
-
84908612662
-
A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina
-
Wang S, Sengel C, Emerson MM and Cepko CL. 2014. A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina. Dev Cell 30(5): 513-527.
-
(2014)
Dev Cell
, vol.30
, Issue.5
, pp. 513-527
-
-
Wang, S.1
Sengel, C.2
Emerson, M.M.3
Cepko, C.L.4
-
174
-
-
84923221641
-
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
-
Wang X, Wang Y, WU X, Wang J, Wang Y, Qiu Z, Chang T, Huang H, Lin RJ and Yee JK. 2015. Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. Nat Biotechnol 33(2): 175-178.
-
(2015)
Nat Biotechnol
, vol.33
, Issue.2
, pp. 175-178
-
-
Wang, X.1
Wang, Y.2
Wu, X.3
Wang, J.4
Wang, Y.5
Qiu, Z.6
Chang, T.7
Huang, H.8
Lin, R.J.9
Yee, J.K.10
-
175
-
-
1542563409
-
Initial sequencing and comparative analysis of the mouse genome
-
Waterston RH et al. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature 420(6915): 520-562.
-
(2002)
Nature
, vol.420
, Issue.6915
, pp. 520-562
-
-
Waterston, R.H.1
-
176
-
-
33749048664
-
Genetical implications of the structure of deoxyribonucleic acid
-
Watson JD and Crick FH. 1953. Genetical implications of the structure of deoxyribonucleic acid. Nature 171(4361): 964-967.
-
(1953)
Nature
, vol.171
, Issue.4361
, pp. 964-967
-
-
Watson, J.D.1
Crick, F.H.2
-
177
-
-
0022270724
-
Molecular biology of the human and mouse Mhc class Iii genes: Phylogenetic conservation, genetics and regulation of expression
-
Whitehead AS and Sackstein R. 1985. Molecular biology of the human and mouse Mhc class Iii genes: phylogenetic conservation, genetics and regulation of expression. Immunol Rev 87: 185-208.
-
(1985)
Immunol Rev
, vol.87
, pp. 185-208
-
-
Whitehead, A.S.1
Sackstein, R.2
-
179
-
-
0037468222
-
Extra-embryonic function of Rb is essential for embryonic development and viability
-
Wu L et al. 2003. Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421(6926): 942-947.
-
(2003)
Nature
, vol.421
, Issue.6926
, pp. 942-947
-
-
Wu, L.1
-
180
-
-
84942168528
-
Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells
-
Wu Y et al. 2014. Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Cell Res.
-
(2014)
Cell Res.
-
-
Wu, Y.1
-
181
-
-
84964313841
-
A CRISPR/Cas9 toolkit for multiplex genome editing in plants
-
Xing HL, Dong L, Wang ZP, Zhang HY, Han CY, Liu B, Wang XC and Chen QJ. 2014. A CRISPR/Cas9 toolkit for multiplex genome editing in plants. BMC Plant Biol 14(1): 327.
-
(2014)
BMC Plant Biol
, vol.14
, Issue.1
, pp. 327
-
-
Xing, H.L.1
Dong, L.2
Wang, Z.P.3
Zhang, H.Y.4
Han, C.Y.5
Liu, B.6
Wang, X.C.7
Chen, Q.J.8
-
182
-
-
84984766752
-
Cytosine methylation targetted to pre-determined sequences
-
Xu GL and Bestor TH. 1997. Cytosine methylation targetted to pre-determined sequences. Nat Genet 17(4): 376-378.
-
(1997)
Nat Genet
, vol.17
, Issue.4
, pp. 376-378
-
-
Xu, G.L.1
Bestor, T.H.2
-
183
-
-
84910619646
-
CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila
-
Xue Z, WU M, Wen K, Ren M, Long L, Zhang X and Gao G. 2014. CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila. G3 (Bethesda) 4(11): 2167-2173.
-
(2014)
G3 (Bethesda)
, vol.4
, Issue.11
, pp. 2167-2173
-
-
Xue, Z.1
Wu, M.2
Wen, K.3
Ren, M.4
Long, L.5
Zhang, X.6
Gao, G.7
-
184
-
-
65449158038
-
A multifunctional reporter mouse line for Cre-and FLP-dependent lineage analysis
-
Yamamoto M, Shook NA, Kanisicak O, Yamamoto S, Wosczyna MN, Camp JR and Goldhamer DJ. 2009. A multifunctional reporter mouse line for Cre-and FLP-dependent lineage analysis. Genesis 47(2): 107-114.
-
(2009)
Genesis
, vol.47
, Issue.2
, pp. 107-114
-
-
Yamamoto, M.1
Shook, N.A.2
Kanisicak, O.3
Yamamoto, S.4
Wosczyna, M.N.5
Camp, J.R.6
Goldhamer, D.J.7
-
185
-
-
84884289608
-
One-step generation of mice carrying reporter and conditional alleles by Crispr/Cas-mediated genome engineering
-
Yang H, Wang H, Shivalila CS, Cheng AW, Shi L and Jaenisch R. 2013. One-step generation of mice carrying reporter and conditional alleles by Crispr/Cas-mediated genome engineering. Cell 154(6): 1370-1379.
-
(2013)
Cell
, vol.154
, Issue.6
, pp. 1370-1379
-
-
Yang, H.1
Wang, H.2
Shivalila, C.S.3
Cheng, A.W.4
Shi, L.5
Jaenisch, R.6
-
186
-
-
9244243137
-
Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors
-
Yang M, Reynoso J, Jiang P, Li L, Moossa AR and Hoffman RM. 2004. Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res 64(23): 8651-8656.
-
(2004)
Cancer Res
, vol.64
, Issue.23
, pp. 8651-8656
-
-
Yang, M.1
Reynoso, J.2
Jiang, P.3
Li, L.4
Moossa, A.R.5
Hoffman, R.M.6
-
187
-
-
84902095353
-
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
-
Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T and anderson DG. 2014. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat Biotechnol 32(6): 551-553.
-
(2014)
Nat Biotechnol
, vol.32
, Issue.6
, pp. 551-553
-
-
Yin, H.1
Xue, W.2
Chen, S.3
Bogorad, R.L.4
Benedetti, E.5
Grompe, M.6
Koteliansky, V.7
Sharp, P.A.8
Jacks, T.9
Anderson, D.G.10
-
188
-
-
80054987997
-
Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells
-
Yusa K et al. 2011. Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells. Nature 478(7369): 391-394.
-
(2011)
Nature
, vol.478
, Issue.7369
, pp. 391-394
-
-
Yusa, K.1
-
189
-
-
84907486054
-
TALEN-mediated somatic mutagenesis in murine models of cancer
-
Zhang S, Li L, Kendrick SL, Gerard RD and Zhu H. 2014. TALEN-mediated somatic mutagenesis in murine models of cancer. Cancer Res 74(18): 5311-5321.
-
(2014)
Cancer Res
, vol.74
, Issue.18
, pp. 5311-5321
-
-
Zhang, S.1
Li, L.2
Kendrick, S.L.3
Gerard, R.D.4
Zhu, H.5
-
190
-
-
0024420342
-
Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
-
Zijlstra M, Li E, Sajjadi F, Subramani S and Jaenisch R. 1989. Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342(6248): 435-438.
-
(1989)
Nature
, vol.342
, Issue.6248
, pp. 435-438
-
-
Zijlstra, M.1
Li, E.2
Sajjadi, F.3
Subramani, S.4
Jaenisch, R.5
|