Proinsulin misfolding and diabetes: Mutant INS gene-induced diabetes of youth

Trends in Endocrinology and Metabolism

Volumn 21, Issue 11, 2010, Pages 652-659

  Liu, Ming ^a   Hodish, Israel ^a   Haataja, Leena ^a   Lara Lemus, Roberto ^a   Rajpal, Gautam ^a   Wright, Jordan ^a   Arvan, Peter ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PREPROINSULIN; PROINSULIN; SIGNAL PEPTIDE;

ALLELE; CELL DEATH; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EPIGENETICS; GENE MUTATION; GENE SEQUENCE; GOLGI COMPLEX; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN SYNTHESIS; MOLECULAR INTERACTION; MUTANT INS GENE INDUCED DIABETES OF YOUTH; PANCREAS ISLET BETA CELL; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FOLDING; PROTEIN MISFOLDING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM; HUMANS; INSULIN-SECRETING CELLS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PROINSULIN; PROTEIN FOLDING; PROTEOSTASIS DEFICIENCIES;

EID: 78049281798     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2010.07.001     Document Type: Review

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