Tetracycline-inducible expression systems: New strategies and practices in the transgenic mouse modeling

Acta Biochimica et Biophysica Sinica

Volumn 39, Issue 4, 2007, Pages 235-246

  Sun, Yan ^a,b   Chen, Xigu ^a   Xiao, Dong ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Cre lox P system; Leaky expression; Lineage specific gene expression; Lineage specific RNAi; Stringent control; Tetracycline inducible expression system; Transgenic mouse modeling

Indexed keywords

CRE RECOMBINASE; INTEGRASE; LOX PROTEIN, MOUSE; PROTEIN LYSINE 6 OXIDASE; SCLEROPROTEIN; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENE VECTOR; GENETIC PROCEDURES; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MOUSE; SHORT SURVEY; TRANSACTIVATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TECHNIQUES; GENETIC VECTORS; HUMANS; INTEGRASES; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; PROTEIN-LYSINE 6-OXIDASE; TETRACYCLINES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 34247191950     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2007.00258.x     Document Type: Short Survey

References (64)

1. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992, 89: 5547-5551
2. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995, 268: 1766-1769
3. Albanese C, Hulit J, Sakamaki T, Pestell RG. Recent advances in inducible expression in transgenic mice. Semin Cell Dev Biol 2002, 13: 129-141
4. Bockamp E, Maringer M, Spangenberg C, Fees S, Fraser S, Eshkind L, Oesch F et al. Of mice and models: Improved animal models for biomedical research. Physiol Genomics 2002, 11: 115-132
5. Lewandoski M. Conditional control of gene expression in the mouse. Nat Rev Genet 2001, 2: 743-755
6. Ryding AD, Sharp MG, Mullins JJ. Conditional transgenic technologies. J Endocrinol 2001, 171: 1-14
7. van der Weyden L, Adams DJ, Bradley A. Tools for targeted manipulation of the mouse genome. Physiol Genomics 2002, 11: 133-164
8. Baron U, Bujard H. Tet repressor-based system for regulated gene expression in eukaryotic cells: Principles and advances. Methods Enzymol 2000, 327: 401-421
9. Berens C, Hillen W. Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem 2003, 270: 3109-3121
10. Xiao D, Sun Y, Gu WW, Chen XG. Tetracycline-controlled transcriptional regulation systems: Countermeasures to eliminate basal transgene leak of Tet-based systems. Progress in Natural Science 2007, 17: 11-19
11. Zhu Z, Zheng T, Lee CG, Homer RJ, Elias JA. Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin Cell Dev Biol 2002, 13: 121-128
12. Xiao D, Xu K, Yue Y, Guo ZM, Huang B, Deng XY, Tang H et al. Temporal and tight hepatitis C virus gene activation in cultured human hepatoma cells mediated by a cell-permeable Cre recombinase. Acta Biochim Biophys Sin 2004, 36: 687-694
13. Zhu Z, Ma B, Homer RJ, Zheng T, Elias JA. Use of the tetracyclinecontrolled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J Biol Chem 2001, 276: 25222-25229
14. Belteki G, Haigh J, Kabacs N, Haigh K, Sison K, Costantini F, Whitsett J et al. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 2005, 33: e51
15. Mao J, Barrow J, McMahon J, Vaughan J, McMahon AP. An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res 2005, 33: e155
16. Miyazaki S, Miyazaki T, Tashiro F, Yamato E, Miyazaki J. Development of a single-cassette system for spatiotemporal gene regulation in mice. Biochem Biophys Res Commun 2005, 338: 1083-1088
17. Yu HM, Liu B, Chiu SY, Costantini F, Hsu W. Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci USA 2005, 102: 8615-8620
18. Nagy A. Cre recombinase: The universal reagent for genome tailoring. Genesis 2000, 26: 99-109
19. Sauer B. Inducible gene targeting in mice using the Cre/lox system. Methods 1998, 14: 381-392
20. Lee P, Morley G, Huang Q, Fischer A, Seiler S, Horner JW, Factor S et al. Conditional lineage ablation to model human diseases. Proc Natl Acad Sci USA 1998, 95: 11371-11376
21. Wakita T, Taya C, Katsume A, Kato J, Yonekawa H, Kanegae Y, Saito I et al. Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system. J Biol Chem 1998, 273: 9001-9006
22. Machida K, Tsukiyama-Kohara K, Seike E, Tone S, Shibasaki F, Shimizu M, Takahashi H et al. Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. J Biol Chem 2001, 276: 12140-12146
23. Takaku S, Nakagawa Y, Shimizu M, Norose Y, Maruyama I, Wakita T, Takanot et al. Induction of hepatic injury by hepatitis C virus-specific CD8+ murine cytotoxic T lymphocytes in transgenic mice expressing the viral structural genes. Biochem Biophys Res Commun 2003, 301: 330-337
24. Wakita T, Katsume A, Kato J, Taya C, Yonekawa H, Kanegae Y, Saito I et al. Possible role of cytotoxic T cells in acute liver injury in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system. J Med Virol 2000, 62: 308-317
25. Chisari FV, Pinkert CA, Milich DR. A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science 1985, 230:1157-1160
26. Tan WJ, Chen G, Li GS, Cong Y, Miao J, Du M, Zhan MY. Production of three transgenic mouse lineages which simultaneously carries structural gene and/or nonstructural gene3 (NS3) region of hepatitis C virus. Prog Biochem Biophys 1998, 25: 279-282
27. Tan WJ, Lang ZW, Cong Y, Yi Y, Zhan MY. Transgenic expression of hepatitis C virus core and NS3 proteins in the mouse is not cytopathic. Chinese Journal of Virology 1998, 14: 302-306
28. Dandri M, Lutgehetmann M, Volz T, Petersen J. Small animal model systems for studying hepatitis B virus replication and pathogenesis. Seminars In Liver Disease 2006, 26: 181-191
29. Milich DR. Transgenic technology and the study of hepatitis viruses: A review of what we have learned. Can J Gastroenterol 2000, 14: 781-787
30. Akbar SK, Onji M. Hepatitis B virus (HBV)-transgenic mice as an investigative tool to study immunopathology during HBV infection. Int J Exp Pathol 1998, 79: 279-291
31. Feitelson MA, Larkin JD. New animal models of hepatitis B and C. ILAR J 2001, 42: 127-138
32. Barde I, Zanta-Boussif MA, Paisant S, Leboeuf M, Rameau P, Delenda C, Danos O. Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector. Mol Ther 2006, 13: 382-390
33. Bornkamm GW, Berens C, Kuklik-Roos C, Bechet JM, Laux G, Bachl J, Korndoerfer M et al. Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res 2005, 33: e137
34. Epanchintsev A, Jung P, Menssen A, Hermeking H. Inducible microRNA expression by an all-in-one episomal vector system. Nucleic Acids Res 2006, 34: e119
35. Knott A, Garke K, Urlinger S, Guthmann J, Muller Y, Thellmann M, Hillen W. Tetracycline-dependent gene regulation: Combinations of transregulators yield a variety of expression windows. Biotechniques. 2002, 32: 796, 798, 800
36. Koponen JK, Kankkonen H, Kannasto J, Wirth T, Hillen W, Bujard H, Yla-Herttuala S. Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo. Gene Ther 2003, 10: 459-466
37. Mizuguchi H, Xu ZL, Sakurai F, Mayumi T, Hayakawa T. Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions. Hum Gene Ther 2003, 14: 1265-1277
38. Salucci V, Scarito A, Aurisicchio L, Lamartina S, Nicolaus G, Giampaoli S, Gonzalez-Paz O et al. Tight control of gene expression by a helperdependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system. Gene Ther 2002, 9: 1415-1421
39. Lena AM, Giannetti P, Sporeno E, Ciliberto G, Savino R. Immune responses against tetracycline-dependent transactivators affect long-term expression of mouse erythropoietin delivered by a helper-dependent adenoviral vector. J Gene Med 2005, 7: 1086-1096
40. Schonig K, Schwenk F, Rajewsky K, Bujard H. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res 2002, 30: e134
41. Wilkinson J 4th, Di X, Schonig K, Buss JL, Kock ND, Cline JM, Saunders TL et al. Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo. Biochem J 2006, 395: 501-507
42. Kerrison JB, Duh EJ, Yu Y, Otteson DC, Zack DJ. A system for inducible gene expression in retinal ganglion cells. Invest Ophthalmol Vis Sci 2005, 46: 2932-2939
43. S-M2 system. Genesis 2005, 43: 205-212
44. Mallo M, Kanzler B, Ohnemus S. Reversible gene inactivation in the mouse. Genomics 2003, 81: 356-360
45. Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W. Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA 2000, 97: 7963-7968
46. Freundlieb S, Schirra-Muller C, Bujard H. A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells. J Gene Med 1999, 1: 4-12
47. Overbeek PA. Factors affecting transgenic animal production. In: Pinkert CA ed. Transgenic Animal Technology: A Laboratory Handbook. San Diego: Academic Press Inc 1994
48. Schultze N, Burki Y, Lang Y, Certa U, Bluethmann H. Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice. Nat Biotechnol 1996, 14: 499-503
49. Juhila J, Roozendaal R, Lassila M, Verbeek SJ, Holthofer H. Podocyte cellspecific expression of doxycycline inducible Cre recombinase in mice. J Am Soc Nephrol 2006, 17: 648-654
50. Lottmann H, Vanselow J, Hessabi B, Walther R. The Tet-On system in transgenic mice: Inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells. J Mol Med 2001, 79: 321-328
51. Utomo AR, Nikitin AY, Lee WH. Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nat Biotechnol 1999, 17: 1091-1096
52. Coumoul X, Deng CX. RNAi in mice: A promising approach to decipher gene functions in vivo. Biochimie 2006, 88: 637-643
53. Coumoul X, Li W, Wang RH, Deng C. Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system. Nucleic Acids Res 2004, 32: e85
54. Fritsch L, Martinez LA, Sekhri R, Naguibneva I, Gerard M, Vandromme M, Schaeffer L et al. Conditional gene knock-down by CRE-dependent short interfering RNAs. EMBO Rep 2004, 5: 178-182
55. Kasim V, Miyagishi M, Taira K. Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res 2004, 32: e66
56. Tiscornia G, Tergaonkar V, Galimi F, Verma IM. CRE recombinaseinducible RNA interference mediated by lentiviral vectors. Proc Natl Acad Sci USA 2004, 101: 7347-7351
57. Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R et al. Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci USA 2004, 101: 10380-10385
58. Yu J, McMahon AP. Reproducible and inducible knockdown of gene expression in mice. Genesis 2006, 44: 252-261
59. Coumoul X, Shukla V, Li C, Wang RH, Deng CX. Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res 2005, 33: e102
60. De Souza AT, Dai X, Spencer AG, Reppen T, Menzie A, Roesch PL, He Y et al. Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice. Nucleic Acids Res 2006, 34: 4486-4494
61. Xia XG, Zhou H, Samper E, Melov S, Xu Z. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet 2006, 2: e10
62. Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D et al. Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet 2005, 37: 1281-1288
63. Li MZ, Elledge SJ. MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules. Nat Genet 2005, 37: 311-319
64. Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci USA 2005, 102: 13212-13217