메뉴 건너뛰기




Volumn 87, Issue 2, 2015, Pages 1323-1348

From gene targeting to genome editing: Transgenic animals applications and beyond

Author keywords

Cre LoxP; CRISPR Cas9; DNA repair; Homologous recombination; TALEN; ZFN

Indexed keywords

ZINC FINGER PROTEIN;

EID: 84942124526     PISSN: 00013765     EISSN: 16782690     Source Type: Journal    
DOI: 10.1590/0001-3765201520140710     Document Type: Article
Times cited : (40)

References (190)
  • 1
    • 84877821168 scopus 로고    scopus 로고
    • Bloomsbury report on mouse embryo phenotyping: Recommendations from the IMPC workshop on embryonic lethal screening
    • Adams D et al. 2013. Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening. Dis Model Mech 6(3): 571-579.
    • (2013) Dis Model Mech , vol.6 , Issue.3 , pp. 571-579
    • Adams, D.1
  • 2
    • 0034708480 scopus 로고    scopus 로고
    • The genome sequence of Drosophila melanogaster
    • Adams MD et al. 2000. The genome sequence of Drosophila melanogaster. Science 287(5461): 2185-2195.
    • (2000) Science , vol.287 , Issue.5461 , pp. 2185-2195
    • Adams, M.D.1
  • 3
    • 4043122029 scopus 로고    scopus 로고
    • Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning
    • Ahn S and Joyner AL. 2004. Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118(4): 505-516.
    • (2004) Cell , vol.118 , Issue.4 , pp. 505-516
    • Ahn, S.1    Joyner, A.L.2
  • 4
    • 84888261840 scopus 로고    scopus 로고
    • Robust ZFN-mediated genome editing in adult hemophilic mice
    • Anguela XM et al. 2013. Robust ZFN-mediated genome editing in adult hemophilic mice. Blood 122(19): 3283-3287.
    • (2013) Blood , vol.122 , Issue.19 , pp. 3283-3287
    • Anguela, X.M.1
  • 6
    • 0001194208 scopus 로고
    • Genetic Control of Biochemical Reactions in Neurospora
    • Beadle GW and Tatum EL. 1941. Genetic Control of Biochemical Reactions in Neurospora. Proc Natl Acad Sci USA 27(11): 499-506.
    • (1941) Proc Natl Acad Sci USA , vol.27 , Issue.11 , pp. 499-506
    • Beadle, G.W.1    Tatum, E.L.2
  • 7
    • 84868342049 scopus 로고    scopus 로고
    • In vivo genome editing using a high-efficiency TALEN system
    • Bedell VM et al. 2012. In vivo genome editing using a high-efficiency TALEN system. Nature 491(7422): 114-118.
    • (2012) Nature , vol.491 , Issue.7422 , pp. 114-118
    • Bedell, V.M.1
  • 8
    • 0034652141 scopus 로고    scopus 로고
    • Positive and negative regulation of endogenous genes by designed transcription factors
    • Beerli RR, Dreier B and Barbas CF. 2000. Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci USA 97(4): 1495-1500.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.4 , pp. 1495-1500
    • Beerli, R.R.1    Dreier, B.2    Barbas, C.F.3
  • 9
    • 84874601177 scopus 로고    scopus 로고
    • Highly active zinc-finger nucleases by extended modular assembly
    • Bhakta MS et al. 2012. Highly active zinc-finger nucleases by extended modular assembly. Genome Res 23(3): 530-538.
    • (2012) Genome Res , vol.23 , Issue.3 , pp. 530-538
    • Bhakta, M.S.1
  • 11
    • 0036021389 scopus 로고    scopus 로고
    • Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases
    • Bibikova M, Golic M, Golic KG and Carroll D. 2002. Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161(3): 1169-1175.
    • (2002) Genetics , vol.161 , Issue.3 , pp. 1169-1175
    • Bibikova, M.1    Golic, M.2    Golic, K.G.3    Carroll, D.4
  • 14
    • 23844505202 scopus 로고    scopus 로고
    • Clustered regularly interspaced short palindrome repeats (Crisprs) have spacers of extrachromosomal origin
    • Bolotin A, Quinquis B, Sorokin A and Ehrlich SD. 2005. Clustered regularly interspaced short palindrome repeats (Crisprs) have spacers of extrachromosomal origin. Microbiology 151(8): 2551-2561.
    • (2005) Microbiology , vol.151 , Issue.8 , pp. 2551-2561
    • Bolotin, A.1    Quinquis, B.2    Sorokin, A.3    Ehrlich, S.D.4
  • 15
    • 84876897705 scopus 로고    scopus 로고
    • Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/beta-cateninresponsive neural stem cells
    • Bowman AN, Van Amerongen R, Palmer TD and Nusse R. 2013. Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/beta-cateninresponsive neural stem cells. Proc Natl Acad Sci USA 110(18): 7324-7329.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.18 , pp. 7324-7329
    • Bowman, A.N.1    Van Amerongen, R.2    Palmer, T.D.3    Nusse, R.4
  • 16
    • 84867332476 scopus 로고    scopus 로고
    • The mammalian gene function resource: The International Knockout Mouse Consortium
    • Bradley A et al. 2012. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome 23(9-10): 580-586.
    • (2012) Mamm Genome , vol.23 , Issue.9-10 , pp. 580-586
    • Bradley, A.1
  • 17
    • 0346503889 scopus 로고    scopus 로고
    • Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
    • Branda CS and Dymecki SM. 2004. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell 6(1): 7-28.
    • (2004) Dev Cell , vol.6 , Issue.1 , pp. 7-28
    • Branda, C.S.1    Dymecki, S.M.2
  • 18
    • 0021183267 scopus 로고
    • Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors
    • Brinster RL, Chen HY, Messing A, Van Dyke T, Levine AJ and Palmiter RD. 1984. Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37(2): 367-379.
    • (1984) Cell , vol.37 , Issue.2 , pp. 367-379
    • Brinster, R.L.1    Chen, H.Y.2    Messing, A.3    Van Dyke, T.4    Levine, A.J.5    Palmiter, R.D.6
  • 19
    • 0019859395 scopus 로고
    • Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs
    • Brinster RL, Chen HY, Trumbauer M, Senear AW, Warren R and Palmiter RD. 1981. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27(1 Pt 2): 223-231.
    • (1981) Cell , vol.27 , Issue.1 , pp. 223-231
    • Brinster, R.L.1    Chen, H.Y.2    Trumbauer, M.3    Senear, A.W.4    Warren, R.5    Palmiter, R.D.6
  • 20
    • 0020083107 scopus 로고
    • Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs
    • Brinster RL, Chen HY, Warren R, Sarthy A and Palmiter RD. 1982. Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs. Nature 296(5852): 39-42.
    • (1982) Nature , vol.296 , Issue.5852 , pp. 39-42
    • Brinster, R.L.1    Chen, H.Y.2    Warren, R.3    Sarthy, A.4    Palmiter, R.D.5
  • 21
    • 84879686686 scopus 로고    scopus 로고
    • Whole-rat conditional gene knockout via genome editing
    • Brown AJ et al. 2013. Whole-rat conditional gene knockout via genome editing. Nat Methods 10(7): 638-640.
    • (2013) Nat Methods , vol.10 , Issue.7 , pp. 638-640
    • Brown, A.J.1
  • 22
    • 0029860719 scopus 로고    scopus 로고
    • Different thermostabilities of FLP and cre recombinases: Implications for applied site-specific recombination
    • Buchholz F, Ringrose L, Angrand PO, Rossi F and Stewart AF. 1996. Different thermostabilities of FLP and cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res 24(21): 4256-4262.
    • (1996) Nucleic Acids Res , vol.24 , Issue.21 , pp. 4256-4262
    • Buchholz, F.1    Ringrose, L.2    Angrand, P.O.3    Rossi, F.4    Stewart, A.F.5
  • 23
    • 0024328536 scopus 로고
    • Altering the genome by homologous recombination
    • Capecchi MR. 1989. Altering the genome by homologous recombination. Science 244(4910): 1288-1292.
    • (1989) Science , vol.244 , Issue.4910 , pp. 1288-1292
    • Capecchi, M.R.1
  • 24
    • 19544371373 scopus 로고    scopus 로고
    • Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century
    • Capecchi MR. 2005. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 6(6): 507-512.
    • (2005) Nat Rev Genet , vol.6 , Issue.6 , pp. 507-512
    • Capecchi, M.R.1
  • 29
    • 84884950106 scopus 로고    scopus 로고
    • Crispr/ Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity
    • Cradick TJ, Fine EJ, Antico CJ and Bao G. 2013. Crispr/ Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res 41(20): 9584-9592.
    • (2013) Nucleic Acids Res , vol.41 , Issue.20 , pp. 9584-9592
    • Cradick, T.J.1    Fine, E.J.2    Antico, C.J.3    Bao, G.4
  • 30
    • 70449209123 scopus 로고
    • On protein synthesis
    • Crick FH. 1958. On protein synthesis. Symp Soc Exp Biol 12: 138-163.
    • (1958) Symp Soc Exp Biol , vol.12 , pp. 138-163
    • Crick, F.H.1
  • 31
    • 84892670583 scopus 로고    scopus 로고
    • Recent progress in genome engineering techniques in the silkworm, bombyx mori
    • Daimon T, Kiuchi T and Takasu Y. 2013. Recent progress in genome engineering techniques in the silkworm, bombyx mori. Dev Growth Differ 56(1): 14-25.
    • (2013) Dev Growth Differ , vol.56 , Issue.1 , pp. 14-25
    • Daimon, T.1    Kiuchi, T.2    Takasu, Y.3
  • 34
    • 84884904381 scopus 로고    scopus 로고
    • Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
    • Dickinson DJ, Ward JD, Reiner DJ and Goldstein B. 2013. engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat Methods 10(10): 1028-1034.
    • (2013) Nat Methods , vol.10 , Issue.10 , pp. 1028-1034
    • Dickinson, D.J.1    Ward, J.D.2    Reiner, D.J.3    Goldstein, B.4
  • 37
    • 56649114274 scopus 로고    scopus 로고
    • A one pot, one step, precision cloning method with high throughput capability
    • Engler C, Kandzia R and Marillonnet S. 2008. A one pot, one step, precision cloning method with high throughput capability. PLoS One 3(11): e3647.
    • (2008) PLoS One , vol.3 , Issue.11
    • Engler, C.1    Kandzia, R.2    Marillonnet, S.3
  • 38
    • 70349559758 scopus 로고    scopus 로고
    • Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh
    • Favaro R et al. 2009. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12(10): 1248-1256.
    • (2009) Nat Neurosci , vol.12 , Issue.10 , pp. 1248-1256
    • Favaro, R.1
  • 39
    • 84914162239 scopus 로고    scopus 로고
    • CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration
    • Fei JF, Schuez M, Tazaki A, Taniguchi Y, Roensch K and Tanaka EM. 2014. CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration. Stem Cell Reports 3(3): 444-459.
    • (2014) Stem Cell Reports , vol.3 , Issue.3 , pp. 444-459
    • Fei, J.F.1    Schuez, M.2    Tazaki, A.3    Taniguchi, Y.4    Roensch, K.5    Tanaka, E.M.6
  • 40
    • 84900018747 scopus 로고    scopus 로고
    • Highly efficient targeted mutagenesis in axolotl using Cas9 RNA-guided nuclease
    • Flowers GP, Timberlake AT, Mclean KC, Monaghan JR and Crews CM. 2014. Highly efficient targeted mutagenesis in axolotl using Cas9 RNA-guided nuclease. Development 141(10): 2165-2171.
    • (2014) Development , vol.141 , Issue.10 , pp. 2165-2171
    • Flowers, G.P.1    Timberlake, A.T.2    McLean, K.C.3    Monaghan, J.R.4    Crews, C.M.5
  • 42
    • 0020396492 scopus 로고
    • Patterns of integration of DNA microinjected into cultured mammalian cells: Evidence for homologous recombination between injected plasmid DNA molecules
    • Folger KR, Wong EA, Wahl G and Capecchi MR. 1982. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol 2(11): 1372-1387.
    • (1982) Mol Cell Biol , vol.2 , Issue.11 , pp. 1372-1387
    • Folger, K.R.1    Wong, E.A.2    Wahl, G.3    Capecchi, M.R.4
  • 43
    • 33748705967 scopus 로고    scopus 로고
    • High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly
    • Forni PE et al. 2006. High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci 26(37): 9593-9602.
    • (2006) J Neurosci , vol.26 , Issue.37 , pp. 9593-9602
    • Forni, P.E.1
  • 44
    • 84923275611 scopus 로고    scopus 로고
    • Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
    • Frock RL, HU J, Meyers RM, Ho YJ, Kii E and Alt FW. 2015. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol 33(2): 179-186.
    • (2015) Nat Biotechnol , vol.33 , Issue.2 , pp. 179-186
    • Frock, R.L.1    Hu, J.2    Meyers, R.M.3    Ho, Y.J.4    Kii, E.5    Alt, F.W.6
  • 45
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
    • Fu Y, Sander JD, Reyon D, Cascio VM and Joung JK. 2014. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol 32(3): 279-284.
    • (2014) Nat Biotechnol , vol.32 , Issue.3 , pp. 279-284
    • Fu, Y.1    Sander, J.D.2    Reyon, D.3    Cascio, V.M.4    Joung, J.K.5
  • 46
    • 84925405886 scopus 로고    scopus 로고
    • CRISPR/Cas9-Based Genome editing in Mice by Single Plasmid Injection
    • Fujihara Y and Ikawa M. 2014. CRISPR/Cas9-Based Genome editing in Mice by Single Plasmid Injection. Methods enzymol 546: 319-336.
    • (2014) Methods enzymol , vol.546 , pp. 319-336
    • Fujihara, Y.1    Ikawa, M.2
  • 48
    • 80052766645 scopus 로고    scopus 로고
    • An unbiased genome-wide analysis of zinc-finger nuclease specificity
    • Gabriel R et al. 2011. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol 29(9): 816-823.
    • (2011) Nat Biotechnol , vol.29 , Issue.9 , pp. 816-823
    • Gabriel, R.1
  • 49
    • 84864439768 scopus 로고    scopus 로고
    • Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
    • Gaj T, Guo J, Kato Y, Sirk SJ and Barbas CF. 2012. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods 9(8): 805-807.
    • (2012) Nat Methods , vol.9 , Issue.8 , pp. 805-807
    • Gaj, T.1    Guo, J.2    Kato, Y.3    Sirk, S.J.4    Barbas, C.F.5
  • 51
    • 0024043517 scopus 로고
    • FLP recombinase is an enzyme
    • Gates CA and Cox MM. 1988. FLP recombinase is an enzyme. Proc Natl Acad Sci USA 85(13): 4628-4632.
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.13 , pp. 4628-4632
    • Gates, C.A.1    Cox, M.M.2
  • 52
    • 0024378286 scopus 로고
    • The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome
    • Golic KG and Lindquist S. 1989. The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59(3): 499-509.
    • (1989) Cell , vol.59 , Issue.3 , pp. 499-509
    • Golic, K.G.1    Lindquist, S.2
  • 55
    • 0031053362 scopus 로고    scopus 로고
    • A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
    • Greisman HA and Pabo CO. 1997. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science 275(5300): 657-661.
    • (1997) Science , vol.275 , Issue.5300 , pp. 657-661
    • Greisman, H.A.1    Pabo, C.O.2
  • 59
    • 0033230616 scopus 로고    scopus 로고
    • Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    • Harada N, Tamai Y, Ishikawa T, Sauer B, Takaku K, Oshima M and Taketo MM. 1999. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18(21): 5931-5942.
    • (1999) EMBO J , vol.18 , Issue.21 , pp. 5931-5942
    • Harada, N.1    Tamai, Y.2    Ishikawa, T.3    Sauer, B.4    Takaku, K.5    Oshima, M.6    Taketo, M.M.7
  • 61
    • 0242609960 scopus 로고    scopus 로고
    • Maternal inheritance of Cre activity in a Sox2Cre deleter strain
    • Hayashi S, Tenzen T and McMahon AP. 2003. Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis 37(2): 51-53.
    • (2003) Genesis , vol.37 , Issue.2 , pp. 51-53
    • Hayashi, S.1    Tenzen, T.2    McMahon, A.P.3
  • 64
    • 84884165315 scopus 로고    scopus 로고
    • DNA targeting specificity of RNA-guided Cas9 nucleases
    • Hsu PD et al. 2013. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol 31(9): 827-832.
    • (2013) Nat Biotechnol , vol.31 , Issue.9 , pp. 827-832
    • Hsu, P.D.1
  • 66
    • 0023600057 scopus 로고
    • Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in escherichia Coli, and identification of the gene product
    • Ishino Y, Shinagawa H, Makino K, Amemura M and Nakata A. 1987. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in escherichia Coli, and identification of the gene product. J Bacteriol 169(12): 5429-5433.
    • (1987) J Bacteriol , vol.169 , Issue.12 , pp. 5429-5433
    • Ishino, Y.1    Shinagawa, H.2    Makino, K.3    Amemura, M.4    Nakata, A.5
  • 67
    • 84882788354 scopus 로고    scopus 로고
    • Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
    • Jao LE, Wente SR and Chen W. 2013. efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci USA 110(34): 13904-13909.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.34 , pp. 13904-13909
    • Jao, L.E.1    Wente, S.R.2    Chen, W.3
  • 68
    • 84899719191 scopus 로고    scopus 로고
    • Essentials of recombinase-based genetic fate mapping in mice
    • Jensen P and Dymecki SM. 2014. essentials of recombinase-based genetic fate mapping in mice. Methods Mol Biol 1092: 437-454.
    • (2014) Methods Mol Biol , vol.1092 , pp. 437-454
    • Jensen, P.1    Dymecki, S.M.2
  • 69
    • 84886926151 scopus 로고    scopus 로고
    • Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in arabidopsis, tobacco, sorghum and rice
    • Jiang W, Zhou H, BI H, Fromm M, Yang B and Weeks DP. 2013. Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res 41(20): e188.
    • (2013) Nucleic Acids Res , vol.41 , Issue.20
    • Jiang, W.1    Zhou, H.2    Bi, H.3    Fromm, M.4    Yang, B.5    Weeks, D.P.6
  • 70
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA and Charpentier E. 2012. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096): 816-821.
    • (2012) Science , vol.337 , Issue.6096 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3    Hauer, M.4    Doudna, J.A.5    Charpentier, E.6
  • 71
    • 0024588265 scopus 로고
    • Production of a mutation in mouse en-2 gene by homologous recombination in embryonic stem cells
    • Joyner AL, Skarnes WC and Rossant J. 1989. Production of a mutation in mouse en-2 gene by homologous recombination in embryonic stem cells. Nature 338(6211): 153-156.
    • (1989) Nature , vol.338 , Issue.6211 , pp. 153-156
    • Joyner, A.L.1    Skarnes, W.C.2    Rossant, J.3
  • 73
    • 84898778301 scopus 로고    scopus 로고
    • A guide to genome engineering with programmable nucleases
    • Kim H and Kim JS. 2014. A guide to genome engineering with programmable nucleases. Nat Rev Genet 15(5): 321-334.
    • (2014) Nat Rev Genet , vol.15 , Issue.5 , pp. 321-334
    • Kim, H.1    Kim, J.S.2
  • 74
    • 84875157258 scopus 로고    scopus 로고
    • A library of TAL effector nucleases spanning the human genome
    • Kim Y et al. 2013a. A library of TAL effector nucleases spanning the human genome. Nat Biotechnol 31(3): 251-258.
    • (2013) Nat Biotechnol , vol.31 , Issue.3 , pp. 251-258
    • Kim, Y.1
  • 75
    • 0030032063 scopus 로고    scopus 로고
    • Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain
    • Kim YG, Cha J and Chandrasegaran S. 1996. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci USA 93(3): 1156-1160.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.3 , pp. 1156-1160
    • Kim, Y.G.1    Cha, J.2    Chandrasegaran, S.3
  • 78
    • 0016669094 scopus 로고
    • Evolution at two levels in humans and chimpanzees
    • King MC and Wilson AC. 1975. evolution at two levels in humans and chimpanzees. Science 188(4184): 107-116.
    • (1975) Science , vol.188 , Issue.4184 , pp. 107-116
    • King, M.C.1    Wilson, A.C.2
  • 79
    • 84914098789 scopus 로고    scopus 로고
    • Pathways disrupted in human Als motor neurons identified through genetic correction of mutant Sod1
    • Kiskinis E et al. 2014. Pathways disrupted in human Als motor neurons identified through genetic correction of mutant Sod1. Cell Stem Cell 14(6): 781-795.
    • (2014) Cell Stem Cell , vol.14 , Issue.6 , pp. 781-795
    • Kiskinis, E.1
  • 80
    • 0024332217 scopus 로고
    • Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells
    • Koller BH, Hagemann LJ, Doetschman T, Hagaman JR, Huang S, Williams PJ, First NL, Maeda N and Smithies O. 1989. Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci USA 86(22): 8927-8931.
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.22 , pp. 8927-8931
    • Koller, B.H.1    Hagemann, L.J.2    Doetschman, T.3    Hagaman, J.R.4    Huang, S.5    Williams, P.J.6    First, N.L.7    Maeda, N.8    Smithies, O.9
  • 81
    • 0025313515 scopus 로고
    • Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
    • Koller BH, Marrack P, Kappler JW and Smithies O. 1990. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248(4960): 1227-1230.
    • (1990) Science , vol.248 , Issue.4960 , pp. 1227-1230
    • Koller, B.H.1    Marrack, P.2    Kappler, J.W.3    Smithies, O.4
  • 83
    • 84891757565 scopus 로고    scopus 로고
    • The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
    • Koscielny G et al. 2014. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res 42(Database issue): D802-809.
    • (2014) Nucleic Acids Res , vol.42 , Issue.Database issue , pp. D802-D809
    • Koscielny, G.1
  • 84
    • 84916219205 scopus 로고    scopus 로고
    • TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human embryonic Stem Cells towards endoderm
    • Krentz NA, Nian C and Lynn FC. 2014. TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human embryonic Stem Cells towards endoderm. PLoS One 9(12): e114275.
    • (2014) PLoS One , vol.9 , Issue.12
    • Krentz, N.A.1    Nian, C.2    Lynn, F.C.3
  • 85
    • 36248958190 scopus 로고    scopus 로고
    • Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
    • Lagace DC et al. 2007. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci 27(46): 12623-12629.
    • (2007) J Neurosci , vol.27 , Issue.46 , pp. 12623-12629
    • Lagace, D.C.1
  • 87
    • 0034026486 scopus 로고    scopus 로고
    • On the possibilities and limitations of rational protein design to expand the specificity of restriction enzymes: A case study employing ecoRV as the target
    • Lanio T, Jeltsch A and Pingoud A. 2000. On the possibilities and limitations of rational protein design to expand the specificity of restriction enzymes: a case study employing ecoRV as the target. Protein eng 13(4): 275-281.
    • (2000) Protein eng , vol.13 , Issue.4 , pp. 275-281
    • Lanio, T.1    Jeltsch, A.2    Pingoud, A.3
  • 88
    • 84865797462 scopus 로고    scopus 로고
    • Mastr: A technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice
    • Lao Z, Raju GP, Bai CB and Joyner AL. 2012. Mastr: a technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice. Cell Rep 2(2): 386-396.
    • (2012) Cell Rep , vol.2 , Issue.2 , pp. 386-396
    • Lao, Z.1    Raju, G.P.2    Bai, C.B.3    Joyner, A.L.4
  • 89
    • 84904737686 scopus 로고    scopus 로고
    • Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice
    • Lee AY and Lloyd KC. 2014. Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice. FEBS Open Bio 4: 637-642.
    • (2014) FEBS Open Bio , vol.4 , pp. 637-642
    • Lee, A.Y.1    Lloyd, K.C.2
  • 90
    • 0037819447 scopus 로고    scopus 로고
    • Transcription regulation and animal diversity
    • Levine M and Tjian R. 2003. Transcription regulation and animal diversity. Nature 424(6945): 147-151.
    • (2003) Nature , vol.424 , Issue.6945 , pp. 147-151
    • Levine, M.1    Tjian, R.2
  • 91
    • 0035491607 scopus 로고    scopus 로고
    • Conditional control of gene expression in the mouse
    • Lewandoski M. 2001. Conditional control of gene expression in the mouse. Nat Rev Genet 2(10): 743-755.
    • (2001) Nat Rev Genet , vol.2 , Issue.10 , pp. 743-755
    • Lewandoski, M.1
  • 92
    • 0031252296 scopus 로고    scopus 로고
    • Cre-mediated chromosome loss in mice
    • Lewandoski M and Martin GR. 1997. Cre-mediated chromosome loss in mice. Nat Genet 17(2): 223-225.
    • (1997) Nat Genet , vol.17 , Issue.2 , pp. 223-225
    • Lewandoski, M.1    Martin, G.R.2
  • 94
    • 79960424171 scopus 로고    scopus 로고
    • In vivo genome editing restores haemostasis in a mouse model of haemophilia
    • Li H et al. 2011. In vivo genome editing restores haemostasis in a mouse model of haemophilia. Nature 475(7355): 217-221.
    • (2011) Nature , vol.475 , Issue.7355 , pp. 217-221
    • Li, H.1
  • 95
    • 84929490224 scopus 로고    scopus 로고
    • Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9
    • Li HL et al. 2014. Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9. Stem Cell Reports.
    • (2014) Stem Cell Reports.
    • Li, H.L.1
  • 96
    • 84903818736 scopus 로고    scopus 로고
    • Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system
    • Liu P, Long L, Xiong K, YU B, Chang N, Xiong JW, Zhu Z and Liu D. 2014. Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system. Cell Res 24(7): 886-889.
    • (2014) Cell Res , vol.24 , Issue.7 , pp. 886-889
    • Liu, P.1    Long, L.2    Xiong, K.3    Yu, B.4    Chang, N.5    Xiong, J.W.6    Zhu, Z.7    Liu, D.8
  • 98
    • 84907200149 scopus 로고    scopus 로고
    • Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline Dna
    • Long C, McAnally JR, Shelton JM, Mireault AA, Bassel-Duby R and Olson EN. 2014. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline Dna. Science 345(6201): 1184-1188.
    • (2014) Science , vol.345 , Issue.6201 , pp. 1184-1188
    • Long, C.1    McAnally, J.R.2    Shelton, J.M.3    Mireault, A.A.4    Bassel-Duby, R.5    Olson, E.N.6
  • 100
    • 0025346057 scopus 로고
    • XY female mice resulting from a heritable mutation in the primary testis-determining gene, TDY
    • Lovell-Badge R and Robertson E. 1990. XY female mice resulting from a heritable mutation in the primary testis-determining gene, TDY. Development 109(3): 635-646.
    • (1990) Development , vol.109 , Issue.3 , pp. 635-646
    • Lovell-Badge, R.1    Robertson, E.2
  • 101
    • 84892689751 scopus 로고    scopus 로고
    • Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair
    • Low Be, Krebs MP, Joung JK, Tsai SQ, Nishina PM and Wiles MV. 2013. Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci 55(1): 387-395.
    • (2013) Invest Ophthalmol Vis Sci , vol.55 , Issue.1 , pp. 387-395
    • Low, B.E.1    Krebs, M.P.2    Joung, J.K.3    Tsai, S.Q.4    Nishina, P.M.5    Wiles, M.V.6
  • 102
    • 84893756373 scopus 로고    scopus 로고
    • Dynamic expression of N-myc in mouse embryonic development using an enhanced green fluorescent protein reporter gene in the N-myc locus
    • Ma M, Zhao K, WU W, Sun R and Fei J. 2014. Dynamic expression of N-myc in mouse embryonic development using an enhanced green fluorescent protein reporter gene in the N-myc locus. Dev Growth Differ 56(2): 152-160.
    • (2014) Dev Growth Differ , vol.56 , Issue.2 , pp. 152-160
    • Ma, M.1    Zhao, K.2    Wu, W.3    Sun, R.4    Fei, J.5
  • 103
    • 84897068699 scopus 로고    scopus 로고
    • CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori
    • Ma S, Chang J, Wang X, Liu Y, Zhang J, Lu W, Gao J, Shi R, Zhao P and Xia Q. 2014. CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori. Sci Rep 4: 4489.
    • (2014) Sci Rep , vol.4 , pp. 4489
    • Ma, S.1    Chang, J.2    Wang, X.3    Liu, Y.4    Zhang, J.5    Lu, W.6    Gao, J.7    Shi, R.8    Zhao, P.9    Xia, Q.10
  • 104
  • 106
    • 2942512013 scopus 로고    scopus 로고
    • Cell type-specific effects of Rb deletion in the murine retina
    • Macpherson D, Sage J, Kim T, Ho D, Mclaughlin ME and Jacks T. 2004. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev 18(14): 1681-1694.
    • (2004) Genes Dev , vol.18 , Issue.14 , pp. 1681-1694
    • McPherson, D.1    Sage, J.2    Kim, T.3    Ho, D.4    McLaughlin, M.E.5    Jacks, T.6
  • 107
    • 84890048526 scopus 로고    scopus 로고
    • Targeted DNA demethylation and activation of endogenous genes using programmable Tale-Tet1 fusion proteins
    • Maeder ML et al. 2013. Targeted DNA demethylation and activation of endogenous genes using programmable Tale-Tet1 fusion proteins. Nat Biotechnol 31(12): 1137-1142.
    • (2013) Nat Biotechnol , vol.31 , Issue.12 , pp. 1137-1142
    • Maeder, M.L.1
  • 108
    • 47349097567 scopus 로고    scopus 로고
    • Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification
    • Maeder ML et al. 2008. Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell 31(2): 294-301.
    • (2008) Mol Cell , vol.31 , Issue.2 , pp. 294-301
    • Maeder, M.L.1
  • 111
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour SL, Thomas KR and Capecchi MR. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336(6197): 348-352.
    • (1988) Nature , vol.336 , Issue.6197 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 112
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • Martin GR. 1981. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78(12): 7634-7638.
    • (1981) Proc Natl Acad Sci USA , vol.78 , Issue.12 , pp. 7634-7638
    • Martin, G.R.1
  • 114
    • 0026504525 scopus 로고
    • Homeobox genes and axial patterning
    • Mcginnis W and Krumlauf R. 1992. Homeobox genes and axial patterning. Cell 68(2): 283-302.
    • (1992) Cell , vol.68 , Issue.2 , pp. 283-302
    • McGinnis, W.1    Krumlauf, R.2
  • 115
    • 0022803360 scopus 로고
    • Identification of the crossover site during FLP-mediated recombination in the Saccharomyces cerevisiae plasmid 2 microns circle
    • Mcleod M, Craft S and Broach JR. 1986. Identification of the crossover site during FLP-mediated recombination in the Saccharomyces cerevisiae plasmid 2 microns circle. Mol Cell Biol 6(10): 3357-3367.
    • (1986) Mol Cell Biol , vol.6 , Issue.10 , pp. 3357-3367
    • McLeod, M.1    Craft, S.2    Broach, J.R.3
  • 116
    • 84876557961 scopus 로고    scopus 로고
    • Quantitative analysis of TALE-DNA interactions suggests polarity effects
    • Meckler JF et al. 2013. Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res 41(7): 4118-4128.
    • (2013) Nucleic Acids Res , vol.41 , Issue.7 , pp. 4118-4128
    • Meckler, J.F.1
  • 118
    • 77957005768 scopus 로고    scopus 로고
    • Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
    • Meyer M, De Angelis MH, Wurst W and Kuhn R. 2010. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci USA 107(34): 15022-15026.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.34 , pp. 15022-15026
    • Meyer, M.1    De Angelis, M.H.2    Wurst, W.3    Kuhn, R.4
  • 119
    • 34447319080 scopus 로고    scopus 로고
    • An improved zinc-finger nuclease architecture for highly specific genome editing
    • Miller JC et al. 2007. An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol 25(7): 778-785.
    • (2007) Nat Biotechnol , vol.25 , Issue.7 , pp. 778-785
    • Miller, J.C.1
  • 120
    • 79551685675 scopus 로고    scopus 로고
    • A TALE nuclease architecture for efficient genome editing
    • Miller JC et al. 2010. A TALE nuclease architecture for efficient genome editing. Nat Biotechnol 29(2): 143-148.
    • (2010) Nat Biotechnol , vol.29 , Issue.2 , pp. 143-148
    • Miller, J.C.1
  • 121
    • 84887478994 scopus 로고    scopus 로고
    • Live visualization of chromatin dynamics with fluorescent TALEs
    • Miyanari Y, Ziegler-Birling C and Torres-Padilla ME. 2013. Live visualization of chromatin dynamics with fluorescent TALEs. Nat Struct Mol Biol 20(11): 1321-1324.
    • (2013) Nat Struct Mol Biol , vol.20 , Issue.11 , pp. 1321-1324
    • Miyanari, Y.1    Ziegler-Birling, C.2    Torres-Padilla, M.E.3
  • 123
    • 0034034401 scopus 로고    scopus 로고
    • Biological significance of a family of regularly spaced repeats in the genomes of archaea, bacteria and mitochondria
    • Mojica FJ, Diez-Villasenor C, Soria E and Juez G. 2000. Biological significance of a family of regularly spaced repeats in the genomes of archaea, bacteria and mitochondria. Mol Microbiol 36(1): 244-246.
    • (2000) Mol Microbiol , vol.36 , Issue.1 , pp. 244-246
    • Mojica, F.J.1    Diez-Villasenor, C.2    Soria, E.3    Juez, G.4
  • 124
    • 16444385662 scopus 로고    scopus 로고
    • Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
    • Mojica FJ, Diez-Villasenor C, Garcia-Martinez J and Soria E. 2005. Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J Mol evol 60(2): 174-182.
    • (2005) J Mol evol , vol.60 , Issue.2 , pp. 174-182
    • Mojica, F.J.1    Diez-Villasenor, C.2    Garcia-Martinez, J.3    Soria, E.4
  • 125
    • 72149090954 scopus 로고    scopus 로고
    • A simple cipher governs DNA recognition by TAL effectors
    • Moscou MJ and Bogdanove AJ. 2009. A simple cipher governs DNA recognition by TAL effectors. Science 326(5959): 1501.
    • (2009) Science , vol.326 , Issue.5959 , pp. 1501
    • Moscou, M.J.1    Bogdanove, A.J.2
  • 126
    • 84894081986 scopus 로고    scopus 로고
    • Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
    • Niu Y et al. 2014. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156(4): 836-843.
    • (2014) Cell , vol.156 , Issue.4 , pp. 836-843
    • Niu, Y.1
  • 128
    • 0026764280 scopus 로고
    • Tissue-and site-specific DNA recombination in transgenic mice
    • Orban PC, Chui D and Marth JD. 1992. Tissue-and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA 89(15): 6861-6865.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.15 , pp. 6861-6865
    • Orban, P.C.1    Chui, D.2    Marth, J.D.3
  • 129
    • 84878580410 scopus 로고    scopus 로고
    • TALEN-based gene correction for epidermolysis bullosa
    • Osborn MJ et al. 2013. TALEN-based gene correction for epidermolysis bullosa. Mol Ther 21(6): 1151-1159.
    • (2013) Mol Ther , vol.21 , Issue.6 , pp. 1151-1159
    • Osborn, M.J.1
  • 130
    • 0020470466 scopus 로고
    • Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes
    • Palmiter RD, Brinster RL, Hammer RE, Trumbauer Me, Rosenfeld MG, Birnberg NC and Evans RM. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300(5893): 611-615.
    • (1982) Nature , vol.300 , Issue.5893 , pp. 611-615
    • Palmiter, R.D.1    Brinster, R.L.2    Hammer, R.E.3    Trumbauer, M.4    Rosenfeld, M.G.5    Birnberg, N.C.6    Evans, R.M.7
  • 131
    • 84884155038 scopus 로고    scopus 로고
    • High-throughput profiling of off-target Dna cleavage reveals Rna-programmed Cas9 nuclease specificity
    • Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna JA and Liu DR. 2013. High-throughput profiling of off-target Dna cleavage reveals Rna-programmed Cas9 nuclease specificity. Nat Biotechnol 31(9): 839-843.
    • (2013) Nat Biotechnol , vol.31 , Issue.9 , pp. 839-843
    • Pattanayak, V.1    Lin, S.2    Guilinger, J.P.3    Ma, E.4    Doudna, J.A.5    Liu, D.R.6
  • 132
    • 46949095221 scopus 로고    scopus 로고
    • Establishment of Hiv-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
    • Perez EE et al. 2008. establishment of Hiv-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol 26(7): 808-816.
    • (2008) Nat Biotechnol , vol.26 , Issue.7 , pp. 808-816
    • Perez, E.E.1
  • 133
    • 84912101598 scopus 로고    scopus 로고
    • Crispr-Cas9 knockin mice for genome editing and cancer modeling
    • Platt RJ et al. 2014. Crispr-Cas9 knockin mice for genome editing and cancer modeling. Cell 159(2): 440-455.
    • (2014) Cell , vol.159 , Issue.2 , pp. 440-455
    • Platt, R.J.1
  • 134
    • 15844390228 scopus 로고    scopus 로고
    • Crispr elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
    • Pourcel C, Salvignol G and Vergnaud G. 2005. Crispr elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology 151(Pt 3): 653-663.
    • (2005) Microbiology , vol.151 , pp. 653-663
    • Pourcel, C.1    Salvignol, G.2    Vergnaud, G.3
  • 135
    • 84878826580 scopus 로고    scopus 로고
    • High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases
    • Qiu Z et al. 2013. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res 41(11): e120.
    • (2013) Nucleic Acids Res , vol.41 , Issue.11
    • Qiu, Z.1
  • 136
    • 42949083192 scopus 로고    scopus 로고
    • Unexpected failure rates for modular assembly of engineered zinc fingers
    • Ramirez CL et al. 2008. Unexpected failure rates for modular assembly of engineered zinc fingers. Nat Methods 5(5): 374-375.
    • (2008) Nat Methods , vol.5 , Issue.5 , pp. 374-375
    • Ramirez, C.L.1
  • 137
    • 0036195992 scopus 로고    scopus 로고
    • A Hoxa2 mutant conditional allele generated by Flp-and Cre-mediated recombination
    • Ren SY, Pasqualetti M, Dierich A, Le Meur M and Rijli FM. 2002. A Hoxa2 mutant conditional allele generated by Flp-and Cre-mediated recombination. Genesis 32(2): 105-108.
    • (2002) Genesis , vol.32 , Issue.2 , pp. 105-108
    • Ren, S.Y.1    Pasqualetti, M.2    Dierich, A.3    Le Meur, M.4    Rijli, F.M.5
  • 138
    • 84888108873 scopus 로고    scopus 로고
    • Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9
    • Ren X et al. 2013. Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci USA 110(47): 19012-19017.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.47 , pp. 19012-19017
    • Ren, X.1
  • 139
    • 35548939950 scopus 로고    scopus 로고
    • Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene
    • Romer P, Hahn S, Jordan T, Strauss T, Bonas U and Lahaye T. 2007. Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science 318(5850): 645-648.
    • (2007) Science , vol.318 , Issue.5850 , pp. 645-648
    • Romer, P.1    Hahn, S.2    Jordan, T.3    Strauss, T.4    Bonas, U.5    Lahaye, T.6
  • 140
    • 78650863981 scopus 로고    scopus 로고
    • Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)
    • Sander JD et al. 2010. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods 8(1): 67-69.
    • (2010) Nat Methods , vol.8 , Issue.1 , pp. 67-69
    • Sander, J.D.1
  • 141
    • 84900314611 scopus 로고    scopus 로고
    • CRISPR-Cas systems for editing, regulating and targeting genomes
    • Sander JD and Joung JK. 2014. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol 32(4): 347-355.
    • (2014) Nat Biotechnol , vol.32 , Issue.4 , pp. 347-355
    • Sander, J.D.1    Joung, J.K.2
  • 142
    • 0024041732 scopus 로고
    • Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1
    • Sauer B and Henderson N. 1988. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci USA 85(14): 5166-5170.
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.14 , pp. 5166-5170
    • Sauer, B.1    Henderson, N.2
  • 144
    • 34548392767 scopus 로고    scopus 로고
    • Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination
    • Schmidt-Supprian M, Wunderlich FT and Rajewsky K. 2007. excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination. Transgenic Res 16(5): 657-660.
    • (2007) Transgenic Res , vol.16 , Issue.5 , pp. 657-660
    • Schmidt-Supprian, M.1    Wunderlich, F.T.2    Rajewsky, K.3
  • 145
    • 0034610394 scopus 로고    scopus 로고
    • Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
    • Schmidt EE, Taylor DS, Prigge JR, Barnett S and Capecchi MR. 2000. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci USA 97(25): 13702-13707.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.25 , pp. 13702-13707
    • Schmidt, E.E.1    Taylor, D.S.2    Prigge, J.R.3    Barnett, S.4    Capecchi, M.R.5
  • 146
    • 84905483274 scopus 로고    scopus 로고
    • Out with the old, in with the new: Reassessing morpholino knockdowns in light of genome editing technology
    • Schulte-Merker S and Stainier DY. 2014. Out with the old, in with the new: reassessing morpholino knockdowns in light of genome editing technology. Development 141(16): 3103-3104.
    • (2014) Development , vol.141 , Issue.16 , pp. 3103-3104
    • Schulte-Merker, S.1    Stainier, D.Y.2
  • 147
    • 84890033064 scopus 로고    scopus 로고
    • Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
    • Schwank G et al. 2013. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 13(6): 653-658.
    • (2013) Cell Stem Cell , vol.13 , Issue.6 , pp. 653-658
    • Schwank, G.1
  • 148
    • 0024473608 scopus 로고
    • Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells
    • Schwartzberg PL, Goff SP and Robertson EJ. 1989. Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science 246(4931): 799-803.
    • (1989) Science , vol.246 , Issue.4931 , pp. 799-803
    • Schwartzberg, P.L.1    Goff, S.P.2    Robertson, E.J.3
  • 149
    • 0030662479 scopus 로고    scopus 로고
    • Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains
    • Schwenk F, Sauer B, Kukoc N, Hoess R, Muller W, Kocks C, Kuhn R and Rajewsky K. 1997. Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains. J Immunol Methods 207(2): 203-212.
    • (1997) J Immunol Methods , vol.207 , Issue.2 , pp. 203-212
    • Schwenk, F.1    Sauer, B.2    Kukoc, N.3    Hoess, R.4    Muller, W.5    Kocks, C.6    Kuhn, R.7    Rajewsky, K.8
  • 150
    • 80054918967 scopus 로고    scopus 로고
    • In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases
    • Sebastiano V et al. 2011. In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells 29(11): 1717-1726.
    • (2011) Stem Cells , vol.29 , Issue.11 , pp. 1717-1726
    • Sebastiano, V.1
  • 151
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
    • Smithies O, Gregg RG, Boggs SS, Koralewski MA and Kucherlapati RS. 1985. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 317(6034): 230-234.
    • (1985) Nature , vol.317 , Issue.6034 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3    Koralewski, M.A.4    Kucherlapati, R.S.5
  • 152
    • 84892582306 scopus 로고    scopus 로고
    • Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases
    • Sommer D et al. 2014. efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat Commun 5: 3045.
    • (2014) Nat Commun , vol.5 , pp. 3045
    • Sommer, D.1
  • 153
    • 0019967916 scopus 로고
    • Transposition of cloned P elements into Drosophila germ line chromosomes
    • Spradling AC and Rubin GM. 1982. Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218(4570): 341-347.
    • (1982) Science , vol.218 , Issue.4570 , pp. 341-347
    • Spradling, A.C.1    Rubin, G.M.2
  • 154
    • 0019888362 scopus 로고
    • Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites
    • Sternberg N and Hamilton D. 1981. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J Mol Biol 150(4): 467-486.
    • (1981) J Mol Biol , vol.150 , Issue.4 , pp. 467-486
    • Sternberg, N.1    Hamilton, D.2
  • 155
    • 84908042682 scopus 로고    scopus 로고
    • Tissue-specific genome editing in Ciona embryos by Crispr/Cas9
    • Stolfi A, Gandhi S, Salek F and Christiaen L. 2014. Tissue-specific genome editing in Ciona embryos by Crispr/Cas9. Development 141(21): 4115-4120.
    • (2014) Development , vol.141 , Issue.21 , pp. 4115-4120
    • Stolfi, A.1    Gandhi, S.2    Salek, F.3    Christiaen, L.4
  • 156
    • 84938497932 scopus 로고    scopus 로고
    • CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons
    • Straub C, Granger AJ, Saulnier JL and Sabatini BL. 2014. CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons. PLoS One 9(8): e105584.
    • (2014) PLoS One , vol.9 , Issue.8
    • Straub, C.1    Granger, A.J.2    Saulnier, J.L.3    Sabatini, B.L.4
  • 157
    • 34247191950 scopus 로고    scopus 로고
    • Tetracycline-inducible expression systems: New strategies and practices in the transgenic mouse modeling
    • Sun Y, Chen X and Xiao D. 2007. Tetracycline-inducible expression systems: new strategies and practices in the transgenic mouse modeling. Acta Biochim Biophys Sin (Shanghai) 39(4): 235-246.
    • (2007) Acta Biochim Biophys Sin (Shanghai) , vol.39 , Issue.4 , pp. 235-246
    • Sun, Y.1    Chen, X.2    Xiao, D.3
  • 159
    • 34447323568 scopus 로고    scopus 로고
    • Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
    • Szczepek M, Brondani V, Buchel J, Serrano L, Segal DJ and Cathomen T. 2007. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol 25(7): 786-793.
    • (2007) Nat Biotechnol , vol.25 , Issue.7 , pp. 786-793
    • Szczepek, M.1    Brondani, V.2    Buchel, J.3    Serrano, L.4    Segal, D.J.5    Cathomen, T.6
  • 160
    • 0242300262 scopus 로고    scopus 로고
    • Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse
    • Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K and Kaneko T. 2003. Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 467(1): 60-79.
    • (2003) J Comp Neurol , vol.467 , Issue.1 , pp. 60-79
    • Tamamaki, N.1    Yanagawa, Y.2    Tomioka, R.3    Miyazaki, J.4    Obata, K.5    Kaneko, T.6
  • 161
    • 84882792150 scopus 로고    scopus 로고
    • A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation
    • Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B and Cepko CL. 2013. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell 154(4): 928-939.
    • (2013) Cell , vol.154 , Issue.4 , pp. 928-939
    • Tang, J.C.1    Szikra, T.2    Kozorovitskiy, Y.3    Teixiera, M.4    Sabatini, B.L.5    Roska, B.6    Cepko, C.L.7
  • 162
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas KR and Capecchi MR. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51(3): 503-512.
    • (1987) Cell , vol.51 , Issue.3 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 163
    • 0025074908 scopus 로고
    • Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
    • Thomas KR and Capecchi MR. 1990. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346(6287): 847-850.
    • (1990) Nature , vol.346 , Issue.6287 , pp. 847-850
    • Thomas, K.R.1    Capecchi, M.R.2
  • 164
    • 84891509001 scopus 로고    scopus 로고
    • Tissue-specific and ubiquitous gene knockouts by TALEN electroporation provide new approaches to investigating gene function in Ciona
    • Treen N, Yoshida K, Sakuma T, Sasaki H, Kawai N, Yamamoto T and Sasakura Y. 2013. Tissue-specific and ubiquitous gene knockouts by TALEN electroporation provide new approaches to investigating gene function in Ciona. Development 141(2): 481-487.
    • (2013) Development , vol.141 , Issue.2 , pp. 481-487
    • Treen, N.1    Yoshida, K.2    Sakuma, T.3    Sasaki, H.4    Kawai, N.5    Yamamoto, T.6    Sasakura, Y.7
  • 165
    • 0037010178 scopus 로고    scopus 로고
    • When reverse genetics meets physiology: The use of site-specific recombinases in mice
    • Tronche F, Casanova E, Turiault M, Sahly I and Kellendonk C. 2002. When reverse genetics meets physiology: the use of site-specific recombinases in mice. Febs Lett 529(1): 116-121.
    • (2002) Febs Lett , vol.529 , Issue.1 , pp. 116-121
    • Tronche, F.1    Casanova, E.2    Turiault, M.3    Sahly, I.4    Kellendonk, C.5
  • 166
    • 82655181514 scopus 로고    scopus 로고
    • Site-specific recombinases: From tag-and-target-to tag-and-exchange-based genomic modifications
    • Turan S and Bode J. 2011. Site-specific recombinases: from tag-and-target-to tag-and-exchange-based genomic modifications. FASEB J 25(12): 4088-4107.
    • (2011) FASEB J , vol.25 , Issue.12 , pp. 4088-4107
    • Turan, S.1    Bode, J.2
  • 169
    • 84866114887 scopus 로고    scopus 로고
    • Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland
    • Van Amerongen R, Bowman AN and Nusse R. 2012. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11(3): 387-400.
    • (2012) Cell Stem Cell , vol.11 , Issue.3 , pp. 387-400
    • Van Amerongen, R.1    Bowman, A.N.2    Nusse, R.3
  • 170
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC et al. 2001. The sequence of the human genome. Science 291(5507): 1304-1351.
    • (2001) Science , vol.291 , Issue.5507 , pp. 1304-1351
    • Venter, J.C.1
  • 171
    • 0035029433 scopus 로고    scopus 로고
    • A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
    • Vooijs M, Jonkers J and Berns A. 2001. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep 2(4): 292-297.
    • (2001) EMBO Rep , vol.2 , Issue.4 , pp. 292-297
    • Vooijs, M.1    Jonkers, J.2    Berns, A.3
  • 172
    • 84880285567 scopus 로고    scopus 로고
    • TALEN-mediated editing of the mouse Y chromosome
    • Wang H et al. 2013. TALEN-mediated editing of the mouse Y chromosome. Nat Biotechnol 31(6): 530-532.
    • (2013) Nat Biotechnol , vol.31 , Issue.6 , pp. 530-532
    • Wang, H.1
  • 173
    • 84908612662 scopus 로고    scopus 로고
    • A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina
    • Wang S, Sengel C, Emerson MM and Cepko CL. 2014. A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina. Dev Cell 30(5): 513-527.
    • (2014) Dev Cell , vol.30 , Issue.5 , pp. 513-527
    • Wang, S.1    Sengel, C.2    Emerson, M.M.3    Cepko, C.L.4
  • 174
    • 84923221641 scopus 로고    scopus 로고
    • Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
    • Wang X, Wang Y, WU X, Wang J, Wang Y, Qiu Z, Chang T, Huang H, Lin RJ and Yee JK. 2015. Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. Nat Biotechnol 33(2): 175-178.
    • (2015) Nat Biotechnol , vol.33 , Issue.2 , pp. 175-178
    • Wang, X.1    Wang, Y.2    Wu, X.3    Wang, J.4    Wang, Y.5    Qiu, Z.6    Chang, T.7    Huang, H.8    Lin, R.J.9    Yee, J.K.10
  • 175
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Waterston RH et al. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature 420(6915): 520-562.
    • (2002) Nature , vol.420 , Issue.6915 , pp. 520-562
    • Waterston, R.H.1
  • 176
    • 33749048664 scopus 로고
    • Genetical implications of the structure of deoxyribonucleic acid
    • Watson JD and Crick FH. 1953. Genetical implications of the structure of deoxyribonucleic acid. Nature 171(4361): 964-967.
    • (1953) Nature , vol.171 , Issue.4361 , pp. 964-967
    • Watson, J.D.1    Crick, F.H.2
  • 177
    • 0022270724 scopus 로고
    • Molecular biology of the human and mouse Mhc class Iii genes: Phylogenetic conservation, genetics and regulation of expression
    • Whitehead AS and Sackstein R. 1985. Molecular biology of the human and mouse Mhc class Iii genes: phylogenetic conservation, genetics and regulation of expression. Immunol Rev 87: 185-208.
    • (1985) Immunol Rev , vol.87 , pp. 185-208
    • Whitehead, A.S.1    Sackstein, R.2
  • 179
    • 0037468222 scopus 로고    scopus 로고
    • Extra-embryonic function of Rb is essential for embryonic development and viability
    • Wu L et al. 2003. Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421(6926): 942-947.
    • (2003) Nature , vol.421 , Issue.6926 , pp. 942-947
    • Wu, L.1
  • 180
    • 84942168528 scopus 로고    scopus 로고
    • Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells
    • Wu Y et al. 2014. Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Cell Res.
    • (2014) Cell Res.
    • Wu, Y.1
  • 182
    • 84984766752 scopus 로고    scopus 로고
    • Cytosine methylation targetted to pre-determined sequences
    • Xu GL and Bestor TH. 1997. Cytosine methylation targetted to pre-determined sequences. Nat Genet 17(4): 376-378.
    • (1997) Nat Genet , vol.17 , Issue.4 , pp. 376-378
    • Xu, G.L.1    Bestor, T.H.2
  • 183
    • 84910619646 scopus 로고    scopus 로고
    • CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila
    • Xue Z, WU M, Wen K, Ren M, Long L, Zhang X and Gao G. 2014. CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila. G3 (Bethesda) 4(11): 2167-2173.
    • (2014) G3 (Bethesda) , vol.4 , Issue.11 , pp. 2167-2173
    • Xue, Z.1    Wu, M.2    Wen, K.3    Ren, M.4    Long, L.5    Zhang, X.6    Gao, G.7
  • 185
    • 84884289608 scopus 로고    scopus 로고
    • One-step generation of mice carrying reporter and conditional alleles by Crispr/Cas-mediated genome engineering
    • Yang H, Wang H, Shivalila CS, Cheng AW, Shi L and Jaenisch R. 2013. One-step generation of mice carrying reporter and conditional alleles by Crispr/Cas-mediated genome engineering. Cell 154(6): 1370-1379.
    • (2013) Cell , vol.154 , Issue.6 , pp. 1370-1379
    • Yang, H.1    Wang, H.2    Shivalila, C.S.3    Cheng, A.W.4    Shi, L.5    Jaenisch, R.6
  • 186
    • 9244243137 scopus 로고    scopus 로고
    • Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors
    • Yang M, Reynoso J, Jiang P, Li L, Moossa AR and Hoffman RM. 2004. Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res 64(23): 8651-8656.
    • (2004) Cancer Res , vol.64 , Issue.23 , pp. 8651-8656
    • Yang, M.1    Reynoso, J.2    Jiang, P.3    Li, L.4    Moossa, A.R.5    Hoffman, R.M.6
  • 188
    • 80054987997 scopus 로고    scopus 로고
    • Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells
    • Yusa K et al. 2011. Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells. Nature 478(7369): 391-394.
    • (2011) Nature , vol.478 , Issue.7369 , pp. 391-394
    • Yusa, K.1
  • 189
    • 84907486054 scopus 로고    scopus 로고
    • TALEN-mediated somatic mutagenesis in murine models of cancer
    • Zhang S, Li L, Kendrick SL, Gerard RD and Zhu H. 2014. TALEN-mediated somatic mutagenesis in murine models of cancer. Cancer Res 74(18): 5311-5321.
    • (2014) Cancer Res , vol.74 , Issue.18 , pp. 5311-5321
    • Zhang, S.1    Li, L.2    Kendrick, S.L.3    Gerard, R.D.4    Zhu, H.5
  • 190
    • 0024420342 scopus 로고
    • Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
    • Zijlstra M, Li E, Sajjadi F, Subramani S and Jaenisch R. 1989. Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342(6248): 435-438.
    • (1989) Nature , vol.342 , Issue.6248 , pp. 435-438
    • Zijlstra, M.1    Li, E.2    Sajjadi, F.3    Subramani, S.4    Jaenisch, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.