-
1
-
-
0026939055
-
Inducible vectors for expression in mammalian cells
-
Yarranton, G. T. Inducible vectors for expression in mammalian cells. Curr. Opin. Biotechnol. 3, 506-511 (1992).
-
(1992)
Curr. Opin. Biotechnol.
, vol.3
, pp. 506-511
-
-
Yarranton, G.T.1
-
2
-
-
0023905363
-
Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice
-
Khillan, J. S. et al. Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. Nucleic Acids Res. 16, 1423-1430 (1988).
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 1423-1430
-
-
Khillan, J.S.1
-
3
-
-
0027321363
-
A transgenic model of transactivation by the Tax protein of HTLV-1
-
Bieberich, C. J., King, C. M., Tinkle, B. T. & Jay, G. A transgenic model of transactivation by the Tax protein of HTLV-1. Virology 196, 309-318 (1993).
-
(1993)
Virology
, vol.196
, pp. 309-318
-
-
Bieberich, C.J.1
King, C.M.2
Tinkle, B.T.3
Jay, G.4
-
4
-
-
0023189928
-
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice
-
Nerenberg, M., Hinrichs, S. H., Reynolds, R. K., Khoury, G. & Jay, G. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237, 1324-1329 (1987).
-
(1987)
Science
, vol.237
, pp. 1324-1329
-
-
Nerenberg, M.1
Hinrichs, S.H.2
Reynolds, R.K.3
Khoury, G.4
Jay, G.5
-
5
-
-
0024358496
-
Multiplex gene regulation: A two-tiered approach to transgene regulation in transgenic mice
-
Byrne, G. W. & Ruddle, F. H. Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice. Proc. Natl Acad. Sci. USA 86, 5473-5477 (1989).
-
(1989)
Proc. Natl Acad. Sci. USA
, vol.86
, pp. 5473-5477
-
-
Byrne, G.W.1
Ruddle, F.H.2
-
6
-
-
0030049156
-
Spatial and temporal regulation of a lacZ reporter transgene in a binary transgenic mouse system
-
Gardner, D. P., Byrne, G. W., Ruddle, F. H. & Kappen, C. Spatial and temporal regulation of a lacZ reporter transgene in a binary transgenic mouse system. Transgenic Res. 5, 37-48 (1996).
-
(1996)
Transgenic Res.
, vol.5
, pp. 37-48
-
-
Gardner, D.P.1
Byrne, G.W.2
Ruddle, F.H.3
Kappen, C.4
-
7
-
-
0032537457
-
Transactivation of Hox gene expression in a VP16-dependent binary transgenic mouse system
-
Rundle, C. H., Macias, M. P., Yueh, Y. G., Gardner, D. P. & Kappen, C. Transactivation of Hox gene expression in a VP16-dependent binary transgenic mouse system. Biochim. Biophys. Acta 1398, 164-178 (1998).
-
(1998)
Biochim. Biophys. Acta
, vol.1398
, pp. 164-178
-
-
Rundle, C.H.1
Macias, M.P.2
Yueh, Y.G.3
Gardner, D.P.4
Kappen, C.5
-
8
-
-
0033992228
-
Herpes simplex virus transcriptional activator VP16 is detrimental to preimplantation development in mice
-
Yueh, Y. G., Yaworsky, P. J. & Kappen, C. Herpes simplex virus transcriptional activator VP16 is detrimental to preimplantation development in mice. Mol. Reprod. Dev. 55, 37-46 (2000).
-
(2000)
Mol. Reprod. Dev.
, vol.55
, pp. 37-46
-
-
Yueh, Y.G.1
Yaworsky, P.J.2
Kappen, C.3
-
9
-
-
0029021083
-
A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
-
Shockett, P., Difilippantonio, M., Hellman, N. & Schatz, D. G. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc. Natl Acad. Sci. USA 92, 6522-6526 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 6522-6526
-
-
Shockett, P.1
Difilippantonio, M.2
Hellman, N.3
Schatz, D.G.4
-
10
-
-
0030797223
-
Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
-
Baron, U., Gossen, M. & Bujard, H. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res. 25, 2723-2729 (1997).
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 2723-2729
-
-
Baron, U.1
Gossen, M.2
Bujard, H.3
-
11
-
-
0034581163
-
Tet repressor-based system for regulated gene expression in eukaryotic cells: Principles and advances
-
Baron, U. & Bujard, H. Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol. 327, 401-421 (2000). A useful primer of the TetR-based systems for investigators who are considering this approach.
-
(2000)
Methods Enzymol.
, vol.327
, pp. 401-421
-
-
Baron, U.1
Bujard, H.2
-
12
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA 89, 5547-5551 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
13
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen, M. et al. Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-1769 (1995).
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
-
14
-
-
0029763587
-
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
-
Kistner, A. et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc. Natl Acad. Sci. USA 93, 10933-10938 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 10933-10938
-
-
Kistner, A.1
-
15
-
-
0035089060
-
Long-term, noninvasive imaging of regulated gene expression in living mice
-
Hasan, M. T., Schonig, K., Berger, S., Graewe, W. & Bujard, H. Long-term, noninvasive imaging of regulated gene expression in living mice. Genesis 29, 116-122 (2001). This study provides a model for the non-invasive imaging of conditional gene expression in mice, in which the TetR system was used to simultaneously regulate two transgenes, which encode Cre and luciferase, from a bidirectional promoter. A photon-imaging system was then used to follow the expression of luciferase in living mice.
-
(2001)
Genesis
, vol.29
, pp. 116-122
-
-
Hasan, M.T.1
Schonig, K.2
Berger, S.3
Graewe, W.4
Bujard, H.5
-
16
-
-
13144275262
-
Conditional lineage ablation to model human diseases
-
Lee, P. et al. Conditional lineage ablation to model human diseases. Proc. Natl Acad. Sci. USA 95, 11371-11376 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 11371-11376
-
-
Lee, P.1
-
17
-
-
0033518175
-
The temporal requirement for endothelin receptor-B signalling during neural crest development
-
Shin, M. K., Levorse, J. M., Ingram, R. S. & Tilghman, S. M. The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature 402, 496-501 (1999). This paper reports the use of gene targeting to produce three mouse lines in which wild-type Ednrb alleles were replaced with transgenes that encode either tTA or rtTA, or a tetO-Ednrb target gene. These lines were crossed to produce mice in which all Ednrb activity was doxycycline regulatable.
-
(1999)
Nature
, vol.402
, pp. 496-501
-
-
Shin, M.K.1
Levorse, J.M.2
Ingram, R.S.3
Tilghman, S.M.4
-
18
-
-
0035831033
-
Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin
-
Malleret, G. et al. Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell 104, 675-686 (2001). The value of being able to induce and then repress transgene transactivation is shown in this paper, as well as in references 19-24.
-
(2001)
Cell
, vol.104
, pp. 675-686
-
-
Malleret, G.1
-
19
-
-
0032498227
-
Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
-
Mansuy, I. M., Mayford, M., Jacob, B., Kandel, E. R. & Bach, M. E. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92, 39-49 (1998).
-
(1998)
Cell
, vol.92
, pp. 39-49
-
-
Mansuy, I.M.1
Mayford, M.2
Jacob, B.3
Kandel, E.R.4
Bach, M.E.5
-
20
-
-
0029818753
-
Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen
-
Ewald, D. et al. Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen. Science 273, 1384-1386 (1996).
-
(1996)
Science
, vol.273
, pp. 1384-1386
-
-
Ewald, D.1
-
21
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468-472 (1999).
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
-
22
-
-
0033180211
-
Reversible tumorigenesis by MYC in hematopoietic lineages
-
Felsher, D. W. & Bishop, J. M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell 4, 199-207 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 199-207
-
-
Felsher, D.W.1
Bishop, J.M.2
-
23
-
-
0033987718
-
Reversibility of acute B-cell leukaemia induced by BCR-ABL1
-
Huettner, C. S., Zhang, P., Van Etten, R. A. & Tenen, D. G. Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nature Genet. 24, 57-60 (2000).
-
(2000)
Nature Genet.
, vol.24
, pp. 57-60
-
-
Huettner, C.S.1
Zhang, P.2
Van Etten, R.A.3
Tenen, D.G.4
-
24
-
-
0034737299
-
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
-
Yamamoto, A., Lucas, J. J. & Hen, R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 101, 57-66 (2000).
-
(2000)
Cell
, vol.101
, pp. 57-66
-
-
Yamamoto, A.1
Lucas, J.J.2
Hen, R.3
-
25
-
-
0034608802
-
Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
-
Urlinger, S. et al. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc. Natl Acad. Sci. USA 97, 7963-7968 (2000). Investigators considering a TetR-based approach should review the Improved rtTA variants described here, as well as in reference 26.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 7963-7968
-
-
Urlinger, S.1
-
26
-
-
0033208332
-
Codon optimization, genetic insulation, and an rtTA reporter improve performance of the tetracycline switch
-
Wells, K. D., Foster, J. A., Moore, K., Pursel, V. G. & Wall, R. J. Codon optimization, genetic insulation, and an rtTA reporter improve performance of the tetracycline switch. Transgenic Res. 8, 371-381 (1999).
-
(1999)
Transgenic Res.
, vol.8
, pp. 371-381
-
-
Wells, K.D.1
Foster, J.A.2
Moore, K.3
Pursel, V.G.4
Wall, R.J.5
-
27
-
-
0029075822
-
Co-regulation of two gene activities by tetracycline via a bidirectional promoter
-
Baron, U., Freundlieb, S., Gossen, M. & Bujard, H. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res. 23, 3605-3606 (1995).
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 3605-3606
-
-
Baron, U.1
Freundlieb, S.2
Gossen, M.3
Bujard, H.4
-
28
-
-
17144449583
-
High susceptibility to bacterial infection, but no ever dysfunction, in mice compromised for hepatocyte NF-κB activation
-
Lavon, I. et al. High susceptibility to bacterial infection, but no ever dysfunction, in mice compromised for hepatocyte NF-κB activation. Nature Med. 6, 573-577 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 573-577
-
-
Lavon, I.1
-
29
-
-
0033514374
-
Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes
-
Baron, U. et al. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc. Natl Acad. Sci. USA 96, 1013-1018 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 1013-1018
-
-
Baron, U.1
-
30
-
-
0026078836
-
Binary system for regulating transgene expression in mice: Targeting int-2 gene expression with yeast GAL4/UAS control elements
-
Ornitz, D. M., Moreadith, R. W. & Leder, P. Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc. Natl Acad. Sci. USA 88, 698-702 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 698-702
-
-
Ornitz, D.M.1
Moreadith, R.W.2
Leder, P.3
-
31
-
-
0027756145
-
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
-
Echelard, Y. et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430 (1993).
-
(1993)
Cell
, vol.75
, pp. 1417-1430
-
-
Echelard, Y.1
-
32
-
-
0033570359
-
Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
-
Rowitch, D. H. et al. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J. Neurosci. 19, 8954-8965 (1999).
-
(1999)
J. Neurosci.
, vol.19
, pp. 8954-8965
-
-
Rowitch, D.H.1
-
33
-
-
0030965628
-
Ligand-inducible and liver-specific target gene expression in transgenic mice
-
Wang, Y., DeMayo, F. J., Tsai, S. Y. & O'Malley, B. W. Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotechnol. 15, 239-243 (1997).
-
(1997)
Nature Biotechnol.
, vol.15
, pp. 239-243
-
-
Wang, Y.1
DeMayo, F.J.2
Tsai, S.Y.3
O'Malley, B.W.4
-
34
-
-
0033621427
-
Inducible gene knockouts in the small intestinal and colonic epithelium
-
Saam, J. R. & Gordon, J. I. Inducible gene knockouts in the small intestinal and colonic epithelium. J. Biol. Chem. 274, 38071-38082 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 38071-38082
-
-
Saam, J.R.1
Gordon, J.I.2
-
35
-
-
0033587687
-
Development of gene-switch transgenic mice that inducibly express transforming growth factor β1 in the epidermis
-
Wang, X. J., Liefer, K. M., Tsai, S., O'Malley, B. W. & Roop, D. R. Development of gene-switch transgenic mice that inducibly express transforming growth factor β1 in the epidermis. Proc. Natl Acad. Sci. USA 96, 8483-8488 (1999). In this paper, topical application of a synthetic steroid was used to control Tgfb1 expression in mouse skin through the transactivator GLVPc, showing that Tgf-β1 inhibits epidermal cell growth.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 8483-8488
-
-
Wang, X.J.1
Liefer, K.M.2
Tsai, S.3
O'Malley, B.W.4
Roop, D.R.5
-
36
-
-
0035864356
-
Role of TGFβ signaling in skin carcinogenesis
-
Wang, X. Role of TGFβ signaling in skin carcinogenesis. Microsc. Res. Tech. 52, 420-429 (2001).
-
(2001)
Microsc. Res. Tech.
, vol.52
, pp. 420-429
-
-
Wang, X.1
-
37
-
-
0034465668
-
Regulable expression of inhibin A in wild-type and inhibin α null mice
-
Pierson, T. M. et al. Regulable expression of inhibin A in wild-type and inhibin α null mice. Mol. Endocrinol. 14, 1075-1085 (2000).
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 1075-1085
-
-
Pierson, T.M.1
-
38
-
-
0024509412
-
Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome
-
Sauer, B. & Henderson, N. Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome. Nucleic Acids Res. 17, 147-161 (1989).
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 147-161
-
-
Sauer, B.1
Henderson, N.2
-
39
-
-
0025847620
-
Recombinase-mediated gene activation and site-specific integration in mammalian cells
-
O'Gorman, S., Fox, D. T. & Wahl, G. M. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science 251, 1351-1355 (1991).
-
(1991)
Science
, vol.251
, pp. 1351-1355
-
-
O'Gorman, S.1
Fox, D.T.2
Wahl, G.M.3
-
40
-
-
0031874849
-
Improved properties of FLP recombinase evolved by cycling mutagenesis
-
Buchholz, F., Angrand, P. O. & Stewart, A. F. Improved properties of FLP recombinase evolved by cycling mutagenesis. Nature Biotechnol. 16, 657-662 (1998). DNA-shuffling techniques are used here to modify the Flp recombinase so that it can function optimally at the body temperature of mice.
-
(1998)
Nature Biotechnol.
, vol.16
, pp. 657-662
-
-
Buchholz, F.1
Angrand, P.O.2
Stewart, A.F.3
-
41
-
-
0027280936
-
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
-
Gu, H., Zou, Y. R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164 (1993).
-
(1993)
Cell
, vol.73
, pp. 1155-1164
-
-
Gu, H.1
Zou, Y.R.2
Rajewsky, K.3
-
42
-
-
0031462460
-
Analysis of Fgf8 gene function in vertebrate development
-
Lewandoski, M., Meyers, E. N. & Martin, G. R. Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb. Symp. Quant. Biol. 62, 159-168 (1997).
-
(1997)
Cold Spring Harb. Symp. Quant. Biol.
, vol.62
, pp. 159-168
-
-
Lewandoski, M.1
Meyers, E.N.2
Martin, G.R.3
-
43
-
-
0033572912
-
Nuclear targeting determinants of the phage P1 cre DNA recombinase
-
Le, Y., Gagneten, S., Tombaccini, D., Bethke, B. & Sauer, B. Nuclear targeting determinants of the phage P1 cre DNA recombinase. Nucleic Acids Res. 27, 4703-4709 (1999).
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 4703-4709
-
-
Le, Y.1
Gagneten, S.2
Tombaccini, D.3
Bethke, B.4
Sauer, B.5
-
44
-
-
0343415768
-
Mammalian genomes contain active recombinase recognition sites
-
Thyagarajan, B., Guimaraes, M. J., Groth, A. C. & Calos, M. P. Mammalian genomes contain active recombinase recognition sites. Gene 244, 47-54 (2000).
-
(2000)
Gene
, vol.244
, pp. 47-54
-
-
Thyagarajan, B.1
Guimaraes, M.J.2
Groth, A.C.3
Calos, M.P.4
-
45
-
-
0022892746
-
Directionality in FLP protein-promoted site-specific recombination is mediated by DNA-DNA pairing
-
Senecoff, J. F. & Cox, M. M. Directionality in FLP protein-promoted site-specific recombination is mediated by DNA-DNA pairing. J. Biol. Chem. 261, 7380-7386 (1986).
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 7380-7386
-
-
Senecoff, J.F.1
Cox, M.M.2
-
46
-
-
0035979247
-
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
-
Loonstra, A. et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc. Natl Acad. Sci. USA 98, 9209-9214 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 9209-9214
-
-
Loonstra, A.1
-
47
-
-
0034610394
-
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
-
Schmidt, E. E., Taylor, D. S., Prigge, J. R., Barnett, S. & Capecchi, M. R. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc. Natl Acad. Sci. USA 97, 13702-13707 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 13702-13707
-
-
Schmidt, E.E.1
Taylor, D.S.2
Prigge, J.R.3
Barnett, S.4
Capecchi, M.R.5
-
48
-
-
0031443874
-
Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
-
O'Gorman, S., Dagenais, N. A., Qian, M. & Marchuk, Y. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc. Natl Acad. Sci. USA 94, 14602-14607 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 14602-14607
-
-
O'Gorman, S.1
Dagenais, N.A.2
Qian, M.3
Marchuk, Y.4
-
49
-
-
0031080163
-
Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line
-
Lewandoski, M., Wassarman, K. M. & Martin, G. R. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr. Biol. 7, 148-151 (1997).
-
(1997)
Curr. Biol.
, vol.7
, pp. 148-151
-
-
Lewandoski, M.1
Wassarman, K.M.2
Martin, G.R.3
-
50
-
-
0029976272
-
Recycling selectable markers in mouse embryonic stem cells
-
Abuin, A. & Bradley, A. Recycling selectable markers in mouse embryonic stem cells. Mol. Cell. Biol. 16, 1851-1856 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1851-1856
-
-
Abuin, A.1
Bradley, A.2
-
51
-
-
0033757718
-
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
-
Dragatsis, I., Levine, M. S. & Zeitlin, S. Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nature Genet. 26, 300-306 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 300-306
-
-
Dragatsis, I.1
Levine, M.S.2
Zeitlin, S.3
-
52
-
-
0035099411
-
Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis
-
Sakai, T. et al. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nature Med. 7, 324-330 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 324-330
-
-
Sakai, T.1
-
53
-
-
0035094767
-
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
-
Guy, J., Hendrich, B., Holmes, M., Martin, J. E. & Bird, A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nature Genet. 27, 322-326 (2001).
-
(2001)
Nature Genet.
, vol.27
, pp. 322-326
-
-
Guy, J.1
Hendrich, B.2
Holmes, M.3
Martin, J.E.4
Bird, A.5
-
54
-
-
0034254284
-
Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes
-
Brakebusch, C. et al. Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes. EMBO J. 19, 3990-4003 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 3990-4003
-
-
Brakebusch, C.1
-
55
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasts as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase
-
Postic, C. et al. Dual roles for glucokinase in glucose homeostasts as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274, 305-315 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 305-315
-
-
Postic, C.1
-
56
-
-
0028059099
-
Deletion of a DNA polymerase β-gene segment in T cells using cell type-specific gene targeting
-
Gu, H., Marth, J. D., Orban, P. C., Mossmann, H. & Rajewsky, K. Deletion of a DNA polymerase β-gene segment in T cells using cell type-specific gene targeting. Science 265, 103-106 (1994). This paper describes the first tissue-specific gene inactivation and provides a model for using three loxP sites to remove the selection cassette from the conditional allele in vitro. See references 59 and 60 for variations on this strategy.
-
(1994)
Science
, vol.265
, pp. 103-106
-
-
Gu, H.1
Marth, J.D.2
Orban, P.C.3
Mossmann, H.4
Rajewsky, K.5
-
57
-
-
0031916557
-
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
-
Meyers, E. N., Lewandoski, M. & Martin, G. R. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nature Genet. 18, 136-141 (1998). An example of the allelogenic strategy as applied to the Fgf8 locus, in which three alleles (hypomorphic, conditional and null) were generated from one mouse line.
-
(1998)
Nature Genet.
, vol.18
, pp. 136-141
-
-
Meyers, E.N.1
Lewandoski, M.2
Martin, G.R.3
-
58
-
-
0032554783
-
Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
-
Nagy, A. et al. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr. Biol. 8, 661-664 (1998). A demonstration of how to produce an allelic series, which includes alleles with any desirable mutation, using the N-Myc locus as an example.
-
(1998)
Curr. Biol.
, vol.8
, pp. 661-664
-
-
Nagy, A.1
-
59
-
-
0035018190
-
Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches
-
Xu, X. et al. Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches. Genesis 30, 1-6 (2001).
-
(2001)
Genesis
, vol.30
, pp. 1-6
-
-
Xu, X.1
-
60
-
-
0034323074
-
Cre-mediated germline mosaicism: A method allowing rapid generation of several alleles of a target gene
-
Holzenberger, M. et al. Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. Nucleic Acids Res. 28, E92 (2000).
-
(2000)
Nucleic Acids Res.
, vol.28
-
-
Holzenberger, M.1
-
61
-
-
0032146074
-
Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos
-
Partanen, J., Schwartz, L. & Rossant, J. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 12, 2332-2344 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 2332-2344
-
-
Partanen, J.1
Schwartz, L.2
Rossant, J.3
-
62
-
-
0032722672
-
Dosage requirement of Pitx2 for development of multiple organs
-
Gage, P. J., Suh, H. & Camper, S. A. Dosage requirement of Pitx2 for development of multiple organs. Development 126, 4643-4651 (1999).
-
(1999)
Development
, vol.126
, pp. 4643-4651
-
-
Gage, P.J.1
Suh, H.2
Camper, S.A.3
-
63
-
-
0033565746
-
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
-
Sun, X., Meyers, E. N., Lewandoski, M. & Martin, G. R. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 13, 1834-1846 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 1834-1846
-
-
Sun, X.1
Meyers, E.N.2
Lewandoski, M.3
Martin, G.R.4
-
64
-
-
0033575364
-
Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH
-
Meyers, E. N. & Martin, G. R. Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285, 403-406 (1999).
-
(1999)
Science
, vol.285
, pp. 403-406
-
-
Meyers, E.N.1
Martin, G.R.2
-
65
-
-
0033397681
-
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
-
Trumpp, A., Depew, M. J., Rubenstein, J. L. Bishop, J. M. & Martin, G. R. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 13, 3136-3148 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 3136-3148
-
-
Trumpp, A.1
Depew, M.J.2
Rubenstein, J.L.3
Bishop, J.M.4
Martin, G.R.5
-
66
-
-
0033673531
-
Fgf8 signalling from the AER is essential for normal limb development
-
Lewandoski, M., Sun, X. & Martin, G. R. Fgf8 signalling from the AER is essential for normal limb development. Nature Genet. 26, 460-463 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 460-463
-
-
Lewandoski, M.1
Sun, X.2
Martin, G.R.3
-
67
-
-
0033662330
-
Fgf8 is required for outgrowth and patterning of the limbs
-
Moon, A. M. & Capecchi, M. R. Fgf8 is required for outgrowth and patterning of the limbs. Nature Genet. 26, 455-459 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 455-459
-
-
Moon, A.M.1
Capecchi, M.R.2
-
68
-
-
0032923739
-
Generalized lacZ expression with the ROSA26 Cre reporter strain
-
Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet. 21, 70-71 (1999). This reference and reference 72 provide two different models of how to achieve the otherwise difficult goal of near-ubiquitous transgene expression in the mouse. Such expression is ideal for producing mice that are useful as breeding partners for those that carry different tissue-specific cre or FLP transgenes.
-
(1999)
Nature Genet.
, vol.21
, pp. 70-71
-
-
Soriano, P.1
-
69
-
-
0033608980
-
Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice
-
Mao, X., Fujiwara, Y. & Orkin, S. H. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc. Natl Acad. Sci. USA 96, 5037-5042 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 5037-5042
-
-
Mao, X.1
Fujiwara, Y.2
Orkin, S.H.3
-
70
-
-
0035170536
-
Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain
-
Mao, X., Fujiwara, Y., Chapdelaine, A., Yang, H. & Orkin, S. H. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood 97, 324-326 (2001).
-
(2001)
Blood
, vol.97
, pp. 324-326
-
-
Mao, X.1
Fujiwara, Y.2
Chapdelaine, A.3
Yang, H.4
Orkin, S.H.5
-
71
-
-
3042856262
-
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
-
Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
-
(2001)
BMC Dev. Biol.
, vol.1
, Issue.4
-
-
Srinivas, S.1
-
72
-
-
0033561410
-
Z/AP, a double reporter for cre-mediated recombination
-
Lobe, C. G. et al. Z/AP, a double reporter for cre-mediated recombination. Dev. Biol. 208, 281-292 (1999).
-
(1999)
Dev. Biol.
, vol.208
, pp. 281-292
-
-
Lobe, C.G.1
-
73
-
-
0034488835
-
Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision
-
Novak, A., Guo, C., Yang, W., Nagy, A. & Lobe, C. G. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28, 147-155 (2000).
-
(2000)
Genesis
, vol.28
, pp. 147-155
-
-
Novak, A.1
Guo, C.2
Yang, W.3
Nagy, A.4
Lobe, C.G.5
-
74
-
-
0035029433
-
A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
-
Voojs, M., Jonkers, J. & Berns, A. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep. 2, 292-297 (2001).
-
(2001)
EMBO Rep.
, vol.2
, pp. 292-297
-
-
Voojs, M.1
Jonkers, J.2
Berns, A.3
-
75
-
-
0032554790
-
Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system
-
Zinyk, D. L., Mercer, E. H., Harris, E., Anderson, D. J. & Joyner, A. L. Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr. Biol. 8, 665-668 (1998).
-
(1998)
Curr. Biol.
, vol.8
, pp. 665-668
-
-
Zinyk, D.L.1
Mercer, E.H.2
Harris, E.3
Anderson, D.J.4
Joyner, A.L.5
-
76
-
-
0034030119
-
Migration of cardiac neural crest cells in Splotch embryos
-
Epstein, J. A. et al. Migration of cardiac neural crest cells in Splotch embryos. Development 127, 1869-1878 (2000).
-
(2000)
Development
, vol.127
, pp. 1869-1878
-
-
Epstein, J.A.1
-
77
-
-
0034057170
-
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
-
Chai, Y. et al. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127, 1671-1679 (2000).
-
(2000)
Development
, vol.127
, pp. 1671-1679
-
-
Chai, Y.1
-
78
-
-
0034010326
-
Fate of the mammalian cardiac neural crest
-
Jiang, X., Rowitch, D. H., Soriano, P., McMahon, A. P. & Sucov, H. M. Fate of the mammalian cardiac neural crest. Development 127, 1607-1616 (2000).
-
(2000)
Development
, vol.127
, pp. 1607-1616
-
-
Jiang, X.1
Rowitch, D.H.2
Soriano, P.3
McMahon, A.P.4
Sucov, H.M.5
-
79
-
-
0034121735
-
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
-
Herrera, P. L. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127, 2317-2322 (2000).
-
(2000)
Development
, vol.127
, pp. 2317-2322
-
-
Herrera, P.L.1
-
80
-
-
0033542458
-
Modelling T-cell memory by genetic marking of memory T cells in vivo
-
Jacob, J. & Baltimore, D. Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature 399, 593-597 (1999).
-
(1999)
Nature
, vol.399
, pp. 593-597
-
-
Jacob, J.1
Baltimore, D.2
-
81
-
-
0346310346
-
Multiple neuronal identities and migrations specified by a single Hox gene in mice
-
in the press
-
O'Gorman, S. & Barcarse, E. A. Multiple neuronal identities and migrations specified by a single Hox gene in mice. Development (in the press).
-
Development
-
-
O'Gorman, S.1
Barcarse, E.A.2
-
82
-
-
0026638820
-
Targeted oncogene activation by site-specific recombination in transgenic mice
-
Lakso, M. et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl Acad. Sci. USA 89, 6232-6236 (1992). This first demonstration of Cre-mediated transgene activation provides a model for the general strategy. For an elaboration of this model, see reference 88, and for an alternative model, see reference 83.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 6232-6236
-
-
Lakso, M.1
-
83
-
-
0032523802
-
Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss
-
Grieshammer, U., Lewandoski, M., Prevette, D., Oppenheim, R. W. & Martin, G. R. Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss. Dev. Biol. 197, 234-247 (1998).
-
(1998)
Dev. Biol.
, vol.197
, pp. 234-247
-
-
Grieshammer, U.1
Lewandoski, M.2
Prevette, D.3
Oppenheim, R.W.4
Martin, G.R.5
-
84
-
-
0031252296
-
Cre-mediated chromosome loss in mice
-
Lewandoski, M. & Martin, G. R. Cre-mediated chromosome loss in mice. Nature Genet. 17, 223-225 (1997).
-
(1997)
Nature Genet.
, vol.17
, pp. 223-225
-
-
Lewandoski, M.1
Martin, G.R.2
-
85
-
-
0031984304
-
Repeat-induced gene silencing in mammals
-
Garrick, D., Fiering, S., Martin, D. I. & Whitelaw, E. Repeat-induced gene silencing in mammals. Nature Genet. 18, 56-59 (1998).
-
(1998)
Nature Genet.
, vol.18
, pp. 56-59
-
-
Garrick, D.1
Fiering, S.2
Martin, D.I.3
Whitelaw, E.4
-
86
-
-
7844242559
-
Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination
-
Drago, J. et al. Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination. J. Neurosci. 18, 9845-9857 (1998).
-
(1998)
J. Neurosci.
, vol.18
, pp. 9845-9857
-
-
Drago, J.1
-
87
-
-
0034677471
-
Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
-
Lee, K. J., Dietrich, P. & Jessell, T. M. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature 403, 734-740 (2000).
-
(2000)
Nature
, vol.403
, pp. 734-740
-
-
Lee, K.J.1
Dietrich, P.2
Jessell, T.M.3
-
88
-
-
0035258737
-
A method for the generation of conditional gene repair mutations in mice
-
Dragatsis, I. & Zeitlin, S. A method for the generation of conditional gene repair mutations in mice. Nucleic Acids Res. 29, E10 (2001).
-
(2001)
Nucleic Acids Res.
, vol.29
-
-
Dragatsis, I.1
Zeitlin, S.2
-
89
-
-
0035809167
-
Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders
-
Ann, M. J., Longley, M. A., Wang, X. J. & Roop, D. R. Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders. J. Cell Biol. 152, 645-649 (2001).
-
(2001)
J. Cell Biol.
, vol.152
, pp. 645-649
-
-
Ann, M.J.1
Longley, M.A.2
Wang, X.J.3
Roop, D.R.4
-
90
-
-
0035809198
-
An inducible mouse model for epidermolysis bullosa simplex: Implications for gene therapy
-
Cao, T., Longley, M. A., Wang, X. J. & Roop, D. R. An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy. J. Cell Biol. 152, 651-656 (2001).
-
(2001)
J. Cell Biol.
, vol.152
, pp. 651-656
-
-
Cao, T.1
Longley, M.A.2
Wang, X.J.3
Roop, D.R.4
-
91
-
-
0029155706
-
Inducible gene targeting in mice
-
Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
-
(1995)
Science
, vol.269
, pp. 1427-1429
-
-
Kuhn, R.1
Schwenk, F.2
Aguet, M.3
Rajewsky, K.4
-
92
-
-
0032931234
-
VEGF is required for growth and survival in neonatal mice
-
Gerber, H. P. et al. VEGF is required for growth and survival in neonatal mice. Development 126, 1149-1159 (1999).
-
(1999)
Development
, vol.126
, pp. 1149-1159
-
-
Gerber, H.P.1
-
93
-
-
0035131190
-
Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver
-
Alonzi, T. et al. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver. Mol. Cell. Biol. 21, 1621-1632 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1621-1632
-
-
Alonzi, T.1
-
94
-
-
0032004972
-
Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
-
Rohlmam, A., Gotthardt, M., Hammer, R. E. & Herz, J. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J. Clin. Invest. 101, 689-695 (1998).
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 689-695
-
-
Rohlmam, A.1
Gotthardt, M.2
Hammer, R.E.3
Herz, J.4
-
95
-
-
13044294029
-
Liver-derived insulin-like growth factor 1 (IGF-1) is the principal source of IGF-1 in blood but is not required for postnatal body growth in mice
-
Sjogren, K. et al. Liver-derived insulin-like growth factor 1 (IGF-1) is the principal source of IGF-1 in blood but is not required for postnatal body growth in mice. Proc. Natl Acad. Sci. USA 96, 7088-7092 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 7088-7092
-
-
Sjogren, K.1
-
96
-
-
0032573147
-
Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo
-
Lam, K. P. & Rajewsky, K. Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo. Proc. Natl Acad. Sci. USA 95, 13171-13175 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13171-13175
-
-
Lam, K.P.1
Rajewsky, K.2
-
97
-
-
0342711256
-
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
-
Lam, K. P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083 (1997).
-
(1997)
Cell
, vol.90
, pp. 1073-1083
-
-
Lam, K.P.1
Kuhn, R.2
Rajewsky, K.3
-
98
-
-
0033136717
-
Deficient T cell fate specification in mice with an induced inactivation of Notch1
-
Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547-558 (1999).
-
(1999)
Immunity
, vol.10
, pp. 547-558
-
-
Radtke, F.1
-
99
-
-
0033534701
-
Inducible site-specific recombination in the brain
-
Kellendonk, C. et al. Inducible site-specific recombination in the brain. J. Mol. Biol. 285, 175-182 (1999).
-
(1999)
J. Mol. Biol.
, vol.285
, pp. 175-182
-
-
Kellendonk, C.1
-
100
-
-
0029874029
-
Regulation of Cre recombinase activity by the synthetic steroid RU 486
-
Kellendonk, C. et al. Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res. 24, 1404-1411 (1996).
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 1404-1411
-
-
Kellendonk, C.1
-
101
-
-
0029767838
-
Ligand-activated site-specific recombination in mice
-
Feil, R. et al. Ligand-activated site-specific recombination in mice. Proc. Natl Acad. Sci. USA 93, 10887-10890 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 10887-10890
-
-
Feil, R.1
-
102
-
-
0032481124
-
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
-
Danielian, P. S., Muccino, D., Rowitch, D. H., Michael, S. K. & McMahon, A. P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8, 1323-1326 (1998).
-
(1998)
Curr. Biol.
, vol.8
, pp. 1323-1326
-
-
Danielian, P.S.1
Muccino, D.2
Rowitch, D.H.3
Michael, S.K.4
McMahon, A.P.5
-
103
-
-
0031473544
-
Spatio-temporally controlled site-specific somatic mutagenesis in the mouse
-
Brocard, J. et al. Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proc. Natl Acad. Sci. USA 94, 14559-14563 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 14559-14563
-
-
Brocard, J.1
-
104
-
-
2642625666
-
Temporally and spatially regulated somatic mutagenesis in mice
-
Schwenk, F., Kuhn, R., Angrand, P. O., Rajewsky, K. & Stewart, A. F. Temporally and spatially regulated somatic mutagenesis in mice. Nucleic Acids Res. 26, 1427-1432 (1998).
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1427-1432
-
-
Schwenk, F.1
Kuhn, R.2
Angrand, P.O.3
Rajewsky, K.4
Stewart, A.F.5
-
105
-
-
0029164598
-
Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
-
Metzger, D., Clifford, J., Chiba, H. & Chambon, P. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc. Natl Acad. Sci. USA 92, 6991-6995 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 6991-6995
-
-
Metzger, D.1
Clifford, J.2
Chiba, H.3
Chambon, P.4
-
106
-
-
0029962975
-
Inducible site-directed recombination in mouse embryonic stem cells
-
Zhang, Y. et al. Inducible site-directed recombination in mouse embryonic stem cells. Nucleic Acids Res. 24, 543-548 (1996).
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 543-548
-
-
Zhang, Y.1
-
107
-
-
0034842640
-
Site- and time-specific gene targeting in the mouse
-
Metzger, D. & Chambon, P. Site- and time-specific gene targeting in the mouse. Methods 24, 71-80 (2001).
-
(2001)
Methods
, vol.24
, pp. 71-80
-
-
Metzger, D.1
Chambon, P.2
-
108
-
-
0033587776
-
The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
-
Vasioukhin, V., Degenstein, L., Wise, B. & Fuchs, E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl Acad. Sci. USA 96, 8551-8556 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 8551-8556
-
-
Vasioukhin, V.1
Degenstein, L.2
Wise, B.3
Fuchs, E.4
-
109
-
-
0032535491
-
Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk
-
Zhang, Y., Wienands, J., Zurn, C. & Reth, M. Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk. EMBO J. 17, 7304-7310 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 7304-7310
-
-
Zhang, Y.1
Wienands, J.2
Zurn, C.3
Reth, M.4
-
110
-
-
0035836755
-
Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity
-
Imai, T., Jiang, M., Kastner, P., Chambon, P. & Metzger, D. Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity. Proc. Natl Acad. Sci. USA 98, 4581-4586 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 4581-4586
-
-
Imai, T.1
Jiang, M.2
Kastner, P.3
Chambon, P.4
Metzger, D.5
-
111
-
-
0034214414
-
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
-
Kimmel, R. A. et al. Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev. 14, 1377-1389 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 1377-1389
-
-
Kimmel, R.A.1
-
112
-
-
0035874366
-
New variants of inducible Cre recombinase: A novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility
-
Wunderlich, F. T., Wildner, H., Rajewsky, K. & Edenhofer, F. New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility. Nucleic Acids Res. 29, E47 (2001). Investigators considering inducible cre experiments should review these improved Cre-PR variants, as well as the Cre-ER (T2) variant in references 113-115.
-
(2001)
Nucleic Acids Res.
, vol.29
-
-
Wunderlich, F.T.1
Wildner, H.2
Rajewsky, K.3
Edenhofer, F.4
-
113
-
-
0033571243
-
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: Comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases
-
Indra, A. K. et al. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res. 27, 4324-4327 (1999).
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 4324-4327
-
-
Indra, A.K.1
-
114
-
-
0035793045
-
Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
-
Imai, T., Jiang, M., Chambon, P. & Metzger, D. Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc. Natl Acad. Sci. USA 98, 224-228 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 224-228
-
-
Imai, T.1
Jiang, M.2
Chambon, P.3
Metzger, D.4
-
115
-
-
0034609819
-
Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis
-
Li, M. et al. Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis. Nature 407, 633-636 (2000).
-
(2000)
Nature
, vol.407
, pp. 633-636
-
-
Li, M.1
-
116
-
-
0032692949
-
Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice
-
Utomo, A. R., Nikitin, A. Y. & Lee, W. H. Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nature Biotechnol. 17, 1091-1096 (1999).
-
(1999)
Nature Biotechnol.
, vol.17
, pp. 1091-1096
-
-
Utomo, A.R.1
Nikitin, A.Y.2
Lee, W.H.3
-
117
-
-
0034098934
-
Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre)
-
Holzenberger, M., Zaoui, R., Leneuve, P., Harnard, G. & Le Bouc, Y. Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre). Genesis 26, 157-159 (2000).
-
(2000)
Genesis
, vol.26
, pp. 157-159
-
-
Holzenberger, M.1
Zaoui, R.2
Leneuve, P.3
Harnard, G.4
Le Bouc, Y.5
-
118
-
-
0029788269
-
Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter
-
St-Onge, L., Furth, P. A. & Gruss, P. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic Acids Res. 24, 3875-3877 (1996).
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 3875-3877
-
-
St-Onge, L.1
Furth, P.A.2
Gruss, P.3
-
119
-
-
0029959746
-
Sustained somatic gene inactivation by viral transfer of Cre recombinase
-
Rohlmann, A., Gotthardt, M., Willnow, T. E., Hammer, R. E. & Herz, J. Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nature Biotechnol. 14, 1562-1565 (1996).
-
(1996)
Nature Biotechnol.
, vol.14
, pp. 1562-1565
-
-
Rohlmann, A.1
Gotthardt, M.2
Willnow, T.E.3
Hammer, R.E.4
Herz, J.5
-
120
-
-
0029961646
-
Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene
-
Wang, Y., Krushel, L. A. & Edelman, G. M. Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. Proc. Natl Acad. Sci. USA 93, 3932-3936 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 3932-3936
-
-
Wang, Y.1
Krushel, L.A.2
Edelman, G.M.3
-
121
-
-
0030878260
-
Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo
-
Agah, R. et al. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J. Clin. Invest. 100, 169-179 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 169-179
-
-
Agah, R.1
-
122
-
-
0031028680
-
Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase
-
Brooks, A. I., Muhkerjee, B., Panahian, N., Cory-Slechta, D. & Federoff, H. J. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nature Biotechnol. 15, 57-62 (1997).
-
(1997)
Nature Biotechnol.
, vol.15
, pp. 57-62
-
-
Brooks, A.I.1
Muhkerjee, B.2
Panahian, N.3
Cory-Slechta, D.4
Federoff, H.J.5
-
123
-
-
0033977926
-
High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates
-
Christensen, G., Minamisawa, S., Gruber, P. J., Wang, Y. & Chien, K. R. High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates. Circulation 101, 178-184 (2000).
-
(2000)
Circulation
, vol.101
, pp. 178-184
-
-
Christensen, G.1
Minamisawa, S.2
Gruber, P.J.3
Wang, Y.4
Chien, K.R.5
-
124
-
-
0034700176
-
Gene-experience interaction alters the cholinergic septohippocampal pathway of mice
-
Brooks, A. I., Cory-Slechta, D. A. & Federoff, H. J. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proc. Natl Acad. Sci. USA 97, 13378-13383 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 13378-13383
-
-
Brooks, A.I.1
Cory-Slechta, D.A.2
Federoff, H.J.3
-
125
-
-
0030843461
-
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
-
Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120-123 (1997).
-
(1997)
Science
, vol.278
, pp. 120-123
-
-
Shibata, H.1
-
126
-
-
0030765649
-
Disruption of the c/ebp α gene in adult mouse liver
-
Lee, Y. H., Sauer, B., Johnson, P. F. & Gonzalez, F. J. Disruption of the c/ebp α gene in adult mouse liver. Mol. Cell. Biol. 17, 6014-6022 (1997).
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6014-6022
-
-
Lee, Y.H.1
Sauer, B.2
Johnson, P.F.3
Gonzalez, F.J.4
-
127
-
-
0033534726
-
Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion
-
Piston, D. W., Knobel, S. M., Postic, C., Shelton, K. D. & Magnuson, M. A. Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J. Biol. Chem. 274, 1000-1004 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1000-1004
-
-
Piston, D.W.1
Knobel, S.M.2
Postic, C.3
Shelton, K.D.4
Magnuson, M.A.5
-
128
-
-
0030297838
-
FLP-mediated site-specific recombination in microinjected murine zygotes
-
Ludwig, D. L., Stringer, J. R., Wight, D. C., Doetschman, H. C. & Duffy, J. J. FLP-mediated site-specific recombination in microinjected murine zygotes. Transgenic Res. 5, 385-395 (1996).
-
(1996)
Transgenic Res.
, vol.5
, pp. 385-395
-
-
Ludwig, D.L.1
Stringer, J.R.2
Wight, D.C.3
Doetschman, H.C.4
Duffy, J.J.5
-
129
-
-
0029954688
-
Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
-
Dymecki, S. M. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc. Natl Acad. Sci. USA 93, 6191-6196 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 6191-6196
-
-
Dymecki, S.M.1
-
130
-
-
0029860719
-
Different thermostabilities of FLP and Cre recombinases: Implications for applied site-specific recombination
-
Buchholz, F., Ringrose, L., Angrand, P. O., Rossi, F. & Stewart, A. F. Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res. 24, 4256-4262 (1996).
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 4256-4262
-
-
Buchholz, F.1
Ringrose, L.2
Angrand, P.O.3
Rossi, F.4
Stewart, A.F.5
-
131
-
-
0034041160
-
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
-
Rodriguez, C. I. et al. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nature Genet. 25, 139-140 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 139-140
-
-
Rodriguez, C.I.1
-
132
-
-
0032500170
-
Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse
-
Vooijs, M., van der Valk, M., te Riele, H. & Berns, A. Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. Oncogene 17, 1-12 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 1-12
-
-
Vooijs, M.1
Van Der Valk, M.2
Te Riele, H.3
Berns, A.4
-
133
-
-
0029043630
-
Ligand-regulated site-specific recombination
-
Logie, C. & Stewart, A. F. Ligand-regulated site-specific recombination. Proc. Natl Acad. Sci. USA 92, 5940-5944 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5940-5944
-
-
Logie, C.1
Stewart, A.F.2
-
134
-
-
0032230285
-
Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins
-
Logie, C., Nichols, M., Myles, K., Funder, J. W. & Stewart, A. F. Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins. Mol. Endocrinol. 12, 1120-1132 (1998).
-
(1998)
Mol. Endocrinol.
, vol.12
, pp. 1120-1132
-
-
Logie, C.1
Nichols, M.2
Myles, K.3
Funder, J.W.4
Stewart, A.F.5
-
135
-
-
0034487368
-
Widespread recombinase expression using FLPeR (flipper) mice
-
Farley, F. W., Soriano, P., Steffen, L. S. & Dymecki, S. M. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28, 106-110 (2000).
-
(2000)
Genesis
, vol.28
, pp. 106-110
-
-
Farley, F.W.1
Soriano, P.2
Steffen, L.S.3
Dymecki, S.M.4
-
136
-
-
0033681169
-
Origin of the precerebellar system
-
Rodriguez, C. I. & Dymecki, S. M. Origin of the precerebellar system. Neuron 27, 475-486 (2000). Flp expression is used here to permanently mark Wnt1-expressing cells and to trace their descendants. This paper contains an informative discussion of the advantages and potential artefacts of this type of cell-lineage analysis.
-
(2000)
Neuron
, vol.27
, pp. 475-486
-
-
Rodriguez, C.I.1
Dymecki, S.M.2
-
137
-
-
0035815295
-
Pax6 is required for the multipotent state of retinal progenitor cells
-
Marquardt, T. et al. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105, 43-55 (2001).
-
(2001)
Cell
, vol.105
, pp. 43-55
-
-
Marquardt, T.1
-
138
-
-
0034687804
-
Identification of ligands and coligands for the ecdysone-regulated gene switch
-
Saez, E. et al. Identification of ligands and coligands for the ecdysone-regulated gene switch. Proc. Natl Acad. Sci. USA 97, 14512-14517 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 14512-14517
-
-
Saez, E.1
-
139
-
-
0035876445
-
The lac operator-repressor system is functional in the mouse
-
Cronin, C. A., Gluba, W. & Scrable, H. The lac operator-repressor system is functional in the mouse. Genes Dev. 15, 1506-1517 (2001). This paper reports a modified lac operator-repressor system that functions in the mouse and was used to regulate a coat-colour transgene, such that its expression is IPTG responsive.
-
(2001)
Genes Dev.
, vol.15
, pp. 1506-1517
-
-
Cronin, C.A.1
Gluba, W.2
Scrable, H.3
-
140
-
-
0035844251
-
New insights into host factor requirements for prokaryotic β-recombinase-mediated reactions in mammalian cells
-
Diaz, V. et al. New insights into host factor requirements for prokaryotic β-recombinase-mediated reactions in mammalian cells. J. Biol. Chem. 276, 16257-16264 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16257-16264
-
-
Diaz, V.1
-
141
-
-
0035008830
-
Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase
-
Thyagarajan, B., Olivares, E. C., Hollis, R. P., Ginsburg, D. S. & Calos, M. P. Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol. Cell. Biol. 21, 3926-3934 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3926-3934
-
-
Thyagarajan, B.1
Olivares, E.C.2
Hollis, R.P.3
Ginsburg, D.S.4
Calos, M.P.5
-
142
-
-
0034622937
-
Chimeras of the Flp and Cre recombinases: Tests of the mode of cleavage by Flp and Cre
-
Snaikh, A. C. & Sadowski, P. D. Chimeras of the Flp and Cre recombinases: tests of the mode of cleavage by Flp and Cre. J. Mol. Biol. 302, 27-48 (2000).
-
(2000)
J. Mol. Biol.
, vol.302
, pp. 27-48
-
-
Snaikh, A.C.1
Sadowski, P.D.2
-
143
-
-
0032483356
-
Cre mutants with altered DNA binding properties
-
Hartung, M. & Kisters-Woike, B. Cre mutants with altered DNA binding properties. J. Biol. Chem. 273, 22884-22891 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22884-22891
-
-
Hartung, M.1
Kisters-Woike, B.2
-
144
-
-
0029883166
-
Creating conditional mutations in mammals
-
Spencer, D. M. Creating conditional mutations in mammals. Trends Genet. 12, 181-187 (1996).
-
(1996)
Trends Genet.
, vol.12
, pp. 181-187
-
-
Spencer, D.M.1
-
145
-
-
0034700166
-
Small molecule developmental screens reveal the logic and timing of vertebrate development
-
Peterson, R. T., Link, B. A., Dowling, J. E. & Schreiber, S. L. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc. Natl Acad. Sci. USA 97, 12965-12969 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 12965-12969
-
-
Peterson, R.T.1
Link, B.A.2
Dowling, J.E.3
Schreiber, S.L.4
-
146
-
-
0031001166
-
Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator
-
Wang, Y., Xu, J., Pierson, T., O'Malley, B. W. & Tsai, S. Y. Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Ther. 4, 432-441 (1997).
-
(1997)
Gene Ther.
, vol.4
, pp. 432-441
-
-
Wang, Y.1
Xu, J.2
Pierson, T.3
O'Malley, B.W.4
Tsai, S.Y.5
-
147
-
-
0033847132
-
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
-
She, P. et al. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol. Cell. Biol. 20, 6508-6517 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6508-6517
-
-
She, P.1
-
148
-
-
13044278311
-
A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3
-
Wang, Y. et al. A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. Proc. Natl Acad. Sci. USA 96, 4455-4460 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 4455-4460
-
-
Wang, Y.1
-
149
-
-
0035141324
-
Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
-
Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M. & Gonzalez, F. J. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21, 1393-1403 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1393-1403
-
-
Hayhurst, G.P.1
Lee, Y.H.2
Lambert, G.3
Ward, J.M.4
Gonzalez, F.J.5
-
150
-
-
0033393822
-
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
-
Abel, E. D. et al. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J. Clin. Invest. 104, 1703-1714 (1999).
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 1703-1714
-
-
Abel, E.D.1
-
151
-
-
0034981436
-
Genetic dissection of nodal function in patterning the mouse embryo
-
Lowe, L. A., Yamada, S. & Kuehn, M. R. Genetic dissection of nodal function in patterning the mouse embryo. Development 128, 1831-1843 (2001).
-
(2001)
Development
, vol.128
, pp. 1831-1843
-
-
Lowe, L.A.1
Yamada, S.2
Kuehn, M.R.3
-
152
-
-
0035873619
-
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
-
Matsuda, M. et al. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 15, 1206-1216 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 1206-1216
-
-
Matsuda, M.1
-
153
-
-
0034463161
-
Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis
-
Rucker, E. B. et al. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14, 1038-1052 (2000).
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 1038-1052
-
-
Rucker, E.B.1
|