메뉴 건너뛰기




Volumn 2, Issue 10, 2001, Pages 743-755

Conditional control of gene expression in the mouse

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; DNA POLYMERASE; FUNGAL PROTEIN; GAL4 PROTEIN, S CEREVISIAE; INTEGRASE; RECOMBINASE; REPRESSOR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; TETRACYCLINE; TETRACYCLINE RESISTANCE ENCODING TRANSPOSON REPRESSOR PROTEIN; TETRACYCLINE RESISTANCE-ENCODING TRANSPOSON REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

EID: 0035491607     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/35093537     Document Type: Review
Times cited : (646)

References (153)
  • 1
    • 0026939055 scopus 로고
    • Inducible vectors for expression in mammalian cells
    • Yarranton, G. T. Inducible vectors for expression in mammalian cells. Curr. Opin. Biotechnol. 3, 506-511 (1992).
    • (1992) Curr. Opin. Biotechnol. , vol.3 , pp. 506-511
    • Yarranton, G.T.1
  • 2
    • 0023905363 scopus 로고
    • Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice
    • Khillan, J. S. et al. Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. Nucleic Acids Res. 16, 1423-1430 (1988).
    • (1988) Nucleic Acids Res. , vol.16 , pp. 1423-1430
    • Khillan, J.S.1
  • 3
    • 0027321363 scopus 로고
    • A transgenic model of transactivation by the Tax protein of HTLV-1
    • Bieberich, C. J., King, C. M., Tinkle, B. T. & Jay, G. A transgenic model of transactivation by the Tax protein of HTLV-1. Virology 196, 309-318 (1993).
    • (1993) Virology , vol.196 , pp. 309-318
    • Bieberich, C.J.1    King, C.M.2    Tinkle, B.T.3    Jay, G.4
  • 4
    • 0023189928 scopus 로고
    • The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice
    • Nerenberg, M., Hinrichs, S. H., Reynolds, R. K., Khoury, G. & Jay, G. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237, 1324-1329 (1987).
    • (1987) Science , vol.237 , pp. 1324-1329
    • Nerenberg, M.1    Hinrichs, S.H.2    Reynolds, R.K.3    Khoury, G.4    Jay, G.5
  • 5
    • 0024358496 scopus 로고
    • Multiplex gene regulation: A two-tiered approach to transgene regulation in transgenic mice
    • Byrne, G. W. & Ruddle, F. H. Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice. Proc. Natl Acad. Sci. USA 86, 5473-5477 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 5473-5477
    • Byrne, G.W.1    Ruddle, F.H.2
  • 6
    • 0030049156 scopus 로고    scopus 로고
    • Spatial and temporal regulation of a lacZ reporter transgene in a binary transgenic mouse system
    • Gardner, D. P., Byrne, G. W., Ruddle, F. H. & Kappen, C. Spatial and temporal regulation of a lacZ reporter transgene in a binary transgenic mouse system. Transgenic Res. 5, 37-48 (1996).
    • (1996) Transgenic Res. , vol.5 , pp. 37-48
    • Gardner, D.P.1    Byrne, G.W.2    Ruddle, F.H.3    Kappen, C.4
  • 7
    • 0032537457 scopus 로고    scopus 로고
    • Transactivation of Hox gene expression in a VP16-dependent binary transgenic mouse system
    • Rundle, C. H., Macias, M. P., Yueh, Y. G., Gardner, D. P. & Kappen, C. Transactivation of Hox gene expression in a VP16-dependent binary transgenic mouse system. Biochim. Biophys. Acta 1398, 164-178 (1998).
    • (1998) Biochim. Biophys. Acta , vol.1398 , pp. 164-178
    • Rundle, C.H.1    Macias, M.P.2    Yueh, Y.G.3    Gardner, D.P.4    Kappen, C.5
  • 8
    • 0033992228 scopus 로고    scopus 로고
    • Herpes simplex virus transcriptional activator VP16 is detrimental to preimplantation development in mice
    • Yueh, Y. G., Yaworsky, P. J. & Kappen, C. Herpes simplex virus transcriptional activator VP16 is detrimental to preimplantation development in mice. Mol. Reprod. Dev. 55, 37-46 (2000).
    • (2000) Mol. Reprod. Dev. , vol.55 , pp. 37-46
    • Yueh, Y.G.1    Yaworsky, P.J.2    Kappen, C.3
  • 9
    • 0029021083 scopus 로고
    • A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
    • Shockett, P., Difilippantonio, M., Hellman, N. & Schatz, D. G. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc. Natl Acad. Sci. USA 92, 6522-6526 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 6522-6526
    • Shockett, P.1    Difilippantonio, M.2    Hellman, N.3    Schatz, D.G.4
  • 10
    • 0030797223 scopus 로고    scopus 로고
    • Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
    • Baron, U., Gossen, M. & Bujard, H. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res. 25, 2723-2729 (1997).
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2723-2729
    • Baron, U.1    Gossen, M.2    Bujard, H.3
  • 11
    • 0034581163 scopus 로고    scopus 로고
    • Tet repressor-based system for regulated gene expression in eukaryotic cells: Principles and advances
    • Baron, U. & Bujard, H. Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol. 327, 401-421 (2000). A useful primer of the TetR-based systems for investigators who are considering this approach.
    • (2000) Methods Enzymol. , vol.327 , pp. 401-421
    • Baron, U.1    Bujard, H.2
  • 12
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA 89, 5547-5551 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 13
    • 0029022369 scopus 로고
    • Transcriptional activation by tetracyclines in mammalian cells
    • Gossen, M. et al. Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-1769 (1995).
    • (1995) Science , vol.268 , pp. 1766-1769
    • Gossen, M.1
  • 14
    • 0029763587 scopus 로고    scopus 로고
    • Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
    • Kistner, A. et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc. Natl Acad. Sci. USA 93, 10933-10938 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 10933-10938
    • Kistner, A.1
  • 15
    • 0035089060 scopus 로고    scopus 로고
    • Long-term, noninvasive imaging of regulated gene expression in living mice
    • Hasan, M. T., Schonig, K., Berger, S., Graewe, W. & Bujard, H. Long-term, noninvasive imaging of regulated gene expression in living mice. Genesis 29, 116-122 (2001). This study provides a model for the non-invasive imaging of conditional gene expression in mice, in which the TetR system was used to simultaneously regulate two transgenes, which encode Cre and luciferase, from a bidirectional promoter. A photon-imaging system was then used to follow the expression of luciferase in living mice.
    • (2001) Genesis , vol.29 , pp. 116-122
    • Hasan, M.T.1    Schonig, K.2    Berger, S.3    Graewe, W.4    Bujard, H.5
  • 16
    • 13144275262 scopus 로고    scopus 로고
    • Conditional lineage ablation to model human diseases
    • Lee, P. et al. Conditional lineage ablation to model human diseases. Proc. Natl Acad. Sci. USA 95, 11371-11376 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 11371-11376
    • Lee, P.1
  • 17
    • 0033518175 scopus 로고    scopus 로고
    • The temporal requirement for endothelin receptor-B signalling during neural crest development
    • Shin, M. K., Levorse, J. M., Ingram, R. S. & Tilghman, S. M. The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature 402, 496-501 (1999). This paper reports the use of gene targeting to produce three mouse lines in which wild-type Ednrb alleles were replaced with transgenes that encode either tTA or rtTA, or a tetO-Ednrb target gene. These lines were crossed to produce mice in which all Ednrb activity was doxycycline regulatable.
    • (1999) Nature , vol.402 , pp. 496-501
    • Shin, M.K.1    Levorse, J.M.2    Ingram, R.S.3    Tilghman, S.M.4
  • 18
    • 0035831033 scopus 로고    scopus 로고
    • Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin
    • Malleret, G. et al. Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell 104, 675-686 (2001). The value of being able to induce and then repress transgene transactivation is shown in this paper, as well as in references 19-24.
    • (2001) Cell , vol.104 , pp. 675-686
    • Malleret, G.1
  • 19
    • 0032498227 scopus 로고    scopus 로고
    • Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
    • Mansuy, I. M., Mayford, M., Jacob, B., Kandel, E. R. & Bach, M. E. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92, 39-49 (1998).
    • (1998) Cell , vol.92 , pp. 39-49
    • Mansuy, I.M.1    Mayford, M.2    Jacob, B.3    Kandel, E.R.4    Bach, M.E.5
  • 20
    • 0029818753 scopus 로고    scopus 로고
    • Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen
    • Ewald, D. et al. Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen. Science 273, 1384-1386 (1996).
    • (1996) Science , vol.273 , pp. 1384-1386
    • Ewald, D.1
  • 21
    • 0033614962 scopus 로고    scopus 로고
    • Essential role for oncogenic Ras in tumour maintenance
    • Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468-472 (1999).
    • (1999) Nature , vol.400 , pp. 468-472
    • Chin, L.1
  • 22
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher, D. W. & Bishop, J. M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell 4, 199-207 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 23
    • 0033987718 scopus 로고    scopus 로고
    • Reversibility of acute B-cell leukaemia induced by BCR-ABL1
    • Huettner, C. S., Zhang, P., Van Etten, R. A. & Tenen, D. G. Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nature Genet. 24, 57-60 (2000).
    • (2000) Nature Genet. , vol.24 , pp. 57-60
    • Huettner, C.S.1    Zhang, P.2    Van Etten, R.A.3    Tenen, D.G.4
  • 24
    • 0034737299 scopus 로고    scopus 로고
    • Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    • Yamamoto, A., Lucas, J. J. & Hen, R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 101, 57-66 (2000).
    • (2000) Cell , vol.101 , pp. 57-66
    • Yamamoto, A.1    Lucas, J.J.2    Hen, R.3
  • 25
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
    • Urlinger, S. et al. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc. Natl Acad. Sci. USA 97, 7963-7968 (2000). Investigators considering a TetR-based approach should review the Improved rtTA variants described here, as well as in reference 26.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 7963-7968
    • Urlinger, S.1
  • 26
    • 0033208332 scopus 로고    scopus 로고
    • Codon optimization, genetic insulation, and an rtTA reporter improve performance of the tetracycline switch
    • Wells, K. D., Foster, J. A., Moore, K., Pursel, V. G. & Wall, R. J. Codon optimization, genetic insulation, and an rtTA reporter improve performance of the tetracycline switch. Transgenic Res. 8, 371-381 (1999).
    • (1999) Transgenic Res. , vol.8 , pp. 371-381
    • Wells, K.D.1    Foster, J.A.2    Moore, K.3    Pursel, V.G.4    Wall, R.J.5
  • 27
    • 0029075822 scopus 로고
    • Co-regulation of two gene activities by tetracycline via a bidirectional promoter
    • Baron, U., Freundlieb, S., Gossen, M. & Bujard, H. Co-regulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res. 23, 3605-3606 (1995).
    • (1995) Nucleic Acids Res. , vol.23 , pp. 3605-3606
    • Baron, U.1    Freundlieb, S.2    Gossen, M.3    Bujard, H.4
  • 28
    • 17144449583 scopus 로고    scopus 로고
    • High susceptibility to bacterial infection, but no ever dysfunction, in mice compromised for hepatocyte NF-κB activation
    • Lavon, I. et al. High susceptibility to bacterial infection, but no ever dysfunction, in mice compromised for hepatocyte NF-κB activation. Nature Med. 6, 573-577 (2000).
    • (2000) Nature Med. , vol.6 , pp. 573-577
    • Lavon, I.1
  • 29
    • 0033514374 scopus 로고    scopus 로고
    • Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes
    • Baron, U. et al. Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc. Natl Acad. Sci. USA 96, 1013-1018 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 1013-1018
    • Baron, U.1
  • 30
    • 0026078836 scopus 로고
    • Binary system for regulating transgene expression in mice: Targeting int-2 gene expression with yeast GAL4/UAS control elements
    • Ornitz, D. M., Moreadith, R. W. & Leder, P. Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc. Natl Acad. Sci. USA 88, 698-702 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 698-702
    • Ornitz, D.M.1    Moreadith, R.W.2    Leder, P.3
  • 31
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard, Y. et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430 (1993).
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1
  • 32
    • 0033570359 scopus 로고    scopus 로고
    • Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
    • Rowitch, D. H. et al. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J. Neurosci. 19, 8954-8965 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 8954-8965
    • Rowitch, D.H.1
  • 33
    • 0030965628 scopus 로고    scopus 로고
    • Ligand-inducible and liver-specific target gene expression in transgenic mice
    • Wang, Y., DeMayo, F. J., Tsai, S. Y. & O'Malley, B. W. Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotechnol. 15, 239-243 (1997).
    • (1997) Nature Biotechnol. , vol.15 , pp. 239-243
    • Wang, Y.1    DeMayo, F.J.2    Tsai, S.Y.3    O'Malley, B.W.4
  • 34
    • 0033621427 scopus 로고    scopus 로고
    • Inducible gene knockouts in the small intestinal and colonic epithelium
    • Saam, J. R. & Gordon, J. I. Inducible gene knockouts in the small intestinal and colonic epithelium. J. Biol. Chem. 274, 38071-38082 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 38071-38082
    • Saam, J.R.1    Gordon, J.I.2
  • 35
    • 0033587687 scopus 로고    scopus 로고
    • Development of gene-switch transgenic mice that inducibly express transforming growth factor β1 in the epidermis
    • Wang, X. J., Liefer, K. M., Tsai, S., O'Malley, B. W. & Roop, D. R. Development of gene-switch transgenic mice that inducibly express transforming growth factor β1 in the epidermis. Proc. Natl Acad. Sci. USA 96, 8483-8488 (1999). In this paper, topical application of a synthetic steroid was used to control Tgfb1 expression in mouse skin through the transactivator GLVPc, showing that Tgf-β1 inhibits epidermal cell growth.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 8483-8488
    • Wang, X.J.1    Liefer, K.M.2    Tsai, S.3    O'Malley, B.W.4    Roop, D.R.5
  • 36
    • 0035864356 scopus 로고    scopus 로고
    • Role of TGFβ signaling in skin carcinogenesis
    • Wang, X. Role of TGFβ signaling in skin carcinogenesis. Microsc. Res. Tech. 52, 420-429 (2001).
    • (2001) Microsc. Res. Tech. , vol.52 , pp. 420-429
    • Wang, X.1
  • 37
    • 0034465668 scopus 로고    scopus 로고
    • Regulable expression of inhibin A in wild-type and inhibin α null mice
    • Pierson, T. M. et al. Regulable expression of inhibin A in wild-type and inhibin α null mice. Mol. Endocrinol. 14, 1075-1085 (2000).
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1075-1085
    • Pierson, T.M.1
  • 38
    • 0024509412 scopus 로고
    • Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome
    • Sauer, B. & Henderson, N. Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome. Nucleic Acids Res. 17, 147-161 (1989).
    • (1989) Nucleic Acids Res. , vol.17 , pp. 147-161
    • Sauer, B.1    Henderson, N.2
  • 39
    • 0025847620 scopus 로고
    • Recombinase-mediated gene activation and site-specific integration in mammalian cells
    • O'Gorman, S., Fox, D. T. & Wahl, G. M. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science 251, 1351-1355 (1991).
    • (1991) Science , vol.251 , pp. 1351-1355
    • O'Gorman, S.1    Fox, D.T.2    Wahl, G.M.3
  • 40
    • 0031874849 scopus 로고    scopus 로고
    • Improved properties of FLP recombinase evolved by cycling mutagenesis
    • Buchholz, F., Angrand, P. O. & Stewart, A. F. Improved properties of FLP recombinase evolved by cycling mutagenesis. Nature Biotechnol. 16, 657-662 (1998). DNA-shuffling techniques are used here to modify the Flp recombinase so that it can function optimally at the body temperature of mice.
    • (1998) Nature Biotechnol. , vol.16 , pp. 657-662
    • Buchholz, F.1    Angrand, P.O.2    Stewart, A.F.3
  • 41
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
    • Gu, H., Zou, Y. R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164 (1993).
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.R.2    Rajewsky, K.3
  • 43
    • 0033572912 scopus 로고    scopus 로고
    • Nuclear targeting determinants of the phage P1 cre DNA recombinase
    • Le, Y., Gagneten, S., Tombaccini, D., Bethke, B. & Sauer, B. Nuclear targeting determinants of the phage P1 cre DNA recombinase. Nucleic Acids Res. 27, 4703-4709 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 4703-4709
    • Le, Y.1    Gagneten, S.2    Tombaccini, D.3    Bethke, B.4    Sauer, B.5
  • 44
    • 0343415768 scopus 로고    scopus 로고
    • Mammalian genomes contain active recombinase recognition sites
    • Thyagarajan, B., Guimaraes, M. J., Groth, A. C. & Calos, M. P. Mammalian genomes contain active recombinase recognition sites. Gene 244, 47-54 (2000).
    • (2000) Gene , vol.244 , pp. 47-54
    • Thyagarajan, B.1    Guimaraes, M.J.2    Groth, A.C.3    Calos, M.P.4
  • 45
    • 0022892746 scopus 로고
    • Directionality in FLP protein-promoted site-specific recombination is mediated by DNA-DNA pairing
    • Senecoff, J. F. & Cox, M. M. Directionality in FLP protein-promoted site-specific recombination is mediated by DNA-DNA pairing. J. Biol. Chem. 261, 7380-7386 (1986).
    • (1986) J. Biol. Chem. , vol.261 , pp. 7380-7386
    • Senecoff, J.F.1    Cox, M.M.2
  • 46
    • 0035979247 scopus 로고    scopus 로고
    • Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
    • Loonstra, A. et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc. Natl Acad. Sci. USA 98, 9209-9214 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9209-9214
    • Loonstra, A.1
  • 48
    • 0031443874 scopus 로고    scopus 로고
    • Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
    • O'Gorman, S., Dagenais, N. A., Qian, M. & Marchuk, Y. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc. Natl Acad. Sci. USA 94, 14602-14607 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 14602-14607
    • O'Gorman, S.1    Dagenais, N.A.2    Qian, M.3    Marchuk, Y.4
  • 49
    • 0031080163 scopus 로고    scopus 로고
    • Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line
    • Lewandoski, M., Wassarman, K. M. & Martin, G. R. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr. Biol. 7, 148-151 (1997).
    • (1997) Curr. Biol. , vol.7 , pp. 148-151
    • Lewandoski, M.1    Wassarman, K.M.2    Martin, G.R.3
  • 50
    • 0029976272 scopus 로고    scopus 로고
    • Recycling selectable markers in mouse embryonic stem cells
    • Abuin, A. & Bradley, A. Recycling selectable markers in mouse embryonic stem cells. Mol. Cell. Biol. 16, 1851-1856 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1851-1856
    • Abuin, A.1    Bradley, A.2
  • 51
    • 0033757718 scopus 로고    scopus 로고
    • Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
    • Dragatsis, I., Levine, M. S. & Zeitlin, S. Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nature Genet. 26, 300-306 (2000).
    • (2000) Nature Genet. , vol.26 , pp. 300-306
    • Dragatsis, I.1    Levine, M.S.2    Zeitlin, S.3
  • 52
    • 0035099411 scopus 로고    scopus 로고
    • Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis
    • Sakai, T. et al. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nature Med. 7, 324-330 (2001).
    • (2001) Nature Med. , vol.7 , pp. 324-330
    • Sakai, T.1
  • 53
    • 0035094767 scopus 로고    scopus 로고
    • A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    • Guy, J., Hendrich, B., Holmes, M., Martin, J. E. & Bird, A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nature Genet. 27, 322-326 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 322-326
    • Guy, J.1    Hendrich, B.2    Holmes, M.3    Martin, J.E.4    Bird, A.5
  • 54
    • 0034254284 scopus 로고    scopus 로고
    • Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes
    • Brakebusch, C. et al. Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes. EMBO J. 19, 3990-4003 (2000).
    • (2000) EMBO J. , vol.19 , pp. 3990-4003
    • Brakebusch, C.1
  • 55
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasts as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase
    • Postic, C. et al. Dual roles for glucokinase in glucose homeostasts as determined by liver and pancreatic β-cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274, 305-315 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 305-315
    • Postic, C.1
  • 56
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase β-gene segment in T cells using cell type-specific gene targeting
    • Gu, H., Marth, J. D., Orban, P. C., Mossmann, H. & Rajewsky, K. Deletion of a DNA polymerase β-gene segment in T cells using cell type-specific gene targeting. Science 265, 103-106 (1994). This paper describes the first tissue-specific gene inactivation and provides a model for using three loxP sites to remove the selection cassette from the conditional allele in vitro. See references 59 and 60 for variations on this strategy.
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5
  • 57
    • 0031916557 scopus 로고    scopus 로고
    • An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
    • Meyers, E. N., Lewandoski, M. & Martin, G. R. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nature Genet. 18, 136-141 (1998). An example of the allelogenic strategy as applied to the Fgf8 locus, in which three alleles (hypomorphic, conditional and null) were generated from one mouse line.
    • (1998) Nature Genet. , vol.18 , pp. 136-141
    • Meyers, E.N.1    Lewandoski, M.2    Martin, G.R.3
  • 58
    • 0032554783 scopus 로고    scopus 로고
    • Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
    • Nagy, A. et al. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr. Biol. 8, 661-664 (1998). A demonstration of how to produce an allelic series, which includes alleles with any desirable mutation, using the N-Myc locus as an example.
    • (1998) Curr. Biol. , vol.8 , pp. 661-664
    • Nagy, A.1
  • 59
    • 0035018190 scopus 로고    scopus 로고
    • Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches
    • Xu, X. et al. Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches. Genesis 30, 1-6 (2001).
    • (2001) Genesis , vol.30 , pp. 1-6
    • Xu, X.1
  • 60
    • 0034323074 scopus 로고    scopus 로고
    • Cre-mediated germline mosaicism: A method allowing rapid generation of several alleles of a target gene
    • Holzenberger, M. et al. Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. Nucleic Acids Res. 28, E92 (2000).
    • (2000) Nucleic Acids Res. , vol.28
    • Holzenberger, M.1
  • 61
    • 0032146074 scopus 로고    scopus 로고
    • Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos
    • Partanen, J., Schwartz, L. & Rossant, J. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 12, 2332-2344 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2332-2344
    • Partanen, J.1    Schwartz, L.2    Rossant, J.3
  • 62
    • 0032722672 scopus 로고    scopus 로고
    • Dosage requirement of Pitx2 for development of multiple organs
    • Gage, P. J., Suh, H. & Camper, S. A. Dosage requirement of Pitx2 for development of multiple organs. Development 126, 4643-4651 (1999).
    • (1999) Development , vol.126 , pp. 4643-4651
    • Gage, P.J.1    Suh, H.2    Camper, S.A.3
  • 63
    • 0033565746 scopus 로고    scopus 로고
    • Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
    • Sun, X., Meyers, E. N., Lewandoski, M. & Martin, G. R. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 13, 1834-1846 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1834-1846
    • Sun, X.1    Meyers, E.N.2    Lewandoski, M.3    Martin, G.R.4
  • 64
    • 0033575364 scopus 로고    scopus 로고
    • Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH
    • Meyers, E. N. & Martin, G. R. Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285, 403-406 (1999).
    • (1999) Science , vol.285 , pp. 403-406
    • Meyers, E.N.1    Martin, G.R.2
  • 65
    • 0033397681 scopus 로고    scopus 로고
    • Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    • Trumpp, A., Depew, M. J., Rubenstein, J. L. Bishop, J. M. & Martin, G. R. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 13, 3136-3148 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 3136-3148
    • Trumpp, A.1    Depew, M.J.2    Rubenstein, J.L.3    Bishop, J.M.4    Martin, G.R.5
  • 66
    • 0033673531 scopus 로고    scopus 로고
    • Fgf8 signalling from the AER is essential for normal limb development
    • Lewandoski, M., Sun, X. & Martin, G. R. Fgf8 signalling from the AER is essential for normal limb development. Nature Genet. 26, 460-463 (2000).
    • (2000) Nature Genet. , vol.26 , pp. 460-463
    • Lewandoski, M.1    Sun, X.2    Martin, G.R.3
  • 67
    • 0033662330 scopus 로고    scopus 로고
    • Fgf8 is required for outgrowth and patterning of the limbs
    • Moon, A. M. & Capecchi, M. R. Fgf8 is required for outgrowth and patterning of the limbs. Nature Genet. 26, 455-459 (2000).
    • (2000) Nature Genet. , vol.26 , pp. 455-459
    • Moon, A.M.1    Capecchi, M.R.2
  • 68
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet. 21, 70-71 (1999). This reference and reference 72 provide two different models of how to achieve the otherwise difficult goal of near-ubiquitous transgene expression in the mouse. Such expression is ideal for producing mice that are useful as breeding partners for those that carry different tissue-specific cre or FLP transgenes.
    • (1999) Nature Genet. , vol.21 , pp. 70-71
    • Soriano, P.1
  • 69
    • 0033608980 scopus 로고    scopus 로고
    • Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice
    • Mao, X., Fujiwara, Y. & Orkin, S. H. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc. Natl Acad. Sci. USA 96, 5037-5042 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5037-5042
    • Mao, X.1    Fujiwara, Y.2    Orkin, S.H.3
  • 70
    • 0035170536 scopus 로고    scopus 로고
    • Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain
    • Mao, X., Fujiwara, Y., Chapdelaine, A., Yang, H. & Orkin, S. H. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood 97, 324-326 (2001).
    • (2001) Blood , vol.97 , pp. 324-326
    • Mao, X.1    Fujiwara, Y.2    Chapdelaine, A.3    Yang, H.4    Orkin, S.H.5
  • 71
    • 3042856262 scopus 로고    scopus 로고
    • Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    • Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
    • (2001) BMC Dev. Biol. , vol.1 , Issue.4
    • Srinivas, S.1
  • 72
    • 0033561410 scopus 로고    scopus 로고
    • Z/AP, a double reporter for cre-mediated recombination
    • Lobe, C. G. et al. Z/AP, a double reporter for cre-mediated recombination. Dev. Biol. 208, 281-292 (1999).
    • (1999) Dev. Biol. , vol.208 , pp. 281-292
    • Lobe, C.G.1
  • 73
    • 0034488835 scopus 로고    scopus 로고
    • Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision
    • Novak, A., Guo, C., Yang, W., Nagy, A. & Lobe, C. G. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28, 147-155 (2000).
    • (2000) Genesis , vol.28 , pp. 147-155
    • Novak, A.1    Guo, C.2    Yang, W.3    Nagy, A.4    Lobe, C.G.5
  • 74
    • 0035029433 scopus 로고    scopus 로고
    • A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
    • Voojs, M., Jonkers, J. & Berns, A. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep. 2, 292-297 (2001).
    • (2001) EMBO Rep. , vol.2 , pp. 292-297
    • Voojs, M.1    Jonkers, J.2    Berns, A.3
  • 75
    • 0032554790 scopus 로고    scopus 로고
    • Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system
    • Zinyk, D. L., Mercer, E. H., Harris, E., Anderson, D. J. & Joyner, A. L. Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr. Biol. 8, 665-668 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 665-668
    • Zinyk, D.L.1    Mercer, E.H.2    Harris, E.3    Anderson, D.J.4    Joyner, A.L.5
  • 76
    • 0034030119 scopus 로고    scopus 로고
    • Migration of cardiac neural crest cells in Splotch embryos
    • Epstein, J. A. et al. Migration of cardiac neural crest cells in Splotch embryos. Development 127, 1869-1878 (2000).
    • (2000) Development , vol.127 , pp. 1869-1878
    • Epstein, J.A.1
  • 77
    • 0034057170 scopus 로고    scopus 로고
    • Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
    • Chai, Y. et al. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127, 1671-1679 (2000).
    • (2000) Development , vol.127 , pp. 1671-1679
    • Chai, Y.1
  • 79
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
    • Herrera, P. L. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127, 2317-2322 (2000).
    • (2000) Development , vol.127 , pp. 2317-2322
    • Herrera, P.L.1
  • 80
    • 0033542458 scopus 로고    scopus 로고
    • Modelling T-cell memory by genetic marking of memory T cells in vivo
    • Jacob, J. & Baltimore, D. Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature 399, 593-597 (1999).
    • (1999) Nature , vol.399 , pp. 593-597
    • Jacob, J.1    Baltimore, D.2
  • 81
    • 0346310346 scopus 로고    scopus 로고
    • Multiple neuronal identities and migrations specified by a single Hox gene in mice
    • in the press
    • O'Gorman, S. & Barcarse, E. A. Multiple neuronal identities and migrations specified by a single Hox gene in mice. Development (in the press).
    • Development
    • O'Gorman, S.1    Barcarse, E.A.2
  • 82
    • 0026638820 scopus 로고
    • Targeted oncogene activation by site-specific recombination in transgenic mice
    • Lakso, M. et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl Acad. Sci. USA 89, 6232-6236 (1992). This first demonstration of Cre-mediated transgene activation provides a model for the general strategy. For an elaboration of this model, see reference 88, and for an alternative model, see reference 83.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 6232-6236
    • Lakso, M.1
  • 83
    • 0032523802 scopus 로고    scopus 로고
    • Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss
    • Grieshammer, U., Lewandoski, M., Prevette, D., Oppenheim, R. W. & Martin, G. R. Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss. Dev. Biol. 197, 234-247 (1998).
    • (1998) Dev. Biol. , vol.197 , pp. 234-247
    • Grieshammer, U.1    Lewandoski, M.2    Prevette, D.3    Oppenheim, R.W.4    Martin, G.R.5
  • 84
    • 0031252296 scopus 로고    scopus 로고
    • Cre-mediated chromosome loss in mice
    • Lewandoski, M. & Martin, G. R. Cre-mediated chromosome loss in mice. Nature Genet. 17, 223-225 (1997).
    • (1997) Nature Genet. , vol.17 , pp. 223-225
    • Lewandoski, M.1    Martin, G.R.2
  • 86
    • 7844242559 scopus 로고    scopus 로고
    • Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination
    • Drago, J. et al. Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination. J. Neurosci. 18, 9845-9857 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 9845-9857
    • Drago, J.1
  • 87
    • 0034677471 scopus 로고    scopus 로고
    • Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
    • Lee, K. J., Dietrich, P. & Jessell, T. M. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature 403, 734-740 (2000).
    • (2000) Nature , vol.403 , pp. 734-740
    • Lee, K.J.1    Dietrich, P.2    Jessell, T.M.3
  • 88
    • 0035258737 scopus 로고    scopus 로고
    • A method for the generation of conditional gene repair mutations in mice
    • Dragatsis, I. & Zeitlin, S. A method for the generation of conditional gene repair mutations in mice. Nucleic Acids Res. 29, E10 (2001).
    • (2001) Nucleic Acids Res. , vol.29
    • Dragatsis, I.1    Zeitlin, S.2
  • 89
    • 0035809167 scopus 로고    scopus 로고
    • Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders
    • Ann, M. J., Longley, M. A., Wang, X. J. & Roop, D. R. Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders. J. Cell Biol. 152, 645-649 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 645-649
    • Ann, M.J.1    Longley, M.A.2    Wang, X.J.3    Roop, D.R.4
  • 90
    • 0035809198 scopus 로고    scopus 로고
    • An inducible mouse model for epidermolysis bullosa simplex: Implications for gene therapy
    • Cao, T., Longley, M. A., Wang, X. J. & Roop, D. R. An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy. J. Cell Biol. 152, 651-656 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 651-656
    • Cao, T.1    Longley, M.A.2    Wang, X.J.3    Roop, D.R.4
  • 91
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 92
    • 0032931234 scopus 로고    scopus 로고
    • VEGF is required for growth and survival in neonatal mice
    • Gerber, H. P. et al. VEGF is required for growth and survival in neonatal mice. Development 126, 1149-1159 (1999).
    • (1999) Development , vol.126 , pp. 1149-1159
    • Gerber, H.P.1
  • 93
    • 0035131190 scopus 로고    scopus 로고
    • Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver
    • Alonzi, T. et al. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver. Mol. Cell. Biol. 21, 1621-1632 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1621-1632
    • Alonzi, T.1
  • 94
    • 0032004972 scopus 로고    scopus 로고
    • Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
    • Rohlmam, A., Gotthardt, M., Hammer, R. E. & Herz, J. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J. Clin. Invest. 101, 689-695 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 689-695
    • Rohlmam, A.1    Gotthardt, M.2    Hammer, R.E.3    Herz, J.4
  • 95
    • 13044294029 scopus 로고    scopus 로고
    • Liver-derived insulin-like growth factor 1 (IGF-1) is the principal source of IGF-1 in blood but is not required for postnatal body growth in mice
    • Sjogren, K. et al. Liver-derived insulin-like growth factor 1 (IGF-1) is the principal source of IGF-1 in blood but is not required for postnatal body growth in mice. Proc. Natl Acad. Sci. USA 96, 7088-7092 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7088-7092
    • Sjogren, K.1
  • 96
    • 0032573147 scopus 로고    scopus 로고
    • Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo
    • Lam, K. P. & Rajewsky, K. Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo. Proc. Natl Acad. Sci. USA 95, 13171-13175 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 13171-13175
    • Lam, K.P.1    Rajewsky, K.2
  • 97
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam, K. P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083 (1997).
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kuhn, R.2    Rajewsky, K.3
  • 98
    • 0033136717 scopus 로고    scopus 로고
    • Deficient T cell fate specification in mice with an induced inactivation of Notch1
    • Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547-558 (1999).
    • (1999) Immunity , vol.10 , pp. 547-558
    • Radtke, F.1
  • 99
    • 0033534701 scopus 로고    scopus 로고
    • Inducible site-specific recombination in the brain
    • Kellendonk, C. et al. Inducible site-specific recombination in the brain. J. Mol. Biol. 285, 175-182 (1999).
    • (1999) J. Mol. Biol. , vol.285 , pp. 175-182
    • Kellendonk, C.1
  • 100
    • 0029874029 scopus 로고    scopus 로고
    • Regulation of Cre recombinase activity by the synthetic steroid RU 486
    • Kellendonk, C. et al. Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res. 24, 1404-1411 (1996).
    • (1996) Nucleic Acids Res. , vol.24 , pp. 1404-1411
    • Kellendonk, C.1
  • 101
    • 0029767838 scopus 로고    scopus 로고
    • Ligand-activated site-specific recombination in mice
    • Feil, R. et al. Ligand-activated site-specific recombination in mice. Proc. Natl Acad. Sci. USA 93, 10887-10890 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 10887-10890
    • Feil, R.1
  • 102
    • 0032481124 scopus 로고    scopus 로고
    • Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    • Danielian, P. S., Muccino, D., Rowitch, D. H., Michael, S. K. & McMahon, A. P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8, 1323-1326 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 1323-1326
    • Danielian, P.S.1    Muccino, D.2    Rowitch, D.H.3    Michael, S.K.4    McMahon, A.P.5
  • 103
    • 0031473544 scopus 로고    scopus 로고
    • Spatio-temporally controlled site-specific somatic mutagenesis in the mouse
    • Brocard, J. et al. Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proc. Natl Acad. Sci. USA 94, 14559-14563 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 14559-14563
    • Brocard, J.1
  • 105
    • 0029164598 scopus 로고
    • Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
    • Metzger, D., Clifford, J., Chiba, H. & Chambon, P. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc. Natl Acad. Sci. USA 92, 6991-6995 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 6991-6995
    • Metzger, D.1    Clifford, J.2    Chiba, H.3    Chambon, P.4
  • 106
    • 0029962975 scopus 로고    scopus 로고
    • Inducible site-directed recombination in mouse embryonic stem cells
    • Zhang, Y. et al. Inducible site-directed recombination in mouse embryonic stem cells. Nucleic Acids Res. 24, 543-548 (1996).
    • (1996) Nucleic Acids Res. , vol.24 , pp. 543-548
    • Zhang, Y.1
  • 107
    • 0034842640 scopus 로고    scopus 로고
    • Site- and time-specific gene targeting in the mouse
    • Metzger, D. & Chambon, P. Site- and time-specific gene targeting in the mouse. Methods 24, 71-80 (2001).
    • (2001) Methods , vol.24 , pp. 71-80
    • Metzger, D.1    Chambon, P.2
  • 108
    • 0033587776 scopus 로고    scopus 로고
    • The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
    • Vasioukhin, V., Degenstein, L., Wise, B. & Fuchs, E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl Acad. Sci. USA 96, 8551-8556 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 8551-8556
    • Vasioukhin, V.1    Degenstein, L.2    Wise, B.3    Fuchs, E.4
  • 109
    • 0032535491 scopus 로고    scopus 로고
    • Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk
    • Zhang, Y., Wienands, J., Zurn, C. & Reth, M. Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk. EMBO J. 17, 7304-7310 (1998).
    • (1998) EMBO J. , vol.17 , pp. 7304-7310
    • Zhang, Y.1    Wienands, J.2    Zurn, C.3    Reth, M.4
  • 110
    • 0035836755 scopus 로고    scopus 로고
    • Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity
    • Imai, T., Jiang, M., Kastner, P., Chambon, P. & Metzger, D. Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity. Proc. Natl Acad. Sci. USA 98, 4581-4586 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 4581-4586
    • Imai, T.1    Jiang, M.2    Kastner, P.3    Chambon, P.4    Metzger, D.5
  • 111
    • 0034214414 scopus 로고    scopus 로고
    • Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
    • Kimmel, R. A. et al. Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev. 14, 1377-1389 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1377-1389
    • Kimmel, R.A.1
  • 112
    • 0035874366 scopus 로고    scopus 로고
    • New variants of inducible Cre recombinase: A novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility
    • Wunderlich, F. T., Wildner, H., Rajewsky, K. & Edenhofer, F. New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility. Nucleic Acids Res. 29, E47 (2001). Investigators considering inducible cre experiments should review these improved Cre-PR variants, as well as the Cre-ER (T2) variant in references 113-115.
    • (2001) Nucleic Acids Res. , vol.29
    • Wunderlich, F.T.1    Wildner, H.2    Rajewsky, K.3    Edenhofer, F.4
  • 113
    • 0033571243 scopus 로고    scopus 로고
    • Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: Comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases
    • Indra, A. K. et al. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res. 27, 4324-4327 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 4324-4327
    • Indra, A.K.1
  • 114
    • 0035793045 scopus 로고    scopus 로고
    • Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
    • Imai, T., Jiang, M., Chambon, P. & Metzger, D. Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc. Natl Acad. Sci. USA 98, 224-228 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 224-228
    • Imai, T.1    Jiang, M.2    Chambon, P.3    Metzger, D.4
  • 115
    • 0034609819 scopus 로고    scopus 로고
    • Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis
    • Li, M. et al. Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis. Nature 407, 633-636 (2000).
    • (2000) Nature , vol.407 , pp. 633-636
    • Li, M.1
  • 116
    • 0032692949 scopus 로고    scopus 로고
    • Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice
    • Utomo, A. R., Nikitin, A. Y. & Lee, W. H. Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nature Biotechnol. 17, 1091-1096 (1999).
    • (1999) Nature Biotechnol. , vol.17 , pp. 1091-1096
    • Utomo, A.R.1    Nikitin, A.Y.2    Lee, W.H.3
  • 117
    • 0034098934 scopus 로고    scopus 로고
    • Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre)
    • Holzenberger, M., Zaoui, R., Leneuve, P., Harnard, G. & Le Bouc, Y. Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre). Genesis 26, 157-159 (2000).
    • (2000) Genesis , vol.26 , pp. 157-159
    • Holzenberger, M.1    Zaoui, R.2    Leneuve, P.3    Harnard, G.4    Le Bouc, Y.5
  • 118
    • 0029788269 scopus 로고    scopus 로고
    • Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter
    • St-Onge, L., Furth, P. A. & Gruss, P. Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic Acids Res. 24, 3875-3877 (1996).
    • (1996) Nucleic Acids Res. , vol.24 , pp. 3875-3877
    • St-Onge, L.1    Furth, P.A.2    Gruss, P.3
  • 119
    • 0029959746 scopus 로고    scopus 로고
    • Sustained somatic gene inactivation by viral transfer of Cre recombinase
    • Rohlmann, A., Gotthardt, M., Willnow, T. E., Hammer, R. E. & Herz, J. Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nature Biotechnol. 14, 1562-1565 (1996).
    • (1996) Nature Biotechnol. , vol.14 , pp. 1562-1565
    • Rohlmann, A.1    Gotthardt, M.2    Willnow, T.E.3    Hammer, R.E.4    Herz, J.5
  • 120
    • 0029961646 scopus 로고    scopus 로고
    • Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene
    • Wang, Y., Krushel, L. A. & Edelman, G. M. Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. Proc. Natl Acad. Sci. USA 93, 3932-3936 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 3932-3936
    • Wang, Y.1    Krushel, L.A.2    Edelman, G.M.3
  • 121
    • 0030878260 scopus 로고    scopus 로고
    • Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo
    • Agah, R. et al. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J. Clin. Invest. 100, 169-179 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 169-179
    • Agah, R.1
  • 122
    • 0031028680 scopus 로고    scopus 로고
    • Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase
    • Brooks, A. I., Muhkerjee, B., Panahian, N., Cory-Slechta, D. & Federoff, H. J. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nature Biotechnol. 15, 57-62 (1997).
    • (1997) Nature Biotechnol. , vol.15 , pp. 57-62
    • Brooks, A.I.1    Muhkerjee, B.2    Panahian, N.3    Cory-Slechta, D.4    Federoff, H.J.5
  • 123
    • 0033977926 scopus 로고    scopus 로고
    • High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates
    • Christensen, G., Minamisawa, S., Gruber, P. J., Wang, Y. & Chien, K. R. High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates. Circulation 101, 178-184 (2000).
    • (2000) Circulation , vol.101 , pp. 178-184
    • Christensen, G.1    Minamisawa, S.2    Gruber, P.J.3    Wang, Y.4    Chien, K.R.5
  • 124
    • 0034700176 scopus 로고    scopus 로고
    • Gene-experience interaction alters the cholinergic septohippocampal pathway of mice
    • Brooks, A. I., Cory-Slechta, D. A. & Federoff, H. J. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proc. Natl Acad. Sci. USA 97, 13378-13383 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 13378-13383
    • Brooks, A.I.1    Cory-Slechta, D.A.2    Federoff, H.J.3
  • 125
    • 0030843461 scopus 로고    scopus 로고
    • Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
    • Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120-123 (1997).
    • (1997) Science , vol.278 , pp. 120-123
    • Shibata, H.1
  • 126
    • 0030765649 scopus 로고    scopus 로고
    • Disruption of the c/ebp α gene in adult mouse liver
    • Lee, Y. H., Sauer, B., Johnson, P. F. & Gonzalez, F. J. Disruption of the c/ebp α gene in adult mouse liver. Mol. Cell. Biol. 17, 6014-6022 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6014-6022
    • Lee, Y.H.1    Sauer, B.2    Johnson, P.F.3    Gonzalez, F.J.4
  • 127
    • 0033534726 scopus 로고    scopus 로고
    • Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion
    • Piston, D. W., Knobel, S. M., Postic, C., Shelton, K. D. & Magnuson, M. A. Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J. Biol. Chem. 274, 1000-1004 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 1000-1004
    • Piston, D.W.1    Knobel, S.M.2    Postic, C.3    Shelton, K.D.4    Magnuson, M.A.5
  • 129
    • 0029954688 scopus 로고    scopus 로고
    • Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
    • Dymecki, S. M. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc. Natl Acad. Sci. USA 93, 6191-6196 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 6191-6196
    • Dymecki, S.M.1
  • 130
    • 0029860719 scopus 로고    scopus 로고
    • Different thermostabilities of FLP and Cre recombinases: Implications for applied site-specific recombination
    • Buchholz, F., Ringrose, L., Angrand, P. O., Rossi, F. & Stewart, A. F. Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res. 24, 4256-4262 (1996).
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4256-4262
    • Buchholz, F.1    Ringrose, L.2    Angrand, P.O.3    Rossi, F.4    Stewart, A.F.5
  • 131
    • 0034041160 scopus 로고    scopus 로고
    • High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
    • Rodriguez, C. I. et al. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nature Genet. 25, 139-140 (2000).
    • (2000) Nature Genet. , vol.25 , pp. 139-140
    • Rodriguez, C.I.1
  • 132
    • 0032500170 scopus 로고    scopus 로고
    • Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse
    • Vooijs, M., van der Valk, M., te Riele, H. & Berns, A. Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. Oncogene 17, 1-12 (1998).
    • (1998) Oncogene , vol.17 , pp. 1-12
    • Vooijs, M.1    Van Der Valk, M.2    Te Riele, H.3    Berns, A.4
  • 133
    • 0029043630 scopus 로고
    • Ligand-regulated site-specific recombination
    • Logie, C. & Stewart, A. F. Ligand-regulated site-specific recombination. Proc. Natl Acad. Sci. USA 92, 5940-5944 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 5940-5944
    • Logie, C.1    Stewart, A.F.2
  • 134
    • 0032230285 scopus 로고    scopus 로고
    • Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins
    • Logie, C., Nichols, M., Myles, K., Funder, J. W. & Stewart, A. F. Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins. Mol. Endocrinol. 12, 1120-1132 (1998).
    • (1998) Mol. Endocrinol. , vol.12 , pp. 1120-1132
    • Logie, C.1    Nichols, M.2    Myles, K.3    Funder, J.W.4    Stewart, A.F.5
  • 135
    • 0034487368 scopus 로고    scopus 로고
    • Widespread recombinase expression using FLPeR (flipper) mice
    • Farley, F. W., Soriano, P., Steffen, L. S. & Dymecki, S. M. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28, 106-110 (2000).
    • (2000) Genesis , vol.28 , pp. 106-110
    • Farley, F.W.1    Soriano, P.2    Steffen, L.S.3    Dymecki, S.M.4
  • 136
    • 0033681169 scopus 로고    scopus 로고
    • Origin of the precerebellar system
    • Rodriguez, C. I. & Dymecki, S. M. Origin of the precerebellar system. Neuron 27, 475-486 (2000). Flp expression is used here to permanently mark Wnt1-expressing cells and to trace their descendants. This paper contains an informative discussion of the advantages and potential artefacts of this type of cell-lineage analysis.
    • (2000) Neuron , vol.27 , pp. 475-486
    • Rodriguez, C.I.1    Dymecki, S.M.2
  • 137
    • 0035815295 scopus 로고    scopus 로고
    • Pax6 is required for the multipotent state of retinal progenitor cells
    • Marquardt, T. et al. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105, 43-55 (2001).
    • (2001) Cell , vol.105 , pp. 43-55
    • Marquardt, T.1
  • 138
    • 0034687804 scopus 로고    scopus 로고
    • Identification of ligands and coligands for the ecdysone-regulated gene switch
    • Saez, E. et al. Identification of ligands and coligands for the ecdysone-regulated gene switch. Proc. Natl Acad. Sci. USA 97, 14512-14517 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 14512-14517
    • Saez, E.1
  • 139
    • 0035876445 scopus 로고    scopus 로고
    • The lac operator-repressor system is functional in the mouse
    • Cronin, C. A., Gluba, W. & Scrable, H. The lac operator-repressor system is functional in the mouse. Genes Dev. 15, 1506-1517 (2001). This paper reports a modified lac operator-repressor system that functions in the mouse and was used to regulate a coat-colour transgene, such that its expression is IPTG responsive.
    • (2001) Genes Dev. , vol.15 , pp. 1506-1517
    • Cronin, C.A.1    Gluba, W.2    Scrable, H.3
  • 140
    • 0035844251 scopus 로고    scopus 로고
    • New insights into host factor requirements for prokaryotic β-recombinase-mediated reactions in mammalian cells
    • Diaz, V. et al. New insights into host factor requirements for prokaryotic β-recombinase-mediated reactions in mammalian cells. J. Biol. Chem. 276, 16257-16264 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 16257-16264
    • Diaz, V.1
  • 141
    • 0035008830 scopus 로고    scopus 로고
    • Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase
    • Thyagarajan, B., Olivares, E. C., Hollis, R. P., Ginsburg, D. S. & Calos, M. P. Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol. Cell. Biol. 21, 3926-3934 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3926-3934
    • Thyagarajan, B.1    Olivares, E.C.2    Hollis, R.P.3    Ginsburg, D.S.4    Calos, M.P.5
  • 142
    • 0034622937 scopus 로고    scopus 로고
    • Chimeras of the Flp and Cre recombinases: Tests of the mode of cleavage by Flp and Cre
    • Snaikh, A. C. & Sadowski, P. D. Chimeras of the Flp and Cre recombinases: tests of the mode of cleavage by Flp and Cre. J. Mol. Biol. 302, 27-48 (2000).
    • (2000) J. Mol. Biol. , vol.302 , pp. 27-48
    • Snaikh, A.C.1    Sadowski, P.D.2
  • 143
    • 0032483356 scopus 로고    scopus 로고
    • Cre mutants with altered DNA binding properties
    • Hartung, M. & Kisters-Woike, B. Cre mutants with altered DNA binding properties. J. Biol. Chem. 273, 22884-22891 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 22884-22891
    • Hartung, M.1    Kisters-Woike, B.2
  • 144
    • 0029883166 scopus 로고    scopus 로고
    • Creating conditional mutations in mammals
    • Spencer, D. M. Creating conditional mutations in mammals. Trends Genet. 12, 181-187 (1996).
    • (1996) Trends Genet. , vol.12 , pp. 181-187
    • Spencer, D.M.1
  • 145
    • 0034700166 scopus 로고    scopus 로고
    • Small molecule developmental screens reveal the logic and timing of vertebrate development
    • Peterson, R. T., Link, B. A., Dowling, J. E. & Schreiber, S. L. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc. Natl Acad. Sci. USA 97, 12965-12969 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 12965-12969
    • Peterson, R.T.1    Link, B.A.2    Dowling, J.E.3    Schreiber, S.L.4
  • 146
    • 0031001166 scopus 로고    scopus 로고
    • Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator
    • Wang, Y., Xu, J., Pierson, T., O'Malley, B. W. & Tsai, S. Y. Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Ther. 4, 432-441 (1997).
    • (1997) Gene Ther. , vol.4 , pp. 432-441
    • Wang, Y.1    Xu, J.2    Pierson, T.3    O'Malley, B.W.4    Tsai, S.Y.5
  • 147
    • 0033847132 scopus 로고    scopus 로고
    • Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
    • She, P. et al. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol. Cell. Biol. 20, 6508-6517 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6508-6517
    • She, P.1
  • 148
    • 13044278311 scopus 로고    scopus 로고
    • A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3
    • Wang, Y. et al. A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. Proc. Natl Acad. Sci. USA 96, 4455-4460 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 4455-4460
    • Wang, Y.1
  • 149
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M. & Gonzalez, F. J. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21, 1393-1403 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 150
    • 0033393822 scopus 로고    scopus 로고
    • Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
    • Abel, E. D. et al. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J. Clin. Invest. 104, 1703-1714 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1703-1714
    • Abel, E.D.1
  • 151
    • 0034981436 scopus 로고    scopus 로고
    • Genetic dissection of nodal function in patterning the mouse embryo
    • Lowe, L. A., Yamada, S. & Kuehn, M. R. Genetic dissection of nodal function in patterning the mouse embryo. Development 128, 1831-1843 (2001).
    • (2001) Development , vol.128 , pp. 1831-1843
    • Lowe, L.A.1    Yamada, S.2    Kuehn, M.R.3
  • 152
    • 0035873619 scopus 로고    scopus 로고
    • SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
    • Matsuda, M. et al. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 15, 1206-1216 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 1206-1216
    • Matsuda, M.1
  • 153
    • 0034463161 scopus 로고    scopus 로고
    • Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis
    • Rucker, E. B. et al. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14, 1038-1052 (2000).
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1038-1052
    • Rucker, E.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.