Extra-embryonic function of Rb is essential for embryonic development and viability

Nature

Volumn 421, Issue 6926, 2003, Pages 942-947

  Wu, Lizhao ^a   De Bruin, Alain ^a   Saavedra, Harold I ^a   Starovic, Maja ^c   Trimboli, Anthony ^a   Yang, Ying ^d   Opavska, Jana ^a   Wilson, Pamela ^a   Thompson, John C ^a   Ostrowski, Michael C ^a,b   Rosol, Thomas J ^a,b   Woollett, Laura A ^e   Weinstein, Michael ^a,b   Cross, James C ^c   Robinson, Michael L ^a,b,d   Leone, Gustavo ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

^d THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOMEDICAL ENGINEERING; NEUROLOGY; TUMORS;

RETINOBLASTOMA (RB) GENE;

GENES;

RETINOBLASTOMA PROTEIN;

EMBRYONIC DEVELOPMENT; GENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ERYTHROPOIESIS; FETUS; GENE FUNCTION; GENE INACTIVATION; GENE LOSS; KNOCKOUT MOUSE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; PLACENTA; PLACENTA CIRCULATION; PLACENTAL TRANSFER; PRIORITY JOURNAL; TETRAPLOIDY; TRANSGENIC MOUSE; TROPHOBLAST; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL DIVISION; CELL LINEAGE; EMBRYO; EMBRYO LOSS; FATTY ACIDS; FEMALE; FETUS; GENE DELETION; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, KNOCKOUT; PLACENTA; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; TROPHOBLASTS;

ANIMALIA; MUS MUSCULUS;

EID: 0037468222     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01417     Document Type: Article

References (29)

1. Nevins, J. R. The Rb/E2F pathway and cancer. Hum. Mol. Genet. 10, 699-703 (2001).
2. Lee, E. Y. et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359, 288-294 (1992).
3. Jacks, T. et al. Effects of an Rb mutation in the mouse. Nature 359, 295-300 (1992).
4. Clarke, A. R. et al. Requirement for a functional Rb-1 gene in murine development. Nature 359, 328-330 (1992).
5. Zhang, P., Wong, C., DePinho, R. A., Harper, J. W. & Elledge, S. J. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control oftissue growth and development. Genes Dev. 12, 3162-3167 (1998).
6. Faria, T. N., Ogren, L., Talamantes, F., Linzer, D. 1. H. & Soares, M. J. Localization of placental lactogen-I in trophoblast giant cells of the mouse placenta. Biol. Reprod. 44, 327-331 (1991).
7. Linzer, D. I., Lee, S. J., Ogren, L., Talamantes, F. & Nathans, D. Identification of proliferin mRNA and protein in mouse placenta. Proc. Natl. Acad. Sci. USA 82, 4356-4359 (1985).
8. Lescisin, K. R.,Varmuza, S. & Rossant, J. Isolation and characterization of a novel trophoblast-specific cDNA in the mouse. Genes Dev. 2, 1639-1646 (1988).
9. Russ, A. P. et al. Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature 404, 95-99 (2000).
10. Tanaka, S., Kunath, T., Hadjantonakis, A. K., Nagy, A. & Rossant, J. Promotion oftrophoblast stem cell proliferation by FGF4. Science 282, 2072-2075 (1998).
11. Metcalfe, L. D., Schmitz, A. A. & Pelka, J. R. Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal. Chem. 38, 514-515 (1966).
12. James, R. M., Klerkx, A. H., Keighren, M., Flockhart, J. H. & West, J. D. Restricted distribution of tetraploid cells in mouse tetraploid ↔ diploid chimaeras. Dev. Biol. 167, 213-226 (1995).
13. Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J. & Berns, A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14, 994-1004 (2000).
14. Tallquist, M. D. & Soriano, P. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis J. Genet Dev. 26, 113-115 (2000).
15. Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet. 21, 70-71 (1999).
16. Lipinski, M. M. & Jacks, T. The retinoblastoma gene family in differentiation and development. Oncogene 18, 7873-7882 (1999).
17. Copp, A. J. Death before birth: clues from gene knockouts and mutations. Trends Genet. 11, 87-93 (1995).
18. Cross, J. C., Werb, Z. & Fisher, S. J. Implantation and the placenta: key pieces of the development puzzle. Science 266, 1508-1518 (1994).
19. Lipinski, M. M. et al. Cell-autonomous and non-cell-autonomous functions of the Rb tumour suppressor in developing central nervous system. EMBO J. 20, 3402-3413 (2001).
20. Maandag, E. C. et al. Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J. 13, 4260-4268 (1994).
21. Williams, B. O. et al. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 13, 4251-9425 (1994).
22. Zacksenhaus, E. et al. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10, 3051-3064 (1996).
23. Tsai, K. Y. et al. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2, 293-304 (1998).
24. Ziebold, U., Reza, T., Caron, A. & Lees, J. A. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev. 15, 386-391 (2001).
25. Lasorella, A., Noseda, M., Beyna, M., Yokota, Y. & Iavarone, A. ld2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature 407, 592-598 (2000).
26. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. & Roder, J. C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428 (1993).
27. Hogan, B., Beddington, R., Costantini, E. & Lacy, E. Manipulating the Mouse Embryo: a Laboratory Manual (Cold Spring Harbor Laboratory Press, Plainview, New York, 1994).
28. Kurz, H., Zechner, U., Orth, A. & Fundele, R. Lack of correlation between placenta and offspring size in mouse interspecific crosses. Anat. Embryol. 200, 335-343 (1999).
29. Anson-Cartwright, L. et al. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Nature Genet. 25, 311-314 (2000).