Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

Diabetes

Volumn 61, Issue 4, 2012, Pages 828-837

  Liu, Ming ^a,b   Lara Lemus, Roberto ^a   Shan, Shu Ou ^c   Wright, Jordan ^a   Haataja, Leena ^a   Barbetti, Fabrizio ^d   Guo, Huan ^a   Larkin, Dennis ^a   Arvan, Peter ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c California Institute of Technology   (United States)

^d BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PREPROINSULIN; PROINSULIN; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL SUBPOPULATION; CONTROLLED STUDY; DIABETES MELLITUS; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; GENE MUTATION; GLUCOSE HOMEOSTASIS; HETEROZYGOSITY; HUMAN; HUMAN CELL; INSULIN METABOLISM; INSULIN SYNTHESIS; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENES, DOMINANT; HUMANS; INSULIN; MICE; MUTATION; PROTEIN PRECURSORS; PROTEIN SORTING SIGNALS; RATS;

EID: 84859550168     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0878     Document Type: Article

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